Physiologically Speaking

SEPTEMBER 20, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Not only that, if evolution wired us to be lazy, then why do moderate to high levels of physical activity and aerobic fitness correlate with the best health outcomes? These genes are still with us today.

Exercise 114

Exercise Physiology Blood Pressure Obesity 114

Physiologically Speaking

JANUARY 12, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Physical fitness was measured using VO2 peak obtained during a maximal exercise test (the gold standard way to measure this outcome). ” Details can be found at the end of the post!

Physiology 124

Physiology BMI Exercise Diet 124

Physiologically Speaking

JUNE 14, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post! “Inflammation.” ” It’s the word we all fear.

Exercise 104

Exercise Physiology Circulation Outcomes 104

HeartRhythm

JUNE 19, 2024

This risk is not decreased by ventricular pacing avoidance algorithms which cause non-physiologic atrioventricular delays. Objective: To report outcomes in patients with narrow QRS complex, when paced complex is in normal range and physiologic atrioventricular delays are programmed.

Physiology 40

Physiology Outcomes 40

Frontiers in Cardiovascular Medicine

JANUARY 31, 2024

Objectives The purpose of this study was to assess the clinical outcome after right ventricular outflow tract (RVOT) stenting in late presenter patient with unrepaired Fallot physiology. Methods This was a single-center, retrospective study of nonrandomized, palliated Fallot patients. software was used to analyze the statistical data.

Stent 64

Stent Stents Physiology ICU 64

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2024

Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies.

Myocardial Infarction 52

Myocardial Infarction Physiology Biomarkers Innovation 52

Physiologically Speaking

AUGUST 9, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Let’s bring the discussion back to physical activity energy expenditure, as this was the primary outcome after all. To receive new posts and support my work, consider becoming a free or paid subscriber.

Physiology 69

Physiology Diet Cholesterol Biomarkers 69

Physiologically Speaking

JUNE 28, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. No differences in strength outcomes were observed between groups. ICYMI: I appeared as a guest on Siim Land’s podcast to chat about all things VO2 max. You can watch the YouTube video here.

Physiology 64

Physiology Exercise Research Outcomes 64

Heart BMJ

FEBRUARY 23, 2024

Coronary physiology assessment, including epicardial and microvascular investigations, is a fundamental tool in the contemporary management of patients with coronary artery disease. However, revascularisation of coronary stenosis, which induces myocardial ischaemia, has demonstrated better outcome than OMT alone.

Coronary Artery Disease 53

Coronary Artery Disease Physiology Coronary Artery Bypass Graft Quality of Life 53

Physiologically Speaking

JULY 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This irregular sleep pattern misaligns circadian rhythms and disrupts physiology. ICYMI: On Wednesday, I published my video interview with Dr. Andrew Koutnik. “The shorter your sleep, the shorter your life.”

Chronic Disease 64

Chronic Disease Physiology Atrial Flutter Atrial Fibrillation 64

HeartRhythm

SEPTEMBER 1, 2024

Left bundle branch pacing (LBBP) is a novel physiological pacing modality. However, whether it delivers comparable efficacy with different capture sites in heart failure (HF) patients remains unclear.

Heart Failure 75

Heart Failure Physiology Outcomes 75

Physiologically Speaking

JULY 5, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Results Before getting to the 4-year follow-up results, let us take a look at how the outcomes changed from baseline to 1 year (i.e., Now let’s get into the outcomes at the 4-year follow-up time point.

Physiology 64

Physiology Exercise Outcomes 64

Physiologically Speaking

JULY 24, 2024

His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. Part I: 10-Years longitudinal data on KETOGENIC DIET and Safety, Efficacy & Advanced Cardiovascular Physiology in a patient with HIGH RISK cardiovascular disease (Type 1 Diabetes)?

Diabetes 115

Diabetes Diet Physiology Biomarkers 115

Physiologically Speaking

APRIL 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. At baseline, 3 months, and 6 months, the participants physical activity was measured over a period of 7 days to calculate time spent sitting (the primary study outcome).

Blood Pressure 52

Blood Pressure Physiology Exercise Diet 52

Physiologically Speaking

AUGUST 16, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. And thanks to a new study published in Frontiers in Physiology , we’ve got some answers. A quick plug for an exercise app that you need to be using to track your workouts. P.S. Personal Trainer Mode is now live!

Physiology 59

Physiology Exercise Laboratory Research 59

DAIC

MAY 14, 2024

Together, the two companies will work to further the development and commercialization of Medis Quantitative Flow Ratio (Medis QFR), a non-invasive approach to the assessment of coronary physiology, as part of GE HealthCare’s interventional cardiology portfolio built around the Allia Platform.

Coronary Artery Disease 111

Coronary Artery Disease Interventional Cardiology Innovation Physiology 111

Frontiers in Cardiovascular Medicine

JANUARY 19, 2025

Kaplan-Meier survival analysis and multivariate adjusted Cox regression models were employed to assess the association between RAR levels and mortality outcomes within 1 year. Patients were categorized into quartiles (Q1Q4) based on RAR levels. Subgroup analysis was used to evaluate the prognostic impact of RAR across diverse populations.

Heart Failure 52

Heart Failure ICU Physiology Outcomes 52

DAIC

JANUARY 8, 2025

This program aligns with our strategy to develop lorundrostat in conditions driven by dysregulated aldosterone, with poor cardiovascular outcomes and few treatment options, stated Jon Congleton, Chief Executive Officer of Mineralys Therapeutics. Obstructive sleep apnea carries significant physiological and psychological impacts on health.

