Transplant - Cardiovascular Update

Boston Children's performs elective partial heart transplant

Becker's Hospital Review - Cardiology

AUGUST 2, 2024

Discover the groundbreaking work of Boston Children's cardiac surgeons as they perform the first elective partial heart transplant on a 4-year-old boy

Heart Transplant

Heart Transplant Transplant

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. We showed selective and sustainable Treg expansion by mIL-2 in 2 murine models of skin transplantation.

Transplant

Transplant Outcomes

Timely Skin Cancer Screening After Organ Transplant Still Lacking

Med Page Today

SEPTEMBER 26, 2024

(MedPage Today) -- Recent skin cancer risk stratification guidelines did not improve rates of timely dermatologic follow-up visits among solid organ transplant recipients, according to an analysis of claims data. The rate of post-transplant dermatology.

Transplant

Transplant Cancer

Cedars-Sinai Cardiologist Leads the American Society of Transplantation

DAIC

JULY 3, 2024

Jon Kobashigawa, MD, of the Smidt Heart Institute at Cedars-Sinai, is an expert in heart transplantation, heart failure, and other complex cardiac conditions. Kobashigawa will also represent the American Society of Transplantation in discussions with government agencies and policymakers about organ transplant legislation. “Dr.

Transplant

Transplant Heart Transplant Heart Failure Education

Donated Heart Valves Still Growing a Year After World's 1st Partial Heart Transplant

Med Page Today

JANUARY 2, 2024

(MedPage Today) -- The newborn that received the world's first partial heart transplant in 2022 continued to do well a year later, according to a case report from the transplant team. Born with type A2 persistent truncus arteriosus and irreparable.

Heart Transplant

Heart Transplant Transplant Heart Valves

Too Ill for Typical Transplants, Woman Gets a Pig Kidney and Heart Pump Instead

Med Page Today

APRIL 24, 2024

(MedPage Today) -- A 54-year-old New Jersey woman has become the first-ever patient to undergo combined mechanical heart pump and gene-edited pig kidney transplant surgery, doctors announced. The patient, Lisa Pisano, had heart failure and end.

Transplant

Transplant Heart Failure

AI tools better at predicting heart transplant rejection than standard clinical method, finds study

Medical Xpress - Cardiology

FEBRUARY 15, 2024

More than 4,500 heart transplants were performed in the U.S. While the lifesaving operation improves the quality of life and longevity for most recipients, organ rejection remains a risk, with acute rejection occurring in up to 32% of recipients within the first year.

Heart Transplant

Heart Transplant Transplant Quality of Life

Risk Factors for IgA Nephropathy Recurrence After Kidney Transplant

HCPLive

JANUARY 10, 2024

Younger age at the time of kidney transplantation, faster progression to end-stage renal disease, a history of kidney transplantation, and no induction therapy were associated with IgAN recurrence, which was linked to poorer graft survival.

Transplant

Transplant Risk Factors

Iron Deficiency Linked to Poor Outcomes in Kidney Transplant Recipients

HCPLive

MARCH 19, 2024

Iron deficiency, independent of anemia, may be a potentially modifiable target to improve patient-reported outcomes after kidney transplantation.

Transplant

Transplant Outcomes

Revolutionary Genomic Study Sheds Light on Immune Microenvironment in Transplanted Pediatric Hearts

DAIC

FEBRUARY 13, 2024

© THE TEXAS HEART INSTITUTE 2024 milla1cf Tue, 02/13/2024 - 17:56 February 13, 2024 — Pediatric heart transplantation has long been hailed as a life-saving intervention for children suffering from end-stage heart failure. This helps us gain a comprehensive understanding of the immune response dynamics within transplanted hearts."

Transplant

Transplant Pediatrics Heart Transplant Research

Geovanni Faddoul, MD: IgAN Recurrence After Kidney Transplantation

HCPLive

JANUARY 22, 2024

Geovanni Faddoul, MD, discusses findings from his recent study examining the impact of induction and maintenance therapy on IgAN recurrence, graft survival, and mortality in kidney transplantation.

