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Physiology Friday #257: Does Training Frequency Matter for Fitness Gains?

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. link] The training frequency debate From a physiological perspective, higher-frequency training might be beneficial because it provides more frequent stimulation of key adaptive pathways. The conclusion?

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Physiology Friday #255: Strength Training for Endurance, Optimal HIIT Protocols, Omega-3s + a Big Announcement!

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. As a subscriber to Physiologically Speaking , he thought I’d make a capable predecessor and invited me to continue sharing the latest advice on how runners of all levels can improve their performance using science.

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Physiology Friday #237: An Evolutionary Perspective on Why Exercise Promotes Longevity

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. What physiological mechanisms make moderate to high levels of activity so favorable, especially in our modern environment? This week, I’m sharing one of my favorite articles I’ve ever written.

Exercise 114
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White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models

Journal of Clinical Investigation - Cardiology

Healthy adipose tissue is essential for normal physiology. Our results elucidate a pathway for depot-specific maintenance of white adipocyte properties that could enable the development of therapies for obesity and associated diseases.

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GLP-1R–positive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice

Journal of Clinical Investigation - Cardiology

Liraglutide, a glucagon-like peptide-1 (GLP-1) analog, is approved for obesity treatment, but the specific neuronal sites that contribute to its therapeutic effects remain elusive.

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Physiology Friday #230: Cutting Sugar vs. Cutting Carbs for Cardiometabolic Health

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This finding actually detracts somewhat from the carbohydrate insulin model of obesity, which posits that weight gain (and loss) are regulated largely by the body’s insulin levels (insulin promotes fat storage).

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Physiology Friday #228: Identifying Sleep Patterns that Influence Chronic Disease Risk

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This irregular sleep pattern misaligns circadian rhythms and disrupts physiology. ICYMI: On Wednesday, I published my video interview with Dr. Andrew Koutnik. “The shorter your sleep, the shorter your life.”