American College of Cardiology

FEBRUARY 15, 2024

What is the association of treatment with intravenous thrombolysis (IVT) plus thrombectomy versus thrombectomy alone and outcomes modification by the time from stroke symptom onset to treatment?

Thrombolysis 44

Thrombolysis Stroke Strokes Outcomes 44

Stroke Journal

MARCH 11, 2024

NETs are proposed as a mechanism of resistance to thrombolysis. Thrombolysis was remarkably associated with higher NE positivity (average marginal effect, 6.461 [95% CI, 0.7901–12.13];P=0.02555), regardless of the origin of thrombi. BACKGROUND:Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs).

Thrombolysis 40

Thrombolysis Pharmacology Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

2) Creation of a multidisciplinary Thrombolysis Focus Group to analyze data and improve processes. Additional monthly quality improvement meetings were held to discuss all thrombolysis cases with times over our median. 3) Reduction of EMR barriers to recognize metric exclusion criteria and document accordingly. in 2020, to 31.9%

Thrombolysis 40

Thrombolysis Academic Document Stroke 40

The New England Journal of Medicine

JUNE 13, 2024

Aside from the use of thrombolysis for stroke on awakening. Intravenous tenecteplase has been shown to be noninferior to alteplase, with a meta-analysis suggesting superiority,1 and although tenecteplase has been used off label, it is replacing alteplase as the preferred thrombolytic agent for the treatment of acute stroke.

Thrombolysis 40

Thrombolysis Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Trials using advanced imaging have shown a benefit from intravenous thrombolysis in patients with wake-up stroke, but real-world data is limited. 71% of stroke activations had a final diagnosis of ischemic stroke; 32% of cases were eligible per protocol and treated with thrombolysis. Median admission NIHSS was 6.

Thrombolysis 40

Thrombolysis Strokes Stroke Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:IV thrombolysis is a proven treatment for acute ischemic stroke (AIS), but it is still underutilized in real-world clinical practice. Trends in IV thrombolysis rate were respectively analyzed for all patients (cohort 1), patients who arrived at the hospital within 4.5

Thrombolysis 40

Thrombolysis Strokes Stroke Hospital 40

Journal of Cardiothoracic Surgery

JULY 4, 2024

To compare the treatment outcomes among percutaneous mechanical thrombectomy (PMT) with AngioJet, Catheter-directed thrombolysis (CDT), and a combination of both.

Thrombolysis 40

Thrombolysis Thrombosis Outcomes Research 40

Stroke Journal

MARCH 8, 2024

mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set.

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke: Vascular and Interventional Neurology

MARCH 8, 2024

Most respondents (88%) agreed there were barriers to acute stroke thrombolysis in the region. Among 51% of countries surveyed, no acute thrombolytic treatment was provided for acute stroke in the 2021 calendar year. Only 1 center treated >100 cases per year.

Thrombolysis 40

Thrombolysis Strokes Stroke Hospital 40

Stroke Journal

FEBRUARY 1, 2024

SETRAC has demonstrated its efficacy in improving thrombolysis rates in patients with acute ischemic stroke. We performed linear analyses to evaluate the increase in the percentage of patients receiving thrombolysis, and those treated within 45 minutes.Results:31 hospitals reported treating a total of 93,688 patients from 2014-2023.

Thrombolysis 40

Thrombolysis Hospital Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Objectives:To examine whether thrombolysis care metrics have improved in all races and ethnicities with the launch and advance of Target: Stroke (TS) national quality initiatives.Methods:This cohort study included patients presenting to Get With The Guidelines (GWTG)-Stroke participating hospitals within 4.5

Thrombolysis 40

Thrombolysis Stroke Strokes Hospital 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:The benefit of intravenous thrombolysis for acute ischemic stroke declines with longer time from symptom onset. Intravenous thrombolysis showed clinical benefit if it was administered within 2h 20min after symptom onset. Stroke, Volume 55, Issue Suppl_1 , Page A22-A22, February 1, 2024.

