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Random-effects meta-analyses examined the pooled risk difference in the prevalence of each symptom or symptom combination in cases with confirmed SARS-coV-2 infection compared with controls.ResultsEight cohort studies were eligible, including nearly 10 million people.
Fully published results from Athos Therapeutics AZALEA-TIMI 71 trial for its novel Factor XI inhibitor abelacimab, confirming the drugs lower bleeding risks, but leaving researchers uncertain about its ability to prevent stroke in AFib patients. vs. 0.4%) and 4X ischemic stroke rates (csHR = 4.06). year follow-up. per 100 person-year.
The NOTION trial, a pioneering study, sought to compare the long-term clinical and bioprosthesis outcomes of Transcatheter Aortic Valve Implantation (TAVI) versus Surgical Aortic Valve Replacement (SAVR) in patients with severe aortic valve stenosis (AS) at lower surgical risk. No cases of clinical valve thrombosis were reported.
In the meta-analysis of seven randomized trials, published in JSCAI and presented at the 2024 EuroPCR conference in Paris, France, researchers compared the outcomes of 7,785 patients undergoing TAVR (a procedure that delivers a new aortic valve into the heart through a catheter) to those undergoing SAVR for severe aortic stenosis.
Stroke, Volume 56, Issue Suppl_1 , Page AWP143-AWP143, February 1, 2025. Introduction:The majority of patients with cerebral venous thrombosis (CVT) achieve functional independence (modified Rankin Score [mRS] 0-2), although many continue to experience residual symptoms that negatively impact quality of life. female, 74.7% white race).
Stroke, Volume 55, Issue Suppl_1 , Page ATP180-ATP180, February 1, 2024. Background:Coronavirus disease 2019 (COVID-19) increases the risk of cerebral venous sinus thrombosis (CVST), and previous reports derived from small case series reported a high mortality in these patients, up to 40%.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionCerebral venous sinus thrombosis (CVST) is a rare form of stroke that usually affects young females especially during pregnancy and the postpartum period. Only studies with sample sizes larger than 10 were included.
Stroke, Ahead of Print. Ischemic stroke is one of the leading causes of disability and mortality worldwide. Thrombosis is the main pathological process of stroke and is therefore an important therapeutic target in stroke prevention.
Stroke, Volume 55, Issue Suppl_1 , Page AWP149-AWP149, February 1, 2024. Background:Direct oral anticoagulants (DOACs) are suitable for some patients with cerebral venous thrombosis (CVT). The primary outcome at day 90 (D90) was a composite of CVT recurrence/extension and symptomatic intracranial hemorrhage (sICH). 1-4d, 23.8%
Stroke, Volume 55, Issue Suppl_1 , Page ATMP62-ATMP62, February 1, 2024. Introduction:Seizures are a common initial manifestation of cerebral venous thrombosis (CVT). The primary outcome was delayed seizure(s), occurring after 7 days from CVT diagnosis.
Stroke, Volume 55, Issue Suppl_1 , Page A19-A19, February 1, 2024. Background:Preceding respiratory tract infections (RTI) due to bacteria or virus has been linked to an increasing risk of stroke likely by potentiating an inflammatory immune response, endothelial dysfunction, platelet activation, and coagulopathy. aureusinfected WT).
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionCerebral sinus venous thrombosis (CSVT) has traditionally been treated medically with systemic anticoagulation. We included studies that reported outcomes following EVT for CSVT.
These results suggest that abelacimab may be safe across the spectrum of bleeding risk and may make it possible to anticoagulate some of the most vulnerable populations who otherwise would not be treated and therefore left unprotected from the risk of stroke. Data from these trials are expected in the second half of 2026.
We compared procedural complications and clinical outcomes among patients <75 years of age (n=99), those 75 to 84 years of age (n=103), and those 85 years of age (n=71). Recent guidelines and trials have expanded the indications for TAVR to include younger patients with structural valve deterioration.
This study investigates clinical outcomes, aortic remodeling, and abdominal aortic perfusion patterns after TEVAR with the novel Castor device.MethodsFrom November 2020 to June 2023, 29 patients with TBAD involving the LSA were treated with the Castor single-branched stent graft. No in-hospital mortality, paraplegia, or stroke occurred.
