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24: Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials (Session 402) Saturday, April 6 9:30 – 10:30 a.m.
SMART 4 ( NCT04722250 ) studied patients with severe aortic stenosis and a small aortic annulus who underwent transcatheter aortic valve replacement (TAVR). STEP-HFpEF DM 5 ( NCT04916470 ) explored the effects of semaglutide in obesity-related HF with preservedejectionfraction (HFpEF) and type 2 diabetes.
Key Takeaways: Greater Weight Loss, Greater Benefit : Achieving 2-5% weight loss yields metabolic improvements, while over 15% weight loss significantly reduces obesity-related complications like hypertension, NAFLD, and heart failure with preservedejectionfraction (HFpEF).
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