Stroke Journal

MARCH 8, 2024

Stroke, Ahead of Print. Background:Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non–wake-up unwitnessed stroke, non-WUS). In patients with WUS, the frequencies of favorable outcomes were 54.8%

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

DAIC

FEBRUARY 7, 2024

Findings from the highly-anticipated MOST (Multi-Arm Optimization of Stroke Thrombolysis) trial were presented on the first day of the American Stroke Association’s International Stroke Conference, ISC 2024, being held through Feb. The study was looking for improvement in functional outcomes at 90 days.

Stroke 105

Stroke Strokes Outcomes Thrombolysis 105

Medical Xpress - Cardiology

FEBRUARY 12, 2024

nationwide quality initiative Target: Stroke (TS) is associated with improvement in thrombolysis frequency, timeliness, and outcome, according to a study published online Feb. 7 in JAMA Network Open.

Thrombolysis 40

Thrombolysis Stroke Strokes Outcomes 40

Journal of the American Heart Association

DECEMBER 18, 2023

BackgroundIntravenous thrombolysis (IVT) is an effective stroke therapy that remains underused. Outcomes included symptomatic intracranial hemorrhage, any intracranial hemorrhage, serious systemic bleeding, and 90‐day functional independence (modified Rankin scale score 0–2). The rates of symptomatic intracranial hemorrhage (3.4

Thrombolysis 75

Thrombolysis Hemorrhage Stroke Strokes 75

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP107-ATP107, February 1, 2024. Introduction:Emergency-department-based implementation strategies to increase thrombolysis are promising. The study population was limited to ischemic stroke patients admitted to the hospital. Among 1608 hospitals, 1131 (70%) had tPA rates below 10%.

Thrombolysis 40

Thrombolysis Hospital Inpatient Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. ResultsWe included four randomized controlled trials with 1176 patients.

Thrombolysis 40

Thrombolysis Outcomes Embolism Stents 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP117-ATP117, February 1, 2024. Introduction:Reducing door-to-needle (DTN) times lead to improved patient outcomes in acute ischemic stroke. 2) Creation of a multidisciplinary Thrombolysis Focus Group to analyze data and improve processes. in 2020, to 31.9% in 2021, to 59.6%

Thrombolysis 40

Thrombolysis Academic Document Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionOver the past decade, stroke management has significantly improved with the widespread use of intravenous thrombolysis (IVT) and the establishment of endovascular thrombectomy (EVT) as the standard of care for increasing patients.

Thrombolysis 40

Thrombolysis Inpatient Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP179-AWP179, February 1, 2024. Background:Stent-retriever thrombectomy is the first-line therapy for acute stroke with intracranial large vessel occlusion. 4.14, p=0.9502), but it was associated with a functional clinical outcome at 90 days (OR 3.39, 95% CI 1.11-10.43, 10.43, p=0.0325).Conclusions:The

Stents 40

Stents Stent Thrombolysis Angioplasty 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP213-ATP213, February 1, 2024. Background and Purpose:Although intra-arterial thrombolysis (IAT) is widely used as adjunct with mechanical thrombectomy in acute ischemic stroke patients, the patients who are likely to benefit are not known.

Thrombolysis 40

Thrombolysis Stroke Strokes Stents 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP199-AWP199, February 1, 2024. Background:The benefits of endovascular thrombectomy (EVT) for posterior cerebral artery (PCA) occlusion remain controversial, but intravenous thrombolysis (IVT) has proven benefit across nearly all ischemic stroke types.

Atrial Fibrillation 40

Atrial Fibrillation Thrombolysis Outcomes Embolism 40

Stroke Journal

MARCH 11, 2024

Stroke, Ahead of Print. NETs are proposed as a mechanism of resistance to thrombolysis. Thrombolysis was remarkably associated with higher NE positivity (average marginal effect, 6.461 [95% CI, 0.7901–12.13];P=0.02555), regardless of the origin of thrombi. The therapy that is currently administered does not modify NET content.

