American College of Cardiology

FEBRUARY 15, 2024

What is the association of treatment with intravenous thrombolysis (IVT) plus thrombectomy versus thrombectomy alone and outcomes modification by the time from stroke symptom onset to treatment?

Thrombolysis 45

Thrombolysis Stroke Strokes Outcomes 45

Journal of the American Heart Association

DECEMBER 18, 2023

BackgroundIntravenous thrombolysis (IVT) is an effective stroke therapy that remains underused. Journal of the American Heart Association, Ahead of Print. Currently, the use of IVT in patients with recent direct oral anticoagulant (DOAC) intake is not recommended.

Thrombolysis 75

Thrombolysis Hemorrhage Stroke Strokes 75

Heart BMJ

JULY 10, 2024

IC thrombolysis was associated with a significantly lower incidence of MACE (RR=0.65, 95% CI 0.51 Conclusion Adjunctive IC thrombolysis at the time of primary PCI in patients with STEMI improves clinical and myocardial perfusion parameters without an increased rate of bleeding. Results 12 studies with 1915 patients were included.

Myocardial Infarction 52

Myocardial Infarction Thrombolysis STEMI Outcomes 52

Medical Xpress - Cardiology

FEBRUARY 12, 2024

nationwide quality initiative Target: Stroke (TS) is associated with improvement in thrombolysis frequency, timeliness, and outcome, according to a study published online Feb. 7 in JAMA Network Open.

Thrombolysis 40

Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

One of the considered and currently increasingly preferred options is intravenous thrombolysis. According to our data, intravenous thrombolysis is also an effective and safe therapy here. The effectiveness of the intervention was evaluated in two stages.

Thrombolysis 40

Thrombolysis Hemorrhage Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Background:Previous study found that compared with thrombolysis, antiplatelet did not improve outcomes but reduce the risk of symptomatic intracranial hemorrhage(sICH) for mild acute ischemic stroke(AIS) defined as National Institutes of Health Stroke Scale score 0 to 5. Stroke, Volume 56, Issue Suppl_1 , Page ATP25-ATP25, February 1, 2025.

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Introduction:Stroke is a leading cause of disability and mortality worldwide, with thrombolysis as a critical treatment. Studies aiming to assess the outcomes of thrombolysis after ischemic stroke in LMIC were selected. Seven randomized controlled trials (RCTs) were included and analyzed independently.

Thrombolysis 40

Thrombolysis Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Introduction:Intravenous thrombolysis with alteplase (tPA) or tenecteplase (TNK) is a first-line treatment for acute ischemic stroke. We reviewed stroke databases from 2017 to 2024 for patients who received IV thrombolysis with either tPA or TNK and developed sICH within 36 hours of treatment.

Thrombolysis 40

Thrombolysis Hemorrhage Document ICU 40

DAIC

MAY 14, 2024

The new analysis of the trial results, led by UVA Health’s Andrew Southerland , MD, found that high blood sugar shortly after thrombolysis – opening blocked arteries in the brain with a clot-busting drug – was associated with greater risk for potentially deadly brain bleeds, particularly in older patients with more severe strokes.

Stroke 105

Stroke Strokes Thrombolysis Best Practices 105

Stroke Journal

JANUARY 30, 2025

There were also no other complications.Conclusion:Rescue therapy in the form of prolonged low-dose thrombolysis seems to be an effective and safe alternative to therapeutic nihilism in ultra-early stroke recurrence. The incidence of intracerebral hemorrhage was 9.1% and we did not observe symptomatic intracerebral hemorrhage.

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Introduction:Current guidelines suggest using intravenous thrombolysis (IVT) for patients experiencing acute ischemic stroke within 4.5 hours of symptom onset. Nevertheless, recent clinical trials have explored the possibility of extending the IVT treatment window.

Thrombolysis 40

Thrombolysis Stroke Strokes Education 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Emergency-department-based implementation strategies to increase thrombolysis are promising. We sought to quantify the number of hospitals with opportunities to increase thrombolysis under various tPA treatment thresholds.Methods:We used data from the 2018 State Inpatient Databases (SID) from 17 states.

