Iron Deficiency Linked to Poor Outcomes in Kidney Transplant Recipients
HCPLive
MARCH 19, 2024
Iron deficiency, independent of anemia, may be a potentially modifiable target to improve patient-reported outcomes after kidney transplantation.
A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system by expanding Tregs may allow immunosuppression minimization and improve long-term graft outcomes.
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Revolutionary Genomic Study Sheds Light on Immune Microenvironment in Transplanted Pediatric Hearts
DAIC
FEBRUARY 13, 2024
THE TEXAS HEART INSTITUTE 2024 milla1cf Tue, 02/13/2024 - 17:56 February 13, 2024 — Pediatric heart transplantation has long been hailed as a life-saving intervention for children suffering from end-stage heart failure. This helps us gain a comprehensive understanding of the immune response dynamics within transplanted hearts."
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Prolonged Perfusion Preserves Donor Livers, Allows Flexible Transplantation Timeline
HCPLive
JANUARY 12, 2024
Liver transplantation after prolonged preservation with dual hypothermic oxygenated machine perfusion yielded similar outcomes to standard perfusion, showing no compromised donor liver quality and equal safety for recipients.
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Machine Perfusion Could Help Address Transplant Crisis for Pediatric Liver Diseases
HCPLive
NOVEMBER 9, 2024
New data from the UNOS database presented at NASPGHAN 2024 details characteristics and outcomes of pediatric liver transplant patients receiving machine perfused organs.
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Landmark Study Shows CareDx’s HeartCare Outperforms dd-cfDNA Alone in Identifying Rejection and Patients Experienced Excellent Outcomes with Fewer Biopsies
DAIC
MAY 31, 2024
By the end of the study cardiologists performed 10% fewer biopsies in the first year post-transplant and 40% fewer in the second year post-transplant despite an increase in follow-up biopsy rates for dual positives. Hanna , CareDx President and CEO.
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HCV+ Organs Offer Better Waitlist, Survival Outcomes for Transplantation
HCPLive
NOVEMBER 5, 2024
Direct-acting antiviral agents have enabled more availability for organ transplant.
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Minjee Kim, MD: Understanding Sleep’s Impact on Post-Liver Transplant Outcomes
HCPLive
NOVEMBER 17, 2024
Kim explains how poor sleep is linked to negative impacts on mental health, physical health, and frailty after liver transplantation.
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Paragonix SherpaPak Recognized for Maximizing Access to the Donor Pool in New Clinical Study
DAIC
JANUARY 11, 2024
In organ transplantation, an extended criteria donor is defined as having perceived risk factors linked to poor subsequent outcomes, for example, those with age >55 or ischemic times exceeding 4 hours, which sometimes leads to rejection of the donor organ. utilizing the Paragonix SherpaPak CTS (p=0.022).
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Genomic study sheds light on immune microenvironment in transplanted pediatric hearts
Medical Xpress - Cardiology
FEBRUARY 12, 2024
Pediatric heart transplantation has long been hailed as a life-saving intervention for children suffering from end-stage heart failure. While the procedure offers hope, the long-term outcomes for these young patients remain suboptimal due to allograft rejection and graft failure.
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Standardized risk-stratified cardiac assessment and early posttransplant cardiovascular complications in kidney transplant recipients
Frontiers in Cardiovascular Medicine
JANUARY 23, 2024
Introduction Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in kidney transplant recipient (KTR). There is a dearth of standardized guidelines on optimal cardiovascular evaluation of transplant candidates. Posttransplant MACE has a negative effect on grafts and patient outcomes.
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The impact of bleeding on outcomes following lung transplantation: a retrospective analysis using the universal definition of perioperative bleeding
Journal of Cardiothoracic Surgery
JULY 24, 2024
Lung transplantation (LT) represents a high-risk procedure for end-stage lung diseases. This study describes the outcomes of patients undergoing LT that require massive transfusions as defined by the universal.
