Journal of the American Heart Association

DECEMBER 18, 2023

BackgroundIntravenous thrombolysis (IVT) is an effective stroke therapy that remains underused. Outcomes included symptomatic intracranial hemorrhage, any intracranial hemorrhage, serious systemic bleeding, and 90‐day functional independence (modified Rankin scale score 0–2). Journal of the American Heart Association, Ahead of Print.

Thrombolysis 75

Thrombolysis Hemorrhage Strokes Stroke 75

American College of Cardiology

FEBRUARY 15, 2024

What is the association of treatment with intravenous thrombolysis (IVT) plus thrombectomy versus thrombectomy alone and outcomes modification by the time from stroke symptom onset to treatment?

Thrombolysis 44

Thrombolysis Strokes Stroke Outcomes 44

Heart BMJ

JULY 10, 2024

Intracoronary (IC) thrombolytic therapy can reduce microvascular thrombotic burden; however, contemporary studies have produced conflicting outcomes. The primary outcome was major adverse cardiac events (MACE). IC thrombolysis was associated with a significantly lower incidence of MACE (RR=0.65, 95% CI 0.51

Myocardial Infarction 52

Myocardial Infarction Thrombolysis STEMI Outcomes 52

Medical Xpress - Cardiology

FEBRUARY 12, 2024

nationwide quality initiative Target: Stroke (TS) is associated with improvement in thrombolysis frequency, timeliness, and outcome, according to a study published online Feb. 7 in JAMA Network Open.

Thrombolysis 40

Thrombolysis Strokes Stroke Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

We performed sensitivity analysis using propensity score matching.Results:In our study population of 1000 thrombectomy-eligible patients (513 females, median age 77 [67-84, interquartile range]) IVT emerged as predictor of favorable functional outcome (mRS 0-2) independent of mTICI (adjusted OR 0.49; 95% CI [0.32;0.75]; p=0.001).

Thrombolysis 40

Thrombolysis Outcomes Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Emergency-department-based implementation strategies to increase thrombolysis are promising. We sought to quantify the number of hospitals with opportunities to increase thrombolysis under various tPA treatment thresholds.Methods:We used data from the 2018 State Inpatient Databases (SID) from 17 states.

Thrombolysis 40

Thrombolysis Hospital Inpatient Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. However, IVT's efficacy on stent retriever (SR) and aspiration thrombectomy (ASP) outcomes specifically remain unclear. ResultsWe included four randomized controlled trials with 1176 patients.

Thrombolysis 40

Thrombolysis Outcomes Embolism Stents 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Reducing door-to-needle (DTN) times lead to improved patient outcomes in acute ischemic stroke. 2) Creation of a multidisciplinary Thrombolysis Focus Group to analyze data and improve processes. 2) Creation of a multidisciplinary Thrombolysis Focus Group to analyze data and improve processes. in 2020, to 31.9%

Thrombolysis 40

Thrombolysis Academic Document Strokes 40

Stroke Journal

MARCH 11, 2024

NETs are proposed as a mechanism of resistance to thrombolysis. Thrombolysis was remarkably associated with higher NE positivity (average marginal effect, 6.461 [95% CI, 0.7901–12.13];P=0.02555), regardless of the origin of thrombi. BACKGROUND:Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs).

Thrombolysis 40

Thrombolysis Pharmacology Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

We aim to provide an overview of cervical artery dissection in the setting of minor or no reported mechanical trigger with a focus on summarizing the available evidence and providing suggestions on the diagnostic evaluation, treatment approaches, and outcomes. The diagnosis can be challenging both clinically and radiologically.

Genetic predisposition 75

Genetic predisposition Outcomes Thrombolysis Congenital 75

Stroke Journal

FEBRUARY 1, 2024

Background:The benefits of endovascular thrombectomy (EVT) for posterior cerebral artery (PCA) occlusion remain controversial, but intravenous thrombolysis (IVT) has proven benefit across nearly all ischemic stroke types. to 2.87) with no difference in length of hospital stay (adjusted β 0.26, 95% -0.71

Atrial Fibrillation 40

Atrial Fibrillation Thrombolysis Outcomes Embolism 40

Stroke Journal

FEBRUARY 5, 2024

BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. METHODS:We enrolled consecutive patients in the multicenter Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke who had received combined thrombolysis (within 4.5

Thrombolysis 75

Thrombolysis Hemorrhage Atrial Fibrillation Strokes 75

Medical Xpress - Cardiology

OCTOBER 30, 2024

Findings from the first international randomized controlled trial to compare patient outcomes following treatment with large-bore mechanical thrombectomy (LBMT) versus catheter-directed thrombolysis (CDT) for intermediate-risk pulmonary embolism (PE) show that LBMT is superior with respect to the hierarchically-tested aggregated outcome of all-cause (..)

