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Skeletal Muscle Pathology in Pulmonary Arterial Hypertension and Its Contribution to Exercise Intolerance

Journal of the American Heart Association

Pulmonary arterial hypertension is a disease of the pulmonary vasculature, resulting in elevated pressure in the pulmonary arteries and disrupting the physiological coordination between the right heart and the pulmonary circulation. Journal of the American Heart Association, Ahead of Print.

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Development and Evaluation of a Deep Learning–Based Pulmonary Hypertension Screening Algorithm Using a Digital Stethoscope

Journal of the American Heart Association

BackgroundDespite the poor outcomes related to the presence of pulmonary hypertension, it often goes undiagnosed in part because of low suspicion and screening tools not being easily accessible such as echocardiography. Each 15second PCG, recorded using a digital stethoscope, was processed to generate 5second melspectrograms.

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Is the Heart Really a Pump? New Perspectives on Cardiovascular Physiology

Physiologically Speaking

Cardiovascular physiology has long held that the heart is a mechanical pump and that the heart’s propulsive power is the main driver of blood flow throughout the body. While he didn't fully grasp the complete circulatory system, his insights into the pulmonary circulation were notable for the time.

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Bidirectional glenn surgery without palliative pulmonary artery banding in univentricular heart with unrestricted pulmonary flow. Retrospective multicenter experience

Journal of Cardiothoracic Surgery

Although pulmonary artery banding (PAB) has been generally acknowledged as an initial palliative treatment for patients having single ventricle (SV) physiology and unrestrictive pulmonary blood flow (UPBF), it.

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Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation–induced surfactant secretion

Journal of Clinical Investigation - Cardiology

Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease the surface tension and facilitate inspiration. TMEM63A/B were predominantly localized at the limiting membrane of the lamellar body (LB), a lysosome-related organelle that stores pulmonary surfactant and ATP in AT2 cells.

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Physiology Friday #205: What Limits VO2 Max? It Might Depend on Your Fitness Level.

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. There’s a long-running debate in exercise physiology about what limits VO2 max. Physiology is integrative, not isolated. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Upregulation of Angiomotin-like 2 ameliorates experimental pulmonary arterial hypertension by inactivating YAP1 signaling

Journal of Cardiovascular Pharmacology

Abstract: Angiomotin-like 2 (AMOTL2) is related to numerous physiological and pathological conditions by affecting signal transduction. However, whether AMOTL2 is linked to pulmonary arterial hypertension (PAH) has not been addressed. AMOTL2 was downregulated in hypoxia-stimulated pulmonary arterial smooth muscle cells (PASMCs).