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Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. link] The training frequency debate From a physiological perspective, higher-frequency training might be beneficial because it provides more frequent stimulation of key adaptive pathways. The conclusion?
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. As a subscriber to Physiologically Speaking , he thought I’d make a capable predecessor and invited me to continue sharing the latest advice on how runners of all levels can improve their performance using science.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. What physiological mechanisms make moderate to high levels of activity so favorable, especially in our modern environment? This week, I’m sharing one of my favorite articles I’ve ever written.
Healthy adipose tissue is essential for normal physiology. Our results elucidate a pathway for depot-specific maintenance of white adipocyte properties that could enable the development of therapies for obesity and associated diseases.
Liraglutide, a glucagon-like peptide-1 (GLP-1) analog, is approved for obesity treatment, but the specific neuronal sites that contribute to its therapeutic effects remain elusive.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This finding actually detracts somewhat from the carbohydrate insulin model of obesity, which posits that weight gain (and loss) are regulated largely by the body’s insulin levels (insulin promotes fat storage).
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This irregular sleep pattern misaligns circadian rhythms and disrupts physiology. ICYMI: On Wednesday, I published my video interview with Dr. Andrew Koutnik. “The shorter your sleep, the shorter your life.”
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Of course, I should note that the participants did have high blood pressure and an overweight/obese body mass index — these results may not be as strong for normotensive adults.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. The physiology of shivering Cold exposure with shivering activates several physiological responses that can contribute to better metabolic health. You can find more products I’m affiliated with on my website.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Research has linked circadian rhythm disruptions to a wide range of health issues, including cardiovascular disease, diabetes, obesity, and even certain cancers.
Our body’s physiological processes oscillate on a 24-hour cycle known as the circadian rhythm. Day-night oscillations in the release of hormones, body temperature, and a range of other important physiological events orchestrate the complex system that is us. Every process in our body happens rhythmically.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Clinically, about 1/3 of adults have metabolic syndrome — a cluster of conditions including abdominal obesity, high blood pressure, high blood glucose, high triglycerides, and low HDL cholesterol.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Clinically, about 1/3 of adults have metabolic syndrome — a cluster of conditions including abdominal obesity, high blood pressure, high blood glucose, high triglycerides, and low HDL cholesterol.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. For adults with overweight and obesity, resistance exercise increases lean body mass and reduces body fat percentage and fat mass — improving overall body composition.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. For adults with overweight and obesity, resistance exercise increases lean body mass and reduces body fat percentage and fat mass — improving overall body composition.
While weight loss following bariatric surgery often yields resolution of comorbidities related to obesity, it also presents unanticipated changes in underlying physiology. We present a case series of two young patients with obesity-related comorbidities necessitating sleeve gastrectomy which provoked symptomatic sinus bradycardia.
Cancer, atrial fibrillation (AF) and coronary artery disease share some common factors and interact with each other, such as obesity, aging, diabetes, and inflammation, but the potential specific mechanism is still unclear. A growing number of studies have elucidated the association between cancer and CVD.
The etiological risk factors of CVDs are widely known and include dyslipidemia, obesity, diabetes, and chronic cigarette consumption. However, one component that is often underestimated is exposure to heavy metals. The biological perspective explains that different metals play different roles.
Both lactate and BHB naturally increase in response to physiological stresses—lactate during intense exercise and BHB during prolonged fasting or low-carbohydrate diets. This could make LaKe an attractive option for weight management or as part of a dietary intervention for metabolic disorders like obesity and type 2 diabetes.
Other studies have also unearthed more intricate connections which suggests that physiological conditions, underpinned by biological and chemical factors, may also play a pivotal role in influencing cardiovascular disease (CVD).
But the rising trends of obesity, diabetes, and cardiovascular disease and the falling trend of activity levels lead me to a dark conclusion: things probably aren’t going to get any better. I’m an exercise scientist by training. We can promote exercise until we’re red in the face. Unfortunately, this isn’t possible.
The exact mechanisms behind this link are complex, but it’s believed that the combination of lifestyle factors associated with depression (such as poor diet, lack of exercise, and smoking) and the physiological effects of depression on the body (including inflammation and blood clotting) can contribute to heart problems.
