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Researchers report a discovery in cardiac regeneration that offers new hope for the treatment of ischemic heart failure. Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation. The researchers are from the Michael E. DeBakey Department of Surgery at Baylor College of Medicine, the QIMR Berghofer Medical Research Institute in Brisbane, Australia, and collaborating institutions.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
tim.hodson Fri, 03/14/2025 - 11:42 March 11, 2025 CareDx, Inc. The Transplant Company recently announced that AlloSureis now commercially available for pediatric heart transplant patients of all ages and patients who have received a simultaneous pancreas-kidney (SPK) transplant. Both indications are approved by the New York State Clinical Laboratory Evaluation Program, demonstrating that AlloSure has met the most rigorous validation standards for laboratory developed tests (LDTs).
BackgroundVericiguata novel oral soluble guanylate cyclase stimulatorwas developed for the treatment of chronic heart failure (HF). Although the value of vericiguat therapy in chronic HF has been gradually recognized, its safety and efficacy in the acute phase of HF remain elusive.Methods100 patients with acute HF receiving vericiguat therapy at the China-Japan Union Hospital of Jilin University between September 2022 and June 2023 were retrospectively analyzed.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Women with blood pressure levels in a range considered clinically normal during pregnancy but no mid-pregnancy drop in blood pressure face an increased risk of developing hypertension in the five years after giving birth. These women -- about 12% of the population studied -- would not be flagged as high-risk by current medical guidelines, but the new findings could help identify them as candidates for early intervention.
As one of our board certified vascular surgeons, Dr. Nicolas Zea performs a variety of complex procedures, and his dedication to patient care and service is exceptional. What you might not know about him is that he is also an avid adventurer, running ultra marathons and traveling far and wide to embark on trail run excursions and mountain climbing expeditions.
Teenagers who do not get the recommended amount of sleep may be at an increased risk for high blood pressure, according to preliminary research presented at the American Heart Association's Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Scientific Sessions 2025. The meeting is being held in New Orleans, March 69, 2025, and features the latest science on population-based health and wellness and implications for lifestyle.
Teenagers who do not get the recommended amount of sleep may be at an increased risk for high blood pressure, according to preliminary research presented at the American Heart Association's Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Scientific Sessions 2025. The meeting is being held in New Orleans, March 69, 2025, and features the latest science on population-based health and wellness and implications for lifestyle.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Circulation: Cardiovascular Interventions, Ahead of Print. Background:Nickel-containing devices, such as the Amplatzer PFO Occluder and Gore Cardioform Septal Occluder (GSO), are used for transcatheter patent foramen ovale (PFO) closure. However, the impact of nickel hypersensitivity on post-procedural outcomes remains poorly understood. This study aimed to evaluate the risk of adverse events, in patients with nickel hypersensitivity undergoing PFO closure.Methods:Our study was a prospective, do
Circulation: Heart Failure, Ahead of Print. The most common form of hereditary transthyretin cardiac amyloidosis (hATTR-CA) in the United States and the United Kingdom is the p.V142I variant. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA. Nevertheless, clinical manifestations of hATTR-CA appear only late in the fifth and sixth decades of life, despite its clear genetic background.
A new study reveals that encapsulated heating methods, an often-used heat simulation method, significantly increase heart rates and cardiac strain compared to natural heat exposure like those experienced during hot weathers. Understanding how extreme heat impacts heart function is crucial for developing effective strategies to protect vulnerable groups, especially as global temperatures continue to rise.
Coronary artery spasm (CAS), or Prinzmetal angina, is a recognised cause of myocardial ischaemia in non-obstructed coronary arteries which typically presents with anginal chest pain. This case report describes an atypical presentation of CAS in a 68-year-old white British male with cardiovascular risk factors. The patient presented with recurrent palpitations and pre-syncope, with no chest pain.
tim.hodson Tue, 03/11/2025 - 11:19 Mar. 10, 2025-- Corcept Therapeutics Inc., a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, recently announced the initiation of Momentum, a clinical trial examining the prevalence of endogenous hypercortisolism (Cushings syndrome) in patients with resistant hypertension.
