Journal of the American Heart Association

DECEMBER 1, 2023

BackgroundAn increased risk of recurrent stroke is noted in patients with atrial fibrillation despite direct oral anticoagulant (DOAC) use. A total of 84 patients experienced recurrent ischemic stroke after switching to different oral anticoagulants, with a total follow‐up time of 14 years. 0.39] for apixaban, 0.23 [95% CI, 0.14–0.37]

Atrial Fibrillation 75

Atrial Fibrillation Hemorrhage Pharmacology Stroke 75

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP380-ATP380, February 1, 2025. Although progress has been made, the role of lipid metabolism following stroke remains unclear. Recent research on neurodegenerative diseases has highlighted a pathophysiological cascade characterized by abnormal lipid accumulation within the brain.

Stroke 40

Stroke Strokes Pharmacology Cholesterol 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP344-ATP344, February 1, 2025. In a mouse model of ischemic stroke, we found that Chrdl1 is excessively upregulated in astrocytes in the peri-infarct area during the post-stroke plasticity window (230 days post-stroke in the mouse).

Stroke 40

Stroke Strokes Pharmacology 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP369-ATP369, February 1, 2025. In young mice, pharmacological activation or stimulation of the Vagus nerve has been shown to mitigate ischemic stroke injury by reducing brain and peripheral inflammation and oxidative stress.

Stroke 40

Stroke Strokes Pharmacology Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP301-AWP301, February 1, 2024. We hypothesized that pharmacological inhibition of STAT3 activation in mice during the reperfusion phase after middle cerebral artery occlusion (MCAO) will lead to increased infarct size. Interestingly Stattic-treated mice had larger spleens (66.31 ± 5.40

Stroke 40

Stroke Strokes Pharmacology Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP392-AWP392, February 1, 2025. In our lab, we have shown that Ripk2 contributes to secondary injury following ischemic stroke due to neuroinflammation. Additionally, pharmacologically inhibiting Ripk2 is neuroprotective and reduces infarction and deficits after stroke.

Stroke 40

Stroke Strokes Outcomes Pharmacology 40

Circulation

NOVEMBER 11, 2024

Despite comprehensive anticoagulation protocols, discrepancies in pharmacologic responses due to patient-specific factors such as adherence to anticoagulation, renal function, and genetics suggest that imaging studies may still be critical for patient safety. Mortality rates within a year did not differ significantly between the two groups.

Echocardiogram 40

Echocardiogram Atrial Fibrillation Stroke Strokes 40

Hypertension Journal

NOVEMBER 29, 2023

It is the main cause of lacunar stroke and a major source of vascular contributions to cognitive impairment and dementia. Knowledge gaps include initiating factors, molecular pathogenesis, relationships between arterial pathology and tissue damage, possible reversibility, pharmacological targets, and molecular biomarkers.

Dementia 64

Dementia Hypertension Pharmacology Biomarkers 64

Journal of Clinical Investigation - Cardiology

AUGUST 1, 2024

Cerebral arteriovenous malformations represent the most common form of vascular malformations and can cause recurrent bleeding and hemorrhagic stroke. This discovery provides a promising entry point for preventive pharmacological interventions. The current issue of the JCI features an article by Zhao et al.

Pharmacology 40

Pharmacology Article Hemorrhage Stroke 40

Circulation

DECEMBER 28, 2023

Using mediation Mendelian randomization, we explored proteomic mediators of the effects of genetically proxied IL-6 signaling on coronary artery disease, large artery atherosclerotic stroke, and peripheral artery disease.

Atherosclerosis 49

Atherosclerosis Peripheral Arterial Disease Coronary Artery Disease Pharmacology 49

Stroke Journal

MARCH 4, 2025

Stroke, Ahead of Print. Subarachnoid hemorrhage is a critical neurological condition accounting for about 5% of all strokes, and survivors experience long-term cognitive deterioration and increased risk of dementia. Management techniques reviewed include long-term cognitive health, such as endovascular coiling and surgical clipping.

Hemorrhage 40

Hemorrhage Genetic predisposition Genetic Markers Quality of Life 40

ADN Center of Excellence

SEPTEMBER 2, 2024

This miscommunication can cause blood to pool in the atria, increasing the risk of clot formation, which can then lead to strokes. AFib is associated with a fivefold increased risk of stroke, and it is also linked to heart failure, chronic fatigue, and other serious health issues.

