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Network pharmacology-based prediction and molecular docking-based strategy to investigate the potential mechanism of Leonurus japonicus Houtt. Against myocardial ischemia reperfusion injury

Journal of Cardiothoracic Surgery

LJH) has multiple pharmacological effects. Objective To investigate the potential mechanism of LJH in the treatment of myocardial ischemia-reperfusion injury (MIRI) using network pharmacology, molecular docking technology, and in vitro experiments. Background Leonurus japonicus Houtt.

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Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq

Journal of Cardiovascular Pharmacology

A variety of technologies, including network pharmacology, RNA-sequencing, immunohistochemistry, and Western blotting were performed to investigate its underlying mechanisms.

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Cardiac Immunotherapy, Immuno-Cardiology and the Future of Cardiovascular Pharmacology

Journal of Cardiovascular Pharmacology

Recent advances in immune-based therapies, including chimeric antigen receptor (CAR)-T and CAR-macrophage (CAR-M) technologies, have demonstrated potential in impacting on cardiac fibrosis and thus improving surrogate endpoints in preclinical studies.

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Biosense Webster Begins Enrollment of Pivotal Trial Evaluating the Laminar Left Atrial Appendage Elimination Device?

DAIC

The study will compare the safety and efficacy of the Laminar LAAX System to commercially available left atrial appendage (LAA) closure devices, providing a potential non-pharmacologic alternative for eligible patients.  It's exciting to be part of the evolution of the latest technology into a tangible solution for treating patients.

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PO-04-203 LEFT CIRCUMFLEX ARTERY TO LEFT ATRIAL APPENDAGE FISTULA IN A PATIENT WITH PRIOR LEFT ATRIAL APPENDAGE CLOSURE DEVICE

HeartRhythm

Left atrial appendage (LAAC) is frequently employed as a non-pharmacological option for thromboembolic prevention in patients with atrial fibrillation (AF). With contemporary device technology, LAAC has proven to be a safe procedure. However, it is important to be vigilant for unusual complications.

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Anti-platelet agents inhibit platelet adhesion and aggregation on glass surface under physiological flow conditions: Toward a microfluidic platelet functional assay without additional adhesion protein modification

Journal of Cardiovascular Pharmacology

Patient administration of aspirin or (and) clopidogrel inhibited platelet adhesion and aggregation on the glass surface under flow conditions. Patient administration of aspirin or (and) clopidogrel inhibited platelet adhesion and aggregation on the glass surface under flow conditions.

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METTL4-Mediated Mitochondrial DNA N6-Methyldeoxyadenosine Promoting Macrophage Inflammation and Atherosclerosis

Circulation

Through various experimental techniques, such as gene manipulation, pharmacological inhibition, and proteolysis targeting chimera, this study demonstrated that mtDNA 6mA and its specific enzyme METTL4 hold potential as therapeutic targets for atherosclerosis. Natural compound libraries were screened to identify potent METTL4 antagonists.