Fri.Dec 20, 2024

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Using an AI tool, researchers find poor vascular health accelerates brain aging

Medical Xpress - Cardiology

Using an AI tool, researchers at Karolinska Institutet have analyzed brain images from 70-year-olds and estimated their brains' biological age. They found that factors detrimental to vascular health, such as inflammation and high glucose levels, are associated with an older-looking brain, while healthy lifestyles were linked to brains with a younger appearance.

Research 107
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Can the heart heal itself? New study says it can

Science Daily - Heart Disease

Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.

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First dual chamber leadless pacemaker implanted in a child

Medical Xpress - Cardiology

UC Davis Director of Pediatric Electrophysiology Dan Cortez has set another world record: He is the first to implant a dual chamber leadless pacemaker in a child. His case report was published this week in the journal Pacing and Clinical Electrophysiology.

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Chest pain and rapid pacing followed by an unexplained wide complex tachycardia. Time for cardioversion?

Dr. Smith's ECG Blog

Written by Willy Frick with edits by Ken Grauer An older man with a history of non-ischemic HFrEF s/p CRT and mild coronary artery disease presented with chest pain. He said he had had three episodes of chest pain that day while urinating. The following ECG was obtained in the emergency department during active chest pain. ECG 1 What do you think? There is a lot going on in this ECG.

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FDA Issues CRL for Sotagliflozin in Type 1 Diabetes and CKD

HCPLive

The FDA's decision not to approve sotagliflozin as an adjunct in T1D and CKD comes less than 2 months after a negative advisory committee meeting for the application.

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Best Supplements For Heart Health.

Dr. Paddy Barrett

As a cardiologist, I am frequently asked about supplements and heart health. In general, I am not a fan. Personally, I take two supplements. Whey protein for hitting my daily protein targets. Creatine for improving exercise performance and muscle mass. Neither of these supplements is for improving ‘heart health’ During the winter months, I will occasionally take vitamin D if my levels are low, but generally, if I get enough time outside, even during the winter months, I do not need t

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FDA Approves Tirzepatide for Obstructive Sleep Apnea in Obesity

HCPLive

Tirzepatide's approval marks the first and only prescription medicine available for adults with moderate-to-severe obstructive sleep apnea and obesity.

Obesity 59

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Study Highlights Necessity of Image Quality for Deep Learning Model Diagnostic Success

HCPLive

These data resulted from an investigation of the effect of varying image qualities on the diagnostic abilities of a convolutional neural network (CNN) model and clinicians.

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Evaluation of Ventricular Ectopic Beats

All About Cardiovascular System and Disorders

Most of the time ventricular ectopics are quite benign, especially if there is no associated structural heart disease. Occasionally they can be dangerous, mainly if associated with structural heart disease. Sometimes ventricular ectopy can be the forerunner of malignant ventricular arrhythmia.

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FDA Approves First Acellular Tissue Vessel Therapy for Extremity Vascular Trauma

HCPLive

The ATEV therapy, named Symvess, provides revascularization when autologous vein graft or implantation of a synthetic graft is not feasible.

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Are Antibiotics Linked to Dementia? New Study Weighs In

Med Page Today

(MedPage Today) -- Antibiotic use didn't raise the risk of dementia in healthy older adults, a prospective study suggested. Over about 5 years of follow-up, antibiotic use was not tied to higher dementia incidence (HR 1.03, 95% CI 0.84-1.25) compared.

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Advancing the Diagnostic Criteria for Multiple Sclerosis: A New Era of Early Detection and Precision

HCPLive

With new revisions of the MS diagnostic criteria being made, clinicians highlighted key updates and the broader implications it has for diagnosis, treatment, and healthcare practices worldwide.

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First Drug Approved for Familial Chylomicronemia Syndrome

Med Page Today

(MedPage Today) -- The FDA approved olezarsen (Tryngolza) as the first drug for adults with familial chylomicronemia syndrome, a rare genetic disorder that can cause triglyceride levels to reach the thousands. A first-in-class antisense oligonucleotide.