We present the case of a patient with oHCM and HFpEF where data extrapolated from CardioMEMS provided valuable insight to the hemodynamic impact of cardiac myosin inhibitors.Case:A 66-year-old female with hypertension, obesity and oHCM presented with worsening dyspnea and was evaluated for septal myectomy.
A 35-year-old gravida 1, para 0 with biventricular heart failure (LVEF 25%), nonischemic cardiomyopathy, history stroke, history of left ventricular thrombus, class III obesity, and chronic kidney disease who had been followed by Cardio-Obstetrics throughout her pregnancy presented at 34 weeks gestation for planned induction of labor.
While factors like high blood pressure, high cholesterol, obesity, and smoking affect both men and women, certain conditions like diabetes, metabolic syndrome, and mental stress tend to pose a higher risk for women. Hormonal changes, particularly during menopause, also play a significant role, altering women’s cardiovascular health.
Exogenous ketones: a brief overview and physiological effects Ketones are produced by our liver during periods of fasting, low-carbohydrate dieting, and prolonged exercise. In non-exercise contexts, ketone ester supplementation has shown promise in improving cerebral blood flow and various cognitive aspects in adults with obesity.
Exogenous ketones: a brief overview and physiological effects Ketones are produced by our liver during periods of fasting, low-carbohydrate dieting, and prolonged exercise. In non-exercise contexts, ketone ester supplementation has shown promise in improving cerebral blood flow and various cognitive aspects in adults with obesity.
Share For people with OSA during sleep, there are recurrent episodes where the airway collapses and obstructs the passage of air to the lungs, resulting in: Lack of oxygen Significant variations in blood pressure, heart rate and other physiological metrics. Subscribe now How is it treated?
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. The weekend warrior activity pattern was associated with a 23% lower risk for hypertension, a 43% lower risk for diabetes, a 45% lower risk for obesity, and a 43% lower risk for sleep apnea.
Whether it's a PE or a severe asthma attack, the cellular physiology of these cells is acutely the same. She also complained of generalized weakness, lightheadedness, diaphoresis, chest pain, and cough. 2) The cells of the right ventricle do not know why they are having such a hard time when they report their acute strain on the ECG.
However, the importance of nonvesicular sterol movement for physiology and pathophysiology in various tissues is incompletely understood. Here we show that loss of Aster-B leads to diet-induced obesity in female but not in male mice, and that this sex difference is abolished by ovariectomy.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. ICYMI On Wednesday, I published a post discussing the different metabolic effects of the ketogenic diet and exogenous ketones during exercise. It’s been well-established that males and females respond differently to exercise.
Physiologically Speaking is a reader-supported publication. And that’s exactly when obesity began a meteoric rise. Physiologically Speaking is a reader-supported publication. The Scarcity Loop has 3 parts: opportunity, unpredictable rewards, and quick repeatability. More on these later. Who is Michael Easter?
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Physiological processes like the release of hormones and neurotransmitters, blood pressure, and insulin sensitivity oscillate throughout the day. A new study published in the Journal of Physiology sought to find out.
This is due to several factors, including the aging of the population, a rise in obesity, increased detection, and increased survival with AF along with other forms of CVD. Physiologic factors that impact stroke prevention therapy also change over time and can have important implications for proper medication dosing and patient safety.
Importantly, astrocyte kisspeptin signaling also mediated susceptibility to metabolic stressors and the development of obesity-induced hypogonadism, underscoring the physiological and pathological importance of this pathway and revealing the importance of nonneuronal signaling in reproductive health.
These indirect and direct factors can lead to obesity, hypertension, hyperlipidemia, diabetes, ischemia with no obstructive coronary artery disease (INOCA), CAD, myocardial infarction (MI), and stroke via the hypothalamic-pituitary-adrenal axis, sympathetic-adrenal-medullary system, sympathetic nervous system, and hypoestrogenemia.
6 [link] Insufficient sleep has been linked to a greater risk for several health conditions including obesity, diabetes, hypertension, and cognitive decline. 21 22 23 It is worth noting that the literature here is still in its infancy, as research into sex differences is currently an emerging area in physiology.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. As knowledge about sports nutrition and physiology grows, human limits are being redefined, and it’s awesome to see. You can find more products I’m affiliated with on my website.
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