Medical Xpress - Cardiology

OCTOBER 30, 2024

Findings from the first international randomized controlled trial to compare patient outcomes following treatment with large-bore mechanical thrombectomy (LBMT) versus catheter-directed thrombolysis (CDT) for intermediate-risk pulmonary embolism (PE) show that LBMT is superior with respect to the hierarchically-tested aggregated outcome of all-cause (..)

Embolism 52

Embolism Pulmonary ICU Outcomes 52

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. However, IVT's efficacy on stent retriever (SR) and aspiration thrombectomy (ASP) outcomes specifically remain unclear. ResultsWe included four randomized controlled trials with 1176 patients.

Thrombolysis 40

Thrombolysis Outcomes Embolism Stent 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Emergency-department-based implementation strategies to increase thrombolysis are promising. We sought to quantify the number of hospitals with opportunities to increase thrombolysis under various tPA treatment thresholds.Methods:We used data from the 2018 State Inpatient Databases (SID) from 17 states.

Thrombolysis 40

Thrombolysis Hospital Inpatient Stroke 40

Journal of Cardiothoracic Surgery

JULY 4, 2024

To compare the treatment outcomes among percutaneous mechanical thrombectomy (PMT) with AngioJet, Catheter-directed thrombolysis (CDT), and a combination of both.

Thrombolysis 40

Thrombolysis Thrombosis Outcomes Research 40

Stroke Journal

MARCH 11, 2024

NETs are proposed as a mechanism of resistance to thrombolysis. Thrombolysis was remarkably associated with higher NE positivity (average marginal effect, 6.461 [95% CI, 0.7901–12.13];P=0.02555), regardless of the origin of thrombi. BACKGROUND:Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs).

Thrombolysis 40

Thrombolysis Pharmacology Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Reducing door-to-needle (DTN) times lead to improved patient outcomes in acute ischemic stroke. 2) Creation of a multidisciplinary Thrombolysis Focus Group to analyze data and improve processes. 2) Creation of a multidisciplinary Thrombolysis Focus Group to analyze data and improve processes. in 2020, to 31.9%

Thrombolysis 40

Thrombolysis Academic Document Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Background:The benefits of endovascular thrombectomy (EVT) for posterior cerebral artery (PCA) occlusion remain controversial, but intravenous thrombolysis (IVT) has proven benefit across nearly all ischemic stroke types. to 2.87) with no difference in length of hospital stay (adjusted β 0.26, 95% -0.71

Atrial Fibrillation 40

Atrial Fibrillation Thrombolysis Outcomes Embolism 40

Stroke Journal

MARCH 8, 2024

mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. Death occurred in 4.0% and 0.3%, respectively (P=0.194).

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Circulation: Cardiovascular Interventions

JANUARY 24, 2024

BACKGROUND:Prior clinical trials have demonstrated the efficacy of ultrasound-facilitated catheter-directed thrombolysis (USCDT) for the treatment of acute intermediate-risk pulmonary embolism (PE) using reduced thrombolytic doses and shorter infusion durations.

Embolism 75

Embolism Thrombolysis Ultrasound Pulmonary 75

Stroke Journal

JANUARY 4, 2024

BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. Primary outcome was a shift toward better functional outcome on the modified Rankin Scale at 90 days. Stroke, Ahead of Print.

Thrombolysis 40

Thrombolysis Circulation Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Median time from the onset of visual change to thrombolysis was 6.0 [4.5-10.5] One (5.3%) patient had intra-ocular hemorrhage post thrombolysis.Conclusion:Compared to central retinal artery occlusion, patient with branched retinal occlusion have better visual recovery following IA or IV thrombolysis. VA improvement of ≥0.1

Thrombolysis 40

Thrombolysis Outcomes Hemorrhage Stroke 40

Journal of the American Heart Association

DECEMBER 18, 2023

BackgroundIntravenous thrombolysis (IVT) is an effective stroke therapy that remains underused. Outcomes included symptomatic intracranial hemorrhage, any intracranial hemorrhage, serious systemic bleeding, and 90‐day functional independence (modified Rankin scale score 0–2). Journal of the American Heart Association, Ahead of Print.

