Frontiers in Cardiovascular Medicine

JULY 7, 2024

Creation of disease models utilizing hiPSCs in combination with CRISPR/Cas9 gene editing enable mechanistic insights into differential pharmacological responses. RYR2 deficient cardiomyocytes show differential pharmacological responses to L-type channel calcium inhibitors.

Pharmacology 52

Pharmacology Heart Failure Outcomes 52

American College of Cardiology

MAY 7, 2024

The following are key points to remember about a clinical guideline from the American College of Physicians (ACP) on newer pharmacologic treatments in adults with type 2 diabetes.

Pharmacology 45

Pharmacology Diabetes Article 45

Becker's Hospital Review - Cardiology

AUGUST 27, 2024

22 in Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics. GLP-1s reduced mortality and complications from cardiovascular events, according to a study published Aug.

Pharmacology 113

Pharmacology Obesity Diabetes 113

Heart BMJ

DECEMBER 13, 2024

3 Should we continue with a conservative, stepwise approach, beginning with pharmacological management and delaying intervention until MR severity worsens? 2 As the clinical understanding of SMR evolves, so too does the debate over the optimal treatment strategy.

Pharmacology 52

Pharmacology Bicuspid/Mitral Heart Failure Outcomes 52

Med Page Today

DECEMBER 12, 2023

Preventive Services Task Force (USPSTF) plans to recommend intensive behavioral interventions -- but not pharmacologic therapies -- for kids with a high body mass index (BMI). (MedPage Today) -- The U.S. In its draft recommendation statement.

BMI 122

BMI Obesity Pharmacology 122

Frontiers in Cardiovascular Medicine

MARCH 12, 2024

In this narrative review, we discuss the pathophysiology of CS, novel phenotypes, evolving definitions and staging systems, currently available pharmacologic and device-based therapies, standardized, team-based management protocols, and regionalized systems-of-care aimed at improving shock outcomes.

Cardiogenic Shock 145

Cardiogenic Shock Pharmacology Outcomes Research 145

The British Journal of Cardiology

MAY 24, 2024

Optimal pharmacological and non-pharmacological management (including device treatment) have had an enormous beneficial impact on the clinical course of HF. This module will focus on lifestyle modifications and pharmacological treatment.

Pharmacology 40

Pharmacology Heart Failure 40

Frontiers in Cardiovascular Medicine

JANUARY 23, 2025

The primary electrophysiological mechanism of atrial fibrillation (AF) maintenance is poorly defined. AF mapping studies readily record focal activations (defining them as focal sources or breakthroughs) and incomplete reentries (defining them as reentries or would-be-reentries) but do not or rarely detect complete circular activations.

Atrial Fibrillation 52

Atrial Fibrillation Pharmacology Electrophysiology 52

Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

Although no pharmacological interventions are yet approved for CUD, we present the most promising pharmacological interventions being tested.

Pharmacology 94

Pharmacology Innovation Risk Factors 94

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Results Pharmacological/non-pharmacological secondary prevention methods have been efficiently applied. Baseline aggregometry indicated platelet hyperactivity, decreasing gradually and being significantly reduced late, at 12 months ( p  < 0.05).

Laboratory 111

Laboratory Pharmacology Biomarkers 111

HCPLive

SEPTEMBER 26, 2024

The FDA approves Cobenfy, the first pharmacological approach to treating schizophrenia since the 1970s.

Pharmacology 83

Pharmacology 83

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Pharmacologic CTH inhibition suppressed glioblastoma invasion, while CTH knockdown slowed glioblastoma invasion in vivo. A CRISPR metabolic gene screen revealed cystathionine γ-lyase (CTH), which converts cystathionine to the nonessential amino acid cysteine in the transsulfuration pathway, to be essential for glioblastoma invasion.

Pharmacology 136

Pharmacology 136

JAMA Cardiology

OCTOBER 26, 2024

This substudy of the Danish-German (DanGer) Shock randomized clinical trial investigates if the use of a microaxial flow pump reduces the need for pharmacological support and what the effects are on hemodynamics and lactate clearance in patients with ST-elevation myocardial infarction–induced cardiogenic shock.

