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Subclinical leaflet thrombosis is observed in 10%20% of patients, though its clinical significance remains uncertain. Clinical valve thrombosis is rare. Ongoing trials aim to clarify optimal antithrombotic regimens and strategies for preventing subclinical leaflet thrombosis.
Intra-cardiac thrombosis is a potentially devastating complication of extracorporeal membrane oxygenation (ECMO) mechanical circulatory support. We present here a patient who suffered complete thrombosis of a.
The optimal management of isolated, distal deep vein thrombosis (DVT) remains unclear. Data from recent studies suggest that certain patients may benefit from anticoagulation.
Subclinical leaflet thrombosis (SLT) has raised concerns about the long-term durability and outcomes of transcatheter aortic valve replacement (TAVR). Clinical valve thrombosis (CVT) is a rare complication after TAVR with an incidence of 0.62.8%
Notably, acute massive pulmonary embolism (PE) with bilateral atrial thrombosis is an exceptional occurrence in CAPS. Acute massive PE combined with bilateral atrial thrombosis has an even higher mortality rate. Acute pulmonary embolism (PE) is a common cardiovascular disease that progresses rapidly and has a high mortality rate.
Background:Coronavirus disease 2019 (COVID-19) increases the risk of cerebral venous sinus thrombosis (CVST), and previous reports derived from small case series reported a high mortality in these patients, up to 40%. Median age did not differ between the groups (43 vs 44years,P=0.6)
Introduction:The majority of patients with cerebral venous thrombosis (CVT) achieve functional independence (modified Rankin Score [mRS] 0-2), although many continue to experience residual symptoms that negatively impact quality of life. Stroke, Volume 56, Issue Suppl_1 , Page AWP143-AWP143, February 1, 2025. vs 53.810.4;
By inhibiting Factor XI (an anticoagulation enzyme), drugs like abelacimab potentially prevent thrombosis without increasing spontaneous bleeding risks. Unfortunately, DOACs often cause gastrointestinal bleeding, which prompted the development of new stroke-prevention methods like Factor XI inhibition. year follow-up.
BACKGROUND:In patients with post-thrombotic syndrome, stent recanalization of iliofemoral veins or the inferior vena cava can restore venous patency and improve functional outcomes. The risk of stent thrombosis is particularly increased during the first 6 months after intervention. points (P=0.36), respectively.
Background:Direct oral anticoagulants (DOACs) are suitable for some patients with cerebral venous thrombosis (CVT). We examined duration of PA prior to DOAC initiation and outcomes in ACTION-CVT, an international retrospective study.Methods:We compared three groups: no lead-in PA, 1-4 days (d) of PA, and 5-21d of PA. 1-4d, 23.8%
Outcomes included heart failure (HF), venous thromboembolism (VTE) and arterial thrombosis/thromboembolism (ATE) recorded in four time windows after SARS-CoV-2 infection: 0–30, 31–90, 91–180 and 181–365 days. Conclusions COVID-19 vaccination reduced the risk of post-COVID-19 cardiac and thromboembolic outcomes.
There are conflicting sources regarding the relationship between hyperglycemia and outcomes in STEMI patients. We aimed to compile evidence to assess the association between hyperglycemia and adverse outcomes. Mortality was the most often outcome reported related to hyperglycemia. 3.45) and 4.47 (95% CI: 2.54–7.87),
Introduction:Seizures are a common initial manifestation of cerebral venous thrombosis (CVT). The primary outcome was delayed seizure(s), occurring after 7 days from CVT diagnosis. The primary outcome was delayed seizure(s), occurring after 7 days from CVT diagnosis. Variables with P-value < 0.2
IntroductionCerebral sinus venous thrombosis (CSVT) has traditionally been treated medically with systemic anticoagulation. We included studies that reported outcomes following EVT for CSVT. The primary outcome of interest was rate of modified Rankin Scale (mRS) 0‐2.
It enrolled 162 subjects at 30 centers with three patient populations – non-thrombotic iliac vein lesion (NIVL), post-thrombotic syndrome (PTS) and acute deep vein thrombosis (aDVT). Ultimately, the new device promises to enable excellent clinical outcomes and drive significant quality of life improvements.” Res Pract Thromb Haemost.
We compared procedural complications and clinical outcomes among patients <75 years of age (n=99), those 75 to 84 years of age (n=103), and those 85 years of age (n=71). Recent guidelines and trials have expanded the indications for TAVR to include younger patients with structural valve deterioration.
Venita Chandra, director of vascular surgery, Stanford University School of Medicine, showed that DA followed by DCB achieved a significantly lower provisional stent rate with comparable safety and efficacy outcomes compared to standard predilatation prior to DCB, making it a viable alternative for treating long and highly calcified lesions.
This study investigates clinical outcomes, aortic remodeling, and abdominal aortic perfusion patterns after TEVAR with the novel Castor device.MethodsFrom November 2020 to June 2023, 29 patients with TBAD involving the LSA were treated with the Castor single-branched stent graft. Of the 102 abdominal aortic branches, 94.1%
Precision Medicine: Personalizing Prevention for Better Outcomes Precision medicine provides tools to customize prevention and treatment plans based on individual risk factors. Precision medicine, primordial prevention, and addressing systemic barriers can improve outcomes and reduce the burden of CVD globally.
Principal safety outcomes were independently adjudicated International Society on Thrombosis and Haemostasis major bleeding at 72 hours post-treatment and mortality within 12 months of treatment. However, utilization and safety of such strategies in broader PE populations remain unclear.
MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection; myocardial disorders, including myocarditis, takotsubo cardiomyopathy, and other cardiomyopathies. This is in spite of the known proclivity of tighter stenoses to thrombose.