Embolism 52

Embolism Pulmonary Outcomes ICU 52

Stroke Journal

JANUARY 4, 2024

BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. Primary outcome was a shift toward better functional outcome on the modified Rankin Scale at 90 days. Stroke, Ahead of Print.

Thrombolysis 40

Thrombolysis Circulation Hemorrhage Outcomes 40

Stroke Journal

MARCH 8, 2024

mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. Death occurred in 4.0% and 0.3%, respectively (P=0.194).

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Journal of Cardiothoracic Surgery

JULY 4, 2024

To compare the treatment outcomes among percutaneous mechanical thrombectomy (PMT) with AngioJet, Catheter-directed thrombolysis (CDT), and a combination of both.

Thrombolysis 40

Thrombolysis Thrombosis Outcomes Research 40

Stroke Journal

FEBRUARY 1, 2024

Median time from the onset of visual change to thrombolysis was 6.0 [4.5-10.5] One (5.3%) patient had intra-ocular hemorrhage post thrombolysis.Conclusion:Compared to central retinal artery occlusion, patient with branched retinal occlusion have better visual recovery following IA or IV thrombolysis. VA improvement of ≥0.1

Thrombolysis 40

Thrombolysis Outcomes Hemorrhage Stroke 40

Stroke Journal

FEBRUARY 1, 2024

The role of adjunctive intravenous thrombolysis, such as intravenous tissue plasminogen activator (IVtPA), with MT remains unclear, especially for medium vessel occlusion (MeVO). In univariable regression, all outcomes were comparable between the two groups, except for higher mRS 0-2 rates in the MT+IVtPA group.

Thrombolysis 40

Thrombolysis Academic Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

We defined two binary outcomes: (1) functional clinical outcome (modified Rankin Scale 0-2) and (2) early symptomatic intracerebral hemorrhage (sICH). 4.14, p=0.9502), but it was associated with a functional clinical outcome at 90 days (OR 3.39, 95% CI 1.11-10.43, 10.43, p=0.0325).Conclusions:The

Stents 40

Stents Stent Thrombolysis Angioplasty 40

The American Journal of Cardiology

DECEMBER 21, 2024

Publication date: Available online 20 December 2024 Source: The American Journal of Cardiology Author(s): Peiren Zhang, Bin Luo, Peilan Zhang, Xiaoqing Yu, Xiaoyue Long, Yuxuan Du, Haozhi Tian, Liwen Wang

Thrombolysis 40

Thrombolysis Outcomes Strokes Stroke 40

DAIC

SEPTEMBER 10, 2024

2. Expand and invest in infrastructures for essential stroke services, including stroke units and intravenous thrombolysis.* Professor Sheila Martins, President of the World Stroke Organization, said: “ The impact of thrombolysis and thrombectomy on stroke patient outcomes has been established for more than a decade.

Strokes 96

Strokes Stroke Blood Clot Thrombolysis 96

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionOver the past decade, stroke management has significantly improved with the widespread use of intravenous thrombolysis (IVT) and the establishment of endovascular thrombectomy (EVT) as the standard of care for increasing patients. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023.

Thrombolysis 40

Thrombolysis Inpatient Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Background and Purpose:Although intra-arterial thrombolysis (IAT) is widely used as adjunct with mechanical thrombectomy in acute ischemic stroke patients, the patients who are likely to benefit are not known. Minimum procedure time and lesser number of passes for thrombectomy are related with good neurological outcomes at 90 days.

Thrombolysis 40

Thrombolysis Strokes Stroke Stents 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Language barriers between acute ischemic stroke patients and clinicians can create challenges in use of intravenous thrombolysis (IVT) as successful administration hinges on quick information gathering, shared decision making and consent with the patient and family. Mean DTN times were 48.8 min and 48.2

Thrombolysis 40

Thrombolysis Document Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 10, 2024

BACKGROUNDPrediction of successful revascularization and achieving a favorable functional outcome may help determine the optimal treatment strategy and improve the management of stroke. Nine studies involved only the administration of intravenous thrombolysis, whereas 24 studies intervened by endovascular thrombectomy. 2.66];P= 0.007).CONCLUSIONThe

Thrombolysis 40

Thrombolysis Strokes Stroke Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Intravenous thrombolysis (IVT) is efficacious treatment of acute ischemic stroke (AIS). Outcomes of interest were symptomatic intracranial hemorrhage (sICH), any ICH, serious systemic bleeding (SSB), and 90-day functional independence (mRS 0-2). Stroke, Volume 55, Issue Suppl_1 , Page A25-A25, February 1, 2024.