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Using stem cell-derived heart muscle cells to advance heart regenerative therapy
Science Daily - Heart Disease
APRIL 26, 2024
Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. The highly positive outcomes observed in primate models highlight the potential of this strategy. However, the risk of arrhythmias following this procedure is reportedly high.
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Qazi Corner, Edition 7: ERCP Timing, GLP-1 RA Considerations, Seronegative Villous Atrophy
HCPLive
AUGUST 23, 2024
The third quarterly issue of 2024 reviews early versus late ERCP outcomes post-transplant, the impact of GLP-1RA use on endoscopic management, and the differential diagnosis of seronegative villous atrophy.
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Outcome of Cardiac Implantable Electronic Devices in Pediatric Heart Transplant Recipients
HeartRhythm
AUGUST 21, 2024
Among pediatric patients undergoing orthotopic heart transplantation (OHT), 1-12% are reported to need a permanent pacemaker (PPM).1 1 There are limited studies on the outcomes of PPM placement, and the role of implantable cardioverter-defibrillator (ICD) in pediatric OHT remains unclear.
Determinants of survival following heart transplantation in adults with congenital heart disease
Journal of Cardiothoracic Surgery
FEBRUARY 9, 2024
We examine the factors associated with heart transplant outcomes in this challenging population with complex anatomy requiring redo-sur. Adult patients surviving with congenital heart disease (ACHD) is growing.
Toxic epidermal necrolysis following heart transplantation may caused by cefoperazone sodium and sulbactam sodium
Journal of Cardiothoracic Surgery
SEPTEMBER 22, 2024
The outcome of heart transplantation is significantly affected by perioperative infections. Individualised immunosuppression strategies are essential to reduce the risk of such infections.
Hematopoietic Stem Cell Transplantation Improves Pediatric SCD Outcomes
HCPLive
APRIL 9, 2024
A systematic review and meta-analysis of HSCT in children with sickle cell disease demonstrated pooled survival rates exceeding 90%.
Early Heart Transplant Experience With Normothermic Regional Perfusion
American College of Cardiology
DECEMBER 4, 2024
For heart transplantation following donation after circulatory death (DCD HT), what are the short-term outcomes associated with organ procurement using a normothermic regional perfusion (NRP) strategy compared to a direct procurement and perfusion (DPP) strategy?
Right Ventricular Function on Cardiovascular Magnetic Resonance Imaging and Long-Term Outcomes in Stable Heart Transplant Recipients
Circulation: Cardiovascular Imaging
APRIL 2, 2024
BACKGROUND:In heart transplant recipients, right ventricular (RV) dysfunction may occur for a variety of reasons. Whether RV dysfunction in the stable phase after heart transplantation is associated with long-term adverse outcomes is unknown. years after heart transplantation were included. Over a median follow-up of 4.4
Ochsner Children’s Hospital Advocates to Close the Gap in Pediatric Heart Care
DAIC
FEBRUARY 21, 2024
As the only pediatric heart transplant program in Louisiana and the only program in the state to offer advanced mechanical support options for pediatric cardiology patients, Ochsner Children’s Hospital is committed to advocating for additional medical devices to enhance its high-quality care to pediatric patients awaiting transplant.
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Heart transplantation for pediatric patients with malignant arrhythmias: Indications and Outcomes
HeartRhythm
OCTOBER 7, 2024
When intractable, heart transplant (HTX) can become the only viable treatment. Arrhythmias can lead to cardiac arrest (CA) and heart failure. This rare, high-risk cohort has not been reported as a distinct group.
What happens to patients awaiting urgent transplantation for refractory electrical storm when they are not transplanted?
HeartRhythm
SEPTEMBER 17, 2024
Urgent heart transplantation (HTx) may be considered when all previous strategies fail (1), albeit with substantial post-operative mortality (1). Although HTx is considered as a bail-out strategy, no data exist regarding outcomes of refractory ES patients listed for urgent HTx but ultimately not transplanted during the acute phase.
