Open Heart

SEPTEMBER 19, 2024

Background Inflammation plays a pivotal role in atherogenesis and is a causal risk factor for atherosclerotic cardiovascular disease. Non-invasive coronary CT angiography (CCTA) enables evaluation of coronary plaque phenotype. Baseline total plaque volume was 1394 (1036, 1993) mm 3. Results The mean±SD age was 65.4±8.4

Plaque 52

Plaque Coronary Artery Disease Risk Factors Cardiovascular Disease 52

Dr. Paddy Barrett

APRIL 22, 2025

Multiple studies have shown plaque build up in people from their teenage years onwards with significant amounts present by mid 20’s. This is why addressing risk factors such as high cholesterol early in life is so important. I presume most of you who are reading this are well past your twenties.

Heart Attack 53

Heart Attack Heart attacks Cholesterol Heart Disease 53

Journal of the American Heart Association

FEBRUARY 26, 2025

BackgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. After multivariate adjustment, every 0.1mmol/L increase in timeaveraged sdLDLC conferred a 1.2fold increased risk of PP.ConclusionsOur findings suggest that sdLDLC is an independent risk factor of PP in patients with coronary artery disease.

Ultrasound 56

Ultrasound Plaque Cholesterol Coronary Artery Disease 56

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. CCTA also has the potential to de-risk clinical endpoint-based trials both financially and by enrichment of participants at higher likelihood of MACE.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

MIBHS

JANUARY 15, 2025

Inflammation and Plaque Buildup: Smoking damages the endothelium (the inner lining of blood vessels), triggering inflammation. This damage accelerates the formation of plaques, leading to atherosclerosisa condition where arteries narrow and harden, restricting blood flow.

Coronary Artery Bypass Graft 52

Coronary Artery Bypass Graft Blood Clot Blood Pressure Plaque 52

MIBHS

FEBRUARY 15, 2025

Artery Damage : Hypertension damages the inner lining of your arteries, making them less elastic and more prone to plaque buildup. This condition, called atherosclerosis, narrows the arteries, restricting blood flow and increasing the risk of heart attacks and strokes.

Blood Pressure 52

Blood Pressure Hypertension Chest Pain Aneurysm 52

Frontiers in Cardiovascular Medicine

JULY 24, 2024

Although the entire vascular bed is constantly exposed to the same risk factors, atherosclerosis manifests a distinct intra-individual pattern in localization and progression within the arterial vascular bed.

Atherosclerosis 52

Atherosclerosis Plaque Coronary Artery Disease Risk Factors 52

Stroke Journal

JANUARY 30, 2025

Advancements in magnetic resonance angiography (MRA) with vessel wall imaging (VWI) have enabled the identification of vulnerable plaques, aiding in risk stratification for neurovascular events. A retrospective chart review was conducted to extract pertinent clinical data including cardiovascular risk factors and medications.

Plaque 40

Plaque Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 9, 2024

BACKGROUND:HIV and hepatitis C virus (HCV) are associated with increased risk of carotid artery atherosclerotic plaque and stroke. Plaques were characterized from 6 areas of the right carotid artery. 2.78]) were each associated with higher prevalence of predominantly echogenic plaque. Stroke, Ahead of Print.

Plaque 40

Plaque Ultrasound Risk Factors Stroke 40

DAIC

FEBRUARY 3, 2025

Lp(a) is emerging as an important, yet under-recognized, potential risk factor for cardiovascular disease due to its ability to promote the development of plaques within artery walls, clot formation and aortic valve calcification. The development of the Tina-quant Lipoprotein (a) Gen.2

Cardiovascular Disease 52

Cardiovascular Disease Aortic valve Biomarkers Innovation 52

Stroke Journal

JANUARY 12, 2024

Incident carotid plaques and their vulnerability were detected by carotid ultrasound at follow-up (2021). Higher sdLDL-C or sdLDL-C/LDL-C ratio, but not LDL-C, was significantly associated with an increased risk of incident carotid plaques. years (SD=0.14). years (SD=0.14). 9.90];P=0.027;Pfor linear trend=0.025).

Plaque 40

Plaque Cholesterol Ultrasound Stenosis 40

Journal of the American Heart Association

MARCH 6, 2024

We used carotid ultrasounds to detect plaque at baseline and follow‐up in 2006 to 2009 (median follow‐up=5.5 had incident plaque (109/1104 plaque‐free participants with baseline and follow‐up ultrasounds), 11.0% We evaluated SHFS participants, who were 15 to 39 years old at the baseline examination in 2001 to 2003 (n=1440).

Plaque 75

Plaque Cholesterol Ultrasound Education 75

Stroke Journal

FEBRUARY 1, 2024

Atherosclerotic plaque formation is modulated by genetic and environmental interactions. In this study, we examined the effects of ApoE deficiency and high fat diet (HFD) on plaque formation and immunomodulatory cellular and molecular mechanisms in mice models.Methods:Wild type and ApoE knockout (KO) mice were fed with normal or HFD.