Thrombolysis 40

Thrombolysis Hospital Inpatient Stroke 40

Stroke Journal

MARCH 11, 2024

NETs are proposed as a mechanism of resistance to thrombolysis. Thrombolysis was remarkably associated with higher NE positivity (average marginal effect, 6.461 [95% CI, 0.7901–12.13];P=0.02555), regardless of the origin of thrombi. BACKGROUND:Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs).

Thrombolysis 40

Thrombolysis Pharmacology Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

hour window, and reperfusion through thrombolysis has been shown to enhance functional outcomes in patients with salvageable brain tissue beyond this timeframe.Objective:The aim of this study is to assess the efficacy and safety of thrombolysis administered more than 4.5 These modalities can identify viable brain tissue beyond the 4.5-hour

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Introduction:Prior studies have demonstrated social determinants of health (SDoH) are associated with reduced rates of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS), including in disadvantaged populations. 24hrs through Tufts Late Presenter Thrombolysis protocol. IVT was offered in the standard 0-4.5hr window and 4.5-24hrs

Thrombolysis 40

Thrombolysis Stroke Strokes Research 40

Stroke Journal

JANUARY 30, 2025

Introduction:Prior studies have demonstrated social determinants of health (SDH) are associated with reduced rates of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS), including in disadvantaged populations. 24hrs through Tufts Late Presenter Thrombolysis protocol. IVT was offered in the standard 0-4.5hr window and 4.5-24hrs

Thrombolysis 40

Thrombolysis Stroke Strokes Research 40

Journal of the American Heart Association

MARCH 8, 2024

Journal of the American Heart Association, Ahead of Print.

Thrombolysis 45

Thrombolysis Outcomes Stroke Strokes 45

Stroke Journal

JANUARY 30, 2025

Background:Patients with acute ischemic stroke and a large vessel occlusion (LVO) admitted to primary stroke centers (PSC) often require inter-facility transfer for thrombectomy.

Thrombolysis 40

Thrombolysis Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Introduction:The tenecteplase versus standard of care for minor ischemic stroke with proven occlusion (TEMPO-2) trial showed that patients presenting with minor deficits up to 12 h do not benefit from intravenous thrombolysis. h, if they were not eligible for standard-of-care thrombolysis. mg/kg) or non-thrombolytic standard of care.

Thrombolysis 40

Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

The effectiveness and safety of intravenous thrombolysis (IVT) for acute ischemic stroke in these cases, particularly those involving large vessel occlusions, are debated. Stroke, Volume 56, Issue Suppl_1 , Page AWP9-AWP9, February 1, 2025. Background:Acute ischemic stroke can result from extracranial arterial dissection.

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

2) Creation of a multidisciplinary Thrombolysis Focus Group to analyze data and improve processes. Additional monthly quality improvement meetings were held to discuss all thrombolysis cases with times over our median. 3) Reduction of EMR barriers to recognize metric exclusion criteria and document accordingly. in 2020, to 31.9%

Thrombolysis 40

Thrombolysis Academic Document Innovation 40

American College of Cardiology

OCTOBER 29, 2024

The goal of the trial was to compare the efficacy and safety of large-bore mechanical thrombectomy (LBMT) with catheter-directed thrombolysis (CDT) in the treatment of intermediate-high risk pulmonary embolism (PE).

Thrombolysis 40

Thrombolysis Embolism Pulmonary Article 40

The New England Journal of Medicine

JUNE 13, 2024

Aside from the use of thrombolysis for stroke on awakening. Intravenous tenecteplase has been shown to be noninferior to alteplase, with a meta-analysis suggesting superiority,1 and although tenecteplase has been used off label, it is replacing alteplase as the preferred thrombolytic agent for the treatment of acute stroke.

Thrombolysis 40

Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Whether intravenous thrombolysis (IVT) is safe and effective for acute ischemic stroke (AIS) patients with CAA is largely unknown.Methods:This was an explorative analysis of a nationwide database of hospitalizations in the United States.

