Nature Reviews - Cardiology

MARCH 25, 2024

Nature Reviews Cardiology, Published online: 26 March 2024; doi:10.1038/s41569-024-00997-0 In this Review, Bozkurt provides an overview of the management of patients with heart failure across the full range of left ventricular ejection fraction, derived from the recommendations in the latest US and European guidelines.

Heart Failure 98

Heart Failure Pharmacology 98

Journal of Cardiovascular Pharmacology

JUNE 3, 2024

A variety of technologies, including network pharmacology, RNA-sequencing, immunohistochemistry, and Western blotting were performed to investigate its underlying mechanisms.

Pharmacology 40

Pharmacology Hypertension Technology Article 40

Open Heart

NOVEMBER 17, 2022

Associations between pharmacological treatment and long-term survival were analysed using Cox proportional hazards models. Methods From Swedish medical registers, all patients diagnosed with AD in 2006–2015 were identified. Results Of 3951 patients hospitalised with acute AD, 3046 (77%) were discharged and alive at 30 days.

Pharmacology 52

Pharmacology Aortic Outcomes 52

Stroke Journal

FEBRUARY 1, 2024

In this study, we investigated the effect of pharmacological activation of MerTK-mediated efferocytosis using the Gas6 in intracranial aneurysms.Methods:We used 10-week-old male C57BL/6J mice. Our previous study suggested that MerTK knockout mice increased the rupture rate of intracranial aneurysms due to impaired efferocytosis.

Aneurysm 40

Aneurysm Pharmacology Hypertension Stroke 40

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Tumor reliance on glycolysis is a hallmark of cancer. Immunotherapy is more effective in controlling glycolysis-low tumors lacking lactate dehydrogenase (LDH) due to reduced tumor lactate efflux and enhanced glucose availability within the tumor microenvironment (TME).

Pharmacology 52

Pharmacology Cancer 52

Becker's Hospital Review - Cardiology

AUGUST 27, 2024

22 in Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics. GLP-1s reduced mortality and complications from cardiovascular events, according to a study published Aug.

Pharmacology 113

Pharmacology Obesity Diabetes 113

Cardiovascular Diabetology

JUNE 30, 2024

The available evidence on the impact of specific non-pharmacological interventions on glycaemic control is currently limited. Consequently, there is a need to determine which interventions could provide the mo.

Pharmacology 144

Pharmacology Diabetes 144

Hypertension Journal

JANUARY 2, 2024

Pharmacological inhibition of EGFR or downstream ER stress may be a promising therapeutic strategy for preventing aneurysm rupture and subarachnoid hemorrhage.

Aneurysm 45

Aneurysm Pharmacology Atherosclerosis Hemorrhage 45

HeartRhythm

APRIL 30, 2024

Microneurography showed that central alpha-2 agonists such as clonidine could acutely suppress sympathetic nerve activity (SNA). The acute and long-term neuromodulation effects of clonidine are unknown.

Pharmacology 40

Pharmacology 40

The New England Journal of Medicine

MAY 12, 2024

In April 1964, leading cardiologists, cardiovascular surgeons, and pathologists convened in London for a 2-day symposium to discuss a relatively new disease entity that we now know as obstructive hypertrophic cardiomyopathy (HCM).1 1 The proceedings kicked off with a comment by the group’s chairman: “I have never before taken.

Cardiomyopathy 40

Cardiomyopathy Pharmacology 40

Journal of Cardiovascular Pharmacology

DECEMBER 12, 2023

An abstract is unavailable. This article is available as a PDF only.

Pharmacology 52

Pharmacology Article 52

Stroke Journal

FEBRUARY 1, 2024

These results support the hypothesis that PFKFB3 inhibitors may be used as a novel pharmacological treatment for reducing delayed cell death after ischemic stroke. Future studies are underway to investigate the molecular mechanisms and cell types involved in the protection conferred by PFKFB3 blockade in the context of ischemic stroke.

Pharmacology 40

Pharmacology Stroke Strokes 40

HeartRhythm

APRIL 30, 2024

Loss-of-function SCN5A channelopathies, such as Brugada syndrome (BrS), are cardiac disorders marked by diminished sodium current (INa), conduction slowing, and lethal arrhythmias.