Transplant

NBA Champion, 'Survivor' Contestant Receives Heart Transplant

Med Page Today

FEBRUARY 23, 2024

(MedPage Today) -- NBA champion and "Survivor" contestant Scot Pollard is "awake and feeling great" a day after a heart transplant, his wife said Saturday on social media. Scot has a new heart!" Dawn Pollard posted Friday night on X, formerly.

Heart Transplant

Heart Transplant Transplant

Phosphatidylethanol Aids Detection of Alcohol Relapse Post-Liver Transplant

HCPLive

NOVEMBER 5, 2024

Alcohol relapses were detected more frequently after the introduction of phosphatidylethanol in orthotopic liver transplant recipients.

Transplant

Policy Changes Boost Survival in Pediatric Liver Transplants

HCPLive

OCTOBER 15, 2024

The study found that, following gradual policy changes, children with acute liver failure requiring a transplant now face a reduced risk of both mortality and graft failure from 1989.

Transplant

Transplant Pediatrics

Normothermic perfusion system extends life of organs waiting for transplant

Science Daily - Heart Disease

MAY 16, 2024

In the United States, about 30-40% of donor hearts aren't considered for transplant due to inadequate function in the donor. This leads to a drop in the number of donated hearts that are available to be matched with someone who needs a heart transplant.

Transplant

Transplant Heart Transplant

Neighborhood Segregation Linked to Racial Disparities in Access to Live Donor Kidney Transplantation

HCPLive

FEBRUARY 19, 2024

Findings suggest segregated residential and transplant center neighborhoods contribute to racial disparities in access to living donor kidney transplantation.

Transplant

New York hospital performs 1st 'domino' heart transplant on babies

Becker's Hospital Review - Cardiology

JANUARY 18, 2024

New York City-based NewYork-Presbyterian Morgan Stanley Children's Hospital performed the first "domino" heart transplant on babies, according to an American Hospital Association report.

Heart Transplant

Heart Transplant Transplant Hospital

Normothermic Machine Perfusion Shows Promise in High-Acuity Liver Transplants

HCPLive

NOVEMBER 5, 2024

Normothermic machine perfusion in liver transplants improves preservation, reduces early complications, and shows promise in complex cases.

Transplant

Pegcetacoplan Offers Potential Benefit in Post-Transplant C3G, IC-MPGN

HCPLive

MAY 26, 2024

The phase 2 NOBLE trial shows pegcetacoplan reduces disease activity in post-transplant C3G and IC-MPGN, with benefits persisting through the 40-week double-blind period.

Transplant

Trauma History Linked to Reduced Access to Liver Transplant in Women

HCPLive

AUGUST 26, 2024

A study found that women with trauma history have reduced liver transplant access compared to men, with gender disparities not driven by psychiatric symptoms.

Transplant

World's first partial heart transplant proves successful in first year

Medical Xpress - Cardiology

JANUARY 3, 2024

The world's first partial heart transplant has achieved what researchers have spent more than a year hoping for—functioning valves and arteries that grow along with the young patient, as hypothesized by the pioneering team behind the procedure at Duke Health.

Heart Transplant

Heart Transplant Transplant Research

Heart transplantation and biomarkers: a review about their usefulness in clinical practice

Frontiers in Cardiovascular Medicine

JANUARY 23, 2024

Advanced heart failure (AdvHF) can only be treated definitively by heart transplantation (HTx), yet problems such right ventricle dysfunction (RVD), rejection, cardiac allograft vasculopathy (CAV), and primary graft dysfunction (PGD) are linked to a poor prognosis.

