The New England Journal of Medicine

JUNE 13, 2024

Intravenous tenecteplase has been shown to be noninferior to alteplase, with a meta-analysis suggesting superiority,1 and although tenecteplase has been used off label, it is replacing alteplase as the preferred thrombolytic agent for the treatment of acute stroke. Aside from the use of thrombolysis for stroke on awakening.

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Thrombolysis Stroke Strokes 40

American College of Cardiology

SEPTEMBER 10, 2024

The goal of the MOST trial was to evaluate argatroban vs. eptifibatide vs. placebo among patients with acute ischemic stroke treated with intravenous thrombolytic therapy.

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Thrombolysis Stroke Strokes Article 45

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP16-AWP16, February 1, 2024. Introduction:Trials using advanced imaging have shown a benefit from intravenous thrombolysis in patients with wake-up stroke, but real-world data is limited. in those able to receive perfusion imaging). in those able to receive perfusion imaging).

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Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP8-ATP8, February 1, 2025. Introduction:Treatment of acute stroke has its clear rules and established standards. The neurological deficit corresponded to 5 points in the median NIHSS after a previous stroke, 11 points at the time of recurrence, and 7 points after rescue therapy.

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Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP11-AWP11, February 1, 2025. Introduction:Stroke is a leading cause of disability and mortality worldwide, with thrombolysis as a critical treatment. Studies aiming to assess the outcomes of thrombolysis after ischemic stroke in LMIC were selected.

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Thrombolysis Outcomes Stroke Strokes 40

Journal of the American Heart Association

MARCH 8, 2024

Journal of the American Heart Association, Ahead of Print. We performed sensitivity analysis using propensity score matching. 0.75];P=0.001).

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Thrombolysis Outcomes Stroke Strokes 45

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP13-AWP13, February 1, 2025. Introduction:Strokes affecting the posterior circulation (PCS) account for 20% of all ischemic strokes. The number of stroke mimics presenting with isolated dizziness who received thrombolysis was 11 in 2021, 16 in 2022, 9 in 2023, and 11 in 2024.

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Thrombolysis Stroke Strokes Circulation 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP100-AWP100, February 1, 2024. Introduction:IV thrombolysis is a proven treatment for acute ischemic stroke (AIS), but it is still underutilized in real-world clinical practice. Urgent interventions to increase IV thrombolysis rates are needed to improve acute stroke care.

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Thrombolysis Stroke Strokes Hospital 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A43-A43, February 1, 2024. hours of ischemic stroke onset from 2003 to 2021. hours of ischemic stroke onset from 2003 to 2021. Thrombolysis rates and speed of treatment during TS phase I (2010-2013), II (2014-2018), and III (2019-2021) were compared with the pre-TS period (2003-2009).Results:Among

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Thrombolysis Stroke Strokes Hospital 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP107-ATP107, February 1, 2024. Introduction:Emergency-department-based implementation strategies to increase thrombolysis are promising. The study population was limited to ischemic stroke patients admitted to the hospital. Among 1608 hospitals, 1131 (70%) had tPA rates below 10%.

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Thrombolysis Hospital Inpatient Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A4-A4, February 1, 2025. Introduction:The tenecteplase versus standard of care for minor ischemic stroke with proven occlusion (TEMPO-2) trial showed that patients presenting with minor deficits up to 12 h do not benefit from intravenous thrombolysis. vs control 2.1%, P=0.005.

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Thrombolysis Stroke Strokes Outcomes 40

Stroke: Vascular and Interventional Neurology

MARCH 8, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. Among 51% of countries surveyed, no acute thrombolytic treatment was provided for acute stroke in the 2021 calendar year. Most respondents (88%) agreed there were barriers to acute stroke thrombolysis in the region.

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Thrombolysis Stroke Strokes Hospital 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP3-ADP3, February 1, 2025. Background:Current guidelines for ischemic stroke recommend initiating intravenous thrombolytic therapy within 4.5 hours after stroke onset or the last known well time. These modalities can identify viable brain tissue beyond the 4.5-hour h to standard of care.

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Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AHUP6-AHUP6, February 1, 2025. Introduction:Prior studies have demonstrated social determinants of health (SDoH) are associated with reduced rates of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS), including in disadvantaged populations.

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Thrombolysis Stroke Strokes Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP299-ATP299, February 1, 2025. Introduction:Prior studies have demonstrated social determinants of health (SDH) are associated with reduced rates of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS), including in disadvantaged populations.

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Thrombolysis Stroke Strokes Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP9-AWP9, February 1, 2025. Background:Acute ischemic stroke can result from extracranial arterial dissection. The effectiveness and safety of intravenous thrombolysis (IVT) for acute ischemic stroke in these cases, particularly those involving large vessel occlusions, are debated.

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Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP115-ATP115, February 1, 2024. Background:The SouthEast Texas Regional Advisory Council (SETRAC) has actively engaged representatives from regional healthcare systems who collectively work towards advancing stroke care delivery. The rates of thrombolysis increased from 7.10% in 2014 to 11.8%

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Thrombolysis Hospital Stroke Strokes 40

Medical Xpress - Cardiology

FEBRUARY 12, 2024

nationwide quality initiative Target: Stroke (TS) is associated with improvement in thrombolysis frequency, timeliness, and outcome, according to a study published online Feb. 7 in JAMA Network Open.