Atherosclerosis 40

Atherosclerosis Risk Factors Diet Plaque 40

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

Nevertheless, most cardiovascular risk models, including SCORE2, still do not take educational status into account even if this factor is easily assessed and costs nothing to acquire. Even after adjusting for common risk factors including metabolic syndrome and SCORE2, the relationship was maintained. 2.06; and 0.0.63

Education 52

Education Plaque Risk Factors Cardiovascular Disease 52

DAIC

JUNE 4, 2024

fold higher risk for cardiac mortality and 5.5-fold fold higher risk for major adverse cardiac events (MACE) Caristo's AI-Risk model, CaRi-Heart Risk Score, outperformed other scores in routine clinical use for prediction of cardiac mortality, and when presented to clinicians, resulted in changes of management decision in 45% of the patients.

Technology 116

Technology Heart Attack Heart attacks Coronary Artery Disease 116

Journal of the American Heart Association

DECEMBER 20, 2023

The degree of CCA stenosis was associated with increased risks of incident CVD, coronary heart disease, and stroke, with multivariable‐adjusted HRs (95% CIs) for <25%, 25%–49%, and ≥50% stenosis with plaque compared with no CCA plaque of 1.37 (1.07–1.76), 1.76), 1.72 (1.23–2.40), 2.40), and 2.49 (1.69–3.67),

Stenosis 78

Stenosis Cardiovascular Disease Plaque Heart Disease 78

Journal of the American Heart Association

JANUARY 23, 2025

Carotid plaque (CP) is an independent risk factor for cardiovascular diseases. However, evidence for association of MHR with risk of CP is scarce.Methods and ResultsThis study involved 5260 participants aged >18 years old from the Dalian health management cohort in 2014 to 2022.

Plaque 40

Plaque Cardiovascular Disease Risk Factors 40

Ken Grauer, MD

FEBRUARY 3, 2024

Non-obstructive coronary disease at the time cardiac cath is done does not necessarily imply there was no plaque rupture with thrombus. These plaques will often not be recognized as "culprits" — because no fissuring or ulceration is seen. Longterm prognosis of patients with MINOCA clearly depends on the underlying etiology.

Blog 163

Blog Cardiac Arrest STEMI Plaque 163

Dr. Smith's ECG Blog

NOVEMBER 15, 2023

MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection; myocardial disorders, including myocarditis, takotsubo cardiomyopathy, and other cardiomyopathies. Thus, intracoronary imaging modalities are crucial in this setting. From Gue at al.

Coronary Angiogram 109

Coronary Angiogram Plaque Thrombosis STEMI 109

NEJM Journal Watch - Cardiology

OCTOBER 24, 2024

Any atherosclerotic plaque is bad, and its presence portends a worse prognosis if modifiable risk factors like hypertension and smoking are not addressed.

Atherosclerosis 40

Atherosclerosis Plaque Risk Factors Hypertension 40

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

We investigated whether treatment with LDE-paclitaxel changes plaque progression by coronary CT angiography and is safe in patients with chronic coronary artery disease. Baseline demographics, risk factors, and laboratory results were not different between groups.

Coronary Artery Disease 59

Coronary Artery Disease Laboratory Plaque Myocardial Infarction 59

Dr. Smith's ECG Blog

DECEMBER 19, 2023

The commonest causes of MINOCA include: atherosclerotic causes such as plaque rupture or erosion with spontaneous thrombolysis, and non-atherosclerotic causes such as coronary vasospasm (sometimes called variant angina or Prinzmetal's angina), coronary embolism or thrombosis, possibly microvascular dysfunction. It is not rare.

Plaque 126

Plaque Angina Blog Stent 126

Dr. Smith's ECG Blog

MAY 20, 2024

The scan also showed “scattered coronary artery plaques”. __ Smith comment 1 : the appropriate management at this point is to lower the blood pressure (lower afterload, which increases myocardial oxygen demand). Smith comment : Is the ACS (rupture plaque) with occlusion that is now reperfusing?

Chest Pain 124

Chest Pain Blood Pressure Ischemia STEMI 124

Frontiers in Cardiovascular Medicine

MAY 21, 2024

Angiography showed a donor renal artery dissection distal to the moderately stenosed anastomosis site with calcified atherosclerotic plaque confirmed by IVUS. Our case showed that endovascular intervention can replace surgery to repair very early vascular complications such as dissection and help patients avoid high-risk operations.

Transplant 52

Transplant Ultrasound Plaque Atherosclerosis 52

Dr. Smith's ECG Blog

DECEMBER 7, 2023

I quickly reviewed the patient’s records and saw that she was a 53 year old woman with a history of BMI 40, but no other identifiable risk factors for coronary artery disease. Learning Points: Type 1 MI is the type we are most familiar with: rupture of atherosclerotic plaque with production thrombus or platelet fibrin aggregates.

