Iron Deficiency Linked to Poor Outcomes in Kidney Transplant Recipients
HCPLive
MARCH 19, 2024
Iron deficiency, independent of anemia, may be a potentially modifiable target to improve patient-reported outcomes after kidney transplantation.
Outcome of Cardiac Implantable Electronic Devices in Pediatric Heart Transplant Recipients
HeartRhythm
AUGUST 21, 2024
Among pediatric patients undergoing orthotopic heart transplantation (OHT), 1-12% are reported to need a permanent pacemaker (PPM).1 1 There are limited studies on the outcomes of PPM placement, and the role of implantable cardioverter-defibrillator (ICD) in pediatric OHT remains unclear.
The impact of bleeding on outcomes following lung transplantation: a retrospective analysis using the universal definition of perioperative bleeding
Journal of Cardiothoracic Surgery
JULY 24, 2024
Lung transplantation (LT) represents a high-risk procedure for end-stage lung diseases. This study describes the outcomes of patients undergoing LT that require massive transfusions as defined by the universal.
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A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system by expanding Tregs may allow immunosuppression minimization and improve long-term graft outcomes.
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Prolonged Perfusion Preserves Donor Livers, Allows Flexible Transplantation Timeline
HCPLive
JANUARY 12, 2024
Liver transplantation after prolonged preservation with dual hypothermic oxygenated machine perfusion yielded similar outcomes to standard perfusion, showing no compromised donor liver quality and equal safety for recipients.
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Genomic study sheds light on immune microenvironment in transplanted pediatric hearts
Medical Xpress - Cardiology
FEBRUARY 12, 2024
Pediatric heart transplantation has long been hailed as a life-saving intervention for children suffering from end-stage heart failure. While the procedure offers hope, the long-term outcomes for these young patients remain suboptimal due to allograft rejection and graft failure.
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Right Ventricular Function on Cardiovascular Magnetic Resonance Imaging and Long-Term Outcomes in Stable Heart Transplant Recipients
Circulation: Cardiovascular Imaging
APRIL 2, 2024
BACKGROUND:In heart transplant recipients, right ventricular (RV) dysfunction may occur for a variety of reasons. Whether RV dysfunction in the stable phase after heart transplantation is associated with long-term adverse outcomes is unknown. years after heart transplantation were included. Over a median follow-up of 4.4
Determinants of survival following heart transplantation in adults with congenital heart disease
Journal of Cardiothoracic Surgery
FEBRUARY 9, 2024
We examine the factors associated with heart transplant outcomes in this challenging population with complex anatomy requiring redo-sur. Adult patients surviving with congenital heart disease (ACHD) is growing.
Qazi Corner, Edition 7: ERCP Timing, GLP-1 RA Considerations, Seronegative Villous Atrophy
HCPLive
AUGUST 23, 2024
The third quarterly issue of 2024 reviews early versus late ERCP outcomes post-transplant, the impact of GLP-1RA use on endoscopic management, and the differential diagnosis of seronegative villous atrophy.
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Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A Scientific Statement From the American Heart Association
Circulation
MARCH 11, 2024
Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, but guidelines are lacking.
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Hematopoietic Stem Cell Transplantation Improves Pediatric SCD Outcomes
HCPLive
APRIL 9, 2024
A systematic review and meta-analysis of HSCT in children with sickle cell disease demonstrated pooled survival rates exceeding 90%.
An explainable machine learning approach using contemporary UNOS data to identify patients who fail to bridge to heart transplantation
Frontiers in Cardiovascular Medicine
MAY 19, 2024
BackgroundThe use of Intra-aortic Balloon Pump (IABP) and Impella devices as a bridge to heart transplantation (HTx) has increased significantly in recent times. Out of them, 12% had primary outcomes indicating Status 2 failure. Our ML models were based on 19 variables from the UNOS data.