Pharmacology 40

Pharmacology Defibrillator Innovation Arrhythmia 40

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Together, these findings offer critical insights into the functional role of LSGLP-1R neurons in the physiological regulation of energy homeostasis and delineate their instrumental role in mediating the pharmacological efficacy of liraglutide.

Pharmacology 116

Pharmacology Obesity Physiology 116

Med Page Today

DECEMBER 12, 2023

Preventive Services Task Force (USPSTF) plans to recommend intensive behavioral interventions -- but not pharmacologic therapies -- for kids with a high body mass index (BMI). (MedPage Today) -- The U.S. In its draft recommendation statement.

BMI 124

BMI Obesity Pharmacology 124

HCPLive

JUNE 26, 2024

Jennifer Goldman, RPh, PharmD, discusses how the pharmacologic advancements in recent years have shifted discussion around lipid, and cardiovascular risk, management in diabetes.

Diabetes 81

Diabetes Pharmacology 81

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Emerging approaches, including cellular and gene therapy and novel pharmacologic approaches, are described. Current and emerging approaches to treat cancer therapy–induced dry mouth are presented using radiation-induced salivary dysfunction as a model. Limitations of current sialagogues and salivary analogues are presented.

Cancer 120

Cancer Quality of Life Anatomy Pharmacology 120

Heart BMJ

JUNE 25, 2024

Despite the existence of well-established risk factors and effective pharmacological treatments for major cardiovascular disease (CVD), these conditions remain among the leading causes of premature death and disability, exerting a substantial burden on health systems worldwide.

Pharmacology 59

Pharmacology Blood Pressure Risk Factors Cardiovascular Disease 59

HCPLive

JULY 20, 2024

At 24 weeks, the oral therapy was well-tolerated and the safety profile remained in line with previous brepocitinib studies and the pharmacological class.

Pharmacology 59

Pharmacology 59

HCPLive

JULY 8, 2024

Emerging treatments for CSA include hypochlorite phrenic nerve stimulation and pharmacological intervention, Badr told HCPLive.

Pharmacology 59

Pharmacology 59

HeartRhythm

APRIL 30, 2024

Atrial fibrillation (AF) in children is rare. Chemical cardioversion using oral flecainide and ß-blockade is a well-described practice in adults. No data as to the safety and efficacy of this practice in pediatric patients is available.

Atrial Fibrillation 40

Atrial Fibrillation Pediatrics Pharmacology 40

HeartRhythm

APRIL 30, 2024

Contemporary antiarrhythmic treatment of Timothy syndrome 1 (TS1) is inadequate to prevent sudden cardiac death. We thus developed a knock-in TS1 porcine model that reproduces all cardinal features of the human disease and as such represents a unique platform for drug testing.

Sudden Cardiac Death 40

Sudden Cardiac Death Pharmacology Electrophysiology Arrhythmia 40

HeartRhythm

AUGUST 31, 2024

Pharmacological rhythm control with class III antiarrhythmic drugs (AADs) is an alternative to catheter ablation in appropriately selected AF patients. However, sotalol and/or dofetilide may significantly prolong the QT/QTc interval during initiation and inpatient initiation for these drugs remains standard.

Inpatient 40

Inpatient Pharmacology Ablation 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP312-ATP312, February 1, 2024. Traumatic brain injury (TBI) afflicts 70 million people worldwide annually and is the 3rd overall risk factor for developing Alzheimer's disease (AD), behind genetics and aging.

Pharmacology 40

Pharmacology Risk Factors Stroke Strokes 40

Frontiers in Cardiovascular Medicine

MARCH 12, 2024

In this narrative review, we discuss the pathophysiology of CS, novel phenotypes, evolving definitions and staging systems, currently available pharmacologic and device-based therapies, standardized, team-based management protocols, and regionalized systems-of-care aimed at improving shock outcomes.

