Physiologically Speaking

JUNE 14, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post! “Inflammation.” ” It’s the word we all fear.

Exercise 104

Exercise Physiology Circulation Outcomes 104

HeartRhythm

JUNE 19, 2024

This risk is not decreased by ventricular pacing avoidance algorithms which cause non-physiologic atrioventricular delays. Objective: To report outcomes in patients with narrow QRS complex, when paced complex is in normal range and physiologic atrioventricular delays are programmed.

Physiology 40

Physiology Outcomes 40

Frontiers in Cardiovascular Medicine

JANUARY 31, 2024

Objectives The purpose of this study was to assess the clinical outcome after right ventricular outflow tract (RVOT) stenting in late presenter patient with unrepaired Fallot physiology. Methods This was a single-center, retrospective study of nonrandomized, palliated Fallot patients. software was used to analyze the statistical data.

Stents 64

Stents Stent Physiology ICU 64

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2024

Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies.

Myocardial Infarction 52

Myocardial Infarction Physiology Biomarkers Innovation 52

Physiologically Speaking

AUGUST 9, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Let’s bring the discussion back to physical activity energy expenditure, as this was the primary outcome after all. To receive new posts and support my work, consider becoming a free or paid subscriber.

Physiology 69

Physiology Diet Cholesterol Biomarkers 69

Physiologically Speaking

JUNE 28, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. No differences in strength outcomes were observed between groups. ICYMI: I appeared as a guest on Siim Land’s podcast to chat about all things VO2 max. You can watch the YouTube video here.

Physiology 64

Physiology Exercise Research Outcomes 64

Heart BMJ

FEBRUARY 23, 2024

Coronary physiology assessment, including epicardial and microvascular investigations, is a fundamental tool in the contemporary management of patients with coronary artery disease. However, revascularisation of coronary stenosis, which induces myocardial ischaemia, has demonstrated better outcome than OMT alone.

Coronary Artery Disease 53

Coronary Artery Disease Physiology Coronary Artery Bypass Graft Quality of Life 53

Physiologically Speaking

JULY 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This irregular sleep pattern misaligns circadian rhythms and disrupts physiology. ICYMI: On Wednesday, I published my video interview with Dr. Andrew Koutnik. “The shorter your sleep, the shorter your life.”

Chronic Disease 64

Chronic Disease Physiology Atrial Flutter Atrial Fibrillation 64

HeartRhythm

SEPTEMBER 1, 2024

Left bundle branch pacing (LBBP) is a novel physiological pacing modality. However, whether it delivers comparable efficacy with different capture sites in heart failure (HF) patients remains unclear.

Heart Failure 75

Heart Failure Physiology Outcomes 75

Physiologically Speaking

JULY 5, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Results Before getting to the 4-year follow-up results, let us take a look at how the outcomes changed from baseline to 1 year (i.e., Now let’s get into the outcomes at the 4-year follow-up time point.

Physiology 64

Physiology Exercise Outcomes 64

Frontiers in Cardiovascular Medicine

APRIL 3, 2025

However, the causal link between SCH and cardiovascular outcomes remains unclear due to study design heterogeneity and overreliance on TSH levels. Evidence suggests SCH may exacerbate atherosclerosis and cardiac dysfunction through mechanisms such as increased LDL synthesis, oxidative stress, and impaired vascular endothelial function.

Cardiovascular Disease 52

Cardiovascular Disease Research Public Health Atherosclerosis 52

Physiologically Speaking

JULY 24, 2024

His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. Part I: 10-Years longitudinal data on KETOGENIC DIET and Safety, Efficacy & Advanced Cardiovascular Physiology in a patient with HIGH RISK cardiovascular disease (Type 1 Diabetes)?

Diabetes 115

Diabetes Diet Physiology Biomarkers 115

Physiologically Speaking

APRIL 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. At baseline, 3 months, and 6 months, the participants physical activity was measured over a period of 7 days to calculate time spent sitting (the primary study outcome).