External Validation of Proposed American Heart Association Algorithm for Cardiovascular Screening Before Kidney Transplantation
Journal of the American Heart Association
DECEMBER 12, 2023
BackgroundScreening for cardiovascular disease is currently recommended before kidney transplantation. Outcomes were degree of coronary heart disease, revascularization rate following screening, major adverse cardiovascular events, and all‐cause death. 10.8]; and HR, 2.1 [95% 3.9]) and all‐cause death (HR, 12.0 [95% 95% [CI, 4.6–31.4];
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Feasibility Value of Right Ventricular Longitudinal Shortening Fraction and the Prognostic Implications in Patients With Heart Transplantation
Journal of the American Heart Association
MARCH 8, 2024
The value of RVLSF in the assessment of RV systolic function in recipients of heart transplantation (HT) and whether RVLSF can replace strain parameters remains unknown.Methods and ResultsA total of 153 adult patients who underwent HT were consecutively enrolled in this prospective longitudinal study.
Heart Failure Treatment Outcomes and Contraindications
HCPLive
MAY 21, 2024
Ashley Malliett, DMSc, MPAS, PA-C, discusses the importance of timely diagnosis and initiated care, as well as contraindications for transplants and LVAD.
Paragonix SherpaPak Recognized for Maximizing Access to the Donor Pool in New Clinical Study
DAIC
JANUARY 11, 2024
In organ transplantation, an extended criteria donor is defined as having perceived risk factors linked to poor subsequent outcomes, for example, those with age >55 or ischemic times exceeding 4 hours, which sometimes leads to rejection of the donor organ. utilizing the Paragonix SherpaPak CTS (p=0.022).
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Using stem cell-derived heart muscle cells to advance heart regenerative therapy
Science Daily - Heart Disease
APRIL 26, 2024
Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. The highly positive outcomes observed in primate models highlight the potential of this strategy. However, the risk of arrhythmias following this procedure is reportedly high.
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In-Center Hemodialysis Patient Outcomes Negatively Impacted by Patient Care Technician Understaffing
HCPLive
MARCH 12, 2024
A greater patient-to-patient care technician ratio was associated with increased mortality and hospitalization with lower rates of waitlisting and transplantation among patients receiving in-center hemodialysis.
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3-Year Left Ventricular Assist Device Outcomes and Strategy After Heart Transplant Allocation Score Change
The American Journal of Cardiology
JULY 6, 2024
Publication date: Available online 6 July 2024 Source: The American Journal of Cardiology Author(s): Jacob Agronin, Meredith Brown, Hannah Calvelli, Huaqing Zhao, Val Rakita, Yoshiya Toyoda, Mohammed Abul Kashem
Emergency Department Use and Hospital Mortality Among Heart Transplant Recipients in the United States
Journal of the American Heart Association
FEBRUARY 29, 2024
BackgroundAnnual heart transplant (HT) volumes have increased, as have post‐HT outpatient care needs. Multivariable logistic regression was used to predict outcomes of hospital admission and death. Journal of the American Heart Association, Ahead of Print. HT volumes and HT‐related ED visits increased from 2009 to 2018.
Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias
Frontiers in Cardiovascular Medicine
JULY 8, 2024
BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation.
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Waitlist Outcomes in Candidates With Rare Causes of Heart Failure After Implementation of the 2018 French Heart Allocation Scheme
Circulation: Heart Failure
FEBRUARY 1, 2024
BACKGROUND:In 2018, an algorithm-based allocation system for heart transplantation (HT) was implemented in France. The cumulative incidence of waitlist mortality estimated with competing risk analysis and incidence of transplantation were compared between diagnosis groups. 4.24];P=0.03).CONCLUSIONS:Our
Smidt Heart Institute Experts Selected to Join JACC Editorial Team
DAIC
JUNE 24, 2024
Kittleson, director of Heart Failure Research and director of Post Graduate Medical Education in Heart Failure and Transplantation, is an associate editor specializing in heart failure. She has been a section editor for Circulation: Cardiovascular Outcomes and Research, authored book chapters, and in 2022 was a finalist for the Samuel A.
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Ochsner Children’s Hospital Advocates to Close the Gap in Pediatric Heart Care
DAIC
FEBRUARY 21, 2024
As the only pediatric heart transplant program in Louisiana and the only program in the state to offer advanced mechanical support options for pediatric cardiology patients, Ochsner Children’s Hospital is committed to advocating for additional medical devices to enhance its high-quality care to pediatric patients awaiting transplant.
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RELIEVE-HF: Interatrial shunt in patients with heart failure
Cardiology Update
APRIL 25, 2024
The primary endpoint was a composite of all-cause mortality, left ventricular assist device (LVAD)/heart transplantation, HF hospitalizations, worsening HF, and KCCQ score changes. Among patients with HFpEF, those who received the shunt experienced poor outcomes than those who did not.