Cardiogenic Shock 145

Cardiogenic Shock Pharmacology Outcomes Research 145

Nature Reviews - Cardiology

JANUARY 25, 2024

Nature Reviews Cardiology, Published online: 26 January 2024; doi:10.1038/s41569-023-00986-9 In this Review, Varga and colleagues provide an overview of the evidence on immune checkpoint inhibitor-induced heart failure and cardiac dysfunction that is unrelated to myocarditis, and discuss how pharmacological targeting of immune checkpoints might be (..)

Heart Failure 89

Heart Failure Physiology Pharmacology 89

HeartRhythm

APRIL 30, 2024

Pharmacologic therapy is often preferred in pregnant patients. When pharmacologic therapy fails, fluoroless catheter ablation utilizing electroanatomic mapping systems and intracardiac echocardiography (ICE) may be considered. Supraventricular tachycardias are the most common arrhythmias that occur during pregnancy.

Tachycardia 40

Tachycardia Pharmacology Ablation Arrhythmia 40

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Results Pharmacological/non-pharmacological secondary prevention methods have been efficiently applied. Baseline aggregometry indicated platelet hyperactivity, decreasing gradually and being significantly reduced late, at 12 months ( p  < 0.05).

Laboratory 111

Laboratory Pharmacology Biomarkers 111

Journal of Cardiovascular Pharmacology

JUNE 24, 2024

A personalised management plan including rationalising medications, patient education, identification, and avoidance of triggers, as well as non-pharmacological therapies such as compression devices, dietary modifications, and postural aids, make the first steps.

Pharmacology 40

Pharmacology Hypertension Education Article 40

HCPLive

MAY 28, 2024

Medical professionals discuss their ideal patients for surgery, and who would be best suited for pharmacologic intervention.

Pharmacology 52

Pharmacology 52

The British Journal of Cardiology

AUGUST 14, 2024

Faculty member Affiliation Professor Amitava Banerjee Professor of Clinical Data Science, Institute of Health Informatics, University College London; Consultant Cardiologist, University College London Hospitals and Barts Health NHS Trust Professor Sir Mark Caulfield Professor of Clinical Pharmacology, Queen Mary Un.

Cardiovascular Disease 52

Cardiovascular Disease Patient Care Innovation Pharmacology 52

HCPLive

FEBRUARY 2, 2024

The 2021 ACR Guideline for the Treatment of Rheumatoid Arthritis provides updated recommendations for the pharmacologic management of RA. In honor of Rheumatoid Arthritis Awareness Day, test your knowledge with this quiz:

Pharmacology 64

Pharmacology 64

HeartRhythm

SEPTEMBER 4, 2024

highlight the misperception that pharmacologic heart rate lowering is beneficial, which has resulted in an overprescription of beta-blockers in HFpEF and AF. Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are comorbid conditions that are increasingly prevalent and have a high socioeconomic burden.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Atrial Fibrillation Heart Failure Quality of Life 40

HCPLive

MARCH 25, 2024

Experts discuss the management of dry eye using conventional and new pharmacological treatments, as well as strategies for tailoring treatment approaches to individual patient characteristics.

Pharmacology 52

Pharmacology 52

DAIC

FEBRUARY 2, 2024

Optional Pre-conference Workshop to be held Friday afternoon includes a number of topics: Pharmacology 101 Pharmacology 101 – Workshop: Alana Ferrari, PharmD, BCOP How Do I Grow My Career in Cardio-Oncology? An overview of sessions, focus topics and presenters follows. Friday, February 9 Registration (1:00 - 6:00 p.m.)

Cardio Oncology 95

Cardio Oncology Cancer Pharmacology RN 95

HCPLive

MARCH 14, 2024

Experts discuss the management of dry eye using conventional and new pharmacological treatments, as well as strategies for tailoring treatment approaches to individual patient characteristics.

Pharmacology 52

Pharmacology 52

Frontiers in Cardiovascular Medicine

AUGUST 6, 2024

Despite significantly improving atherogenic dyslipidaemia, the most recent clinical trial outcome has cast doubt on the utility of pharmacologically lowering triglyceride concentrations using fibrates. Results from pharmacologically lowering triglyceride are conflicting.

Cardiovascular Disease 52

Cardiovascular Disease Pharmacology Cholesterol Risk Factors 52