Stroke, Volume 55, Issue Suppl_1 , Page ATP267-ATP267, February 1, 2024. Introduction:Exposure to high altitude environment is a risk factor of cerebral venous thrombosis (CVT) probably due to the hypercoagulability. Favorable outcome (modified Ranking Score, mRS 0-2) at follow-up was observed in 81.6% respectively.
Stroke, Volume 56, Issue Suppl_1 , Page AWP355-AWP355, February 1, 2025. Strokeoutcomes were assessed at 24 hours.Results:Exposure to long wavelength red light resulted in a significant reduction in infarct volume following stroke (mice-red 38.817.6 mm3 vs. mice-white 73.315.0 mm3; p<0.01 vs mice-blue 72.927.9
Stroke, Volume 56, Issue Suppl_1 , Page AWMP59-AWMP59, February 1, 2025. Background and Purpose:External counterpulsation (ECP) is a novel noninvasive method used to improve the perfusion of vital organs, which may benefit ischemic stroke patients. Therefore, 184 patients (97.4%) with moderate neurological deficit (mean NIHSS, 8.2)
Stroke, Volume 56, Issue 2 , Page 527-532, February 1, 2025. BACKGROUND:Acute ischemic stroke treatment typically involves tissue-type plasminogen activator (tPA) or tenecteplase, but about 50% of patients do not achieve successful reperfusion. DNase-I, which degrades neutrophil extracellular traps, could improve thrombolytic efficacy.
Patient characteristics and clinical outcomes were collected via electronic medical record system. The primary outcome was major adverse cardiac and cerebrovascular event (MACCE), namely a composite of death from cardiovascular causes, myocardial infarction (MI), stroke, stent thrombosis within 12 month.
Colchicine, a cheap and widely used anti-inflammatory has shown promise in improving cardiovascular outcomes. Results The use of colchicine in patients who underwent PCI significantly reduced MACE outcomes (risk ratio 0.73 (95% CI 0.61 This has been shown to increase the likelihood of further major adverse cardiovascular events (MACE).
Stroke, Volume 56, Issue Suppl_1 , Page ATMP117-ATMP117, February 1, 2025. Introduction:Despite timely recanalization, some ischemic stroke patients treated with endovascular thrombectomy experience persistent neurological deterioration. Experimental stroke models have indicated a critical role for platelets in this process.
Stroke-volume:50 ml. MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection; myocardial disorders, including myocarditis, takotsubo cardiomyopathy, and other cardiomyopathies. Left ventricular end-diastolic volume: 99 ml.
Stroke, Volume 56, Issue Suppl_1 , Page AWP328-AWP328, February 1, 2025. Migraine with aura(MwA) is associated with an increased risk of stroke and adverse vascular outcomes compared to those with migraine without aura (MwoA). Patients with any adverse vascular outcomes before the index ECG were excluded. p < 001).
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. This study aims to investigate the incidence, complications, and outcomes of SAH patients who develop HIT.MethodsICD‐9‐CM and ICD‐10‐CM codes were used to query the National Inpatient Sample for patients with SAH between 2010 and 2019.
Stroke, Volume 56, Issue 1 , Page 5-13, January 1, 2025. BACKGROUND:Lack of a dedicated thrombectomy device for cerebral venous thrombosis hinders the recanalization ability of endovascular treatment (EVT). The primary efficacy outcome was the proportion of immediate complete recanalization during EVT.
Stroke, Volume 55, Issue Suppl_1 , Page A134-A134, February 1, 2024. In severe OHSS, increases in capillary permeability can result in hemoconcentration and hypercoagulability leading to thrombotic events, including stroke and cerebral venous thrombosis. were included from each dataset.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionPediatric patients presenting with atypical stroke symptoms pose a diagnostic challenge, which often causes delays in management. Around a quarter of pediatric stroke patients will present with new onset seizures.
Stroke, Volume 56, Issue Suppl_1 , Page ATMP85-ATMP85, February 1, 2025. However, long-term outcomes remain poorly described, and the prognostic significance of the radiographic findings is uncertain.Methods:We extracted demographics and clinical variables for all infants with DMVT at our institution from 2007 to 2023.