Cardiogenic Shock 90

Cardiogenic Shock Myocardial Infarction Pharmacology 90

Journal of Cardiovascular Pharmacology

JUNE 3, 2024

A variety of technologies, including network pharmacology, RNA-sequencing, immunohistochemistry, and Western blotting were performed to investigate its underlying mechanisms.

Pharmacology 40

Pharmacology Hypertension Technology Article 40

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Together, these findings offer critical insights into the functional role of LSGLP-1R neurons in the physiological regulation of energy homeostasis and delineate their instrumental role in mediating the pharmacological efficacy of liraglutide.

Pharmacology 117

Pharmacology Physiology Obesity 117

HCPLive

JUNE 26, 2024

Jennifer Goldman, RPh, PharmD, discusses how the pharmacologic advancements in recent years have shifted discussion around lipid, and cardiovascular risk, management in diabetes.

Diabetes 81

Diabetes Pharmacology 81

Journal of Cardiothoracic Surgery

JANUARY 9, 2025

Various pharmacological and non-pharmacological methods are available t. Removing the chest tube in cardiac patients after surgery is one of the worst experiences of hospitalization in the intensive care units.

Pharmacology 59

Pharmacology Hospital Research 59

DAIC

FEBRUARY 2, 2024

Optional Pre-conference Workshop to be held Friday afternoon includes a number of topics: Pharmacology 101 Pharmacology 101 – Workshop: Alana Ferrari, PharmD, BCOP How Do I Grow My Career in Cardio-Oncology? An overview of sessions, focus topics and presenters follows. Friday, February 9 Registration (1:00 - 6:00 p.m.)

Cardio Oncology 95

Cardio Oncology Cancer Pharmacology RN 95

Hypertension Journal

JANUARY 2, 2024

Pharmacological inhibition of EGFR or downstream ER stress may be a promising therapeutic strategy for preventing aneurysm rupture and subarachnoid hemorrhage.

Aneurysm 45

Aneurysm Pharmacology Atherosclerosis Hemorrhage 45

Nature Reviews - Cardiology

JANUARY 25, 2024

Nature Reviews Cardiology, Published online: 26 January 2024; doi:10.1038/s41569-023-00986-9 In this Review, Varga and colleagues provide an overview of the evidence on immune checkpoint inhibitor-induced heart failure and cardiac dysfunction that is unrelated to myocarditis, and discuss how pharmacological targeting of immune checkpoints might be (..)

Heart Failure 88

Heart Failure Physiology Pharmacology 88

Medical Xpress - Cardiology

JANUARY 10, 2025

A research team in the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), found that hip fractures not only result in both physical and psychological injuries, but may also induce adverse cardiovascular events.

Heart Failure 64

Heart Failure Pharmacology Research 64

Frontiers in Cardiovascular Medicine

JULY 24, 2024

This review delves into the current therapeutic strategies for CTEPH, including surgical pulmonary endarterectomy (PEA), balloon pulmonary angioplasty (BPA), and targeted pharmacological treatments such as PDE5 inhibitors, endothelin receptor antagonists, sGC stimulators, and prostanoids.

Pulmonary 98

Pulmonary Hypertension Angioplasty Pharmacology 98

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Genetic and pharmacologic inhibition of BET bromodomain activity reduced DMG cell proliferation and enhanced radiation-induced DNA damage by inhibiting DNA repair pathways. Using high-throughput radiosensitivity screening, we identified bromo- and extraterminal domain (BET) protein inhibitors as potent radiosensitizers in DMG cells.

Pharmacology 105

Pharmacology Cancer 105

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Emerging approaches, including cellular and gene therapy and novel pharmacologic approaches, are described. Current and emerging approaches to treat cancer therapy–induced dry mouth are presented using radiation-induced salivary dysfunction as a model. Limitations of current sialagogues and salivary analogues are presented.

Cancer 90

Cancer Quality of Life Anatomy Pharmacology 90

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Importantly, pharmacological blockade of ADORA2A profoundly represses neuroendocrine prostate and lung cancer growth in vivo. Therefore, we believe that ADORA2A can be used as a promising therapeutic target to govern the epigenetic reprogramming in neuroendocrine malignancies.

