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Novel device therapies in heart failure: focus on patient selection

Frontiers in Cardiovascular Medicine

The increasing prevalence of heart failure (HF) has led to advancements in therapeutic strategies, including the development of new pharmacological treatments and the expansion of guideline recommendations across the spectrum of left ventricular ejection fractions.

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Cancer therapy–related salivary dysfunction

Journal of Clinical Investigation - Cardiology

We discuss salivary gland anatomy and physiology to understand how anticancer therapies such as chemotherapy, bone marrow transplantation, immunotherapy, and radiation therapy impair salivary function. Emerging approaches, including cellular and gene therapy and novel pharmacologic approaches, are described.

Cancer 95
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American College of Cardiology (ACC) Program Set for Cardiac Oncology Conference, “Advancing the Cardiovascular Care of the Oncology Patient”

DAIC

Optional Pre-conference Workshop to be held Friday afternoon includes a number of topics: Pharmacology 101 Pharmacology 101 – Workshop: Alana Ferrari, PharmD, BCOP How Do I Grow My Career in Cardio-Oncology? An overview of sessions, focus topics and presenters follows. Friday, February 9 Registration (1:00 - 6:00 p.m.)

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METTL4-Mediated Mitochondrial DNA N6-Methyldeoxyadenosine Promoting Macrophage Inflammation and Atherosclerosis

Circulation

We explored the mechanism of METTL4 involvement in atherosclerosis usingMettl4Mac-KO-Apoe-/-andMettl4MUT-Apoe-/-mice and cell models, as well as bone marrow transplantation. Natural compound libraries were screened to identify potent METTL4 antagonists.

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Targeting pharmacotherapies for inflammatory and cardiorenal endpoints in kidney disease

Journal of Cardiovascular Pharmacology

Finally, emerging therapies in CKD such as IL-6 inhibition, small-interfering RNA against lipoproteins, AhR inhibitors, and therapies adopted from the renal transplant population including mTOR inhibitors and T regulatory cell promoters may have benefits for cardiorenal and inflammatory endpoints but require further investigation in clinical trials.

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Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease

Journal of Clinical Investigation - Cardiology

Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation.

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Remembering Dr. Stephen Harrison 

Cardiometabolic Health Congress

His contributions significantly shaped the current state of hepatology and the broader scientific community, evidenced by his role as an associate editor of Hepatology and Alimentary Pharmacology and Therapeutics and as a peer reviewer for over 20 prestigious medical journals. Reau, MD, FAASLD, AGAF , Richard B.