Blood Pressure 52

Blood Pressure Physiology Exercise Diet 52

Physiologically Speaking

AUGUST 16, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. And thanks to a new study published in Frontiers in Physiology , we’ve got some answers. A quick plug for an exercise app that you need to be using to track your workouts. P.S. Personal Trainer Mode is now live!

Physiology 59

Physiology Exercise Laboratory Research 59

Frontiers in Cardiovascular Medicine

JANUARY 19, 2025

Kaplan-Meier survival analysis and multivariate adjusted Cox regression models were employed to assess the association between RAR levels and mortality outcomes within 1 year. Patients were categorized into quartiles (Q1Q4) based on RAR levels. Subgroup analysis was used to evaluate the prognostic impact of RAR across diverse populations.

Heart Failure 52

Heart Failure ICU Physiology Outcomes 52

DAIC

JANUARY 8, 2025

This program aligns with our strategy to develop lorundrostat in conditions driven by dysregulated aldosterone, with poor cardiovascular outcomes and few treatment options, stated Jon Congleton, Chief Executive Officer of Mineralys Therapeutics. Obstructive sleep apnea carries significant physiological and psychological impacts on health.

Blood Pressure 52

Blood Pressure Hypertension Kidney Disease BMI 52

Physiologically Speaking

JULY 19, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This is an important outcome as drastic dietary changes can sometimes lead to worsened mood or “hanger” (a scientific term), reducing their sustainability.

Physiology 59

Physiology Exercise Diet Outcomes 59

Physiologically Speaking

JUNE 7, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. What’s the best way to spend our time when health is the outcome of interest? To receive new posts and support my work, consider becoming a free or paid subscriber. Is this helping or hurting my health?

Physiology 52

Physiology Exercise Blood Pressure Outcomes 52

Physiologically Speaking

DECEMBER 22, 2023

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Though rooted in physiology, the literature regarding the circadian timing of exercise hasn’t been in agreement. The Journal of Physiology. ” Details can be found at the end of the post!

Exercise 52

Exercise Physiology Blood Pressure Cholesterol 52

Physiologically Speaking

DECEMBER 22, 2023

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Though rooted in physiology, the literature regarding the circadian timing of exercise hasn’t been in agreement. The Journal of Physiology. ” Details can be found at the end of the post!

Exercise 52

Exercise Physiology Blood Pressure Cholesterol 52

Physiologically Speaking

MARCH 15, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Social jetlag impairs exercise volume and attenuates physiological and metabolic adaptations to voluntary exercise training. Journal of Applied Physiology. That’s what a new study suggests. 00632.2023.

Exercise 52

Exercise Physiology Blood Pressure Outcomes 52

Physiologically Speaking

APRIL 5, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Overnight, brain activity and other physiological metrics were measured using a technique known as polysomnography (PSG). ICYMI On Monday, I posted a video interview that I recorded with Aidan Chariton from Shortcut U.

Physiology 52

Physiology Blood Pressure Research Outcomes 52

Stroke Journal

JANUARY 30, 2025

Introduction:Intracerebral hemorrhage (ICH) is commonly associated with poor neurologic outcomes. 3B) of LME analysis indicates that aged mice are more vulnerable to the BBB disruption following ICH.Conclusion:Our study highlights the potential of physiological imaging biomarkers for detecting early microvascular dysfunctions in ICH.

Biomarkers 40

Biomarkers Physiology Hemorrhage Stroke 40

Physiologically Speaking

MAY 24, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post!

Diet 52

Diet Physiology Exercise Research 52

HeartRhythm

APRIL 30, 2024

By coupling AF biophysical simulations with Deep Learning (DL) algorithms, patient-specific models can be developed to predict the outcomes of various ablation strategies. However, choosing the most appropriate input features is a non-trivial task.

Ablation 40

Ablation Physiology Outcomes 40

American College of Cardiology

SEPTEMBER 25, 2024

The benefit of physiology-guided complete revascularization in patients presenting with myocardial infarction (MI) remains uncertain.

