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Nature Reviews Cardiology, Published online: 17 September 2024; doi:10.1038/s41569-024-01070-6 The gut microbiota has emerged as a riskfactor that affects thrombotic phenotypes in several cardiovascular diseases.
DALLAS, January 29, 2024 — A new scientific statement from the American Heart Association emphasizes the need to increase patients’ and physicians’ awareness of cerebral venous thrombosis (CVT) to improve the recognition of this condition and initiate.
Explore actionable, evidence-based strategies to combat traditional and emerging riskfactors, with a focus on precision approaches and primordial prevention. Precision Medicine: Personalizing Prevention for Better Outcomes Precision medicine provides tools to customize prevention and treatment plans based on individual riskfactors.
Active cancer is a strong riskfactor for venous thromboembolism (VTE) events and recurrent events following discontinuation of anticoagulation therapy, and cancer patients are also at a heightened risk for bleeding complications related to anticoagulation treatment.
In this phenomenon, a thrombus forms within the lumen of the stent graft component of the frozen elephant trunk prosthesis and puts the patient at risk for downstream embolization with visceral or lower limb ischemia.
Introduction:Seizures are a common initial manifestation of cerebral venous thrombosis (CVT). Riskfactors included intracranial hemorrhage (OR 2.0 Variables with P-value < 0.2 were included in the backward stepwise regression model with 0.2 Delayed seizures occurred in 37 (6.1%) patients. p=0.046), respectively.
MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection; myocardial disorders, including myocarditis, takotsubo cardiomyopathy, and other cardiomyopathies. This is in spite of the known proclivity of tighter stenoses to thrombose.
Inferior vena cava (IVC) agenesis is a rare congenital anomaly that has been implicated in up to 5% of unprovoked deep vein thrombosis (DVT) cases in young men under 30 years old. A hypercoagulability workup was positive for a heterozygous Factor V Leiden (FVL) mutation, an additional thrombophilic riskfactor.
Updated with the latest research since the 2020 edition, this comprehensive report underscores the potential to prevent or significantly delay dementia by targeting modifiable riskfactors. The report now identifies 14 modifiable riskfactors for dementia.
Baseline data were analyzed using univariate analysis, and potential independent riskfactors associated with PE were further identified through univariate and multivariate logistic regression analysis. Participants were randomly divided into a training group (70%) and a validation group (30%).
Endothelial damage, prothrombotic factor release, and a higher prevalence of cardiovascular riskfactors in those receiving ART have been invoked to explain this association. The study exposure was use of ART. Individual stroke subtypes (IS, SAH, ICH, and CVT) were evaluated as secondary endpoints.
Genetic protein S (PS) deficiency caused by PROS1 gene mutation is an important riskfactor for hereditary thrombophilia.Case introductionIn this case, we report a 28-year-old male patient who developed a severe pulmonary embolism during his visit. Ultrasound showed no thrombosis in the veins of both lower limbs.
Age, proximal and distal deep vein thrombosis (DVT) vs. distal DVT, active cancer, history of long-term immobilization, VTE was detected in the intensive care unit, active/recurrent bleeding, IVC thrombosis, and history of venous thromboembolism were independent predictive riskfactors for non-retrieval of filters.
However, it subjects patients to lifelong warfarin therapy after MHVR, with the attendant risk of bleeding and thrombosis. The percentage of time in the therapeutic range (TTR) was used as the primary outcome while bleeding, thrombosis, and other events were the secondary outcomes.Results:A total of 721 patients were enrolled.
Background:Patients with intracerebral hemorrhage (ICH) are known to have a higher risk of venous thromboembolism (VTE) than patients with acute ischemic stroke, but the factors underlying this difference have not been clearly identified.
Elevated levels of Lp(a) are an independent and causal riskfactor for atherosclerotic cardiovascular diseases through mechanisms associated with increased atherogenesis, inflammation, and thrombosis. Having elevated Lp(a) can increase risk of heart attack, stroke, and peripheral artery disease.It
The underlying etiology and riskfactors remain unclear due to the limited number of reported cases and the incomplete understanding of the underlying mechanisms. The suggested DCV pathophysiologic mechanisms involve vascular inflammation and delayed cerebral thrombosis (DCT).
Background Left atrial (LA) hemodynamics after lung lobectomies with pulmonary vein (PV) resection is widely understood to be a riskfactor for LA thrombosis.
Cases had a maternal stroke (ischemic, hemorrhagic, subarachnoid hemorrhage, or cerebral venous thrombosis) during pregnancy or PP, identified from a stroke registry.
All the patients were observed during their hospital stay for postprocedure in-hospital morbidity (pump failure, contrast-induced nephropathy, major bleeding, cerebrovascular accident/stroke, access site complications or stent thrombosis) and mortality. The mean BMI was 27.48±4.93 kg/m 2 and 23.2% (255) were categorised as obese.
We hypothesized that pregnant or postpartum patients with acute hemorrhagic stroke would have higher odds of delayed or missed diagnosis at the time of their initial presentation, compared with those with thrombotic strokes (arterial ischemic stroke [AIS] or cerebral venous thrombosis [CVT]).Methods:We
Von Willebrand factor (VWF) plays a crucial role in hemostasis and thrombosis by promoting platelet adhesion to the subendothelial matrix and factor VIII stabilization. VWF activity is regulated by the protease ADAMTS13. aureusor vehicle on days 0, 2, and 5.
Doppler of lower extremities showed deep vein thrombosis in the left femoral vein. He was worked up for any infectious etiology because he continued to have a leukocytosis with an eosinophil count as high as 49%. Going back to the basics and reviewing simple laboratory tests like cell blood count can be the initial clue for diagnosis.