However, the presence of residual trabeculation did not contribute to PDL or device-related thrombosis at follow-up or affect the clinical outcomes. The clinical outcomes were compared between patients with and without angiographically detected residual trabeculation. vs. 1.4%, p =0.50; 6.9% vs. 6.0%, p =0.69, respectively).
Methods A search was conducted on five databases for randomised controlled trials (RCTs) conducted between 1 January 2000 and 17 July 2022, which included an ADP-specific platelet function assays and P2Y 12 antagonists as part of dual antiplatelet therapy (DAPT) and have reported the efficacy and/or safety outcomes.
Stroke: Vascular and Interventional Neurology, Ahead of Print. The most common cerebrovascular disease complicating bacterial meningitis are cerebral infarctions (9%25%), intracerebral hemorrhage (1%7%), cerebral venous thrombosis (1%10%), and subarachnoid hemorrhage (1%5%).Streptococcus
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. In order to improve treatment outcomes in these difficult cases, the use of stent‐assisted embolization has been attempted in endovascular treatment of intracranial aneurysms.
Eligible were all aetiological studies evaluating risk of cardiovascular outcomes after exposure to common RTIs within any follow-up duration. to 11.0)), stroke (3.5 (1.2 to 44.9)) and deep venous thrombosis (7.8 (4.3 to 4.9)) and stroke (2.6 (95% Evidence was pooled using random-effects models if data allowed.
Previous studies about heart valve disease have focused on procedural or device outcomes, and less on patient-centered and disease-related outcomes that are relevant to patients physical and mental well-being and quality of life. tim.hodson Tue, 02/18/2025 - 16:41 Feb. tim.hodson Tue, 02/18/2025 - 16:41 Feb.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue 6 , November 1, 2023. BackgroundProcedural intravenous cangrelor has been proposed as an effective platelet inhibition strategy for stenting in acute ischemic stroke. Similarly, the rate of in‐stent thrombosis was not significantly different between the 2 groups (1.8%
Stroke, Volume 56, Issue Suppl_1 , Page ATP7-ATP7, February 1, 2025. Introduction:Venous thromboembolism (VTE)manifesting as deep vein thrombosis (DVT) and pulmonary embolus (PE) and arterial thromboembolism (ATE) manifesting as acute ischemic stroke (AIS) result in ~1 million US deaths annually.
The primary endpoint was the net clinical benefit as a composite of all-cause death, myocardial infarction, definite or probable stent thrombosis, stroke, and major bleeding at 1 year after the index procedure in the intention-to-treat population. versus 3.4%; HR, 0.35 [95% CI, 0.20–0.61];P<0.001).Conclusions:This
3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heart attack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4 Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2
Stroke, Volume 56, Issue Suppl_1 , Page ATP39-ATP39, February 1, 2025. Outcomes were assessed at 30- and 90-days. The primary outcome for which the trial was powered was adherence (completing 80% of sessions). Secondary outcomes included percentage of sessions completed and pain/discomfort scores from patient diaries.
A meta-analysis was performed on primary outcomes of major adverse cardiac events (MACE) and all-cause mortality. A random-effects model was used for outcomes with high heterogeneity.Results:We included 4 RCTs with 3173 patients comparing FFR-guided CR with culprit-only PCI in patients with STEMI and multivessel coronary artery diseases.
In the early years of percutaneous coronary intervention (PCI), studies indicated a heightened risk of major adverse cardiac events (MACE) in patients with reduced left ventricular ejection fraction (LVEF), involving outcomes such as death, Q-wave myocardial infarction (MI), stent thrombosis, and repeat revascularization.
vs. 30.4%, p =0.07) and device related thrombosis (4.5% Results Patients were younger in the combined ( n =72) than in the control group ( n =144, 70.27.3 years, p <0.001) but otherwise comparable with a mean CHA 2 D 2 -VASc score of 4.21.1 and 4.41.2 ( p =0.26) and HAS-BLED score of 2.20.8 and 2.30.7 ( p =0.34). Both major (1.4%
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