Blood Pressure 52

Blood Pressure Hypertension Kidney Disease BMI 52

Physiologically Speaking

MARCH 28, 2025

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. The small sample size, limited time frame of follow-up measures, and lack of functional outcomes prevent me from thinking any of this is indicative of meaningful long-term brain damage. Should marathoners be worried?

Exercise 71

Exercise Research Physiology Outcomes 71

Physiologically Speaking

APRIL 5, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Overnight, brain activity and other physiological metrics were measured using a technique known as polysomnography (PSG). ICYMI On Monday, I posted a video interview that I recorded with Aidan Chariton from Shortcut U.

Physiology 52

Physiology Blood Pressure Research Outcomes 52

Physiologically Speaking

JULY 19, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This is an important outcome as drastic dietary changes can sometimes lead to worsened mood or “hanger” (a scientific term), reducing their sustainability.

Physiology 59

Physiology Exercise Diet Outcomes 59

Physiologically Speaking

JUNE 7, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. What’s the best way to spend our time when health is the outcome of interest? To receive new posts and support my work, consider becoming a free or paid subscriber. Is this helping or hurting my health?

Physiology 52

Physiology Exercise Blood Pressure Outcomes 52

Journal of the American Heart Association

JANUARY 23, 2025

BackgroundAcute psychological stress may induce physiological changes predisposing individuals to adverse health outcomes through hemodynamic and vascular effects. The outcome was a composite of cardiovascular death, nonfatal myocardial infarction, and heart failure hospitalizations during followup.

Coronary Artery Disease 56

Coronary Artery Disease Outcomes Myocardial Infarction Risk Factors 56

Physiologically Speaking

DECEMBER 22, 2023

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Though rooted in physiology, the literature regarding the circadian timing of exercise hasn’t been in agreement. The Journal of Physiology. ” Details can be found at the end of the post!

Exercise 52

Exercise Physiology Blood Pressure Cholesterol 52

Physiologically Speaking

DECEMBER 22, 2023

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Though rooted in physiology, the literature regarding the circadian timing of exercise hasn’t been in agreement. The Journal of Physiology. ” Details can be found at the end of the post!

Exercise 52

Exercise Physiology Blood Pressure Cholesterol 52

Physiologically Speaking

DECEMBER 15, 2023

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Participating in any resistance training is associated with a 15%–17% lower risk for these outcomes compared to non-participation. ” Details can be found at the end of the post!

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

Physiologically Speaking

DECEMBER 15, 2023

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Participating in any resistance training is associated with a 15%–17% lower risk for these outcomes compared to non-participation. ” Details can be found at the end of the post!

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

Physiologically Speaking

MARCH 15, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Social jetlag impairs exercise volume and attenuates physiological and metabolic adaptations to voluntary exercise training. Journal of Applied Physiology. That’s what a new study suggests. 00632.2023.

Exercise 52

Exercise Physiology Blood Pressure Outcomes 52

Stroke Journal

JANUARY 30, 2025

Introduction:Intracerebral hemorrhage (ICH) is commonly associated with poor neurologic outcomes. 3B) of LME analysis indicates that aged mice are more vulnerable to the BBB disruption following ICH.Conclusion:Our study highlights the potential of physiological imaging biomarkers for detecting early microvascular dysfunctions in ICH.

Biomarkers 40

Biomarkers Physiology Hemorrhage Stroke 40

Physiologically Speaking

MAY 24, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post!

Diet 52

Diet Physiology Exercise Research 52

HeartRhythm

APRIL 30, 2024

By coupling AF biophysical simulations with Deep Learning (DL) algorithms, patient-specific models can be developed to predict the outcomes of various ablation strategies. However, choosing the most appropriate input features is a non-trivial task.

Ablation 40

Ablation Physiology Outcomes 40

NEJM Journal Watch - Cardiology

APRIL 8, 2024

New data suggest no benefit over culprit-lesion revascularization alone.

Physiology 40

Physiology Outcomes 40

Open Heart

DECEMBER 14, 2023

The excess risk of COVID-19 hospitalisation and death rose with increasing physiological severity of CHD (presence of pulmonary vascular disease and/or cyanosis), rather than anatomical complexity. Of patients with a positive COVID-19 test, patients with CHD were more likely than controls to be hospitalised (22.4% to 1.89); p=7.00e–08).

COVID-19 98

COVID-19 Congenital Heart Disease Congenital Heart Disease 98

Frontiers in Cardiovascular Medicine

MARCH 3, 2024

Background Objective tools to define the optimal time for referral for advanced therapies and to help guide escalation and de-escalation of support can improve management decisions and outcomes for patients with advanced heart failure.

Heart Failure 85

Heart Failure Cardiogenic Shock Physiology Transplant 85

Physiologically Speaking

JANUARY 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. However, there’s not great evidence that multivitamins benefit specific health outcomes. What if your calendar was the key to living a longer, healthier life? Nutritional insurance? Perhaps not.

Physiology 52

Physiology Diet Cardiovascular Disease BMI 52

American College of Cardiology

SEPTEMBER 25, 2024

The benefit of physiology-guided complete revascularization in patients presenting with myocardial infarction (MI) remains uncertain.

Myocardial Infarction 43

Myocardial Infarction Physiology Outcomes Article 43

DAIC

FEBRUARY 26, 2025

A key element of Heartflows approach is close collaboration with clinical teams to improve patient experiences, create efficient care pathways and reach more patients with personalized insights, ensuring the best possible outcomes. In the U.S., 1 Many of the estimated 18 million adults in the U.S.

Coronary Artery Disease 59

Coronary Artery Disease Heart attacks Heart Attack Technology 59