CONFIRM II: AI-QCT Assessment of Coronary Plaque Feature Confers Higher Relative Risk of MACE in Women
American College of Cardiology
MARCH 31, 2025
25 in Chicago and simultaneously published in Circulation: Cardiovascular Imaging.
Plaque Related Topics 
Very high LDL no impact on plaque progression
Dr. Malcolm Kendrick
DECEMBER 10, 2023
10th December 2023 A very important study – please watch Very high low density lipoprotein levels with no impact on plaque progression I interrupt my series on what is wrong with the health service to bring you breaking news. He states that five years is more than sufficient to detect any difference in plaque progression.
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Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation
JAMA Cardiology
JULY 16, 2024
This study investigates the impact of lipoprotein(a) levels on long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue inflammation.
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What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?
Frontiers in Cardiovascular Medicine
JANUARY 23, 2025
Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque characterization.
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Atherosclerotic plaque stabilization and regression: a review of clinical evidence
Nature Reviews - Cardiology
JANUARY 3, 2024
Nature Reviews Cardiology, Published online: 04 January 2024; doi:10.1038/s41569-023-00979-8 In this Review, Sarraju and Nissen summarize the clinical trial evidence for coronary atherosclerotic plaque stabilization and regression with plasma LDL-cholesterol-lowering therapy and other treatments.
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Cholesterol may not be the only lipid involved in trans fat-driven cardiovascular disease
Medical Xpress - Cardiology
NOVEMBER 14, 2024
Excess cholesterol is known to form artery-clogging plaques that can lead to stroke, arterial disease, heart attack, and more, making it the focus of many heart health campaigns.
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Analysis and validation of biomarkers and immune cell infiltration profiles in unstable coronary atherosclerotic plaques using bioinformatics and machine learning
Frontiers in Cardiovascular Medicine
FEBRUARY 13, 2025
IntroductionDecreased stability of coronary atherosclerotic plaques correlates with a heightened risk of acute coronary syndrome (ACS). Thus, early diagnosis and treatment of unstable plaques are imperative in averting adverse cardiovascular events.
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HeartFlow AI Plaque Analysis Achieves Major Milestone Towards Medicare Coverage
DAIC
JUNE 4, 2024
milla1cf Tue, 06/04/2024 - 20:54 June 4, 2024 — HeartFlow, a leader in cardiovascular healthcare technology, is pleased to announce a key Medicare policy development, which should allow for future expanded patient access to their Plaque Analysis product.
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HeartFlow Introduces Next Generation Interactive Plaque Analysis Platform to Assess Patient Risk in Suspected Coronary Artery Disease
DAIC
JULY 18, 2024
a leader in non-invasive artificial intelligence (AI) heart care solutions, introduced the next generation HeartFlow Plaque Analysis with an interactive experience. Having access to a patient’s whole coronary picture, with both quantified plaque and physiology, is a game changer as a clinician. F.A.C.C.
Early Win for Preemptive Stents on Vulnerable Coronary Plaque
Med Page Today
APRIL 8, 2024
(MedPage Today) -- ATLANTA -- The concept of using stents to seal off non-flow-limiting vulnerable plaques, before they have a chance to rupture, worked out in the first major trial testing this provocative idea. Compared with standard medical.
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Physiology Friday #199: High-Intensity Interval Training Reduces Coronary Artery Plaque
Physiologically Speaking
JANUARY 5, 2024
In this 6-month randomized controlled study, twice-weekly HIIT reduced coronary plaque volume, increased aerobic fitness, and improved body composition in adults with stable heart disease, suggesting benefits for cardiovascular disease progression. Does this greater plaque presence put athletes at a greater risk of CVD events?
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Plaque Psoriasis: Comorbidities, Classification, and Testing Practices
HCPLive
JUNE 25, 2024
Linda Stein Gold, MD, and Bruce Strober, MD PhD, discuss classification and monitoring practices for patients with plaque psoriasis.
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Mapping of atherosclerotic plaque cells may predict future risk of stroke or heart attack
Science Daily - Heart Disease
NOVEMBER 20, 2024
Researchers show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions to cause a stroke or heart attack. The new knowledge can be used to improve the risk assessment and treatment of patients with atherosclerosis in the future.
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Oral Systemics for the Treatment of Plaque Psoriasis
HCPLive
MARCH 13, 2024
Armstrong, MD, MPH, discusses emerging therapies in oral systemics for the treatment of plaque psoriasis and shares developments in TYK2 inhibition.
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The Evolving Role of Advanced Practice Providers Treating Plaque Psoriasis
HCPLive
MARCH 29, 2024
Dermatology physician assistants are talking about the evolving role of their profession in taking care of patients with plaque psoriasis.
