Sat.Nov 16, 2024 - Fri.Nov 22, 2024

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Over 50% of U.S. Adults Qualify for Ozempic, Wegovy

Med Page Today

(MedPage Today) -- More than half of all adults in the U.S. are eligible for semaglutide (Ozempic, Wegovy, Rybelsus), researchers estimated. Among 25,531 participants in the National Health and Nutrition Examination Survey (NHANES) from 2015 to.

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In a small international trial, novel oral medication muvalaplin lowered Lp(a)

American Heart News - Heart News

Research Highlights: The oral medication muvalaplin may safely lower high levels of lipoprotein(a), also known as Lp(a), an independent, inherited risk factor for cardiovascular disease. Muvalaplin is a small molecule inhibitor that prevents the.

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Mapping the intersection of sudden cardiac death and COVID-19: a comprehensive bibliometric analysis (2020–2024)

Frontiers in Cardiovascular Medicine

IntroductionA direct causal link between Sudden Cardiac Death (SCD) and COVID-19 is unproven, although current data suggest a plausible association.AimThis study aims to map and analyze the intersection of research on sudden cardiac death and COVID-19 through a comprehensive bibliometric analysis.MethodologyThis study searched the literature by applying the keywords “COVID-19” AND “Sudden Cardiac Death (SCD)”.

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Obesity-Related Heart Disease Deaths Rose Roughly 180% Since 1999

HCPLive

Obesity-related ischemic heart disease deaths rose from 1999 to 2020, particularly in middle-aged men and Black adults, per CDC WONDER data.

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Fitness Level May Offset Genetic Dementia Risk

Med Page Today

(MedPage Today) -- Genetic risk for Alzheimer's disease and dementia appeared to be partly offset by high levels of cardiorespiratory fitness, U.K. Biobank data suggested. Overall, high cardiorespiratory fitness was associated with better global.

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Tirzepatide lowered risk of worsening heart failure and CVD death for obese adults

American Heart News - Heart News

Research Highlights: In an international trial of 713 adults in nine countries including the U.S. called SUMMIT, participants with heart failure with preserved ejection fraction (HFpEF) and obesity taking tirzepatide for an average of 2 years had.

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Charting the future of cardiology with large language model artificial intelligence

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 November 2024; doi:10.1038/s41569-024-01105-y Large language models represent a transformative leap in artificial intelligence and natural language processing, offering exciting potential across cardiology, from clinical care to education and research. However, several crucial challenges limit the practical implementation of large language models in cardiology.

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Tirzepatide Officially Puts GLP-1 Meds on the Map for Obesity-Related Heart Failure

Med Page Today

(MedPage Today) -- CHICAGO -- A long-acting GIP/GLP-1 receptor agonist conferred significant clinical benefit for people with obesity and accompanying heart failure with preserved ejection fraction (HFpEF), according to the SUMMIT trial. Incident.

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Ablation may be better than medication for those with dangerous heartbeat after heart attack

American Heart News - Heart News

Research Highlights: A new, multicenter study demonstrated that ablation treatment may be a better first option than medication for many heart attack survivors who develop abnormal electrical short circuits in their heart, which are episodes of.

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Acute chest pain and an abnormal ECG. Do precordial leads show benign T-wave inversion or ischemia?

Dr. Smith's ECG Blog

Written by Willy Frick A 51 year old man with hypertension presented with three hours of acute onset, severe midsternal chest pain associated with two episodes of nausea and vomiting. ECG 1 What do you think? Smith : Inferior leads have subtle ST Elevation with reciprocal STD in aVL. The end of the T-wave in all of II, III, aVF has a rapid downturn, suggesting early T-wave inversion.

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Oussama Wazni, MD, MBA: OPTION Trial and the Role of LAAC in Atrial Fibrillation

HCPLive

Oussama Wazni, MD, discusses the results of the OPTION trial examining LAAC in atrial fibrillation as well as its reception as AHA 2024.