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Thrombolysis Stroke Strokes Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionOver the past decade, stroke management has significantly improved with the widespread use of intravenous thrombolysis (IVT) and the establishment of endovascular thrombectomy (EVT) as the standard of care for increasing patients.

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Thrombolysis Inpatient Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP20-ATP20, February 1, 2025. The primary outcome was 3-month functional outcome by modified Rankin scale (mRS). Patients with elevated traditional risk factors at admission may benefit more from thrombolytic therapy compared to those with high inflammatory response indicators.

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Thrombolysis Stroke Strokes Risk Factors 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP1-ADP1, February 1, 2025. Whether intravenous thrombolysis (IVT) is safe and effective for acute ischemic stroke (AIS) patients with CAA is largely unknown.Methods:This was an explorative analysis of a nationwide database of hospitalizations in the United States.

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Thrombolysis Stroke Strokes Cerebrovascular Disease 40

Med Page Today

FEBRUARY 8, 2025

(MedPage Today) -- LOS ANGELES -- The HOPE trial made another case for extending the therapeutic window for IV thrombolysis in acute ischemic stroke, potentially widening the pool of people eligible for therapy. Among patients with stroke clots.

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Stroke Strokes Thrombolysis 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP5-AWMP5, February 1, 2024.

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Thrombolysis Outcomes Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP117-ATP117, February 1, 2024. Introduction:Reducing door-to-needle (DTN) times lead to improved patient outcomes in acute ischemic stroke. 2) Creation of a multidisciplinary Thrombolysis Focus Group to analyze data and improve processes. in 2020, to 31.9% in 2021, to 59.6%

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Thrombolysis Academic Document Innovation 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP1-AWP1, February 1, 2025. Background and aims:Central retinal artery occlusion (CRAO) is a rare but significantly underestimated form of ischemic stroke. One of the considered and currently increasingly preferred options is intravenous thrombolysis. years, 46.9%

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Thrombolysis Hemorrhage Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A26-A26, February 1, 2024. The access to acute stroke treatments, especially intravenour thrombolysis and mechanical thrombectomy, is limited. The average stroke centres per million (SCPM) population was 0.41 for IVT-C and EVT-C, respectively. hours, respectively.

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Thrombolysis Stroke Strokes Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP14-AWP14, February 1, 2025. Introduction:The use of IV thrombolysis (IVT) in acute ischemic stroke patients presenting with an NIHSS of 5 has failed to demonstrate benefit, particularly when the symptoms are considered non-disabling. Kappa = 0.26 [95% CI 0.23 0.29]) (Table 1).

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Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP253-AWP253, February 1, 2025. Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation.

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Thrombolysis Stroke Strokes Stents 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP270-ATP270, February 1, 2024. Objective:A proportion of acute ischemic stroke (AIS) patients suffer from early neurological deterioration (END) within 24 hours following intravenous thrombolysis (IVT), which greatly increases the risk of poor prognosis of these patients.

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Thrombolysis BMI Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP6-AWP6, February 1, 2025. Background and Purpose:Whether imaging markers of cerebral small vessel disease on computed tomography (CT-CSVD) relates to early clinical outcomes after intravenous thrombolysis for acute ischemic stroke remains not well understood. 1.95, p = 0.019).Conclusion:This

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Thrombolysis Outcomes Biomarkers Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP19-AWP19, February 1, 2025. We aim to assess the ability of ChatGPT to guide the decision for intravenous thrombolysis (IVT) in patients with acute ischemic strokes (AIS).Methods:The Introduction:Artificial intelligence is emerging as an adjunct promising tool in medicine.

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Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2025. Introduction:Current guidelines recommend 24-hours of high-intensity monitoring (HIM) for acute ischemic stroke patients post-intravenous thrombolysis (IVT) due to risk of bleeding complications including symptomatic intracranial hemorrhage (sICH).

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Thrombolysis ICU Stroke Strokes 40

Frontiers in Cardiovascular Medicine

FEBRUARY 24, 2025

This case report describes a unique instance of a patient developing AEF following AF ablation, accompanied by ischemic stroke and myocardial infarction. A 71-year-old male admitted to the emergency department on July 19, 2024, with acute loss of consciousness and convulsions.

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Atrial Fibrillation Ablation Cardiogenic Shock Myocardial Infarction 52

Journal of the American Heart Association

DECEMBER 24, 2024

Journal of the American Heart Association, Ahead of Print.

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Thrombolysis Hospital Stroke Strokes 45

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP213-ATP213, February 1, 2024. Background and Purpose:Although intra-arterial thrombolysis (IAT) is widely used as adjunct with mechanical thrombectomy in acute ischemic stroke patients, the patients who are likely to benefit are not known. in group A and 3.25±2.01 in group B (p=0.002).

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Thrombolysis Stroke Strokes Stents 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP115-ATP115, February 1, 2025. Background:Mechanical thrombectomy (MT) as treatment for acute ischemic stroke (AIS) has demonstrated superior functional outcomes compared to intravenous thrombolysis (IVT).

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Thrombolysis Stroke Strokes Quality of Life 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP11-ATP11, February 1, 2025. Introduction:Current guidelines suggest using intravenous thrombolysis (IVT) for patients experiencing acute ischemic stroke within 4.5 IVT patients had similar stroke severity at baseline (median NIHSS 4.5 (2.0-6.0) hours of symptom onset.

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Thrombolysis Stroke Strokes Education 40