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Yehuda Handelsman, MD: Key Highlights, Takeaways from WCIRDC 2024

HCPLive

Yehuda Handelsman, MD reflects on the WCIRDC 2024s comprehensive approach to advancing cardiometabolic care through multidisciplinary collaboration.

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Resveratrol promotes cholesterol efflux from dendritic cells and controls costimulation and T-cell activation in high-fat and lipopolysaccharide-driven atherosclerotic mice

Frontiers in Cardiovascular Medicine

Cholesterol aggregation in dendritic cells (DCs) triggers an inflammatory response and accelerates the development of atherosclerosis (AS). Resveratrol (RES), a natural compound with anti-inflammatory and cholesterol metabolism regulatory properties, has been shown to influence the maturation and inflammatory functions of DCs. However, its relationship with cholesterol metabolism remains unclear.

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Kimberly A. Davidow, MD: Elucidating Risk of Autoimmune Disease in Childhood Cancer Survivors

HCPLive

Davidow discussed how a new cohort study has helped support findings of an older European study and the need for a prospective trial to confirm the increased risk.

Cancer 52
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Prognostic value of the derived inflammatory marker SIRI in postmenopausal women with coronary artery disease

Frontiers in Cardiovascular Medicine

ObjectiveThe aim of this study was to explore the predictive value of the Systemic Inflammatory Response Index (SIRI) for the prognosis of older postmenopausal women with coronary artery disease (CAD).Patients and methodsThis retrospective cohort study included 617 postmenopausal female patients aged 50 years or older with a CAD diagnosis confirmed by coronary angiography seen at the First Affiliated Hospital of Zhengzhou University from January 2019 to December 2020.

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CASPAR Criteria May Identify More Patients With Juvenile PsA Than ILAR Criteria

HCPLive

A prospective study also found that the presence of psoriasis and dactylitis at disease onset were the strongest predictors for the development of PsA.

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Association between asthma and cardiovascular disease: evidence from the national health and nutrition examination survey 1999–2018

Frontiers in Cardiovascular Medicine

BackgroundCardiovascular disease(CVD) remains a significant global challenge. Asthma, which is characterized by airway hyperresponsiveness and reversible and limited airflow, plays an important role in cardiovascular diseases. This study aimed to investigate the association between asthma and CVD.MethodsThis cross-sectional study included demographic, laboratory, and questionnaire data from the National Health and Nutrition Examination Survey (NHANES) 19992018.

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Study Highlights Impact of Smoking on Surgical Outcomes for HS

HCPLive

In this analysis, investigators conducted a systematic review of studies evaluating the effects of smoking tobacco on surgical outcomes for those with hidradenitis suppurativa.

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Case Report: A missed diagnosis of cardiac amyloidosis using echocardiography due to immunoglobulin light chain amyloidosis with normal wall thickness in the early stage

Frontiers in Cardiovascular Medicine

BackgroundCardiac amyloidosis (CA) is a challenging diagnosis, particularly when the classic signs, such as increased wall thickness in a non-dilated left ventricle (LV), are absent. This makes the diagnosis more difficult in patients with normal LV wall thickness. We present a case of CA without increased wall thickness and without the characteristic granular sparkling echotexture in a non-dilated LV.Case summaryA 50-year-old female patient presented with worsening breathlessness on exertion, p

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Sedentary Behavior Linked to Increased Gout Risk Even Without Hyperuricemia

HCPLive

A study found the association between sedentary behavior and gout remained strong even when adjusting for physical activity.

