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Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. One of the biggest risk factors for CVD development is the buildup of plaque in the coronary arteries (the arteries surrounding the heart that provide it with its own blood supply).
Although it is statistically unlikely, multiple plaque ruptures are possible. On intravascular ultrasound (IVUS), the mid RCA plaque was described as "cratered, inflamed, and bulky," and the OM plaque was described as "bulky with evidence of inflammation and probably ulceration." Additional findings: No ST elevation."
The deformable gel constituted an 8mm long replaceable stenotic segment at the level of M1‐MCA simulating an atherosclerotic plaque with a 0.5mm internal diameter. mL/min.ConclusionThe developed ICAD model is anatomically accurate and offers realistic physiological and procedural features.
The axiom of "type 1 (ACS, plaque rupture) STEMIs are not tachycardic unless they are in cardiogenic shock" is not applicable outside of sinus rhythm. This case represents the same physiologic event as OMI in terms of the result on the myocardium, therefore with identical ECG features, however there may not be ACS!
It is also unique because it works using the Doppler effect, you can get not only an anatomical evaluation of the heart but also physiological assessment. An echo is easy to do, risk free and easily accessible. It is operator dependant and requires specialised machinery The images you get may vary from patient to patient.
He was taken to the cath lab and underwent emergent intervention: Thrombotic stenosis of the proximal RCA (95% with evidence of plaque rupture) is the culprit for the patient's inferoposterior STEMI. He was successfully stented.
After stent deployment, we often see improvement in the ST-T within seconds or minutes. Here is the final angiogram following placement of a stent in the ostial RCA. 2:04 PM, post stent deployment You can see that even after complete restoration of flow, the ECG still looks terrible, V most of all.
The reason being, there is a huge healthy population ( with zero risk factor) , but showing insignificant or minimal coronary plaques. In adults, some of these streaks become prominent locally and turn out to be plaque. The argument for intensive statin therapy is to stabilize these plaques. Reference 1. J Am Coll Cardiol.
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