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Reused Pacemakers Good as New in Early Safety Data

Med Page Today

(MedPage Today) -- CHICAGO -- Secondhand permanent pacemaker use in poorer countries, following thorough cleaning and repackaging, has not resulted in patient harm so far, according to the My Heart Your Heart trialists. In patients who could.

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Spironolactone, a blood pressure medication, may help reduce risk of new heart failure

American Heart News - Heart News

Research Highlights: The CLEAR SYNERGY trial found that spironolactone may reduce the risk of new or worsening heart failure; however, it did not significantly impact the rate of death, new heart attack or stroke. More research is needed to further.

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Is this OMI reperfused or active?

Dr. Smith's ECG Blog

These ECGs were texted to me by one of our previous ultrasound fellows, Will Smoot An elderly male arrived via EMS for acute substernal chest pain with radiation to left shoulder and arm that awakened him from sleep at 0030. He took two full strength aspirin prior to EMS arrival. The pain was relieved by one prehospital NTG spray. He arrived at the ED just shy of two hours after onset, pain free.

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Intensive Blood Pressure Regimen Lowers CVD Risk in People with T2D

HCPLive

Reducing systolic blood pressure to less than 120 mmHg lowered the risk of major cardiovascular events for most people with diabetes in the BPROAD trial.

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Opioids Tied to Higher Dementia Risk, but Only After a Point

Med Page Today

(MedPage Today) -- After a certain threshold, cumulative opioid use was associated with higher dementia risk, a study of adults over age 60 in Denmark showed. In a nested case-control study, opioid use above 90 total standardized doses (TSDs.

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Email reminders improved flu shot rates in Denmark, notably among heart attack survivors

American Heart News - Heart News

Research Highlights: An electronic message to "nudge" patients to get a flu vaccine highlighting the cardiovascular benefits of flu shots improved vaccination rates among more than two million adults in three clinical trials in Denmark. The research.

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JACC Study Finds Sitting Too Long Can Harm Heart Health

American College of Cardiology

More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease and death, according to a study presented at AHA 2024 and simultaneously published in JACC.

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Emapalumab May Improve Response Rates in MAS Treatment

HCPLive

Findings from the first and only controlled study for macrophage activation syndrome were presented at the ACR Convergence.

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Spironolactone Misses the Mark in Acute MI Without HF

Med Page Today

(MedPage Today) -- CHICAGO -- A mineralocorticoid receptor antagonist (MRA) was unable to further improve 3-year outcomes of acute myocardial infarction (MI) in the modern era, based on the CLEAR OASIS 9 trial. Among heart attack survivors without.

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Nasal spray version of common diuretic has potential to help treat heart failure

Science Daily - Heart Disease

A study testing a new nasal spray form of the medication bumetanide, a commonly prescribed diuretic, was found to be as safe and well-tolerated (meaning with no significant nasal irritation) in healthy adults in comparison to the oral and intravenous forms of the medication. The existing oral and intravenous forms of bumetanide are commonly prescribed for people with heart failure because they ease tissue swelling, a common cause of symptoms for people with heart failure.

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Two Studies Assess Echocardiography Evaluation Performance, Relationship Between Markers of Early LV Dysfunction and Mortality in Aortic Regurgitation

American College of Cardiology

American Society of Echocardiography (ASE) guidelines for echocardiographic evaluation of aortic regurgitation (AR) were found to “display very good performance” in detecting significant AR, according to a study published Nov. 13 in JACC: Cardiovascular Imaging.

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Finding a Role for GLP-1 RAs, Incretin Therapies in Heart Failure, with Muthiah Vaduganathan, MD, MPH

HCPLive

Muthiah Vaduganathan, MD, MPH, discusses the need for cardiology to embrace a role for GLP-1 receptor agonists and incretin therapies, with a focus on obesity-related HFpEF.

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Small Benefit, Persistent Toxic Risk With Adjuvant Anthracycline in Breast Cancer

Med Page Today

(MedPage Today) -- Adding an anthracycline to adjuvant chemotherapy for TOP2A-normal early breast cancer significantly improved disease-free survival (DFS) but not overall survival (OS) at 10 years, and doubled the risk of heart failure, a randomized.

