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Brugada syndrome (BrS) is associated with an increased risk of ventricular fibrillation (VF), leading to suddencardiacdeath. 1 However, variations in the efficacy of these drugs remain unclear, particularly regarding low-dose quinidine.
The increased risk of arrhythmias and suddencardiacdeath (SCD) caused by drug-induced QT prolongation has been a prominent safety pharmacology concern for the last 30 years.
Contemporary antiarrhythmic treatment of Timothy syndrome 1 (TS1) is inadequate to prevent suddencardiacdeath. Using electroanatomic mapping (EAM) we discovered cardiac activation delay, which creates the milieu for functional reentrant ventricular arrhythmias.
Recent reports have spotlighted the potential of pharmacological tests with sodium channel blockers (SCB) in unmasking short-coupled premature ventricular contractions (ScPVCs), most frequently of Purkinje origin, in patients at risk for suddencardiacdeath (SCD).1,2
New HCM Guidelines Updated recommendations in the guideline reflect recent evidence about HCM treatment and management including new forms of pharmacologic management; participation in vigorous recreational activities and competitive sports; and risk stratification for suddencardiacdeath (SCD) with an emphasis on pediatric patients.
21-23 hsCRP is nonspecific inflammatory marker and an acute phase reactant that predicts the likelihood of a heart attack, stroke, peripheral artery disease and suddencardiacdeath among healthy individuals with no history of CV disease, and recurrent events and death in patients with known ASCVD.22 2015;45(3):341-350.
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