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Functional assessment of coronary artery disease in patients with severe aortic stenosis: a review

Heart BMJ

A significant proportion of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) have concomitant coronary artery disease (CAD). A better understanding of how we assess and interpret coronary physiology in these patients is required to optimise treatment pathways.

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The role of physiology in the contemporary management of coronary artery disease

Heart BMJ

Coronary physiology assessment, including epicardial and microvascular investigations, is a fundamental tool in the contemporary management of patients with coronary artery disease. However, revascularisation of coronary stenosis, which induces myocardial ischaemia, has demonstrated better outcome than OMT alone.

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Pathophysiology, Diagnosis, and Management of Coronary Artery Disease in the Setting of Atrial Fibrillation

Journal of the American Heart Association

The clinical impact of correct assessment of coronary artery stenosis in AF is especially high, due to the antithrombotic therapy imposed by both AF and coronary stenting. Until recently, an in‐depth characterization of coronary microcirculation in AF was lacking.

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Aerodynamic evaluation of surgical design for the stenosis correction of airway

Frontiers in Cardiovascular Medicine

Introduction Congenital tracheal stenosis (CTS) is a rare but life-threatening disease that can lead to respiratory dysfunction in children. The order of correction for CTS or OSAS greatly affected the aerodynamic parameters and turbulence flows downstream of tracheal stenosis and upstream of epiglottis.

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Heartflow Rebrands, Reaffirms Commitment to Improving CAD Care Management

DAIC

Coronary computed tomography angiography (CCTA) was a major advancement in CAD diagnostics, helping physicians estimate if a stenosis was significant and requiring intervention. Technologies like Heartflow fractional flow reserve computed tomography (FFR CT ) provide lesion-specific physiology, which enhances CCTAs diagnostic accuracy.

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Abstract WP347: Evaluating Brain Microvascular Endothelial Cell Dysfunction to Stenosis in a Tissue-Engineered Model of the Blood-Brain Barrier

Stroke Journal

Our objective is to use human-based, tissue-engineered microvessel models to capture these details in response to stenosis, a hallmark of ischemic stroke.Methods:Pluripotent stem cells were differentiated into BMECs (iBMECs), validated for BBB phenotype, and seeded into 150 m channels in collagen I/Matrigel hydrogels.

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Compunction: The Present Tense of Physiology to Guide Coronary Revascularization in Severe Aortic Stenosis

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Ahead of Print.