Heart Transplant

Heart Transplant Biomarkers Transplant Heart Failure

Prolonged Perfusion Preserves Donor Livers, Allows Flexible Transplantation Timeline

HCPLive

JANUARY 12, 2024

Liver transplantation after prolonged preservation with dual hypothermic oxygenated machine perfusion yielded similar outcomes to standard perfusion, showing no compromised donor liver quality and equal safety for recipients.

Transplant

Transplant Outcomes

Study Details Impact of Pancreas Transplantation on Kidney Function

HCPLive

DECEMBER 19, 2023

More than half of patients who received a pancreas transplant alone experienced >50% decline in eGFR, had eGFR < 30 mL/min/1.73 m2, and/or received a kidney transplant 10 years after their initial pancreas transplant.

Transplant

Mitochondrial transplantation: the advance to therapeutic application and molecular modulation

Frontiers in Cardiovascular Medicine

DECEMBER 14, 2023

Mitochondrial transplantation provides a novel methodology for rescue of cell viability and cell function following ischemia-reperfusion injury and applications for other pathologies are expanding. In this review we present our methods and acquired data and evidence accumulated to support the use of mitochondrial transplantation.

Transplant

Transplant Ischemia

HCV Recurrence Unlikely Post-Renal Transplant After DAA Treatment Response

HCPLive

MARCH 1, 2024

of patients who were treated for HCV with DAA therapy and underwent renal transplantation did not experience HCV recurrence. Results showed 95.8%

Transplant

Iron Therapy Underutilized in Post-Kidney Transplant Anemia, Study Finds

HCPLive

OCTOBER 7, 2024

This retrospective analysis examined the current management of early and late anemia in a representative sample of the kidney transplant population in Spain.

Transplant

Artificially transplanted mitochondria in endothelial cells promote mitophagy

Nature Reviews - Cardiology

MAY 20, 2024

Nature Reviews Cardiology, Published online: 21 May 2024; doi:10.1038/s41569-024-01041-x A study in Nature describes a single-cell-type strategy for vascular cell therapies that involves the artificial transplantation of mitochondria to endothelial cells, which promotes mitophagy and facilitates the formation of functional vessels in ischaemic tissue (..)

Transplant

Heplisav-B Vaccine Bests Standard 3-Dose Series in Heart, Lung Transplant Candidates

HCPLive

SEPTEMBER 24, 2024

Heplisav-B provided a greater vaccine completion rate and higher HBV seroprotection than the conventional 3-dose Recombivax HB in thoracic organ transplant candidates.

Transplant

Transplant Advocates Sound Alarm Over Proposed Medicare Test Coverage Policy

Med Page Today

DECEMBER 6, 2023

(MedPage Today) -- WASHINGTON -- Heart transplant patient Eddie Garcia was "feeling like a million bucks" one day in the summer of 2021. He had just gotten back from a 3-mile walk, something he couldn't do prior to his transplant in 2020 -.

Transplant

Transplant Medicare Heart Transplant

Machine Perfusion Could Help Address Transplant Crisis for Pediatric Liver Diseases

HCPLive

NOVEMBER 9, 2024

New data from the UNOS database presented at NASPGHAN 2024 details characteristics and outcomes of pediatric liver transplant patients receiving machine perfused organs.

Transplant

Transplant Pediatrics Outcomes

Do Organ Transplants Cause Personality Changes?

Med Page Today

FEBRUARY 22, 2024

(MedPage Today) -- I have received some unusual phone calls in my nearly 40-year career as a psychiatrist, but Mary's* call was unique. "Dr. Liester," she began, "I don't need to see you as a patient. I just want you to tell me if I'm crazy.

Transplant

Updating allocation algorithms could help donor hearts reach the transplant patients who need them most

Medical Xpress - Cardiology

FEBRUARY 13, 2024

Receiving a heart transplant is a matter of life and death for many patients. Every time a heart becomes available, a "match run" is created to generate a list of transplant candidates ranked by an algorithm based on medical urgency, geography and pediatric status.