AFIB 59

AFIB Atrial Fibrillation Innovation Heart Rhythm 59

Journal of the American Heart Association

DECEMBER 29, 2023

AF increases the risk of stroke, heart failure, dementia, and hospitalization. However, studies on how obesity affects pharmacologic or interventional AF treatments are limited. Journal of the American Heart Association, Ahead of Print. ABSTRACTAtrial fibrillation (AF) is the most common cardiac arrhythmia.

Obesity 45

Obesity Atrial Fibrillation Heart Failure Pharmacology 45

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP189-ATP189, February 1, 2025. Contributing factors such as hypocholesterolemia and hypertension amplify the risk of ICH and subsequent hematoma expansion, underscoring the urgent need for effective interventions.

Hemorrhage 40

Hemorrhage Pharmacology Hypertension Outcomes 40

Journal of the American Heart Association

APRIL 10, 2025

BackgroundPoststroke depression (PSD) is a prevalent neuropsychiatric complication of stroke. HCN channels were downregulated by pharmacological inhibitor or neuronspecific adenoassociated virus. Journal of the American Heart Association, Ahead of Print. However, the mechanisms underlying PSD are still unclear.

Ischemia 40

Ischemia Pharmacology Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP51-AWP51, February 1, 2024. Background:Stroke is a debilitating condition and patients with acute stroke usually stays about a week in the acute hospital. The APN would identify stroke patients admitting to CH for further rehabilitation.

Nursing 40

Nursing Hospital Outpatient Thrombosis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A103-A103, February 1, 2024. Introduction:Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult after stroke. However, the microglial heterogeneity and the underlying mechanisms remain unclear.

Ischemia 40

Ischemia Pharmacology Stroke Strokes 40

ADN Center of Excellence

SEPTEMBER 2, 2024

This miscommunication can cause blood to pool in the atria, increasing the risk of clot formation, which can then lead to strokes. AFib is associated with a fivefold increased risk of stroke, and it is also linked to heart failure, chronic fatigue, and other serious health issues.

AFIB 52

AFIB Atrial Fibrillation Innovation Heart Rhythm 52

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP364-ATP364, February 1, 2025. This suggests that intranasally targeting the NgR1 pathway may be a viable pharmacologic mechanism of facilitating neuronal recovery in patients exposed to air pollution.

Pharmacology 40

Pharmacology Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP322-AWP322, February 1, 2024. Hyperhomocysteinemia (Hhcy), a metabolic disorder is recognized as a risk factor for ischemic stroke. However, the impact of Hhcy on stroke outcome is not known.

Ischemia 40

Ischemia Pharmacology Stroke Strokes 40

Stroke Journal

DECEMBER 21, 2023

Stroke, Ahead of Print. The motivation for developing a suitable PRES model is 2-fold: to fill in knowledge gaps of the pathophysiological mechanisms involved, and to open new perspectives for clinical assessment of pharmacological targets to improve therapeutic management of PRES.

Hypertension 40

Hypertension Pharmacology Diet Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP400-AWP400, February 1, 2025. SARS-COV-2 causes neurological and cognitive impairments and aggravates Alzheimers Disease-Related Dementia (ADRD). Yet, the molecular mechanism is not fully understood.

Dementia 40

Dementia COVID-19 Pharmacology Stroke 40

Stroke: Vascular and Interventional Neurology

DECEMBER 8, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDLocal angiotensin activity is thought to play a critical role in arterial wall homeostasis and remodeling, and impaired arterial wall integrity contributes to the pathogenesis of subarachnoid hemorrhage (SAH).

Hypertension 40

Hypertension Hemorrhage Pharmacology Aneurysm 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP114-AWMP114, February 1, 2024. CAA may lead to dementia and stroke; however effective options currently are very limited to treat or halt CAA progression. Pharmacological inhibition of EZH2 improved cognitive outcomes in CAA mice, suggesting a possible therapeutic target.

Pharmacology 40

Pharmacology Dementia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP211-ATP211, February 1, 2025. Pharmacologic mitigators of neurotoxicity have the potential to lengthen this therapeutic window, extending the opportunity for favorable surgical outcomes.