Cancer 109

Cancer Pharmacology Ablation 109

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Tumor reliance on glycolysis is a hallmark of cancer. Immunotherapy is more effective in controlling glycolysis-low tumors lacking lactate dehydrogenase (LDH) due to reduced tumor lactate efflux and enhanced glucose availability within the tumor microenvironment (TME).

Pharmacology 52

Pharmacology Cancer 52

Journal of Clinical Investigation - Cardiology

JUNE 3, 2024

Pharmacological targeting of this receptor with a brain penetrant CB2R inverse agonist/antagonist selectively reduces neuroinflammation without deleteriously affecting systemic GVHD severity.

Pharmacology 98

Pharmacology Transplant 98

HeartRhythm

APRIL 30, 2024

Microneurography showed that central alpha-2 agonists such as clonidine could acutely suppress sympathetic nerve activity (SNA). The acute and long-term neuromodulation effects of clonidine are unknown.

Pharmacology 40

Pharmacology 40

HCPLive

FEBRUARY 2, 2024

The 2021 ACR Guideline for the Treatment of Rheumatoid Arthritis provides updated recommendations for the pharmacologic management of RA. In honor of Rheumatoid Arthritis Awareness Day, test your knowledge with this quiz:

Pharmacology 64

Pharmacology 64

Heart BMJ

JUNE 25, 2024

Despite the existence of well-established risk factors and effective pharmacological treatments for major cardiovascular disease (CVD), these conditions remain among the leading causes of premature death and disability, exerting a substantial burden on health systems worldwide.

Pharmacology 59

Pharmacology Blood Pressure Risk Factors Cardiovascular Disease 59

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Pharmacological prevention of lipid droplet formation reverses the suppression of NO production in cell culture and in vivo and blunts blood pressure elevation in response to a high-fat diet.

Blood Pressure 102

Blood Pressure Obesity Pharmacology Diet 102

Journal of Clinical Investigation - Cardiology

JULY 15, 2024

Moreover, we identified 4 compounds that activate VCP primarily by increasing D2 ATPase activity, where pharmacologic VCP activation appears to enhance clearance of insoluble intranuclear TDP-43 aggregate.

Dementia 99

Dementia Pharmacology 99

The New England Journal of Medicine

MAY 12, 2024

In April 1964, leading cardiologists, cardiovascular surgeons, and pathologists convened in London for a 2-day symposium to discuss a relatively new disease entity that we now know as obstructive hypertrophic cardiomyopathy (HCM).1 1 The proceedings kicked off with a comment by the group’s chairman: “I have never before taken.

Cardiomyopathy 40

Cardiomyopathy Pharmacology 40

DAIC

FEBRUARY 27, 2024

The study will compare the safety and efficacy of the Laminar LAAX System to commercially available left atrial appendage (LAA) closure devices, providing a potential non-pharmacologic alternative for eligible patients.  This is particularly important for the nearly 40% of AFib patients who cannot tolerate long-term blood thinners3,4. 

Atrial Fibrillation 105

Atrial Fibrillation Innovation AFIB Pharmacology 105

HCPLive

JULY 8, 2024

Emerging treatments for CSA include hypochlorite phrenic nerve stimulation and pharmacological intervention, Badr told HCPLive.

Pharmacology 59

Pharmacology 59

Frontiers in Cardiovascular Medicine

MARCH 18, 2024

Against this backdrop, the quest for pharmacological agents capable of addressing the diverse subtypes of heart failure becomes a paramount pursuit. From this viewpoint, the present article focuses on Omecamtiv Mecarbil (OM), an emerging chemical compound said to exert inotropic effects without altering calcium homeostasis.

Heart Failure 94

Heart Failure Article Pharmacology 94

HCPLive

JULY 20, 2024

At 24 weeks, the oral therapy was well-tolerated and the safety profile remained in line with previous brepocitinib studies and the pharmacological class.

Pharmacology 59

Pharmacology 59