Thrombolysis 75

Thrombolysis Stroke Strokes Hemorrhage 75

DAIC

FEBRUARY 7, 2024

Findings from the highly-anticipated MOST (Multi-Arm Optimization of Stroke Thrombolysis) trial were presented on the first day of the American Stroke Association’s International Stroke Conference, ISC 2024, being held through Feb. The study was looking for improvement in functional outcomes at 90 days. 9 Phoenix, AZ. Adeoye, M.D.,

Stroke 105

Stroke Strokes Outcomes Thrombolysis 105

Stroke Journal

FEBRUARY 1, 2024

The role of adjunctive intravenous thrombolysis, such as intravenous tissue plasminogen activator (IVtPA), with MT remains unclear, especially for medium vessel occlusion (MeVO). In univariable regression, all outcomes were comparable between the two groups, except for higher mRS 0-2 rates in the MT+IVtPA group.

Thrombolysis 40

Thrombolysis Academic Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

We defined two binary outcomes: (1) functional clinical outcome (modified Rankin Scale 0-2) and (2) early symptomatic intracerebral hemorrhage (sICH). 4.14, p=0.9502), but it was associated with a functional clinical outcome at 90 days (OR 3.39, 95% CI 1.11-10.43, 10.43, p=0.0325).Conclusions:The

Stents 40

Stents Stent Thrombolysis Angioplasty 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionOver the past decade, stroke management has significantly improved with the widespread use of intravenous thrombolysis (IVT) and the establishment of endovascular thrombectomy (EVT) as the standard of care for increasing patients. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023.

Thrombolysis 40

Thrombolysis Inpatient Stroke Strokes 40

DAIC

FEBRUARY 26, 2024

Contemporary treatments to remove the clot include intravenous thrombolysis or mechanical thrombectomy using a catheter. Many stroke patients recover poorly despite timely treatment To treat these symptoms and restore blood flow to the brain, the obstructed vessel needs to be “declogged”, or recanalized.

Blood Clot 105

Blood Clot Stroke Strokes Outcomes 105

Stroke Journal

FEBRUARY 1, 2024

Background and Purpose:Although intra-arterial thrombolysis (IAT) is widely used as adjunct with mechanical thrombectomy in acute ischemic stroke patients, the patients who are likely to benefit are not known. Minimum procedure time and lesser number of passes for thrombectomy are related with good neurological outcomes at 90 days.

Thrombolysis 40

Thrombolysis Stroke Strokes Stents 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Language barriers between acute ischemic stroke patients and clinicians can create challenges in use of intravenous thrombolysis (IVT) as successful administration hinges on quick information gathering, shared decision making and consent with the patient and family. Mean DTN times were 48.8 min and 48.2

Thrombolysis 40

Thrombolysis Document Stroke Strokes 40

DAIC

MAY 14, 2024

These data from the SHINE trial continue to inform the national stroke community about potential approaches to treating hyperglycemic stroke patients to assure better outcomes,” she said. Of the 1,151 SHINE trial participants, 725, or 63%, underwent thrombolysis. Slightly more than half were men, and the median age was 65.

Stroke 105

Stroke Strokes Thrombolysis Hemorrhage 105

Stroke: Vascular and Interventional Neurology

FEBRUARY 10, 2024

BACKGROUNDPrediction of successful revascularization and achieving a favorable functional outcome may help determine the optimal treatment strategy and improve the management of stroke. Nine studies involved only the administration of intravenous thrombolysis, whereas 24 studies intervened by endovascular thrombectomy. 2.66];P= 0.007).CONCLUSIONThe

Thrombolysis 40

Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Intravenous thrombolysis (IVT) is efficacious treatment of acute ischemic stroke (AIS). Outcomes of interest were symptomatic intracranial hemorrhage (sICH), any ICH, serious systemic bleeding (SSB), and 90-day functional independence (mRS 0-2). Stroke, Volume 55, Issue Suppl_1 , Page A25-A25, February 1, 2024.

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Recent studies report similar outcomes with antiplatelet drugs and intravenous thrombolysis (IVT) in patients with minor nondisabling ischemic stroke. Stroke, Volume 55, Issue Suppl_1 , Page ATMP13-ATMP13, February 1, 2024.

Thrombolysis 40

Thrombolysis Stroke Strokes Academic 40

Dr. S. Venkatesan MD

NOVEMBER 8, 2024

08/11, 12:07] Dr S Venkatesan: Is the therapeutic time window for primary PCI and thrombolysis same ? [08/11, Thrombolysis has a broader time window, but efficacy decreases significantly after 6 hours. [ Thrombolysis has a broader time window, but efficacy decreases significantly after 6 hours. [ How can they be different? [08/11,

Thrombolysis 40

Thrombolysis Ischemia Hospital Outcomes 40

Circulation: Cardiovascular Interventions

FEBRUARY 27, 2024

Background:The role of advanced therapies (systemic thrombolysis, catheter-based treatment, and surgical thrombectomy) for the management of right heart thrombus is poorly defined. Circulation: Cardiovascular Interventions, Ahead of Print. 1.22]), in-hospital mortality (odds ratio, 0.64 [95% CI, 0.17–2.19]),

Outcomes 40

Outcomes Thrombolysis Embolism Pulmonary 40

Stroke Journal

DECEMBER 21, 2023

BACKGROUND:The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. The magnitude of this effect is more pronounced in symptomatic infections, which also present less favorable recanalization outcomes.

