Dr. S. Venkatesan MD

OCTOBER 2, 2024

Doctor, do you have any investigation to know how much the total plaque burden is in my coronary artery? I recently read in Forbes Sunday health supplement, It says ,it is better to know the thickness of the cap covering the plaque. to decode the histological, biochemical, pathological secrets within the atherosclerotic plaques.

Plaque 52

Plaque Atherosclerosis Education Cholesterol 52

DAIC

FEBRUARY 26, 2025

Technologies like Heartflow fractional flow reserve computed tomography (FFR CT ) provide lesion-specific physiology, which enhances CCTAs diagnostic accuracy. Now Heartflow Plaque Analysis leverages AI to quantify and characterize the amount and type of plaque present in the arteries from a single CCTA scan.

Coronary Artery Disease 59

Coronary Artery Disease Heart attacks Heart Attack Technology 59

Frontiers in Cardiovascular Medicine

JUNE 16, 2024

In recent years, the role of macrophages as the primary cell type contributing to foam cell formation and atheroma plaque development has been widely acknowledged. Recent studies have further supported the notion that SMCs constitute the majority of foam cells in advanced atherosclerotic plaques.

Atherosclerosis 52

Atherosclerosis Plaque Physiology Innovation 52

DAIC

FEBRUARY 23, 2024

Cleerly ISCHEMIA was purposely designed to output estimates of FFR values that are guideline-recommended by professional societies, and to allow comprehensive mapping of both anatomic and physiologic data for each and every coronary lesion across the entire vascular tree." With Plaque Features Associated with False Positives.

Ischemia 105

Ischemia Coronary Artery Disease Physiology Cardiovascular Imaging 105

Dr. Smith's ECG Blog

JANUARY 5, 2024

Although it is statistically unlikely, multiple plaque ruptures are possible. On intravascular ultrasound (IVUS), the mid RCA plaque was described as "cratered, inflamed, and bulky," and the OM plaque was described as "bulky with evidence of inflammation and probably ulceration." Additional findings: No ST elevation."

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Angina Plaque Document Stents 120

Dr. S. Venkatesan MD

DECEMBER 2, 2023

This has important clinical significance , as many successfully lysed STEMI patient might have minimal segments of dissection/deep plaque fissures. , Spontaneous coronary dissection vs Iatrogenic dissection SCAD is a rare , different entity , enjoys a popular space in the patho-physiology of CAD. Is plaque fissure painful ?

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SCAD Plaque Angina STEMI 52

Frontiers in Cardiovascular Medicine

AUGUST 6, 2024

Myocardial infarction (MI) stands at top global causes of death in developed countries, owing mostly to atherosclerotic plaque growth and endothelial injury-induced reduction in coronary blood flow. While early reperfusion techniques have improved outcomes, long-term treatment continues to be difficult.

Myocardial Infarction 52

Myocardial Infarction Plaque Physiology Cardiovascular Disease 52

DAIC

MAY 8, 2024

It provides anatomic data, plaque identification and characterization, as well as the calculations of FFR CT , a coronary physiological simulation, computed from simulated pressure, velocity and blood flow information obtained from a 3D computer model generated from static coronary CT images.

Coronary Artery Disease 111

Coronary Artery Disease Chest Pain Ischemia Myocardial Infarction 111

Physiologically Speaking

FEBRUARY 28, 2024

” While an awe-inspiring anecdote, our knowledge of human limits, physiology, and the sheer number of participants in endurance sports is enough evidence to conclude that running a marathon won’t kill you. Physiologically Speaking is a reader-supported publication. Pheidippides’ story is provocative.

Exercise 98

Exercise Sudden Cardiac Death Physiology Congenital 98

Dr. S. Venkatesan MD

JANUARY 8, 2024

While the total body seems to do little in determining cholesterol levels, what is more scientifically shocking is slope of the curve between blood LDL levels and plaque burden is rarely linear. Final message The tendency to portray a vital physiological molecule LDL, as a sole villain for CAD is not correct. Mind you LDL constitutes.000025%

Cholesterol 52

Cholesterol Atherosclerosis Plaque Physiology 52

Open Heart

MARCH 21, 2022

FFR CT was measured 1 cm distal to the coronary plaque or in the middle of the segments if no coronary lesions were present. Future research is required to evaluate the physiological relevance and prognostic value of FFR CT. Materials and methods We included 60 symptomatic patients who underwent coronary CT angiography.

Plaque 40

Plaque Physiology Stenosis Risk Factors 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

The deformable gel constituted an 8mm long replaceable stenotic segment at the level of M1‐MCA simulating an atherosclerotic plaque with a 0.5mm internal diameter. mL/min.ConclusionThe developed ICAD model is anatomically accurate and offers realistic physiological and procedural features.

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Stenosis Angioplasty Anatomy Plaque 40

Dr. Sanjay Gupta

DECEMBER 19, 2022

She had some very minor plaque but certainly nothing that could explain the heart attack and therefore she was discharged with a diagnosis of MINOCA i.e Genetics and physiological stress are also risk factors. She agreed and we performed an angiogram and we were fully expecting a blockage but interestingly there weren’t any.