Impact of Advanced Therapy Centers on Characteristics and Outcomes of Heart Failure Admissions
Circulation: Heart Failure
MARCH 8, 2024
Centers performing at least 1 heart transplant or left ventricular assist device were classified as ATCs. Patient characteristics, outcomes, and procedural volume were compared among 3 cohorts: admissions to non-ATCs, admissions to ATCs, and transfers to ATCs.
Extracorporeal Perfusion for Extended Criteria Donor Hearts
American College of Cardiology
JANUARY 26, 2024
For extended criteria donor (ECD) hearts in donation after brain death (DBD), what is the impact of the use of portable extracorporeal perfusion on donor heart utilization and post-transplant outcomes?
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Uric acid in advanced heart failure: relation to central haemodynamics and outcome
Open Heart
NOVEMBER 25, 2022
Cox models were created to investigate if UA was a significant predictor of adverse outcome where log1.1(UA) UA) was used to estimate the effect on outcome associated with a 10% increase in UA levels. Regression analyses were constructed to investigate the association between UA and haemodynamic variables.
Long?term outcome after upgrade to cardiac resynchronization therapy: A propensity score?matched analysis
European Journal of Heart Failure
NOVEMBER 9, 2023
However, data on long-term outcome after upgrade to CRT are scarce. The primary composite endpoint included all-cause mortality, heart transplantation, or ventricular assist device implantation.
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Case report of belt electrode-skeletal muscle electrical stimulation for acute heart failure with severe obesity: a novel therapeutic option for acute phase rehabilitation
Frontiers in Cardiovascular Medicine
MARCH 7, 2024
Background Belt electrode skeletal muscle electrical stimulation (B-SES) is an emerging therapy anticipated to yield more favorable outcomes than conventional neuromuscular electrical stimulation (NMES), owing to its larger stimulation area. However, information on its efficacy and safety in patients with heart failure remains limited.
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Trends in Ductus Arteriosus Stent Versus Blalock?Taussig?Thomas Shunt Use and Comparison of Cost, Length of Stay, and Short?Term Outcomes in Neonates With Ductal?Dependent Pulmonary Blood Flow: An Observational Study Using the Pediatric Health Information Systems Database
Journal of the American Heart Association
DECEMBER 1, 2023
We performed generalized linear mixed‐effects modeling to evaluate trends in intervention and intercenter variation, propensity score adjustment and inverse probability weighting with linear mixed‐effects modeling to analyze length of stay and cost of hospitalization, and generalized linear mixed modeling to analyze differences in 30‐day outcomes.
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Using Stem Cell-derived Heart Muscle Cells to Advance Heart Regenerative Therapy
DAIC
APRIL 30, 2024
Image courtesy of Hideki Kobayashi from Shinshu University milla1cf Tue, 04/30/2024 - 12:53 April 30, 2024 — Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. The highly positive outcomes observed in primate models highlight the potential of this strategy.
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105 2023 American Heart Association Focused Update on Adult Advanced Cardiovascular Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Circulation
DECEMBER 18, 2023
Advanced cardiac life support measures are commonly used to improve outcomes. Last, we consider how the cardiac arrest population may make up an important pool of organ donors for those awaiting organ transplantation. Circulation, Ahead of Print.
Predictors of outcome in a contemporary cardiac sarcoidosis population: Role of brain natriuretic peptide, left ventricular function and myocardial inflammation
European Journal of Heart Failure
NOVEMBER 7, 2023
BNP, CMR-LVEF and SUVmax in FDG-PET: independent predictors of outcome in a contemporary cardiac sarcoidosis population remaining robust in subgroup subanalysis. Here, we describe baseline characteristics at presentation along with prognosis and predictors of outcome in a sizable and deeply phenotyped contemporary cohort of CS patients.
Predictors and outcomes of pacemaker implantation in patients with cardiac amyloidosis
Heart BMJ
DECEMBER 15, 2023
The associations between PPM implantation and mortality, heart failure (HF) or a composite endpoint of mortality, cardiac transplantation and HF were analysed. Clinical, laboratory and instrumental data were analysed. Results 81 (10.3%) patients had a PPM before initial evaluation. Over a median follow-up time of 21.7 months (IQR 9.6–45.2),
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Left ventricular assist device and transcatheter edge-to-edge mitral valve repair in advanced heart failure: allies or enemies?