Thrombolysis 40

Thrombolysis Pharmacology Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

SEPTEMBER 12, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue 6 , November 1, 2023. BackgroundIt is unclear whether all patient subgroups with acute ischemic stroke have benefited from advances in reperfusion therapy. Outcomes included favorable outcome (modified Rankin scale score 0–2 at discharge).ResultsOf to 29.8%.

Stroke 40

Stroke Strokes Outcomes Thrombolysis 40

Stroke Journal

JANUARY 4, 2024

Stroke, Ahead of Print. BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. Primary outcome was a shift toward better functional outcome on the modified Rankin Scale at 90 days.

Thrombolysis 40

Thrombolysis Circulation Hemorrhage Outcomes 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 10, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDPrediction of successful revascularization and achieving a favorable functional outcome may help determine the optimal treatment strategy and improve the management of stroke. 2.27];P= 0.02) and favorable functional outcome (OR: 1.76 [1.17–2.66];P=

Thrombolysis 40

Thrombolysis Outcomes Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP13-ATMP13, February 1, 2024. Introduction:Recent studies report similar outcomes with antiplatelet drugs and intravenous thrombolysis (IVT) in patients with minor nondisabling ischemic stroke.

Thrombolysis 40

Thrombolysis Stroke Strokes Academic 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP93-AWMP93, February 1, 2024. Introduction:Comprehensive Stroke Centers are skilled, highly trained facilities that provide advanced care to an array of stroke patients. minutes), compared to the Comprehensive Stroke Centers (Median: 39.50) (Mann Whitney U-Test: p <0.0001).

Stroke 40

Stroke Strokes Thrombolysis Outcomes 40

Stroke Journal

DECEMBER 21, 2023

Stroke, Volume 55, Issue 1 , Page 78-88, January 1, 2024. BACKGROUND:The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. 1.99]; aOR, 1.63 [95% CI, 1.14–2.32], 2.32], respectively). versus 85.6%;P<0.001),

COVID-19 40

COVID-19 Outcomes Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2024. Median time from the onset of visual change to thrombolysis was 6.0 [4.5-10.5] Introduction:Branch retinal artery occlusion (BRAO) results from the blood flow compromise in of the branches of the central retinal artery. VA improvement of ≥0.1

Thrombolysis 40

Thrombolysis Outcomes Hemorrhage Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A25-A25, February 1, 2024. Introduction:Intravenous thrombolysis (IVT) is efficacious treatment of acute ischemic stroke (AIS). Outcomes of interest were symptomatic intracranial hemorrhage (sICH), any ICH, serious systemic bleeding (SSB), and 90-day functional independence (mRS 0-2).

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP5-AWP5, February 1, 2024. Background:Diabetes mellitus (DM) is one of the risk factors for acute ischemic stroke, usually leading to poor prognosis. While DM can reduce the effect of intravenous thrombolysis, metformin can have a positive outcome on AIS patients.

Diabetes 40

Diabetes Stroke Strokes Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP202-AWP202, February 1, 2024. Background:Mechanical thrombectomy (MT) has demonstrated superiority over medical therapy for acute ischemic stroke (AIS) with large vessel occlusion (LVO). Propensity score matching was performed to create two well-balanced groups: MT alone and MT+IVtPA.

Thrombolysis 40

Thrombolysis Academic Hemorrhage Outcomes 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 19, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. Patients were dichotomized into those with 90‐day good functional outcome (modified Rankin scale [mRS] score 0–2) and poor functional outcome (mRS score ≥3). Good functional outcome was observed in 44 patients (40%). < 0.05 versus 83.3%;P versus 62.1%;P

Circulation 40

Circulation Stents Stent Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP37-ATMP37, February 1, 2024. Introduction:In Latin America (LATAM), the prevalence of stroke is alarmingly high. The advancement of artificial intelligence (AI) technologies has potential to dramatically improve healthcare outcomes.