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Higher Noncalcified Plaque Volume Is Associated With Increased Plaque Vulnerability and Vascular Inflammation
Circulation: Cardiovascular Imaging
JANUARY 11, 2024
BACKGROUND:Recently, it was reported that noncalcified plaque (NCP) volume was an independent predictor for cardiac events. Plaque volume was measured by computed tomography angiography, plaque vulnerability by optical coherence tomography, and the level of coronary inflammation by PCAT attenuation. versus 75.9%;P<0.001),
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Mapping of atherosclerotic plaque cells may predict future risk of stroke or heart attack
Medical Xpress - Cardiology
NOVEMBER 20, 2024
In a new study published in the European Heart Journal, researchers at Karolinska Institutet show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions for causing a stroke or heart attack.
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94 Position Statement Expands Definition of High-Risk Plaque
American College of Cardiology
FEBRUARY 26, 2025
The definition of a high-risk plaque should be expanded beyond the traditional focus on plaque rupture and thin-cap fibroatheroma in the setting of acute coronary syndromes (ACS), according to a new JACC: Cardiovascular Imaging Position Statement.
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New genetic risk score identifies individuals at risk for heart disease who may benefit most from cholesterol-lowering therapies
Science Daily - Heart Disease
FEBRUARY 26, 2025
Atherosclerosis, or the buildup of plaque in the arteries, develops when low-density lipoprotein cholesterol (LDL-C) enters the blood vessel walls through dysfunctional endothelial cells (EC), leading to the formation of plaques.
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Memory CD8 T cells promote pathogenic plaque buildup of the arteries in aged mice: Study
Medical Xpress - Cardiology
DECEMBER 13, 2023
Aging is known to be a risk factor for the biological changes that create the dangerous buildup of plaque in arteries called atherosclerosis, and aging also induces a buildup of memory CD8 T cells, a type of immune cell, in mice and humans.
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Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis
Nature Reviews - Cardiology
JANUARY 1, 2025
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01110-1 In this Review, Dey and colleagues explore the pathobiology of coronary atherosclerotic plaques and perivascular adipose tissue, describe their phenotyping with computed tomography coronary angiography, and discuss potential future applications in clinical (..)
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Calcium Burden, Vascular Inflammation, and Plaque Vulnerability
American College of Cardiology
SEPTEMBER 13, 2024
Is calcified plaque burden (CPB) associated with vascular inflammation and plaque vulnerability?
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New cardiovascular imaging approach provides a better view of dangerous plaques
Science Daily - Heart Disease
MARCH 5, 2024
Researchers have developed a new catheter-based device that combines two powerful optical techniques to image the dangerous plaques that can build up inside the arteries that supply blood to the heart.
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High-Risk Plaques on Coronary CTA: Correlation With OCT
American College of Cardiology
APRIL 12, 2024
Are high-risk plaque (HRP) features on coronary computed tomography angiography (CTA) associated with vulnerable plaque on optical coherence tomography (OCT)?
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Topical Roflumilast 0.3% Superior to Vehicle in Treating Plaque Psoriasis
HCPLive
AUGUST 24, 2024
In this systematic review and meta-analysis, the investigators highlighted topical roflumilast’s success in clinical milestones such as IGA and PASI score success.
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Coronary Atherosclerotic Plaque Activity and Risk of MI
American College of Cardiology
MAY 30, 2024
Is vessel-level coronary atherosclerotic plaque activity using coronary 18F-sodium fluoride positron emission tomography (PET) associated with patient vessel-level myocardial infarction (MI)?
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CVD Risks Tied to Teeny-Tiny Plastics Lodged in Atherosclerotic Plaque
Med Page Today
MARCH 6, 2024
(MedPage Today) -- It was common for tiny plastic particles from the environment to infiltrate people's vascular lesions, foreshadowing future cardiovascular disease in patients who underwent carotid endarterectomy, an observational study showed.
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Fibroblast-like cells promote plaque stability in response to anti-IL-1? therapy
Nature Reviews - Cardiology
JANUARY 22, 2024
Nature Reviews Cardiology, Published online: 23 January 2024; doi:10.1038/s41569-024-00993-4 Anti-inflammatory therapy involving IL-1β inhibition might reduce the risk of cardiovascular events in individuals with clonal haematopoiesis by increasing the number of fibroblast-like cells in the fibrous cap region of atherosclerotic plaques, thereby stabilizing (..)
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Icotrokinra, Plaque Psoriasis, and ICONIC-LEAD, with Robert Bissonnette, MD
HCPLive
MARCH 8, 2025
Robert Bissonnette, MD, discusses data from the ICONIC-LEAD trial and the potential role of icotrokinra in plaque psoriasis.