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Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure

JAMA Cardiology

This multicenter secondary analysis of the FINEARTS-HF randomized clinical trial examines the treatment effect of finerenone, relative to placebo, on clinical outcomes based on postrandomization potassium levels.

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SUMMIT: Tirzepatide Improves Outcomes and Quality of Life For Patients With HFpEF and Obesity

American College of Cardiology

In patients with obesity and heart failure with preserved ejection fraction (HFpEF), weekly treatment with tirzepatide over approximately two years reduced the risk of worsening heart failure events, based on findings from the SUMMIT trial.

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IgAN vs Other Glomerular Diseases

HCPLive

Panelists discuss the immune system dysregulation underlying IgA nephropathy and highlight how this mechanism differs from those seen in other glomerular diseases.

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Sacubitril/Valsartan Curbs Cardiotoxicity From Chemotherapy

Med Page Today

(MedPage Today) -- CHICAGO -- Sacubitril/valsartan (Entresto) was effective at keeping cardiotoxicity at bay in high-risk people receiving anthracycline chemotherapy in the SARAH trial. Cancer patients were less likely to have a greater than.

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Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction

JAMA Cardiology

This prespecified secondary analysis of a randomized clinical trial examines the efficacy and safety of finerenone in women and men with heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction.

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ALPACAR: Zerlasiran vs. Placebo in Reducing Lp(a) Concentration in Patients With ASCVD

American College of Cardiology

Zerlasiran, a short-interfering RNA, was well-tolerated and reduced time-averaged lipoprotein(a) [Lp(a)] concentration by more than 80% during 36 weeks of treatment in patients with atherosclerotic cardiovascular disease (ASCVD).

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Shreena K. Gandhi, MBBS: Recognizing Fibromyalgia as a Continuous Variable, Trait Diagnosis

HCPLive

Gandhi discussed examining social security disability rates and how SSD criteria may clash with a trait disease like fibromyalgia.

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Ablation Bests Drugs for Ventricular Tachycardia After Heart Attack

Med Page Today

(MedPage Today) -- CHICAGO -- For patients with ventricular tachycardia (VT) and ischemic cardiomyopathy, going right to catheter ablation improved outcomes compared with trying antiarrhythmic drugs first, the VANISH2 trial showed. Death or.

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Two-medication combo pill lowered blood pressure among adults in India

American Heart News - Heart News

Research Highlights: A study of three pills that combined two types of blood-pressure-lowering medications into one pill found that all combinations worked equally well among adults in India. Results from the TOPSPIN trial found that any.

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Cholesterol is not the only lipid involved in trans fat-driven cardiovascular disease

Science Daily - Heart Disease

Salk scientists have tracked the flow of trans fats using mouse models to describe the molecular mechanisms that cause trans fats to promote atherosclerotic cardiovascular disease (ASCVD), explaining how industrially produced trans-unsaturated fatty acids in our food significantly promote ASCVD and encouraging lawmakers to impose regulations on the use of these fats in food.

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New Medical Guidance Provides Insurance Recommendations for Allergen Immunotherapy

HCPLive

In these guidelines compiled by the ACAAI, the AAAAI, and the AAOA, recommendations are provided to insurance companies for documentation needed for allergen immunotherapy.

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Study: Statins Mitigate Heart Risks From JAK Inhibitors

Med Page Today

(MedPage Today) -- WASHINGTON -- Patients taking Janus kinase (JAK) inhibitors for rheumatoid arthritis (RA) may not have to worry so much about increased cardiovascular risk -- if they're taking statins, research presented here suggested.

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Exenatide, a GLP-1 analog, by IV during cardiac surgery did not reduce organ injury or death

American Heart News - Heart News

Research Highlights: The GLORIOUS trial found that an intravenous infusion of exenatide, a glucagon-like peptide-1 (GLP-1) during heart surgeries involving bypass did not result in significant benefits at preventing death, stroke or organ injury.