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This review addresses the pathophysiology, diagnostic approaches, and management strategies associated with INOCA, emphasizing epicardial coronary spasms and coronary microvascular dysfunction (CMD) as underlying mechanisms and myocardial bridging (MB) as a riskfactor.
Statement Highlights: It is essential for health care professionals to routinely screen pregnant and postpartum women for depression and anxiety, address modifiable riskfactors and consider behavioral and pharmacological interventions to improve.
Hence, to date, no single pharmacological option exists to treat them. Genetic modification in a mouse model of IAs, including deletion or overexpression of a particular gene, provides an excellent means for examining basic mechanisms behind disease pathophysiology and developing novel pharmacological approaches.
Several modifiable riskfactors, including increased blood pressure (BP), significantly contribute to cardiovascular risk in CCS. Therefore, optimal secondary prevention includes managing BP through lifestyle changes and pharmacological therapy.
We will first describe the epidemiology and burden of disease of CUD, including riskfactors associated with CUD (both in terms of general risk and genetic risk variants). Although no pharmacological interventions are yet approved for CUD, we present the most promising pharmacological interventions being tested.
Lp(a) (lipoprotein [a]) has recently garnered attention as an independent riskfactor for astherosclerotic cardiovascular disease, with proinflammatory and prothrombotic mechanisms contributing to its atherogenicity. Atherosclerotic cardiovascular disease is a major health concern worldwide and requires effective preventive measures.
Despite the existence of well-established riskfactors and effective pharmacological treatments for major cardiovascular disease (CVD), these conditions remain among the leading causes of premature death and disability, exerting a substantial burden on health systems worldwide.
BackgroundAbdominal aortic aneurysm (AAA) is a severe aortic disease for which no pharmacological interventions have yet been developed. Colocalization analysis pinpointed 13 proteins with strong evidence of colocalization with AAA.
We have previously shown that apart from common vascular riskfactor modification, adipose tissue-specific factors, such as adiponectin, may mediate the relationship between body fat and vascular risk.
They also theorize that other riskfactors for CAVD, such as high blood levels of lipoprotein, can contribute to calcification both directly and indirectly through the mechanisms that involve amyloid accumulation. “We
Hypertension is a leading riskfactor for cardiovascular morbidity and mortality. Despite the widespread availability of both pharmacological and lifestyle therapeutic options, blood pressure control rates across the globe are worsening. Hypertension, Ahead of Print.
Primordial prevention is changing the environment around you so you do not develop the riskfactors for heart disease and, by extension, do not get the disease early in life. Blood Pressure Control High blood pressure is the riskfactor associated with the greatest number of deaths worldwide. J Am Heart Assoc.
The term cardiometabolic risk describes the chances that a person has of damaging the cardiovascular system when one or more riskfactors appear together. These factors include obesity, dyslipidemia, hypertension, and insulin resistance — also known as metabolic syndrome.
Despite significantly improving atherogenic dyslipidaemia, the most recent clinical trial outcome has cast doubt on the utility of pharmacologically lowering triglyceride concentrations using fibrates. Results from pharmacologically lowering triglyceride are conflicting.
Traumatic brain injury (TBI) afflicts 70 million people worldwide annually and is the 3rd overall riskfactor for developing Alzheimer's disease (AD), behind genetics and aging. Stroke, Volume 55, Issue Suppl_1 , Page ATP312-ATP312, February 1, 2024.
The key riskfactor for cardioembolic stroke is atrial fibrillation or flutter, and oral anticoagulation (OAC) is recommended in all but the lowest-risk patients with evidence of these arrhythmias. Riskfactors for thrombotic stroke overlap strongly with those for other atherosclerotic cardiovascular diseases (ASCVDs).
Implementation of a multispecialty care team approach, including expertise in riskfactor management, guideline directed medical therapies, wound and foot care and endovascular and surgical revascularization procedures, may improve outcomes for people with PAD. and Global Data From the American Heart Association.
The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional riskfactors. Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide.
1 While much effort has been directed at pharmacological and interventional techniques to improve outcomes for those living with these conditions, less has been directed towards identifying factors associated with increased incident risk of AF and non-AF arrhythmias, and strategies to ameliorate them.
The study, “Comprehensive Cardiovascular RiskFactor Control with a Mobile Health Cardiovascular Risk Self-Management Program,” highlights the potential use of digital health technology in the comprehensive control of riskfactors for cardiovascular disease (CVD), the leading cause of death and disability in the United States.
Optimal medical therapy for coronary artery disease includes lifestyle modifications and intensive pharmacologic interventions, according to the contemporary guideline directed medical therapy for secondary prevention. Half of the participants were randomly assigned to receive PCI plus medical therapy and half received medical therapy alone.
From advances in pharmacological treatments to innovative procedures like catheter ablation, the landscape of AFib treatment is continually evolving. Key Considerations for AFib Management Effective management of AFib requires a comprehensive approach that includes accurate diagnosis, risk stratification, and individualized treatment plans.
Considerable advances in our understanding of the biological mechanisms of aging have been made; yet, cardiovascular disease remains the leading cause of death in the United States urging a continued search for novel riskfactors to target for preventing and treating disease.