Transplant

Transplant Heart Transplant Pediatrics

Longitudinal analysis of viral dynamics in HIV+-to-HIV+ HOPE Act kidney-transplant recipients

Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

These donor-derived env sequences were amplified from recipient urine, urine-derived renal epithelial cells, and plasma between 12 and 96 hours after transplant and remained detectable up to 16 days after transplant. years after transplantation as a result of antiretroviral therapy (ART) interruption.

Transplant

Transplant Kidney Disease Diabetes

Better transplantations with 'heart-in-a-box': Study finds method reduces early heart failure risk

Medical Xpress - Cardiology

AUGUST 16, 2024

The risk of early heart failure after heart transplantation is lower if the donor heart is stored in a so-called heart-in-a-box instead of in the usual cooler with ice. This is according to a study by researchers at the University of Gothenburg.

Transplant

Transplant Heart Failure Heart Transplant Research

Usefulness Questioned for Transplant Center Report Cards

Med Page Today

APRIL 11, 2024

(MedPage Today) -- Public report cards for heart transplant centers are under fire for not being meaningful -- potentially even misrepresentative of care quality -- as a given center's ratings may vary wildly from year to year, a study found.

Transplant

Transplant Heart Transplant

Vanderbilt, Deaconess open transplant, heart failure clinic

Becker's Hospital Review - Cardiology

DECEMBER 20, 2023

based Vanderbilt Transplant Center partnered with Evansville, Ind.-based based Deaconess Health System to open a new transplant clinic in Newburgh, Ind. Nashville, Tenn.-based

Transplant

Transplant Heart Failure

Pulmonary transplant complications: a radiologic review

Journal of Cardiothoracic Surgery

MAY 2, 2024

Lung transplantation has become the definitive treatment for end stage respiratory disease. Numbers and survival rates have increased over the past decade, with transplant recipients living longer and with gre.

Transplant

Transplant Pulmonary

Cardiovascular Risk Stratification of Patients Undergoing Hematopoietic Stem Cell Transplantation: The CARE?BMT Risk Score

Journal of the American Heart Association

DECEMBER 29, 2023

BackgroundEvidence guiding the pre‐hematopoietic stem cell transplantation (HSCT) cardiovascular evaluation is limited. The score was externally validated in a separate cohort of 919 HSCT recipients (mean age at transplant 54 years; 20.4%

Transplant

Transplant Peripheral Arterial Disease Coronary Artery Disease Myocardial Infarction

Felzartamab Proves Safety, Potential for Therapeutic Benefit on Antibody-Mediated Rejection Following Kidney Transplant

HCPLive

MAY 25, 2024

Hear from Katharina Mayer, MD, and Georg Böhmig, MD, on the results of the phase 2 trial of felzartamab in patients with antibody-mediated rejection following kidney transplantation.

Transplant

Katie Ross-Driscoll, PhD, MPH: Disparities in Liver Transplant Referral, Evaluation

HCPLive

JUNE 20, 2024

Ross-Driscoll explains how disparities in the liver transplant process begin prior to waitlisting and how findings from her research on referral and evaluation may inform interventions.

Transplant

Transplant Research

Duke reports success in world's 1st partial heart transplant

Becker's Hospital Review - Cardiology

JANUARY 2, 2024

Nearly a year after a newborn received the world's first partial heart transplant, the transplanted valves and arteries are functioning well and growing along with the child's heart — a key measure of success in the procedure paving the way for future advancements.

Heart Transplant

Heart Transplant Transplant

Heart transplant patients from socioeconomically deprived areas face higher risk for postoperative complications, earlier death than others

Science Daily - Heart Disease

SEPTEMBER 30, 2024

Heart transplant patients who live in socioeconomically disadvantaged areas are more likely to experience post-surgical complications and die within five years than patients who live in more advantaged areas, even when those patients were transplanted at topnotch high-volume hospitals.