Background Mechanical stress on the heart is commonly considered the sole stimulus explaining the synthesis and release of circulating natriuretic peptides and their derivatives. While one of the most critical paradigms in cardiology is that mechanical load increases oxygen consumption, clinical studies on these peptides have neglected the relationship between mechanical stress and oxygen metabolism.
One of the biggest risk factors for patients who need coronary revascularization is diabetes, and a new study in JAMA suggests CABG could be a better option than FFR-guided PCI when it comes to long term outcomes for these patients. The debate has been heating up over the last few years on PCI vs. CABG for improving heart bloodflow, but few studies have looked at the benefits for patients with T2D.
There is a ‘Rule Of Halves’ about blood pressure that everyone should know. Half of all adults have high blood pressure. Half of those people don’t even know they have high blood pressure. Half of those with recognised high blood pressure are treated. Half of those who are on treatment are not at target. This is a long-winded way of saying that we do a very bad job of identifying and managing high blood pressure.
The immune response plays a vital role in the development of cardiovascular diseases (CVDs). As a crucial component of the innate immune system, neutrophils are involved in the initial inflammatory response following cardiovascular injury, thereby inducing subsequent damage and promoting recovery. Neutrophils exert their functional effects in tissues through various mechanisms, including activation and the formation of neutrophil extracellular traps (NETs).
In developing hearts, cells shuffle around, bumping into each other to find their place, and the stakes are high: pairing with the wrong cell could mean the difference between a beating heart and one that falters. A study demonstrates how heart cells go about this 'matchmaking' process. The researchers model the intricate movements of these cells and predict how genetic variations could disrupt the heart development process in fruit flies.
Nature Reviews Cardiology, Published online: 03 March 2025; doi:10.1038/s41569-025-01140-3 The brainheart axis comprises the anatomical and functional interaction between the neural and cardiovascular systems that regulate physiological, cognitive and emotional states in both health and disease. In this Review, Valenza and colleagues explore the three primary pathways of the brainheart axis neural, mechanical and biochemical discussing the regulatory mechanisms generated by each individual pat
Introduction Atrial fibrillation is the most prevalent sustained arrhythmia worldwide and is expected to increase substantially within the coming years. Although lifestyle changes and risk factor modification are now acknowledged as central components of atrial fibrillation management, the effects of exercise on disease-specific outcomes are still not extensively documented due to few high-quality randomised trials.
The Complex Relationship Between Alcohol and Heart Health Alcohol and heart health have long been subjects of debate. Some studies suggest that moderate alcohol consumption may provide cardiovascular benefits, while excessive or binge drinking can significantly harm the heart. Understanding the effects of alcohol on heart disease, blood pressure, and heart muscle function is essential for making informed decisions about alcohol intake.
tim.hodson Mon, 03/17/2025 - 14:56 March 17, 2025 Being born with a heart defect may be associated with an increased cancer risk for babies and their moms, according to new research published today in the American Heart Associations flagship journal Circulation. According to the American Heart Association, the most common birth defects in the U.S. are forms of congenital heart defects (CHD).
ObjectiveThis study aimed to investigate the effects of Enhanced External Counterpulsation (EECP) on anxiety and depression in patients with Paroxysmal Atrial Fibrillation (PAF).MethodsA cohort of 100 patients diagnosed with PAF at the Fuzhou First Hospital between January 2023 and June 2024 were enrolled in this study. Patients were randomly assigned to either the control group (n=50) or the EECP group (n=50) in this randomized controlled trial.
Its not surprising that Alnylams Amvuttra (vutrisiran) received FDA approval for ATTR-CM last week, but what shocked many was Alnylams choice to price the drug at nearly half a million dollars per year in a segment where its incumbent competitors cost half as much. Amvuttra is now the third FDA-approved therapy for ATTR-CM, following Pfizers Vyndaqel and BridgeBios Attruby/Beyonttra.
