Piperine Shows Potential Pharmacological Benefit for NAFLD, Early Cirrhosis
HCPLive
JANUARY 18, 2024
Consuming a 5mg piperine capsule once daily for 12 weeks was linked to several pharmacological improvements in patients with NAFLD.
Pharmacology Related Topics 
Contemporary pharmacological treatment and management of heart failure
Nature Reviews - Cardiology
MARCH 25, 2024
Nature Reviews Cardiology, Published online: 26 March 2024; doi:10.1038/s41569-024-00997-0 In this Review, Bozkurt provides an overview of the management of patients with heart failure across the full range of left ventricular ejection fraction, derived from the recommendations in the latest US and European guidelines.
Current Mouse Models of Intracranial Aneurysms: Analysis of Pharmacological Agents Used to Induce Aneurysms and Their Impact on Translational Research
Journal of the American Heart Association
JANUARY 23, 2024
Hence, to date, no single pharmacological option exists to treat them. Genetic modification in a mouse model of IAs, including deletion or overexpression of a particular gene, provides an excellent means for examining basic mechanisms behind disease pathophysiology and developing novel pharmacological approaches.
Pharmacology 
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Pharmacological Management of Cardiac Arrhythmias in the Fetal and Neonatal Periods: A Scientific Statement From the American Heart Association
Circulation
FEBRUARY 5, 2024
This scientific statement discusses the mechanism of arrhythmias, pharmacological treatment options, and distinct aspects of pharmacokinetics for the fetus and neonate.
Pharmacology 78
78 
The Pharmacological Aspects of Adalimumab Biosimilars
HCPLive
APRIL 5, 2024
A clinical pharmacist reviews the various pharmacological aspects of the available adalimumab biosimilars.
Pharmacology 52
52 Pharmacology 52
52 
Nonpharmacological interventions on glycated haemoglobin in youth with type 1 diabetes: a Bayesian network meta-analysis
Cardiovascular Diabetology
JUNE 30, 2024
The available evidence on the impact of specific non-pharmacological interventions on glycaemic control is currently limited. Consequently, there is a need to determine which interventions could provide the mo.
Pharmacology 144
144 
Lifestyle Changes and Non-Pharmacological Options for Fibromyalgia
HCPLive
AUGUST 14, 2024
A key opinion leaders explore effective non-pharmacological therapies and lifestyle modifications that have shown significant promise in managing fibromyalgia symptoms, complementing traditional medication-based approaches.
Pharmacology 52
52 Pharmacology 52
52 
Optimising management of moderate secondary mitral regurgitation: insights into pharmacological and interventional approaches
Heart BMJ
DECEMBER 13, 2024
3 Should we continue with a conservative, stepwise approach, beginning with pharmacological management and delaying intervention until MR severity worsens? 2 As the clinical understanding of SMR evolves, so too does the debate over the optimal treatment strategy.
Pharmacology 52
52 
ACP Guideline on Pharmacologic Treatments for Diabetes: Key Points
American College of Cardiology
MAY 7, 2024
The following are key points to remember about a clinical guideline from the American College of Physicians (ACP) on newer pharmacologic treatments in adults with type 2 diabetes.
Pharmacology 49
49 
RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses
Frontiers in Cardiovascular Medicine
JULY 7, 2024
Creation of disease models utilizing hiPSCs in combination with CRISPR/Cas9 gene editing enable mechanistic insights into differential pharmacological responses. RYR2 deficient cardiomyocytes show differential pharmacological responses to L-type channel calcium inhibitors.
Pharmacology 52
52 
GLP-1s reduce cardiovascular mortality: Study
Becker's Hospital Review - Cardiology
AUGUST 27, 2024
22 in Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics. GLP-1s reduced mortality and complications from cardiovascular events, according to a study published Aug.
Pharmacology 113
113 
USPSTF Draft Calls for Lifestyle Shift -- Not Meds -- for Kids With Obesity
Med Page Today
DECEMBER 12, 2023
Preventive Services Task Force (USPSTF) plans to recommend intensive behavioral interventions -- but not pharmacologic therapies -- for kids with a high body mass index (BMI). (MedPage Today) -- The U.S. In its draft recommendation statement.