Hemorrhage 40

Hemorrhage Pharmacology Stroke Strokes 40

Stroke Journal

MARCH 11, 2024

Stroke, Ahead of Print. This study supports the need to investigate new pharmacological approaches added to thrombolysis to prevent NET formation or enhance their disruption, such as recombinant human DNase I (deoxyribonuclease I). BACKGROUND:Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs).

Thrombolysis 40

Thrombolysis Pharmacology Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP74-AWMP74, February 1, 2024. TCR activation was pharmacologically inhibited using the TCR-specific inhibitor AX-024, administered (10 mg/kg, i.p.) However, brain-infiltrating T cells precise activation mechanisms and resulting pathological impacts remain largely unexplored.

Hemorrhage 40

Hemorrhage Outcomes Pharmacology Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP50-ADP50, February 1, 2025. Background:Local angiotensin activity is thought to play a critical role in arterial wall homeostasis and remodeling, which contributes to the pathogenesis of subarachnoid hemorrhage (SAH).

Hemorrhage 40

Hemorrhage Hypertension Aneurysm Pharmacology 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThrombolysis with recombinant tissue plasminogen activator remains vital to acute ischemic stroke (AIS) therapy. The admission National Institutes of Health Stroke Scale scores (NIHSS) were similar. min, p=0.00021).

Thrombolysis 40

Thrombolysis Pharmacology Risk Factors Stroke 40

DAIC

FEBRUARY 29, 2024

24 will focus on the following three current guideline updates: American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines 2023 Atrial Fibrillation Guideline - Pharmacology II: Strokes vs. Bleeds, What Do the Guidelines Tell Us About Practical Management in A-fib? The Guidelines Sessions at ACC.24

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

Journal of Cardiovascular Pharmacology

APRIL 21, 2024

During a median follow-up of 53 months, we recorded venous thromboembolism (VTE), ischemic stroke or myocardial infarction, along with major bleeding. We observed 4 (6.1%, 3 VTE and 1 ischemic stroke) thrombotic events in patients on apixaban and 12 events (14%, 9 VTE, 2 ischemic strokes and 1 myocardial infarction) in VKA patients.

Myocardial Infarction 40

Myocardial Infarction Thrombosis Stroke Strokes 40

Journal of Cardiovascular Pharmacology

AUGUST 1, 2024

Thrombosis continues to pose a significant challenge in cardiovascular and cerebrovascular diseases, contributing to severe health complications such as myocardial infarction, acute ischemic stroke, and venous thromboembolism.

Cerebrovascular Disease 40

Cerebrovascular Disease Myocardial Infarction Thrombosis Stroke 40

Journal of Cardiovascular Pharmacology

MARCH 4, 2024

Peripheral arterial disease (PAD) is the third leading cause of atherosclerotic morbidity after coronary heart disease and stroke yet is widely underdiagnosed and undertreated. Treatment of risk factors such as diabetes and cigarette smoking can benefit patients with PAD.

Peripheral Arterial Disease 40

Peripheral Arterial Disease Blood Pressure Risk Factors Nursing 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP364-AWP364, February 1, 2025. proposed an innovative thromboembolic stroke model in mice where murine thrombin is injected into the M2 segment of the middle cerebral artery (MCA) to induce arterial thrombosis. Introduction:In 2007, Orset et al.

Pharmacology 40

Pharmacology Stroke Strokes Thrombosis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP339-AWP339, February 1, 2025. Background:Ischemic stroke triggers the metabolic reprogramming of cells in the infarct core and surrounding penumbra. Previous research in our lab supports a neuroprotective effect of PFKFB3 inhibition after stroke in young male mice.

Pharmacology 40

Pharmacology Stroke Strokes Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP310-AWP310, February 1, 2024. Background:A major hallmark of stroke is the dysregulation of normal metabolic functions. These results support the hypothesis that PFKFB3 inhibitors may be used as a novel pharmacological treatment for reducing delayed cell death after ischemic stroke.

Pharmacology 40

Pharmacology Stroke Strokes 40

Heart BMJ

JUNE 25, 2024

The 91 villages underwent random allocation into two arms: the control arm, encompassing 45 clusters, was subjected to non-pharmacological intervention (educational training on healthy lifestyle), whereas the intervention arm, comprising 46 clusters, received the non-pharmacological interventions in conjunction with a once-daily polypill tablet.

Cardiovascular Disease 59

Cardiovascular Disease Myocardial Infarction Pharmacology Angina 59