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Early sickle cell disease intervention may lower stroke risk

Medical Xpress - Cardiology

Bone marrow transplantation (BMT) can potentially cure sickle cell disease, an inherited and painful blood disorder, but because of its potential drawbacks and costs, patients and caregivers often face the difficult decision of whether to undergo the procedure.

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Stroke rates increasing in individuals living with SCD despite treatment guidelines

Science Daily - Heart Disease

The incidence of stroke continues to increase for adults and children living with sickle cell disease (SCD) despite the Stroke Prevention Trial in Sickle Cell Anemia (STOP) establishing standards of care like transfusions and tests to measure blood flow in the brain for those deemed high-risk, according to a new study.

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Blood clots on a chip: New model could improve thromboinflammation treatment

Medical Xpress - Cardiology

Blood clots are associated with life-threatening conditions such as sepsis, sickle cell disease, heart attack, and stroke.

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Stroke rates increasing in individuals living with sickle cell disease despite treatment guidelines: Study

Medical Xpress - Cardiology

The incidence of stroke continues to increase for adults and children living with sickle cell disease (SCD), despite the Stroke Prevention Trial in Sickle Cell Anemia (STOP) establishing standards of care like transfusions and tests to measure blood flow in the brain for those deemed high-risk, according to a study published in Blood.

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Abstract TP147: Assessment of Inter-Rater Reliability of Fazekas Scoring on Magnetic Resonance Imaging in Patients With Sickle Cell Disease

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATP147-ATP147, February 1, 2024. Background:White matter disease is a common phenomenon in patients with sickle cell disease, that has been linked to cognitive impairment. However, there is no standardized approach for quantification of the cerebral disease burden.

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Abstract TMP7: Disruption of Blood Brain Barrier is Associated With Silent Cerebral Infarcts in Patients With Sickle Cell Disease

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATMP7-ATMP7, February 1, 2024. Background:Microvascular thromboinflammation is a major pathomechanism underlying vaso-occlusive crisis in patients with sickle cell disease (SCD), yet its role underlying the elevated stroke risk in SCD is unclear.

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Abstract TMP12: Large Vessel Vasculopathy is Associated With Oxygen Metabolic Stress in Children and Young Adults With Sickle Cell Disease

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATMP12-ATMP12, February 1, 2024. Background:Large-vessel vasculopathy (LVV), such as moyamoya syndrome, increases stroke risk with sickle cell disease (SCD). Hemispheric OEF, as an indicator of increased stroke risk, may guide medical management and surgical intervention.