While it is known to increase serotonin levels in the brain and gastrointestinal tract, its pharmacology remains largely unexplored. After adjusting for conventional riskfactors, the association between 5-HTP and calcification remained significant (p < 0.05).Conclusion:Higher
From advances in pharmacological treatments to innovative procedures like catheter ablation, the landscape of AFib treatment is continually evolving. Key Considerations for AFib Management Effective management of AFib requires a comprehensive approach that includes accurate diagnosis, risk stratification, and individualized treatment plans.
Implementing preventive programs and increasing the control of cardiovascular riskfactors may have a significant social and health impact by helping to reduce mortality and costs for the Spanish National Health System.
BackgroundCardiac hypertrophy (CH) is a well‐established riskfactor for many cardiovascular diseases and a primary cause of mortality and morbidity among older adults. Currently, no pharmacological interventions have been specifically tailored to treat CH. Journal of the American Heart Association, Ahead of Print.
11 Despite the link between inflammation and cardiovascular disease has been proven by extensive research, most physicians have focused on treating high-risk patients with lipid lowering therapies including statin therapy.1,12,13 mg) to reduce the risks of heart attack, stroke, coronary revascularization, and CV death.29 Circulation.
Hyperhomocysteinemia (Hhcy), a metabolic disorder is recognized as a riskfactor for ischemic stroke. In a subset of Hhcy rats, NVP-AAM077, a pharmacological inhibitor of GluN2A-NMDAR was injected intravenously at the onset of stroke. Stroke, Volume 55, Issue Suppl_1 , Page AWP322-AWP322, February 1, 2024.
Treatment of riskfactors such as diabetes and cigarette smoking can benefit patients with PAD. Treatment of riskfactors such as diabetes and cigarette smoking can benefit patients with PAD. Patients should have adequate blood pressure and lipid control to decrease clinical manifestations and symptoms of PAD.
These conditions often intersect, sharing common riskfactors and underlying mechanisms. Pharmacological Interventions : Use of antihypertensive medications, lipid-lowering agents, and antidiabetic drugs. Surgical and Procedural Interventions : Including bariatric surgery and revascularization procedures.
Cox proportion hazards regression models were used to examine the effect of SGLT2I and riskfactors on the risk of developing ED, presented as a hazard ratio (HR) with a 95% confidence interval (CI). 159773 DM patients using SGLT2I and 159773 PS-matching DM patients who had never used SGLT2I was included.
Included is an up-to-date review of the current and rapidly evolving literature on CV risk in patients with IMIDs on JAKi therapy, including identification of potential riskfactors for future VTE and CV events on JAKi therapy.
24 will focus on the following three current guideline updates: American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines 2023 Atrial Fibrillation Guideline - Pharmacology II: Strokes vs. Bleeds, What Do the Guidelines Tell Us About Practical Management in A-fib? The Guidelines Sessions at ACC.24
Modifiable riskfactors, such as hypertension and dyslipidemia can be managed through lifestyle and pharmacotherapy treatments to reduce the risk of primary and secondary major cardiovascular events in patients with elevated risk. Abstract: Cardiovascular disease continues to be the leading cause of mortality globally.
Lipoprotein(a) [Lp(a)] is a riskfactor for coronary disease. Lipoprotein(a) [Lp(a)] is a riskfactor for coronary disease. Although levels are primarily genetically determined, data from patients with inflammatory diseases indicate that the inflammatory milieu is associated with increased Lp(a) levels.
There was no difference between the ALT and TNK cohorts in their baseline demographic characteristics or premorbid vascular riskfactors. Of the 165 patients undergoing thrombolysis, 75 also underwent EVT, with 55 patients treated with ALT compared to 20 patients treated with TNK.
Concluding Thoughts With the increased interventions of promising weight loss drugs not just for weight reduction, but also for improvement in associated riskfactors, patients and providers are offered renewed hope.
Cardiac hypertrophy is a crucial riskfactor for heart failure when the heart is confronted with physiological or pathological stimuli. Cardiac hypertrophy is a crucial riskfactor for heart failure when the heart is confronted with physiological or pathological stimuli.
Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major riskfactor for cardiometabolic disease. There are significant data that show that if you have obesity, you have a high risk of developing coronary heart disease, heart failure, type 2 diabetes (T2D) or riskfactors such as hypertension and dyslipidemia. [1]
Fourthly, we need to educate the patient on the condition in jargon-free and reassuring language on what riskfactors and lifestyle choices may have led to the development of the condition and on practical ways to modify those riskfactors as aggressively as possible. The next step is to talk about treatments.
Crit Care Med 1991; 19:694) Concentrated Potassium Chloride Infusions in Critically Ill Patients with Hypokalemia The Journal of Clinical Pharmacology. Furthermore, these results were independent of the patient's underlying renal function or associated diuretic administration.
Currently, there are no specific pharmacological treatments for CSVD, and the use of conventional antidementia drugs is not recommended. Mechanistic pathways underlying the neurocognitive benefits of exercise include the control of vascular riskfactors, improving endothelial function, and upregulating exerkines.
Meschia is a pioneer in the study of inherited riskfactors for ischemic stroke and has had a longstanding commitment to providing the latest evidence for carotid revascularization as a means for stroke prevention. Meschia is certified by the American Board of Psychiatry and Neurology (ABPN) in neurology and vascular neurology.
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