Myocardial Infarction 46

Myocardial Infarction Physiology Outcomes Article 46

Physiologically Speaking

JANUARY 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. However, there’s not great evidence that multivitamins benefit specific health outcomes. What if your calendar was the key to living a longer, healthier life? Nutritional insurance? Perhaps not.

Physiology 52

Physiology Diet Cardiovascular Disease BMI 52

NEJM Journal Watch - Cardiology

APRIL 8, 2024

New data suggest no benefit over culprit-lesion revascularization alone.

Physiology 40

Physiology Outcomes 40

All About Cardiovascular System and Disorders

MAY 26, 2024

Later it was shown that index of microvascular resistance which quantified the inability of microcirculation to vasodilate and improve coronary flow after primary PCI, was associated with worst outcomes independent of epicardial coronary flow. Immediate Microvascular Physiology After Mechanical Coronary Reperfusion of STEMI.

STEMI 52

STEMI Outcomes Coronary Artery Disease Myocardial Infarction 52

DAIC

JULY 29, 2024

In these patients, limb symptoms may reduce quality of life, and the devastating outcome of limb amputation results in social and economic burdens for both patient and family. The VasoGuard V-Series signifies a significant step forward for physiologic testing in international standards compliance.

Certification 111

Certification Peripheral Arterial Disease Cerebrovascular Disease Quality of Life 111

Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

HSD3B1 was also associated with OS after accounting for known clinical variables.

Cancer 75

Cancer Pharmacology Physiology Outcomes 75

The American Journal of Cardiology

APRIL 5, 2025

Publication date: Available online 4 April 2025 Source: The American Journal of Cardiology Author(s): Wen Yang, Zhixin Jiang, Shengchan Wang, Chun Chen, Xiujuan Zhou, Qijun Shan

Physiology 40

Physiology Cardiomyopathy Ablation Outcomes 40

Journal of Cardiovascular Electrophysiology

FEBRUARY 13, 2024

Abstract Introduction Clinical outcomes of long-term ventricular septal pacing (VSP) without His-Purkinje capture remain unknown. This study evaluated the differences in clinical outcomes between conduction system pacing (CSP), VSP, and right ventricular pacing (RVP).

Bradycardia 40

Bradycardia Physiology Pacemaker Heart Failure 40

Journal of the American Heart Association

JANUARY 9, 2025

Areas for future intervention that could lead to improved care and outcomes for those with congenital heart disease are noted. Focus is placed on the indications for exercise testing, expected findings, and how exercise testing should guide the management of patients with various congenital heart disease subtypes.

Congenital Heart Disease 75

Congenital Heart Disease Congenital Exercise Heart Disease 75

Circulation

NOVEMBER 11, 2024

Physiological class (PC) was determined by clinicians according to the 2018 AHA/ACC guidelines. Conclusion:MRI-measured global longitudinal strain holds promise as a prognostic indicator for clinical outcomes in adults with systemic RV dysfunction. Clinical events (e.g., for each) except 3D global radial strain.

Outcomes 40

Outcomes Congenital Physiology Heart Failure 40

Circulation

NOVEMBER 11, 2024

Frailty and CVD are often interrelated, affecting disease and treatment outcomes. Frailty is a syndrome of physiological decline, characterized by marked vulnerability to adverse health outcomes. Frailty is prevalent in adults with IHD requiring PCI. 10.23), intracranial hemorrhage (AOR = 4.65, 95% CI: 2.18-10.82),

Heart Disease 40

Heart Disease Hospital Inpatient Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Our study aims to describe the trends and outcomes of patients with Subarachnoid Hemorrhage (SAH) using a Nationwide Inpatient Sample (NIS) database.Methods:We examined the 2016-2020 NIS database, focusing on patients aged 18 years and older with a primary SAH discharge diagnosis.

COVID-19 40

COVID-19 Hemorrhage Outcomes Inpatient 40