Heart attacks 40

Heart attacks Heart Attack Blood Clot Chest Pain 40

EMS 12-Lead

AUGUST 22, 2022

The combination of prolonged QT and deep T wave inversion throughout the precordium is typical of Takotsubo syndrome, or Stress Cardiomyopathy – which can occur in the context of a physiologically distressed ICU patient, further compromising their hemodynamics. The coronary angiogram revealed no critical stenosis, or acute plaque ulceration.

Tachycardia 52

Tachycardia Cardiomyopathy Electrophysiology ICU 52

Dr. Smith's ECG Blog

OCTOBER 10, 2022

As in all ischemia interpretations with OMI findings, the findings can be due to type 1 AMI (example: acute coronary plaque rupture and thrombosis) or type 2 AMI (with or without fixed CAD, with severe regional supply/demand mismatch essentially equaling zero blood flow).

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Cardiac Arrest Chest Pain Embolism Pulmonary 52

Dr. Smith's ECG Blog

NOVEMBER 26, 2018

The axiom of "type 1 (ACS, plaque rupture) STEMIs are not tachycardic unless they are in cardiogenic shock" is not applicable outside of sinus rhythm. This case represents the same physiologic event as OMI in terms of the result on the myocardium, therefore with identical ECG features, however there may not be ACS!

Ischemia 52

Ischemia Atrial Flutter Arrhythmia Tachycardia 52

Physiologically Speaking

MAY 17, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Numerous reports in the last decade have found that lifetime endurance athletes have higher levels of coronary artery calcification and plaque compared to age-matched non-athletes.

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Physiology Exercise Biomarkers Cardiovascular Disease 98

Dr. Sanjay Gupta

MARCH 6, 2022

It is also unique because it works using the Doppler effect, you can get not only an anatomical evaluation of the heart but also physiological assessment. An echo is easy to do, risk free and easily accessible. It is operator dependant and requires specialised machinery The images you get may vary from patient to patient.

Heart attacks 52

Heart attacks Heart Attack Heart Rhythm Exercise 52

Physiologically Speaking

FEBRUARY 26, 2024

Physiologically Speaking is a reader-supported publication. Even the oldest among the tribe, people well past 70 years old, showed zero evidence of heart plaque buildup. Physiologically Speaking is a reader-supported publication. The Scarcity Loop has 3 parts: opportunity, unpredictable rewards, and quick repeatability.

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Diet Cardiovascular Disease Exercise Research 52

Dr. Smith's ECG Blog

OCTOBER 7, 2019

He was taken to the cath lab and underwent emergent intervention: Thrombotic stenosis of the proximal RCA (95% with evidence of plaque rupture) is the culprit for the patient's inferoposterior STEMI. Before transport, a final ECG was recorded: There is, again, inferior reperfusion, but persistent marked anterior STE.

Bradycardia 40

Bradycardia Cardiogenic Shock STEMI Ischemia 40

Heart BMJ

JANUARY 13, 2025

We investigated potential associations between cumulative atherosclerotic plaque burden quantified using the Gensini score, novel invasive indices of coronary microvascular function (microvascular resistance reserve (MRR); resistive reserve ratio (RRR)) and related INOCA endotypes. Results In 151 participants (median age 61 years; 73.5%

Plaque 52

Plaque Coronary Artery Disease Angina Physiology 52

DAIC

OCTOBER 30, 2024

Data confirm the use of FFR CT and Plaque Analysis helps assess long-term risks, informing more personalized and effective treatment plans for patients with coronary artery disease. The prospective data with long-term follow-up in ADVANCE-DK alongside Plaque Analysis data gave us far more than that. 27, 2024 — HeartFlow, Inc.

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Plaque Outcomes Coronary Artery Disease Chest Pain 52

Physiologically Speaking

DECEMBER 17, 2024

Cross-sectional studies reveal that endurance athletes, particularly middle-aged and older men, often exhibit higher coronary artery calcium scores (CACS) and plaque prevalence compared to less-active individuals. Notably, athletes engaging in very vigorous-intensity exercise are more likely to develop calcified plaques.

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Risk Factors Genetic predisposition Plaque Exercise 105

Dr. Smith's ECG Blog

MARCH 8, 2025

In my review of the literature, there are many articles which purport to demonstrate an acutely increased risk of plaque rupture from emotional stress, but I could not find any credible case reports that were not at least as likely to be takotsubo. Mechanisms of plaque formation and rupture. Coronary plaque disruption.

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Cardiomyopathy Myocardial Infarction Defibrillator Bradycardia 75

Dr. S. Venkatesan MD

DECEMBER 8, 2024

The reason being, there is a huge healthy population ( with zero risk factor) , but showing insignificant or minimal coronary plaques. In adults, some of these streaks become prominent locally and turn out to be plaque. The argument for intensive statin therapy is to stabilize these plaques. Reference 1. J Am Coll Cardiol.

Plaque 52

Plaque Risk Factors Document Physiology 52