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ECPR for cardiac arrest caused by abnormal uterine bleeding and coronary vasospasm: a case report

Frontiers in Cardiovascular Medicine

IntroductionCardiac arrest during pregnancy is receiving increasing attention. However, there are few reports on cardiac arrest in nonpregnant women caused by abnormal uterine bleeding (AUB). We report a case in which extracorporeal cardiopulmonary resuscitation (ECPR) was used in a patient with cardiac arrest caused by AUB and coronary vasospasm.Patient presentationA 52-year-old female patient presented to the emergency department because of sudden chest pain, with a history of hypertension, co

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Study Shows a U-Shaped Association Between HDL-C, Major Adverse Cardiovascular Events

HCPLive

A study finds that individuals with low or high LDL cholesterol levels face a greater cardiovascular risk than those with medium levels.

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When Is Enough Enough? Additional Evidence of the Power of Zero

Circulation: Cardiovascular Imaging

Circulation: Cardiovascular Imaging, Ahead of Print.

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Belapectin Misses Primary Endpoint in Phase 3 MASH Cirrhosis, Portal Hypertension Trial

HCPLive

The phase 2b/3 NAVIGATE trial missed its primary endpoint for the prevention of varices in patients with MASH cirrhosis and portal hypertension.

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Papillary Muscle Structural Abnormalities and Site of Origin of Arrhythmias

American College of Cardiology

Does the finding of structural abnormalities on the papillary muscles have an association with site of origin of arrhythmias? Can multimodality imaging be of benefit in planning ablation procedures?

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CagriSema Achieves 22.7% Weight Loss in Phase 3 REDEFINE 1 Trial

HCPLive

CagriSema, a fixed dose of cagrilintide 2.4 mg and semaglutide 2.4 mg, achieved statistically significant weight loss after 68 weeks versus placebo.

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Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy

American College of Cardiology

The goal of the VALOR-HCM trial was to assess the safety and efficacy of adding mavacamten to maximally tolerated medical therapy among patients with obstructive hypertrophic cardiomyopathy (HCM).

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New Data Supports Liver Retransplantation for Patients with PSC Recurrence

HCPLive

Retransplantation outcomes were similar or better in patients with PSC compared with patients with other liver disease etiologies.

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Immune Checkpoint Inhibitors and Venous Thromboembolism

American College of Cardiology

Does an early rise in C-reactive protein (CRP) levels during immune checkpoint inhibitor (ICI) therapy predict the risk of venous thromboembolism (VTE) in cancer patients?

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Corrigendum to ‘Non-Invasive Assessment of Left Ventricular Pressure-Volume Relations: Inter- and Intra-Observer Variability and Assessment Across Heart Failure Subtypes’ [American Journal of Cardiology 184 (2022) 48-55]

The American Journal of Cardiology

Publication date: Available online 19 December 2024 Source: The American Journal of Cardiology Author(s): Jonathan Edlund, Per M. Arvidsson, Anders Nelsson, J.

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compariSon of secOnd-generation seLf-expandable vs. balloon-expandable Valves and gEneral vs. local anaesthesia in Transcatheter Aortic Valve Implantation

American College of Cardiology

The goal of the SOLVE-TAVI trial was to compare the safety and efficacy of the Edwards Sapien S3 valve vs. Medtronics CoreValve among patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. Further, in a 2x2 factorial design, the trial also sought to compare conscious sedation vs. general anesthesia in this patient population.

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RSNA 2024: AI Reaches Critical Mass

Cassling

At the annual meeting of the Radiological Society of North America in Chicago, radiologists, technologists and assorted medical professionals from all around the country once again gathered to catch a glimpse of the latest technological breakthroughs in the radiology space. In the last couple years, artificial intelligence has garnered the most headlines, and with good reason.

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Cardiovascular Risk in Prostate Cancer: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on cardiovascular (CV) risk in prostate cancer (PC).

Cancer 40
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Physiology Friday #249: Does Carbohydrate Distribution and Quality Matter for Optimizing Training Adaptations?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.

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Chlorthalidone vs. Hydrochlorothiazide and Kidney Outcomes

American College of Cardiology

Is chlorthalidone superior to hydrochlorothiazide in preventing kidney outcomes when used for hypertension treatment?