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Case report of belt electrode-skeletal muscle electrical stimulation for acute heart failure with severe obesity: a novel therapeutic option for acute phase rehabilitation
Frontiers in Cardiovascular Medicine
MARCH 7, 2024
Background Belt electrode skeletal muscle electrical stimulation (B-SES) is an emerging therapy anticipated to yield more favorable outcomes than conventional neuromuscular electrical stimulation (NMES), owing to its larger stimulation area. However, information on its efficacy and safety in patients with heart failure remains limited.
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An explainable machine learning approach using contemporary UNOS data to identify patients who fail to bridge to heart transplantation
Frontiers in Cardiovascular Medicine
MAY 19, 2024
BackgroundThe use of Intra-aortic Balloon Pump (IABP) and Impella devices as a bridge to heart transplantation (HTx) has increased significantly in recent times. Out of them, 12% had primary outcomes indicating Status 2 failure. Our ML models were based on 19 variables from the UNOS data.
RELIEVE-HF: Interatrial shunt in patients with heart failure
Cardiology Update
APRIL 25, 2024
The primary endpoint was a composite of all-cause mortality, left ventricular assist device (LVAD)/heart transplantation, HF hospitalizations, worsening HF, and KCCQ score changes. Among patients with HFpEF, those who received the shunt experienced poor outcomes than those who did not.
Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A Scientific Statement From the American Heart Association
Circulation
MARCH 11, 2024
Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, but guidelines are lacking.
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Organ Donation After Euthanasia Can Safely Expand Kidney Donor Pool, Study Finds
HCPLive
SEPTEMBER 25, 2024
Leveraging deceased donor kidney transplantation data, study results suggest DCD-V kidney transplantation has similar short- and long-term outcomes versus DCD-III and DBD.
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Resynchronization-defibrillation for heart failure shows long-term benefits
Cardiology Update
JANUARY 22, 2024
Long-term outcomes were assessed at the eight highest-enrolling sites. The primary outcome was death from any cause, and the secondary outcome included a composite of death, heart transplantation, or ventricular assist device implantation. Secondary outcomes were experienced by 77.7% to 0.92; P=0.002).
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Smidt Heart Institute Experts Selected to Join JACC Editorial Team
DAIC
JUNE 24, 2024
Kittleson, director of Heart Failure Research and director of Post Graduate Medical Education in Heart Failure and Transplantation, is an associate editor specializing in heart failure. She has been a section editor for Circulation: Cardiovascular Outcomes and Research, authored book chapters, and in 2022 was a finalist for the Samuel A.
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In-Center Hemodialysis Patient Outcomes Negatively Impacted by Patient Care Technician Understaffing
HCPLive
MARCH 12, 2024
A greater patient-to-patient care technician ratio was associated with increased mortality and hospitalization with lower rates of waitlisting and transplantation among patients receiving in-center hemodialysis.
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RELIEVE-HF Trial Outcomes Reported at ACC.24 Find Impact of Interatrial Shunt May Vary by Heart Failure Type
DAIC
APRIL 6, 2024
Gregg Stone, MD “When you examine the outcomes in patients with heart failure across a broad range of left ventricular ejection fraction, the Ventura interatrial shunt was extremely safe but did not improve outcomes compared with no treatment. Researchers tracked outcomes in each participant for at least one year and up to two years.
Abstract 4146828: Downregulation of ADAR1 Attenuates Hypothermic Cardioprotection in Aged Donor Hearts During Transplantation
Circulation
NOVEMBER 11, 2024
Heart transplantation remains a vital treatment for end-stage heart failure, yet the scarcity of suitable donor hearts makes the treatment unavailable to many patients in critical need. Aged donor hearts, despite their availability, exhibit increased primary graft dysfunction and decreased survival rates post-transplantation.
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Heart Failure Treatment Outcomes and Contraindications
HCPLive
MAY 21, 2024
Ashley Malliett, DMSc, MPAS, PA-C, discusses the importance of timely diagnosis and initiated care, as well as contraindications for transplants and LVAD.