Stroke 40

Stroke Strokes Outcomes Technology 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP126-AWP126, February 1, 2024. Introduction:The rapid advancement of artificial intelligence (AI) technologies holds promise for improving healthcare outcomes. Methods:Data for this study were obtained from the Get with the Guidelines Stroke database.

Stroke 40

Stroke Strokes Outcomes Technology 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP10-AWP10, February 1, 2024. Introduction:While observational data suggest that dexmedetomidine may have neuroprotective effects on ischemic brain, its clinical use in acute ischemic stroke is limited due to concerns about cerebral vasoconstriction. vs. 28.8%; p=0.24).

Stroke 40

Stroke Strokes Outcomes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP92-ATMP92, February 1, 2024. Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Results:9 articles were included from 825 screened. 95%CI 1.03

Dementia 40

Dementia Outcomes Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionBackground: Prediction of successful revascularization and achieving a favorable functional outcome may help to determine the optimal recanalization strategy and improve the management of stroke.

Outcomes 40

Outcomes Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP104-ATP104, February 1, 2024. Introduction:Accurate outcome prognostication in acute ischemic stroke (AIS) informs essential medical decision-making for clinicians, patients, and families. independence) were classified as “good” outcomes and mRS 3-6 (non-independent) as “poor” outcomes.

Thrombolysis 40

Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP42-AWMP42, February 1, 2024. Background:Prior studies have shown that individuals who have an in-hospital stroke are less likely to receive thrombolysis. Out of hospital strokes were patients who were not admitted to the hospital when their stroke symptoms.

Hospital 40

Hospital Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP282-ATP282, February 1, 2024. Background:This analysis is based on a prospective database encompassing consecutive patients who underwent EVT for LVO between January 2021 and June 2023 at a comprehensive stroke center (CSC).Main vs. 70.6 ± 14.5). min vs. 394.5 min vs. 45.1 hours vs. 59.3

Stroke 40

Stroke Strokes Thrombolysis ICU 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP193-ATP193, February 1, 2024. Successful recanalization was defined as modified Thrombolysis in Cerebral Ischemia Score≥ 2b. The primary outcome was a 90-day modified Rankin Scale (mRS) of 0-3. The primary outcome was a 90-day modified Rankin Scale (mRS) of 0-3.

Outcomes 40

Outcomes Stroke Strokes Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP82-ATP82, February 1, 2024. Introduction:The incidence of Large Vessel Occlusion-Acute Ischemic Stroke (LVO-AIS) continues to increase in young adults. 31 patients (18%) had stroke etiology as Large Artery Atherosclerosis (per TOAST criteria). received IV thrombolysis and 43.9%

Stroke 40

Stroke Strokes Atherosclerosis Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP186-AWP186, February 1, 2024. A higher burden of WMH is associated with poor functional outcomes after IVT. Overall, higher VSS grade was associated with a lower probability of achieving a good functional outcome, even after adjustments (Figure 1). of 476 patients without WMH (Table 1).Conclusions:Patients

Outcomes 40

Outcomes Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP21-AWP21, February 1, 2024. Introduction:Although prior antiplatelet therapy (APT) could potentially contribute to bleeding risk, the influence of prior APT on intravenous thrombolysis outcomes remains controversial. Of these, 257 (32.9%) patients were receiving prior APT.

Stroke 40

Stroke Strokes Thrombolysis Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP3-AWP3, February 1, 2024. Outcomes included sICH, and inpatient mortality, adjusted for confounders which included age, gender, baseline NIHSS, perfusion grade (TICI) intravenous thrombolysis, history of diabetes and HBA1c.Results:A total of 224 patients (mean age was 68.7

Inpatient 40

Inpatient Stroke Strokes Outcomes 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 6, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDMechanical thrombectomy is established for large‐vessel occlusions in acute ischemic stroke, but the potential role in distal vessel occlusions of medium arteries is less well established. Arterial diameters were measured at all these sites. mm (IQR, 1.47–2.06

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Stent Stents Stroke Strokes 40