Nature Reviews Cardiology, Published online: 20 March 2025; doi:10.1038/s41569-025-01142-1 In this Review, Ravindran and Gustafsson describe the mechanisms involved in regulating mitochondrial quality control in cardiomyocytes, discuss how these pathways are altered in cardiovascular disease and ageing, and highlight the therapeutic potential of targeting mitochondrial quality control pathways in cardiovascular disease.
Introduction and objectives Decision-making regarding prognosticating out-of-hospital cardiac arrest (OHCA) remains challenging at the front door. The MIRACLE2 score provides a simple and practical tool for early neuroprognostication to aid decision-making. The study aims to validate the MIRACLE2 score in a district general hospital (DGH). Material and methods This is a retrospective analysis of the patients with OHCA and return of spontaneous circulation (ROSC) in the community who attended the
Stroke, Ahead of Print. Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking. Understanding the genetic basis of these malformations is critical for uncovering underlying mechanisms, developing targeted prevention strategies, and identifying novel therapeutic targets.
(MedPage Today) -- Healthier diet and lower waist-to-hip ratio throughout midlife were associated with better brain and cognitive health in older age, longitudinal data from the Whitehall II cohort study in England showed. A better midlife diet.
BackgroundCommunity-based models of care with the involvement of pharmacists and other nonphysician healthcare professionals can help improve blood pressure (BP) control. We aimed to synthesize the evidence of effectiveness of pharmacist interventions on BP among patients with hypertension.MethodsWe performed systematic searches to identify randomized controlled trials (RCTs) assessing the effect of pharmacist interventions on BP among outpatients (latest search, March 2024).
Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk. Methods Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk factors, to examine the associations, with false discovery rate adjustment for multiple com
In a move that could mark a serious setback for independent cardiology certification, the American Board of Medical Specialties (ABMS) denied the joint ACC/AHA/HRS/SCAI/HFSA request to launch a new American Board of Cardiovascular Medicine. Cardiologists currently receive board certification through the American Board of Internal Medicine (ABIM), but many feel the process wastes their time and money with few benefits.
Background In congenital aortic stenosis (CAS), commissurotomy is an option in patients not suitable to receive a valve prosthesis. However, there is often a need for future additional interventions on the aortic valve. The fate of the aortic valve is, however, essentially unknown. This study reports the need for reinterventions after surgical commissurotomy, based on a national register.
AI is making its mark across healthcare fields, with over 1,000 AI models now cleared by the FDA. A large portion of these advancements directly impact cardiologymore specifically, cardiac sonography. Interpreting cardiac ultrasounds has become more complex and time-consuming for clinicians: With the shift toward a more quantitative analysis, there are more parameters for clinicians to measure.
(MedPage Today) -- A large-scale longevity study suggested that more butter is bad, more plant oils are good -- and substituting plant-based oils for butter translated into better survival over several decades. After 33 years of follow-up, deaths.
BackgroundHeart failure (HF), a core component of cardiovascular diseases, is characterized by high morbidity and mortality worldwide. By collecting and analyzing routine blood data, machine learning models were built to identify the patterns of changes in blood indicators related to HF.MethodsWe conducted a statistical analysis of routine blood data from 226 patients who visited Zhejiang Provincial Hospital of Traditional Chinese Medicine (Hubin) between May 1, 2024, and June 30, 2024.
Background In patients with tricuspid regurgitation (TR), delayed surgical intervention is associated with poor outcomes, particularly in advanced stages. This study aimed to assess whether earlier tricuspid valve (TV) surgery provides a survival benefit in patients with moderate to severe TR who are considered at low to intermediate risk of adverse clinical or surgical outcomes.
The coffee from most of the coffee machines in workplaces contains relatively high levels of cholesterol-elevating substances. There is a big difference in comparison to coffee made in regular paper filter coffee makers, which filter out most of these substances.
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