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The commonest causes of MINOCA include: atherosclerotic causes such as plaque rupture or erosion with spontaneous thrombolysis, and non-atherosclerotic causes such as coronary vasospasm (sometimes called variant angina or Prinzmetal's angina), coronary embolism or thrombosis, possibly microvascular dysfunction.
As with elevated LDL-cholesterol, high levels of triglycerides and the lipid particles on which they are carried in the blood can contribute to the formation of “plaques” in the arteries that impede blood flow and can lead to heart attacks and strokes. Triglycerides store unused calories and provide energy to the body.
A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty. Angiography : --Culprit for the patient's unstable angina/Wellen syndrome is a ruptured plaque in the mid LAD. --As Am Heart J. 2000;139:430–436.
She was diagnosed with NSTEMI with a thrombolysis in myocardial infarction (TIMI) score of 5. Her EKG showed marked left-axis deviation, ST depressions in V2-V4, and RBBB. PCI, particularly with the Carlino technique, offers a reliable approach.
It is generally believed it is more of a mechanical plaque lesion. RCA and LCX Wellens do occur, making this entity’s perceived unique importance less certain 3. How common is thrombosis in the culprit artery of Wellen syndrome ? However by no means, we can say thrombosis do not occur. Is there a benign face of Wellen syndrome ?
Reperfusion of OMI indicates at least partial thrombolysis of occluding thrombus, but still unstable plaque rupture, which can reocclude at any moment. This case's first EMS ECG shows a rare example of LVH with active anterior and high lateral OMI. Comparison to prior ECG can be very helpful.
This has been termed a “STEMI equivalent” and included in STEMI guidelines, suggesting this patient should receive dual anti-platelets, heparin and immediate cath lab activation–or thrombolysis in centres where cath lab is not available.
The ECG is diagnostic for acute transmural infarction of the anterior and lateral walls, with LAD OMI being the most likely cause (which has various potential etiologies for the actual cause of the acute coronary artery occlusion, the most common of which is of course type 1 ACS, plaque rupture with thrombotic occlusion).
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