Thrombolysis 40

Thrombolysis Stroke Strokes 40

Circulation: Cardiovascular Interventions

JANUARY 24, 2024

BACKGROUND:Prior clinical trials have demonstrated the efficacy of ultrasound-facilitated catheter-directed thrombolysis (USCDT) for the treatment of acute intermediate-risk pulmonary embolism (PE) using reduced thrombolytic doses and shorter infusion durations. Circulation: Cardiovascular Interventions, Ahead of Print.

Embolism 75

Embolism Thrombolysis Ultrasound Pulmonary 75

American College of Cardiology

SEPTEMBER 10, 2024

The goal of the MOST trial was to evaluate argatroban vs. eptifibatide vs. placebo among patients with acute ischemic stroke treated with intravenous thrombolytic therapy.

Thrombolysis 44

Thrombolysis Stroke Strokes Article 44

Stroke Journal

JANUARY 4, 2024

BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. Stroke, Ahead of Print. These studies mainly concerned anterior circulation occlusions.

Thrombolysis 40

Thrombolysis Circulation Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Objective:A proportion of acute ischemic stroke (AIS) patients suffer from early neurological deterioration (END) within 24 hours following intravenous thrombolysis (IVT), which greatly increases the risk of poor prognosis of these patients.

Thrombolysis 40

Thrombolysis Strokes Stroke BMI 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. However, IVT's efficacy on stent retriever (SR) and aspiration thrombectomy (ASP) outcomes specifically remain unclear.

Thrombolysis 40

Thrombolysis Outcomes Embolism Stent 40

Journal of the American Heart Association

DECEMBER 18, 2023

BackgroundIntravenous thrombolysis (IVT) is an effective stroke therapy that remains underused. Journal of the American Heart Association, Ahead of Print. Currently, the use of IVT in patients with recent direct oral anticoagulant (DOAC) intake is not recommended.

Thrombolysis 75

Thrombolysis Strokes Stroke Hemorrhage 75

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionOver the past decade, stroke management has significantly improved with the widespread use of intravenous thrombolysis (IVT) and the establishment of endovascular thrombectomy (EVT) as the standard of care for increasing patients. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023.

Thrombolysis 40

Thrombolysis Inpatient Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

The role of adjunctive intravenous thrombolysis, such as intravenous tissue plasminogen activator (IVtPA), with MT remains unclear, especially for medium vessel occlusion (MeVO). Background:Mechanical thrombectomy (MT) has demonstrated superiority over medical therapy for acute ischemic stroke (AIS) with large vessel occlusion (LVO).

Thrombolysis 40

Thrombolysis Academic Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Background and Purpose:Although intra-arterial thrombolysis (IAT) is widely used as adjunct with mechanical thrombectomy in acute ischemic stroke patients, the patients who are likely to benefit are not known. Stroke, Volume 55, Issue Suppl_1 , Page ATP213-ATP213, February 1, 2024.

Thrombolysis 40

Thrombolysis Strokes Stroke Stent 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Language barriers between acute ischemic stroke patients and clinicians can create challenges in use of intravenous thrombolysis (IVT) as successful administration hinges on quick information gathering, shared decision making and consent with the patient and family.

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Thrombolysis Document Strokes Stroke 40

Journal of the American Heart Association

MARCH 8, 2024

Journal of the American Heart Association, Ahead of Print.

Thrombolysis 45

Thrombolysis Outcomes Stroke Strokes 45

Stroke Journal

FEBRUARY 1, 2024

However, there is conflicting data regarding intracranial hemorrhage risk.Objective:To determine the rate of symptomatic intracranial hemorrhage in ischemic stroke patients after thrombolysis with either tenecteplase or alteplase.Design:Retrospective cohort study.Setting:15 Texas stroke centers.Participants:431 patients that were eligible for thrombolytic (..)

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Background:The benefits of endovascular thrombectomy (EVT) for posterior cerebral artery (PCA) occlusion remain controversial, but intravenous thrombolysis (IVT) has proven benefit across nearly all ischemic stroke types. Stroke, Volume 55, Issue Suppl_1 , Page AWP199-AWP199, February 1, 2024.

Atrial Fibrillation 40

Atrial Fibrillation Thrombolysis Outcomes Embolism 40

Stroke Journal

FEBRUARY 1, 2024

The access to acute stroke treatments, especially intravenour thrombolysis and mechanical thrombectomy, is limited.