Using Stem Cell-derived Heart Muscle Cells to Advance Heart Regenerative Therapy
DAIC
APRIL 30, 2024
Image courtesy of Hideki Kobayashi from Shinshu University milla1cf Tue, 04/30/2024 - 12:53 April 30, 2024 — Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. The highly positive outcomes observed in primate models highlight the potential of this strategy.
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105 Abstract 4146920: Potential Effects of Preoperative Blood Transfusions on Cardiac Transplantation Patient’s Postoperative Condition
Circulation
NOVEMBER 11, 2024
Cox regression results showed that there is an increased risk of mortality in patients who did not receive transfusions before transplant (p<0.0001).Conclusion:While Cox regression results showed that there is an increased risk of mortality in patients who did not receive transfusions before transplant (p<0.0001).Conclusion:While
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Feasibility Value of Right Ventricular Longitudinal Shortening Fraction and the Prognostic Implications in Patients With Heart Transplantation
Journal of the American Heart Association
MARCH 8, 2024
The value of RVLSF in the assessment of RV systolic function in recipients of heart transplantation (HT) and whether RVLSF can replace strain parameters remains unknown.Methods and ResultsA total of 153 adult patients who underwent HT were consecutively enrolled in this prospective longitudinal study.
External Validation of Proposed American Heart Association Algorithm for Cardiovascular Screening Before Kidney Transplantation
Journal of the American Heart Association
DECEMBER 12, 2023
BackgroundScreening for cardiovascular disease is currently recommended before kidney transplantation. Outcomes were degree of coronary heart disease, revascularization rate following screening, major adverse cardiovascular events, and all‐cause death. 10.8]; and HR, 2.1 [95% 3.9]) and all‐cause death (HR, 12.0 [95% 95% [CI, 4.6–31.4];
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40 2023 American Heart Association Focused Update on Adult Advanced Cardiovascular Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Circulation
DECEMBER 18, 2023
Advanced cardiac life support measures are commonly used to improve outcomes. Last, we consider how the cardiac arrest population may make up an important pool of organ donors for those awaiting organ transplantation. Circulation, Ahead of Print.
Procyrion Announces First Patient Enrollments in the DRAIN-HF Pivotal IDE Trial for Aortix Percutaneous Mechanical Circulatory Support Technology
DAIC
DECEMBER 8, 2023
a medical device company dedicated to improving outcomes for patients with cardiac and renal impairment, announced the enrollment of the first patients in the company's IDE pivotal trial. These patients have very poor outcomes in terms of death and rehospitalization and therefore new therapy options are critically needed," stated Dr. Chehab.
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Cardiogenic Shock in Older Adults: A Focus on Age-Associated Risks and Approach to Management: A Scientific Statement From the American Heart Association
Circulation
FEBRUARY 26, 2024
Cardiogenic shock continues to portend poor outcomes, conferring short-term mortality rates of 30% to 50% despite recent scientific advances. As a result, despite the association of advanced age with worse outcomes, focused strategies in the assessment and management of cardiogenic shock in this high-risk and growing population are lacking.
Left ventricular assist device and transcatheter edge-to-edge mitral valve repair in advanced heart failure: allies or enemies?
Frontiers in Cardiovascular Medicine
JANUARY 25, 2024
On the contrary, the use of transcatheter edge-to-edge mitral valve repair (TEER) has exponentially increased over the past decade, expanding its potential use even in patients on the heart transplantation waiting list.
Uric acid in advanced heart failure: relation to central haemodynamics and outcome
Open Heart
NOVEMBER 25, 2022
Cox models were created to investigate if UA was a significant predictor of adverse outcome where log1.1(UA) UA) was used to estimate the effect on outcome associated with a 10% increase in UA levels. Regression analyses were constructed to investigate the association between UA and haemodynamic variables.
Extracorporeal Perfusion for Extended Criteria Donor Hearts
American College of Cardiology
JANUARY 26, 2024
For extended criteria donor (ECD) hearts in donation after brain death (DBD), what is the impact of the use of portable extracorporeal perfusion on donor heart utilization and post-transplant outcomes?
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