BMI 124
124 
Contemporary approach to cardiogenic shock care: a state-of-the-art review
Frontiers in Cardiovascular Medicine
MARCH 12, 2024
In this narrative review, we discuss the pathophysiology of CS, novel phenotypes, evolving definitions and staging systems, currently available pharmacologic and device-based therapies, standardized, team-based management protocols, and regionalized systems-of-care aimed at improving shock outcomes.
Heart failure learning module 3: lifestyle modifications and pharmacological treatment of heart failure
The British Journal of Cardiology
MAY 24, 2024
Optimal pharmacological and non-pharmacological management (including device treatment) have had an enormous beneficial impact on the clinical course of HF. This module will focus on lifestyle modifications and pharmacological treatment.
Pharmacology 40
40 
Microaxial Flow Pump Effects in Infarct-Related Cardiogenic Shock
JAMA Cardiology
OCTOBER 26, 2024
This substudy of the Danish-German (DanGer) Shock randomized clinical trial investigates if the use of a microaxial flow pump reduces the need for pharmacological support and what the effects are on hemodynamics and lactate clearance in patients with ST-elevation myocardial infarction–induced cardiogenic shock.
Cannabis use disorder: from neurobiology to treatment
Journal of Clinical Investigation - Cardiology
OCTOBER 15, 2024
Although no pharmacological interventions are yet approved for CUD, we present the most promising pharmacological interventions being tested.
Pharmacology 98
98 
Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Pharmacologic CTH inhibition suppressed glioblastoma invasion, while CTH knockdown slowed glioblastoma invasion in vivo. A CRISPR metabolic gene screen revealed cystathionine γ-lyase (CTH), which converts cystathionine to the nonessential amino acid cysteine in the transsulfuration pathway, to be essential for glioblastoma invasion.
Pharmacology 138
138 Pharmacology 138
138 
High platelet adrenergic activity and concomitant activation of the pituitary/medullar axis as alarming laboratory parameters in ACS survivors—the STRESS-AMI study
Frontiers in Cardiovascular Medicine
FEBRUARY 20, 2024
Results Pharmacological/non-pharmacological secondary prevention methods have been efficiently applied. Baseline aggregometry indicated platelet hyperactivity, decreasing gradually and being significantly reduced late, at 12 months ( p < 0.05).
Laboratory 111
111 
GLP-1R–positive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice
Journal of Clinical Investigation - Cardiology
SEPTEMBER 3, 2024
Together, these findings offer critical insights into the functional role of LSGLP-1R neurons in the physiological regulation of energy homeostasis and delineate their instrumental role in mediating the pharmacological efficacy of liraglutide.
Pharmacology 123
123 
FDA Approves Xanomeline and Trospium Chloride (Cobenfy) for Schizophrenia
HCPLive
SEPTEMBER 26, 2024
The FDA approves Cobenfy, the first pharmacological approach to treating schizophrenia since the 1970s.
Pharmacology 83
83 Pharmacology 83
83 
Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq
Journal of Cardiovascular Pharmacology
JUNE 3, 2024
A variety of technologies, including network pharmacology, RNA-sequencing, immunohistochemistry, and Western blotting were performed to investigate its underlying mechanisms.
Pharmacology 40
40 
Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress
Hypertension Journal
JANUARY 2, 2024
Pharmacological inhibition of EGFR or downstream ER stress may be a promising therapeutic strategy for preventing aneurysm rupture and subarachnoid hemorrhage.
Aneurysm 45
45 
Abstract 15: Pharmacological Activation of Efferocytosis Prevents Intracranial Aneurysm Rupture
Stroke Journal
FEBRUARY 1, 2024
In this study, we investigated the effect of pharmacological activation of MerTK-mediated efferocytosis using the Gas6 in intracranial aneurysms.Methods:We used 10-week-old male C57BL/6J mice. Our previous study suggested that MerTK knockout mice increased the rupture rate of intracranial aneurysms due to impaired efferocytosis.