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Recent studies report similar outcomes with antiplatelet drugs and intravenous thrombolysis (IVT) in patients with minor nondisabling ischemic stroke. Stroke, Volume 55, Issue Suppl_1 , Page ATMP13-ATMP13, February 1, 2024.

Thrombolysis 40

Thrombolysis Strokes Stroke Academic 40

Circulation: Cardiovascular Interventions

FEBRUARY 27, 2024

Background:The role of advanced therapies (systemic thrombolysis, catheter-based treatment, and surgical thrombectomy) for the management of right heart thrombus is poorly defined. Circulation: Cardiovascular Interventions, Ahead of Print. 1.22]), in-hospital mortality (odds ratio, 0.64 [95% CI, 0.17–2.19]),

Outcomes 40

Outcomes Thrombolysis Embolism Pulmonary 40

Frontiers in Cardiovascular Medicine

JANUARY 3, 2024

This study aimed to investigate the effect of Trichosanthes pericarpium extract (TPE) on improving microcirculation and outcomes in patients with AMI after PCI. The corrected thrombolysis in myocardial infarction frame count (CTFC) and index of microcirculatory resistance (IMR) were used to evaluate myocardial microcirculation.

Myocardial Infarction 59

Myocardial Infarction Outcomes Cardiac Function Thrombolysis 59

Stroke: Vascular and Interventional Neurology

SEPTEMBER 12, 2023

We investigated long‐term trends of reperfusion therapy and outcomes according to the stroke severity.MethodsPatients with acute ischemic stroke registered in the prospective nationwide hospital‐based registry between 2000 and 2020 were examined. Outcomes included favorable outcome (modified Rankin scale score 0–2 at discharge).ResultsOf

Strokes 40

Strokes Stroke Outcomes Thrombolysis 40

Stroke Journal

DECEMBER 21, 2023

BACKGROUND:The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. The magnitude of this effect is more pronounced in symptomatic infections, which also present less favorable recanalization outcomes.

COVID-19 40

COVID-19 Outcomes Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Intravenous thrombolysis was administered in 55 patients (22.1%) while general anesthesia was used in 94/248 patients (37.9%). Favorable clinical outcome (90-day mRS 0-3) was achieved in 99/246 patients (40.2%), with mortality affecting 98/246 patients (39.8%). years [SD 11.7], 208 [83.5%] male) were included.

Circulation 40

Circulation Outcomes Thrombolysis Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Background:Atrial fibrillation (AF) has been shown to be associated with better procedural outcomes in patients with anterior circulation large vessel occlusion (aLVO) undergoing endovascular therapy (EVT). Forty-four percent of the no AC group received intravenous thrombolysis (IVT). In the NOAC group, 59.5%

Atrial Fibrillation 40

Atrial Fibrillation Outcomes Thrombolysis Hemorrhage 40

ECG Cases

JULY 4, 2017

In this part 2 of EM Cases Journal Jam podcast on Thrombolysis and Endovascular Therapy for Stroke Justin Morgenstern, Rory Spiegel and Anton Helman do a deep dive into the world's literature on endovascular therapy for stroke.

Strokes 52

Strokes Stroke Thrombolysis Outcomes 52

Stroke: Vascular and Interventional Neurology

FEBRUARY 19, 2024

Patients were dichotomized into those with 90‐day good functional outcome (modified Rankin scale [mRS] score 0–2) and poor functional outcome (mRS score ≥3). Good functional outcome was observed in 44 patients (40%). P < 0.001) and more likelihood of achieving Thrombolysis in Cerebral Infarction 3 (79.5%

Stents 40

Stents Stent Circulation Strokes 40

Stroke Journal

FEBRUARY 1, 2024

However, clinical outcomes remain similar. This study compares post-thrombectomy outcomes in both groups, matched by initial NIHSS scores.Method:From October 2017 to March 2023, we studied LVO cases undergoing thrombectomy for acute ischemic stroke. Successful recanalization was defined as Thrombolysis in Cerebral Ischemia score ≥2b.

Outcomes 40

Outcomes Embolism Atrial Fibrillation Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

While DM can reduce the effect of intravenous thrombolysis, metformin can have a positive outcome on AIS patients. The outcomes of stroke in diabetic patients receiving metformin is largely unexplored. There is a trend of favorable outcomes of mRS and Mortality, with a non-statistical significance increase of sICH.

Diabetes 40

Diabetes Strokes Stroke Outcomes 40