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Preventive Coronary Intervention on Stenosis With Functionally Insignificant Vulnerable Plaque
American College of Cardiology
APRIL 8, 2024
The goal of the PREVENT trial was to compare the safety and efficacy of medical therapy along with focal preventive PCI of non-flow-limiting vulnerable plaque compared with medical therapy alone.
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Quantitative Coronary Plaque Analysis by Coronary Computed Tomography Angiography: Is it Ready For Primetime?
American College of Cardiology
NOVEMBER 20, 2024
A unique strength of coronary computed tomography angiography (CCTA) is the ability to noninvasively detect nonobstructive and obstructive coronary plaque.
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Metals in the body from pollutants associated with progression of harmful plaque buildup in the arteries
Medical Xpress - Cardiology
SEPTEMBER 18, 2024
Metal exposure from environmental pollution is associated with increased buildup of calcium in the coronary arteries at a level that is comparable to traditional risk factors like smoking and diabetes, according to a study by Columbia University Mailman School of Public Health.
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135 Lp(a) and Coronary Plaque Progression
American College of Cardiology
JULY 24, 2024
What is the association of lipoprotein(a) (Lp[a]) levels with long-term coronary artery plaque progression, development of high-risk plaque, and pericoronary adipose tissue inflammation?
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Electronic Sepsis Alerts; Reducing Plaques in Coronary Arteries
Med Page Today
DECEMBER 21, 2024
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.
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Comparing image quality of coronary CT angiography with and without ECG-gating in wide-detector CT
Frontiers in Cardiovascular Medicine
APRIL 10, 2025
Plaque characterization agreement was assessed using Cohens .ResultsThe Plaque characterization exhibited high agreement (calcified: =0.82; non-calcified: =0.78; mixed: =0.75).ConclusionECG-less A modified ECG-less protocol (Group A2, n=30) was implemented to optimize radiation dose. vs. 1.901.41mSv, p 0.05). and per-patient 94.4%/50%
Mona Shahriari, MD: Evolving Role of Nonsteroidal Topicals in Plaque Psoriasis
HCPLive
JUNE 5, 2024
Mona Shahriari, MD, discusses the evolving role of nonsteroidal topical options the management of plaque psoriasis.
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PREVENT: Preventive PCI Superior to Optimal Medical Therapy Alone to Reduce Cardiac Events From Vulnerable Plaques
American College of Cardiology
APRIL 8, 2024
PCI performed preventively in patients with high-risk vulnerable plaques was found to be superior to optimal medical therapy alone in preventing a serious cardiac event, according to the results of the PREVENT trial, the largest study on preventive PCI to date, presented during a Late-Breaking Clinical Trial session during ACC.24
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Systemic Therapies for Plaque Psoriasis
HCPLive
JUNE 26, 2024
Dermatologists have a comprehensive discussion on systemic therapies for the treatment of plaque psoriasis, covering monitoring practices, and long term efficacy data for novel oral agent deucravacitinib.
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Long-Term Safety Data Highlight Potential of Bimekizumab in Plaque Psoriasis
HCPLive
SEPTEMBER 17, 2024
At Maui Derm NP+PA Fall 2024, bimekizumab data demonstrates a consistent safety profile in moderate to severe plaque psoriasis over 4 years, with decreasing event rates over time.
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Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus
Frontiers in Cardiovascular Medicine
FEBRUARY 4, 2024
Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. The miRNA-29c was reported to promote the phenotype transformation of vascular smooth muscle cells (VSMCs) in diabetes mice, eventually leading to plaque formation and bleeding. However, such studies are rare and limited to animal experiments.
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Interleukin 6 plasma levels are associated with progression of coronary plaques
Open Heart
SEPTEMBER 19, 2024
Non-invasive coronary CT angiography (CCTA) enables evaluation of coronary plaque phenotype. This study investigates the relationship between a comprehensive panel of inflammatory markers and short-term plaque progression on serial CCTA imaging, hypothesising that inflammation is associated with increased plaque volume.
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52 SARS-CoV-2 infection linked to more rapid plaque growth in lesions
Medical Xpress - Cardiology
FEBRUARY 10, 2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with more rapid progression of coronary artery lesion-based plaque volume, according to a study published online Feb. 4 in Radiology.
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Atherosclerosis: How immune cells migrate into plaques
Science Daily - Stroke
FEBRUARY 25, 2025
CD8+ T cells accumulate in atherosclerotic plaques. Researchers identify a crucial signaling pathway -- with therapeutic potential.
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Coronary Plaques Reined in With Coronary Calcium Scans in the Picture
Med Page Today
MARCH 5, 2025
(MedPage Today) -- For select risk-enhanced individuals at intermediate risk of coronary artery disease (CAD), researchers found a way to implement coronary artery calcium (CAC) scores and primary prevention statins together to slow the progression.
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