Aneurysm 40
40 
Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure
Nature Reviews - Cardiology
JANUARY 25, 2024
Nature Reviews Cardiology, Published online: 26 January 2024; doi:10.1038/s41569-023-00986-9 In this Review, Varga and colleagues provide an overview of the evidence on immune checkpoint inhibitor-induced heart failure and cardiac dysfunction that is unrelated to myocarditis, and discuss how pharmacological targeting of immune checkpoints might be (..)
Jennifer Goldman, RPh, PharmD: How Advances in Lipid Management Fit Into Diabetes Care
HCPLive
JUNE 26, 2024
Jennifer Goldman, RPh, PharmD, discusses how the pharmacologic advancements in recent years have shifted discussion around lipid, and cardiovascular risk, management in diabetes.
Diabetes 81
81 
American College of Cardiology (ACC) Program Set for Cardiac Oncology Conference, “Advancing the Cardiovascular Care of the Oncology Patient”
DAIC
FEBRUARY 2, 2024
Optional Pre-conference Workshop to be held Friday afternoon includes a number of topics: Pharmacology 101 Pharmacology 101 – Workshop: Alana Ferrari, PharmD, BCOP How Do I Grow My Career in Cardio-Oncology? An overview of sessions, focus topics and presenters follows. Friday, February 9 Registration (1:00 - 6:00 p.m.)
BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma
Journal of Clinical Investigation - Cardiology
JULY 1, 2024
Genetic and pharmacologic inhibition of BET bromodomain activity reduced DMG cell proliferation and enhanced radiation-induced DNA damage by inhibiting DNA repair pathways. Using high-throughput radiosensitivity screening, we identified bromo- and extraterminal domain (BET) protein inhibitors as potent radiosensitizers in DMG cells.
Pharmacology 110
110 
ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
Importantly, pharmacological blockade of ADORA2A profoundly represses neuroendocrine prostate and lung cancer growth in vivo. Therefore, we believe that ADORA2A can be used as a promising therapeutic target to govern the epigenetic reprogramming in neuroendocrine malignancies.
Cancer 116
116 
Cancer therapy–related salivary dysfunction
Journal of Clinical Investigation - Cardiology
SEPTEMBER 3, 2024
Emerging approaches, including cellular and gene therapy and novel pharmacologic approaches, are described. Current and emerging approaches to treat cancer therapy–induced dry mouth are presented using radiation-induced salivary dysfunction as a model. Limitations of current sialagogues and salivary analogues are presented.
Cancer 96
96 
Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease
Journal of Clinical Investigation - Cardiology
JUNE 3, 2024
Pharmacological targeting of this receptor with a brain penetrant CB2R inverse agonist/antagonist selectively reduces neuroinflammation without deleteriously affecting systemic GVHD severity.
Pharmacology 98
98 
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models
Journal of Clinical Investigation - Cardiology
SEPTEMBER 3, 2024
Tumor reliance on glycolysis is a hallmark of cancer. Immunotherapy is more effective in controlling glycolysis-low tumors lacking lactate dehydrogenase (LDH) due to reduced tumor lactate efflux and enhanced glucose availability within the tumor microenvironment (TME).
Pharmacology 52
52 
VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models
Journal of Clinical Investigation - Cardiology
JULY 15, 2024
Moreover, we identified 4 compounds that activate VCP primarily by increasing D2 ATPase activity, where pharmacologic VCP activation appears to enhance clearance of insoluble intranuclear TDP-43 aggregate.
Dementia 103
103 
Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
Pharmacological prevention of lipid droplet formation reverses the suppression of NO production in cell culture and in vivo and blunts blood pressure elevation in response to a high-fat diet.
Blood Pressure 105
105 
CE-482905-002 USING CLONIDINE FOR PHARMACOLOGICAL NEUROMODULATION
HeartRhythm
APRIL 30, 2024
Microneurography showed that central alpha-2 agonists such as clonidine could acutely suppress sympathetic nerve activity (SNA). The acute and long-term neuromodulation effects of clonidine are unknown.