Heart Transplant

Heart Transplant Transplant Hospital

Oklahoma hospital opens state's 1st pediatric heart transplant program

Becker's Hospital Review - Cardiology

MARCH 6, 2024

Oklahoma City-based Oklahoma Children's Hospital is the first in the state to open a pediatric heart transplant program, ABC affiliate KOCO reported March 5.

Heart Transplant

Heart Transplant Transplant Pediatrics Hospital

Boston Children's performs elective partial heart transplant

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models

Timely Skin Cancer Screening After Organ Transplant Still Lacking

Cedars-Sinai Cardiologist Leads the American Society of Transplantation

Donated Heart Valves Still Growing a Year After World's 1st Partial Heart Transplant

Too Ill for Typical Transplants, Woman Gets a Pig Kidney and Heart Pump Instead

AI tools better at predicting heart transplant rejection than standard clinical method, finds study

Risk Factors for IgA Nephropathy Recurrence After Kidney Transplant

Iron Deficiency Linked to Poor Outcomes in Kidney Transplant Recipients

Revolutionary Genomic Study Sheds Light on Immune Microenvironment in Transplanted Pediatric Hearts

Geovanni Faddoul, MD: IgAN Recurrence After Kidney Transplantation

NBA Champion, 'Survivor' Contestant Receives Heart Transplant

Phosphatidylethanol Aids Detection of Alcohol Relapse Post-Liver Transplant

Policy Changes Boost Survival in Pediatric Liver Transplants

Normothermic perfusion system extends life of organs waiting for transplant

Neighborhood Segregation Linked to Racial Disparities in Access to Live Donor Kidney Transplantation

New York hospital performs 1st 'domino' heart transplant on babies

Normothermic Machine Perfusion Shows Promise in High-Acuity Liver Transplants

Pegcetacoplan Offers Potential Benefit in Post-Transplant C3G, IC-MPGN

Trauma History Linked to Reduced Access to Liver Transplant in Women

World's first partial heart transplant proves successful in first year

Heart transplantation and biomarkers: a review about their usefulness in clinical practice

Prolonged Perfusion Preserves Donor Livers, Allows Flexible Transplantation Timeline

Study Details Impact of Pancreas Transplantation on Kidney Function

Mitochondrial transplantation: the advance to therapeutic application and molecular modulation

HCV Recurrence Unlikely Post-Renal Transplant After DAA Treatment Response

Iron Therapy Underutilized in Post-Kidney Transplant Anemia, Study Finds

Artificially transplanted mitochondria in endothelial cells promote mitophagy

Heplisav-B Vaccine Bests Standard 3-Dose Series in Heart, Lung Transplant Candidates

Transplant Advocates Sound Alarm Over Proposed Medicare Test Coverage Policy

Machine Perfusion Could Help Address Transplant Crisis for Pediatric Liver Diseases

Do Organ Transplants Cause Personality Changes?

Updating allocation algorithms could help donor hearts reach the transplant patients who need them most

Longitudinal analysis of viral dynamics in HIV+-to-HIV+ HOPE Act kidney-transplant recipients

Better transplantations with 'heart-in-a-box': Study finds method reduces early heart failure risk

Usefulness Questioned for Transplant Center Report Cards

Vanderbilt, Deaconess open transplant, heart failure clinic

Pulmonary transplant complications: a radiologic review

Cardiovascular Risk Stratification of Patients Undergoing Hematopoietic Stem Cell Transplantation: The CARE?BMT Risk Score

Felzartamab Proves Safety, Potential for Therapeutic Benefit on Antibody-Mediated Rejection Following Kidney Transplant

Katie Ross-Driscoll, PhD, MPH: Disparities in Liver Transplant Referral, Evaluation

Duke reports success in world's 1st partial heart transplant

Heart transplant patients from socioeconomically deprived areas face higher risk for postoperative complications, earlier death than others

Oklahoma hospital opens state's 1st pediatric heart transplant program

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