BackgroundBehcet's disease (BD) is a systematic vasculitis that affects vessels with various sizes, presenting as venous thrombosis and arterial pseudoaneurysms.
To compare the treatment outcomes among percutaneous mechanical thrombectomy (PMT) with AngioJet, Catheter-directed thrombolysis (CDT), and a combination of both.
Colchicine, a cheap and widely used anti-inflammatory has shown promise in improving cardiovascular outcomes. Results The use of colchicine in patients who underwent PCI significantly reduced MACE outcomes (risk ratio 0.73 (95% CI 0.61 This has been shown to increase the likelihood of further major adverse cardiovascular events (MACE).
This study aims to investigate the incidence, complications, and outcomes of SAH patients who develop HIT.MethodsICD‐9‐CM and ICD‐10‐CM codes were used to query the National Inpatient Sample for patients with SAH between 2010 and 2019. Patients with SAH are an understudied population in terms of assessing incidence and impact of HIT.
Von Willebrand factor (VWF) plays a crucial role in hemostasis and thrombosis by promoting platelet adhesion to the subendothelial matrix and factor VIII stabilization. aureusinfected VWF-deficient mice exhibited reduced infarcts and better long-term functional outcomes (P <0.05 aureusor vehicle on days 0, 2, and 5.
However, long-term outcomes remain poorly described, and the prognostic significance of the radiographic findings is uncertain.Methods:We extracted demographics and clinical variables for all infants with DMVT at our institution from 2007 to 2023. Stroke, Volume 56, Issue Suppl_1 , Page ATMP85-ATMP85, February 1, 2025.
Abelacimab is currently in Phase 3 development with the lead indication for the prevention of stroke and systemic embolism in patients with atrial fibrillation (LILAC-TIMI 76), in addition to two studies in patients with cancer-associated thrombosis (ASTER and MAGNOLIA). Data from these trials are expected in the second half of 2026.
Migraine with aura(MwA) is associated with an increased risk of stroke and adverse vascular outcomes compared to those with migraine without aura (MwoA). Patients with any adverse vascular outcomes before the index ECG were excluded. The prevalences of all vascular outcomes are summarized in Table 1. p < 001).
Thrombosis is the main pathological process of stroke and is therefore an important therapeutic target in stroke prevention. We review the concepts of stroke immunothrombosis and thromboinflammation and the effect of immune cells on vessel recanalization and patient outcome. Stroke, Ahead of Print.
BACKGROUND:Lack of a dedicated thrombectomy device for cerebral venous thrombosis hinders the recanalization ability of endovascular treatment (EVT). The primary efficacy outcome was the proportion of immediate complete recanalization during EVT. Stroke, Volume 56, Issue 1 , Page 5-13, January 1, 2025.
Additionally, acute heart failure (AHF) can occur in up to 40% of cases, and its presence can impact the clinical outcomes of patients with IE. Common embolism sites include the brain, spleen, kidneys, lungs, and intestines. Cardiogenic shock (CGS) is often more likely to occur after AHF has taken place.
Notably, the Supraflex Cruz stent showed a significant reduction in clinically driven target lesion revascularization (TLR) rates and very low rates of stent thrombosis, despite the fact that the enrolled patients were at substantial risk for bleeding and ischemic events. If you enjoy this content, please share it with a colleague
In severe OHSS, increases in capillary permeability can result in hemoconcentration and hypercoagulability leading to thrombotic events, including stroke and cerebral venous thrombosis. The low rate of outcome events after OHSS seen in each of our population-level analyses increases the reliability of these study results.
Previous studies about heart valve disease have focused on procedural or device outcomes, and less on patient-centered and disease-related outcomes that are relevant to patients physical and mental well-being and quality of life. tim.hodson Tue, 02/18/2025 - 16:41 Feb. tim.hodson Tue, 02/18/2025 - 16:41 Feb.
Bleeds were adjudicated using International Society on Thrombosis and Haemostasis criteria. Epistaxis events were less severe than nonepistaxis bleeds (International Society on Thrombosis and Haemostasis major: 3.2% Journal of the American Heart Association, Ahead of Print. versus 20.7%; clinically relevant nonmajor: 64.7% P=0.001).
Eligible were all aetiological studies evaluating risk of cardiovascular outcomes after exposure to common RTIs within any follow-up duration. to 44.9)) and deep venous thrombosis (7.8 (4.3 Methods MEDLINE and EMBASE were systematically searched up to 4 November 2022. Evidence was pooled using random-effects models if data allowed.
This review of the evidence for bivalirudin utilization in ECMO suggests favorable outcomes in circuit-related thrombosis, bleeding, and dosing reliability. This review of the evidence for bivalirudin utilization in ECMO suggests favorable outcomes in circuit-related thrombosis, bleeding, and dosing reliability.
How common is thrombosis in the culprit artery of Wellen syndrome ? However by no means, we can say thrombosis do not occur. Wellens’ syndrome: incidence, characteristics, and long-term clinical outcomes. RCA and LCX Wellens do occur, making this entity’s perceived unique importance less certain 3. Reference 1.
Safety outcomes included rates of symptomatic intracranial hemorrhage, parenchymal hematoma type 2, petechial hemorrhage, and in‐stent thrombosis. Similarly, the rate of in‐stent thrombosis was not significantly different between the 2 groups (1.8% 4.98];P=0.589), or petechial hemorrhage (OR, 1.11 [95% CI, 0.38–3.28];P=0.836).
However, it subjects patients to lifelong warfarin therapy after MHVR, with the attendant risk of bleeding and thrombosis. The percentage of time in the therapeutic range (TTR) was used as the primary outcome while bleeding, thrombosis, and other events were the secondary outcomes.Results:A total of 721 patients were enrolled.
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