Thrombolysis 40

Thrombolysis Strokes Stroke Research 40

Stroke Journal

FEBRUARY 1, 2024

Median time from the onset of visual change to thrombolysis was 6.0 [4.5-10.5] One (5.3%) patient had intra-ocular hemorrhage post thrombolysis.Conclusion:Compared to central retinal artery occlusion, patient with branched retinal occlusion have better visual recovery following IA or IV thrombolysis. VA improvement of ≥0.1

Thrombolysis 40

Thrombolysis Outcomes Hemorrhage Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP5-AWMP5, February 1, 2024.

Thrombolysis 40

Thrombolysis Outcomes Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Recent studies report similar outcomes with antiplatelet drugs and intravenous thrombolysis (IVT) in patients with minor nondisabling ischemic stroke. Stroke, Volume 55, Issue Suppl_1 , Page ATMP13-ATMP13, February 1, 2024.

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Thrombolysis Strokes Stroke Academic 40

ECG Cases

JULY 4, 2017

In this two part EM Cases Journal Jam podcast Justin Morgenstern, Rory Spiegel and Anton Helman do a deep dive into the world's literature on systemic thrombolysis for ischemic stroke followed by an analysis of endovascular therapy for stroke.

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Thrombolysis Strokes Stroke 52

Stroke Journal

FEBRUARY 1, 2024

Introduction:Intravenous thrombolysis (IVT) is efficacious treatment of acute ischemic stroke (AIS). Stroke, Volume 55, Issue Suppl_1 , Page A25-A25, February 1, 2024. However, certain circumstances associated with increased bleeding risk, such as recent direct oral anticoagulation (DOAC) intake limits its use.

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

American College of Cardiology

JULY 12, 2024

The ENGAGE AF-TIMI 48 trial sought to study the safety and efficacy of edoxaban, an oral direct factor Xa inhibitor, as compared with warfarin in the treatment of atrial fibrillation.

Myocardial Infarction 51

Myocardial Infarction Thrombolysis Atrial Fibrillation Article 51

Dr. S. Venkatesan MD

NOVEMBER 8, 2024

08/11, 12:07] Dr S Venkatesan: Is the therapeutic time window for primary PCI and thrombolysis same ? [08/11, Thrombolysis has a broader time window, but efficacy decreases significantly after 6 hours. [ Thrombolysis has a broader time window, but efficacy decreases significantly after 6 hours. [ How can they be different? [08/11,

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Thrombolysis Ischemia Hospital Outcomes 40

DAIC

MAY 14, 2024

The new analysis of the trial results, led by UVA Health’s Andrew Southerland , MD, found that high blood sugar shortly after thrombolysis – opening blocked arteries in the brain with a clot-busting drug – was associated with greater risk for potentially deadly brain bleeds, particularly in older patients with more severe strokes.

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Stroke Strokes Thrombolysis Hemorrhage 105

Medical Xpress - Cardiology

DECEMBER 13, 2023

Renal dysfunction, especially chronic kidney disease, is the biggest risk factor of mortality among thrombolysed stroke patients, according to a retrospective cohort observational study published in Medicine.

Kidney Disease 40

Kidney Disease Thrombolysis Stroke Strokes 40

Medical Xpress - Cardiology

OCTOBER 30, 2024

Findings from the first international randomized controlled trial to compare patient outcomes following treatment with large-bore mechanical thrombectomy (LBMT) versus catheter-directed thrombolysis (CDT) for intermediate-risk pulmonary embolism (PE) show that LBMT is superior with respect to the hierarchically-tested aggregated outcome of all-cause (..)

Embolism 52

Embolism Pulmonary ICU Outcomes 52

American College of Cardiology

FEBRUARY 20, 2024

The goal of the TIMELESS trial was to determine the efficacy and safety of tenecteplase administered between 4.5 and 24 hours after last known well time in patients with acute ischemic stroke and salvageable tissue on perfusion imaging.

Thrombolysis 48

Thrombolysis Stroke Strokes Article 48