Thrombolysis 40

Thrombolysis Stroke Strokes Cerebrovascular Disease 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Trials using advanced imaging have shown a benefit from intravenous thrombolysis in patients with wake-up stroke, but real-world data is limited. 71% of stroke activations had a final diagnosis of ischemic stroke; 32% of cases were eligible per protocol and treated with thrombolysis. Median admission NIHSS was 6.

Thrombolysis 40

Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

MARCH 8, 2024

mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set.

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:IV thrombolysis is a proven treatment for acute ischemic stroke (AIS), but it is still underutilized in real-world clinical practice. Trends in IV thrombolysis rate were respectively analyzed for all patients (cohort 1), patients who arrived at the hospital within 4.5

Thrombolysis 40

Thrombolysis Stroke Strokes Hospital 40

Stroke: Vascular and Interventional Neurology

MARCH 8, 2024

Most respondents (88%) agreed there were barriers to acute stroke thrombolysis in the region. Among 51% of countries surveyed, no acute thrombolytic treatment was provided for acute stroke in the 2021 calendar year. Only 1 center treated >100 cases per year.

Thrombolysis 40

Thrombolysis Stroke Strokes Hospital 40

Stroke Journal

JANUARY 30, 2025

Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation. Stroke, Volume 56, Issue Suppl_1 , Page AWP253-AWP253, February 1, 2025.

Thrombolysis 40

Thrombolysis Stroke Strokes Stent 40

Journal of Cardiothoracic Surgery

JULY 4, 2024

To compare the treatment outcomes among percutaneous mechanical thrombectomy (PMT) with AngioJet, Catheter-directed thrombolysis (CDT), and a combination of both.

Thrombolysis 40

Thrombolysis Thrombosis Outcomes Research 40

American College of Cardiology

JANUARY 21, 2025

Acute pulmonary embolism (PE) remains a diagnostic and therapeutic challenge, with an estimated 60,000-100,000 deaths each year in the United States.

Embolism 61

Embolism Pulmonary Thrombolysis Article 61

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP20-ATP20, February 1, 2025.

Thrombolysis 40

Thrombolysis Stroke Strokes Risk Factors 40

Stroke Journal

JANUARY 30, 2025

Background and Purpose:Whether imaging markers of cerebral small vessel disease on computed tomography (CT-CSVD) relates to early clinical outcomes after intravenous thrombolysis for acute ischemic stroke remains not well understood. Stroke, Volume 56, Issue Suppl_1 , Page AWP6-AWP6, February 1, 2025. 1.02; score 2: OR 0.46, 95%CI 0.26-0.83;

Thrombolysis 40

Thrombolysis Outcomes Biomarkers Stroke 40

Stroke Journal

JANUARY 30, 2025

Introduction:Current guidelines recommend 24-hours of high-intensity monitoring (HIM) for acute ischemic stroke patients post-intravenous thrombolysis (IVT) due to risk of bleeding complications including symptomatic intracranial hemorrhage (sICH). Stroke, Volume 56, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2025.

Thrombolysis 40

Thrombolysis ICU Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Introduction:The use of IV thrombolysis (IVT) in acute ischemic stroke patients presenting with an NIHSS of 5 has failed to demonstrate benefit, particularly when the symptoms are considered non-disabling. Stroke, Volume 56, Issue Suppl_1 , Page AWP14-AWP14, February 1, 2025.

Thrombolysis 40

Thrombolysis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

SETRAC has demonstrated its efficacy in improving thrombolysis rates in patients with acute ischemic stroke. We performed linear analyses to evaluate the increase in the percentage of patients receiving thrombolysis, and those treated within 45 minutes.Results:31 hospitals reported treating a total of 93,688 patients from 2014-2023.

Thrombolysis 40

Thrombolysis Hospital Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Objectives:To examine whether thrombolysis care metrics have improved in all races and ethnicities with the launch and advance of Target: Stroke (TS) national quality initiatives.Methods:This cohort study included patients presenting to Get With The Guidelines (GWTG)-Stroke participating hospitals within 4.5

Thrombolysis 40

Thrombolysis Stroke Strokes Hospital 40