SCAD 123

SCAD Ischemia Coronary Artery Disease Cardiomyopathy 123

EMS 12-Lead

AUGUST 18, 2024

He denied any known history of CAD, but did report ASCVD risk factors to include HTN, HLD, and DM. I interpreted the ECG as VT with two primary etiological possibilities: 1. Abrupt plaque ulceration of Type 1 ACS leading to VT.

Tachycardia 59

Tachycardia Blog RN Echocardiogram 59

Frontiers in Cardiovascular Medicine

FEBRUARY 7, 2024

The vessels with reduced CFR presented a significantly higher prevalence of obstructive CAD (37% vs. 26%; P  < 0.001), diffused atherosclerosis (22% vs. 11%; P  < 0.001), low-attenuation plaque (6% vs. 3%; P  = 0.030), and positive remodeling (7% vs. 2%; P  = 0.001). FAI was higher in vessels with reduced CFR (−80.8 HU HU vs. −81.8 HU;

Coronary Artery Disease 64

Coronary Artery Disease Atherosclerosis Plaque Stenosis 64

DAIC

APRIL 7, 2024

As with elevated LDL-cholesterol, high levels of triglycerides and the lipid particles on which they are carried in the blood can contribute to the formation of “plaques” in the arteries that impede blood flow and can lead to heart attacks and strokes. Triglycerides store unused calories and provide energy to the body. and Canada.

Cholesterol 116

Cholesterol Heart Attack Heart attacks Myocardial Infarction 116

Heart BMJ

MARCH 22, 2024

Immune-mediated inflammatory diseases (IMIDs) are recognised risk factors for accelerated atherosclerotic cardiovascular disease (CVD), particularly in younger individuals and women who lack traditional CVD risk factors.

Plaque 40

Plaque Atherosclerosis Risk Factors Angina 40

Journal of the American Heart Association

DECEMBER 8, 2023

After adjustment for cardiovascular risk factors, depression was not significantly associated with any coronary plaque (adjusted odds ratio [OR], 1.05 [95% CI, 0.78–1.41];P=0.746), 1.41];P=0.746), calcified plaque (OR, 0.95 [95% CI, 0.71–1.29];P=0.758), 1.29];P=0.758), noncalcified plaque (OR, 1.31 [95% CI, 0.79–2.17];P=0.305),

Coronary Artery Disease 40

Coronary Artery Disease Atherosclerosis Plaque Stenosis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionAtherosclerosis, the hardening and narrowing of the arteries, occurs due to the buildup of plaque on the inner walls of the arteries which can result in reduced blood flow to the organs and tissues. Risk factors such as smoking, chronic kidney disease, and aging can contribute to plaque formation.

Risk Factors 40

Risk Factors Blood Pressure Chest Pain Plaque 40

AMS Cardiology

AUGUST 15, 2023

Understanding the risk factors, recognizing the signs and seeking guidance from a cardiologist can play a significant role in preventing and treating this disease. Identifying Those at Risk for Heart Disease Heart disease describes a range of disorders that affect the cardiovascular system and the heart.

Heart Disease 52

Heart Disease Blood Pressure Risk Factors Cholesterol 52

Circulation

NOVEMBER 11, 2024

M-MDSCs phenotype switch, atherosclerotic lesion development and plaque phenotype was studiedin vivo.Results:We observed CCR5 elevation on Monocytic-MDSCs in the early phase of atherosclerosis. MDSCs phenotype and functionality were assessed using CCR5 inhibitorin vitro(10-8M) andin vivo(i.p 3ng/day for 15 days).M-MDSCs

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

Circulation

FEBRUARY 9, 2025

Lp(a) (lipoprotein [a]) has recently garnered attention as an independent risk factor for astherosclerotic cardiovascular disease, with proinflammatory and prothrombotic mechanisms contributing to its atherogenicity. Atherosclerotic cardiovascular disease is a major health concern worldwide and requires effective preventive measures.

Pharmacology 49

Pharmacology Cardiovascular Disease Plaque Risk Factors 49

Stroke Journal

JUNE 26, 2024

High-grade stenosis with poor collaterals can cause hemispheric hypoperfusion, and unstable plaque can cause microemboli, both of which may be treatable risk factors for cognitive impairment. New risk factors are emerging, like exposure to microplastics and nanoplastics.

Stenosis 40

Stenosis Stent Stents Atherosclerosis 40

DAIC

APRIL 7, 2024

High levels of triglycerides and the lipid particles on which they are carried in the blood can contribute to the formation of “plaques” in the arteries that impede blood flow and can lead to heart attacks and strokes. An estimated 1 in 5 U.S. Patients’ average triglyceride level at baseline was about 900 mg/dL.

Heart Attack 110

Heart Attack Heart attacks Plaque Cholesterol 110

Circulation

JANUARY 15, 2024

Nevertheless, the relationship between CAC and the susceptibility of a plaque to provoke a thrombotic event remains incompletely understood. This review summarizes the current understanding and literature on CAC.

Coronary Artery Disease 45

Coronary Artery Disease Atherosclerosis Laboratory Plaque 45