COVID-19 40

COVID-19 Outcomes Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

SEPTEMBER 12, 2023

We investigated long‐term trends of reperfusion therapy and outcomes according to the stroke severity.MethodsPatients with acute ischemic stroke registered in the prospective nationwide hospital‐based registry between 2000 and 2020 were examined. Outcomes included favorable outcome (modified Rankin scale score 0–2 at discharge).ResultsOf

Stroke 40

Stroke Strokes Outcomes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

We aim to provide an overview of cervical artery dissection in the setting of minor or no reported mechanical trigger with a focus on summarizing the available evidence and providing suggestions on the diagnostic evaluation, treatment approaches, and outcomes. The diagnosis can be challenging both clinically and radiologically.

Genetic predisposition 75

Genetic predisposition Outcomes Thrombolysis Congenital 75

Stroke Journal

FEBRUARY 5, 2024

BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. METHODS:We enrolled consecutive patients in the multicenter Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke who had received combined thrombolysis (within 4.5

Thrombolysis 75

Thrombolysis Hemorrhage Atrial Fibrillation Stroke 75

Stroke Journal

FEBRUARY 1, 2024

Intravenous thrombolysis was administered in 55 patients (22.1%) while general anesthesia was used in 94/248 patients (37.9%). Favorable clinical outcome (90-day mRS 0-3) was achieved in 99/246 patients (40.2%), with mortality affecting 98/246 patients (39.8%). years [SD 11.7], 208 [83.5%] male) were included.

Circulation 40

Circulation Outcomes Thrombolysis Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Background:Atrial fibrillation (AF) has been shown to be associated with better procedural outcomes in patients with anterior circulation large vessel occlusion (aLVO) undergoing endovascular therapy (EVT). Forty-four percent of the no AC group received intravenous thrombolysis (IVT). In the NOAC group, 59.5%

Atrial Fibrillation 40

Atrial Fibrillation Outcomes Thrombolysis Hemorrhage 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 19, 2024

Patients were dichotomized into those with 90‐day good functional outcome (modified Rankin scale [mRS] score 0–2) and poor functional outcome (mRS score ≥3). Good functional outcome was observed in 44 patients (40%). P < 0.001) and more likelihood of achieving Thrombolysis in Cerebral Infarction 3 (79.5%

Stents 40

Stents Stent Circulation Stroke 40

Stroke Journal

FEBRUARY 1, 2024

However, clinical outcomes remain similar. This study compares post-thrombectomy outcomes in both groups, matched by initial NIHSS scores.Method:From October 2017 to March 2023, we studied LVO cases undergoing thrombectomy for acute ischemic stroke. Successful recanalization was defined as Thrombolysis in Cerebral Ischemia score ≥2b.

Outcomes 40

Outcomes Embolism Atrial Fibrillation Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

The primary outcome of interest was symptomatic intracranial hemorrhage (sICH) within 36 hours of tPA administration. A secondary outcome was modified Rankin Scale (mRS) at discharge. The exposure of interest was pre-stroke antiplatelet use categorized as none, single (SAPT), and dual antiplatelet therapy (DAPT). no antiplatelet, 36.7%

Hemorrhage 40

Hemorrhage Thrombolysis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

While DM can reduce the effect of intravenous thrombolysis, metformin can have a positive outcome on AIS patients. The outcomes of stroke in diabetic patients receiving metformin is largely unexplored. There is a trend of favorable outcomes of mRS and Mortality, with a non-statistical significance increase of sICH.

Diabetes 40

Diabetes Stroke Strokes Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Primary outcome was defined as favorable 90-day outcome (modified Rankin Scale (mRS) score 0-2). Results:9 articles were included from 825 screened. 95%CI 1.03

Dementia 40

Dementia Stroke Strokes Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionBackground: Prediction of successful revascularization and achieving a favorable functional outcome may help to determine the optimal recanalization strategy and improve the management of stroke. A growing body of literature has implicated a prognostic value for thrombus imaging characteristics for stroke outcomes [1‐5].MethodsWe

Outcomes 40

Outcomes Stroke Strokes Thrombolysis 40