Pharmacology 40
40 Pharmacology 40
40 
Polypill: a harmonious blend of stoicism and pragmatism in primary cardiovascular prevention
Heart BMJ
JUNE 25, 2024
Despite the existence of well-established risk factors and effective pharmacological treatments for major cardiovascular disease (CVD), these conditions remain among the leading causes of premature death and disability, exerting a substantial burden on health systems worldwide.
Pharmacology 59
59 
Quiz: ACR Clinical Guideline for the Treatment of Rheumatoid Arthritis
HCPLive
FEBRUARY 2, 2024
The 2021 ACR Guideline for the Treatment of Rheumatoid Arthritis provides updated recommendations for the pharmacologic management of RA. In honor of Rheumatoid Arthritis Awareness Day, test your knowledge with this quiz:
Pharmacology 64
64 Pharmacology 64
64 
Biosense Webster Begins Enrollment of Pivotal Trial Evaluating the Laminar Left Atrial Appendage Elimination Device?
DAIC
FEBRUARY 27, 2024
The study will compare the safety and efficacy of the Laminar LAAX System to commercially available left atrial appendage (LAA) closure devices, providing a potential non-pharmacologic alternative for eligible patients. This is particularly important for the nearly 40% of AFib patients who cannot tolerate long-term blood thinners3,4.
Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice
Journal of Clinical Investigation - Cardiology
JULY 15, 2024
The genetic deletion or pharmacological inhibition of the MC3R, or subthreshold doses of an MC4R agonist, improved the dose responsiveness to glucagon-like peptide 1 (GLP1) agonists, as assayed by inhibition of food intake and weight loss.
Pharmacology 98
98 
Sixty Years of Hemodynamic Pharmacology in Obstructive Hypertrophic Cardiomyopathy
The New England Journal of Medicine
MAY 12, 2024
In April 1964, leading cardiologists, cardiovascular surgeons, and pathologists convened in London for a 2-day symposium to discuss a relatively new disease entity that we now know as obstructive hypertrophic cardiomyopathy (HCM).1 1 The proceedings kicked off with a comment by the group’s chairman: “I have never before taken.
Abstract WP310: Pharmacological Inhibition of 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3) is Neuroprotective in an Acute Mouse Model of Ischemic Stroke
Stroke Journal
FEBRUARY 1, 2024
These results support the hypothesis that PFKFB3 inhibitors may be used as a novel pharmacological treatment for reducing delayed cell death after ischemic stroke. Future studies are underway to investigate the molecular mechanisms and cell types involved in the protection conferred by PFKFB3 blockade in the context of ischemic stroke.
Pharmacology 40
40 
M. Safwan Badr, MD: Novel Treatments for Central Sleep Apnea in Last 10 Years
HCPLive
JULY 8, 2024
Emerging treatments for CSA include hypochlorite phrenic nerve stimulation and pharmacological intervention, Badr told HCPLive.
Pharmacology 59
59 Pharmacology 59
59 
The real-world incidence of severe QT prolongation in patients taking antipsychotic drugs
HeartRhythm
JANUARY 13, 2024
The increased risk of arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation has been a prominent safety pharmacology concern for the last 30 years.
Omecamtiv Mecarbil in the treatment of heart failure: the past, the present, and the future
Frontiers in Cardiovascular Medicine
MARCH 18, 2024
Against this backdrop, the quest for pharmacological agents capable of addressing the diverse subtypes of heart failure becomes a paramount pursuit. From this viewpoint, the present article focuses on Omecamtiv Mecarbil (OM), an emerging chemical compound said to exert inotropic effects without altering calcium homeostasis.
NEPTUNE: Oral Brepocitinib Effective in Non-infectious Uveitis at 24 Weeks
HCPLive
JULY 20, 2024
At 24 weeks, the oral therapy was well-tolerated and the safety profile remained in line with previous brepocitinib studies and the pharmacological class.
Pharmacology 59
59 Pharmacology 59
59 
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