Frontiers in Cardiovascular Medicine
JANUARY 25, 2024
On the contrary, the use of transcatheter edge-to-edge mitral valve repair (TEER) has exponentially increased over the past decade, expanding its potential use even in patients on the heart transplantation waiting list.
Resynchronization-defibrillation for heart failure shows long-term benefits
Cardiology Update
JANUARY 22, 2024
Long-term outcomes were assessed at the eight highest-enrolling sites. The primary outcome was death from any cause, and the secondary outcome included a composite of death, heart transplantation, or ventricular assist device implantation. Secondary outcomes were experienced by 77.7% to 0.92; P=0.002).
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Endotronix Receives FDA Premarket Approval of the Cordella PA Sensor System for the Treatment of Heart Failure
DAIC
JUNE 24, 2024
The Cordella platform is the first and only PA pressure-guided platform to offer comprehensive patient management using daily PA pressure and vital signs from home to guide therapeutic management and improve patient outcomes. This approval is very exciting and has the potential to transform care for HF patients.
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Cardiogenic Shock in Older Adults: A Focus on Age-Associated Risks and Approach to Management: A Scientific Statement From the American Heart Association
Circulation
FEBRUARY 26, 2024
Cardiogenic shock continues to portend poor outcomes, conferring short-term mortality rates of 30% to 50% despite recent scientific advances. As a result, despite the association of advanced age with worse outcomes, focused strategies in the assessment and management of cardiogenic shock in this high-risk and growing population are lacking.
Abstract TP286: Spatial Transcriptome Profile of Stem Cell-Mediated Recovery in Stroke-Injured Rat Brains
Stroke Journal
FEBRUARY 1, 2024
Introduction:Intraparenchymal stem cell transplantation shows therapeutic promise for chronic ischemic stroke patients. Visium identified specific gene clusters for the stroke injury, transplant/needle-track, stem cell graft, and the cortical ‘FLAIR’ region. Stroke, Volume 55, Issue Suppl_1 , Page ATP286-ATP286, February 1, 2024.
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Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study
Circulation: Arrhythmia and Electrophysiology
FEBRUARY 12, 2024
Outcomes were analyzed at early (3 months), intermediate (1 year), and late follow-up (≥2 years) after CRT implantation.RESULTS:A total of 44 patients (40.3±19.2 The transplant-free survival rates at 3, 5, and 8 years after CRT implantation were 85%, 79%, and 73%.CONCLUSIONS:In years) with tetralogy of Fallot and CRT were enrolled.
Zinc-aspirin preconditioning reduces endothelial damage of arterial grafts in a rodent model of revascularization
Frontiers in Cardiovascular Medicine
JANUARY 3, 2024
Discussion Preconditioning with zinc-aspirin could be a promising way to protect the function and structural integrity of free arterial grafts, thus improving the outcomes of CABG. Functional measurements using organ bath and histomorphological changes using immunohistochemistry were analyzed.
Abstract 146: Trained Immunity Induced by Dietary Salt Impedes Long-Term Brain Recovery in Experimental Intracerebral Hemorrhage
Stroke Journal
FEBRUARY 1, 2024
However, whether and how a high salt diet (HSD) impacts long-term stroke outcomes - even after salt reduction/withdrawal prior to a stroke is unknown.Methods:Intracerebral hemorrhage (ICH) was modeled by blood or collagenase injections in mice. Lack of NR4a1 in MDMs recapitulated HSD-induced negative impacts on ICH outcomes.
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Lantheus Announces the FDA Approval of DEFINITY as Ultrasound Enhancing Agent for Use in Certain Pediatric Cardiovascular Patients
DAIC
MARCH 6, 2024
Food and Drug Adminstration (FDA) has approved DEFINITY (Perflutren Lipid Microsphere) as an ultrasound enhancing agent for use in pediatric patients with suboptimal echocardiograms, including those who have undergone heart transplant, or have Kawasaki disease or a congenital cardiovascular anomaly. 5 Kutty, S., et al (2016).
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