6 However, multiple studies have suggested that medical management alone is likely not sufficient in reducing the recurrent stroke risk caused by CaWs.5,7 Most patients are treated with antiplatelet therapy, but some elect to treat with anticoagulation due to the focal hemostasis caused by CaWs.6
Given the consistency of the clinical profile with typical angina, associated riskfactors, and abnormal ECG findings, a cardiology consult was promptly requested. Category 1 : Sudden narrowing of a coronary artery due to ACS (plaque rupture with thrombosis and/or downstream showering of platelet-fibrin aggregates.
The commonest causes of MINOCA include: atherosclerotic causes such as plaque rupture or erosion with spontaneous thrombolysis, and non-atherosclerotic causes such as coronary vasospasm (sometimes called variant angina or Prinzmetal's angina), coronary embolism or thrombosis, possibly microvascular dysfunction.
Coronary thrombosis or embolism can result in MINOCA, either with or without a hypercoagulable state. If there is any evidence of atherosclerosis, modifiable CAD riskfactors should be treated aggressively. Coronary microvascular dysfunction may contribute to MINOCA and requires further investigation.
Despite the DP-DES group exhibiting significantly higher rates of riskfactors, such as arterial hypertension (63.1% vs 35.2%, p<0.001), the rate of acute stent thrombosis (ST) was significantly lower than in the BP-DES group (HR 0.240, 95% CI 0.075 to 0.766; p=0.016).
BackgroundEffective therapies for reducing cardiovascular disease (CVD) risk in people with elevated lipoprotein(a) are lacking, especially for primary prevention. Because of the potential association of lipoprotein(a) with thrombosis, we evaluated the relationship between aspirin use and CVD events in people with elevated lipoprotein(a).Methods
IntroductionCerebral venous sinus thrombosis (CVST) is a rare form of stroke that usually affects young females especially during pregnancy and the postpartum period. The symptoms of cerebral venous sinus thrombosis can vary depending on the location and extent of the clot.
To quote Dr. Stephen Smith: "The worst riskfactor for a bad outcome in acute MI is young age." This may occur as a result of blunt chest trauma or other acute stress that produces a sudden extreme shear force on a coronary artery ( that can result in an intimal tear that leads to intraluminal thrombosis ).
Background:Prognostication following cerebral venous thrombosis (CVT) remains challenging. Stroke, Volume 55, Issue Suppl_1 , Page ATMP108-ATMP108, February 1, 2024. Mortality is an uncommon yet catastrophic outcome after CVT. ACTION-CVT was an international retrospective study that enrolled consecutive patients with CVT across 27 centers.
Introduction:Exposure to high altitude environment is a riskfactor of cerebral venous thrombosis (CVT) probably due to the hypercoagulability. Stroke, Volume 55, Issue Suppl_1 , Page ATP267-ATP267, February 1, 2024.
The American Heart Association draws attention to nonalcoholic fatty liver disease, which affects about one in four adults and is a riskfactor for atherosclerotic cardiovascular disease.
11 Despite the link between inflammation and cardiovascular disease has been proven by extensive research, most physicians have focused on treating high-risk patients with lipid lowering therapies including statin therapy.1,12,13 mg) to reduce the risks of heart attack, stroke, coronary revascularization, and CV death.29 Circulation.
Smith Major Learning Point: The worst riskfactor for a bad outcome in OMI is young age because cardiologists cannot believe that a young person can have an OMI. He was readmitted a few weeks later for a heart failure exacerbation, diuresed, and discharged again. This gets drilled into them. Was this coincidence? —
The use of recreational cocaine in young adults is well known to be responsible for acute ischemic and hemorrhagic strokes in individuals who lack other vascular riskfactors. What is significantly rarer with few reported cases, however, is cocaine‐related ASCIS as the etiology of non‐traumatic acute spinal cord myelopathy [3‐7].MethodsN/AResultsA
Introduction:Active cancer is a known riskfactor for cerebral venous thrombosis (CVT), but it is unknown whether CVT is also associated with occult cancer. Stroke, Volume 55, Issue Suppl_1 , Page A136-A136, February 1, 2024.
Introduction:COVID-19 infection has thus emerged to be a new riskfactor for Cerebral Venous Thrombosis (CVT). Acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), epilepsy, deep vein thrombosis and pulmonary embolism were secondary outcomes. vs 5.5%; HR=2.16; 95% CI=1.23-3.64
Multivariable logistic regression was employed to identify riskfactors for incomplete occlusion and PDL.ResultsPeri-procedural complication rates were low among all groups, with 2.9% Persistent AF and SCr were significant riskfactors for incomplete occlusion and PDL. in the RFCA combined with the LAAO group.
Deep Vein Thrombosis (DVT) : A blood clot occurring in a deep vein. Causes include infection, malignancy, surgery, scar tissue formation, trauma, deep vein thrombosis (DVT), radiation or other cancer treatment. Carotid Ultrasound : Evaluates blood flow to the brain and detects stroke riskfactors.
Imge courtesy of Won-Young Kim from Chung-Ang University milla1cf Thu, 01/11/2024 - 08:30 January 11, 2024 — Acute cardiovascular manifestations of COVID-19 , such as heart failure, thrombosis, and dysrhythmia, are associated with increased mortality.
We recorded several key outcomes, including early and late intervention-related complications, the need for reintervention, the interval between the NP and the first intervention, shunt patency following the intervention, associated morbidities, and thrombosis-related sudden events. kg), respectively.
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