Dr. Smith's ECG Blog

SEPTEMBER 18, 2024

Thus, it has recently become generally accepted that most plaque ruptures resulting in myocardial infarction occur in plaques that narrow the lumen diameter by 40% of the arterial cross section may be involved by plaque. Fig 1 shows typical examples of two such plaques.

Ischemia 116

Ischemia Plaque Stenosis Myocardial Infarction 116

Frontiers in Cardiovascular Medicine

FEBRUARY 8, 2024

Objective Assessing the impact of lumbar disc herniation (LDH) on the plaque burden of coronary atherosclerosis is our objective. Gensini scores were calculated to assess the plaque burden of coronary. The association between lumbar disc lesions grading and coronary plaque burden was analysed by Spearman's correlation test.

Plaque 59

Plaque Angina Myocardial Infarction Risk Factors 59

Frontiers in Cardiovascular Medicine

DECEMBER 13, 2023

Background To investigate the correlation between lg (circSCMH1/miR-874) and acute coronary syndrome (ACS), acute myocardial infarction (AMI), and carotid plaque stability. Compared with the low-risk plaque and control groups, the lg (circSCMH1/miR-874) value of medium-high risk plaque group decreased ( P  < 0.05).

Plaque 59

Plaque SCAD Coronary Artery Disease Myocardial Infarction 59

DAIC

JULY 18, 2024

This registry will aim to provide world-wide physicians the most accurate information on coronary plaque to improve cardiovascular risk prediction and support the selection of patient-specific treatment,” said Dr. De Cecco. The ultimate goal is to positively impact cardiovascular health globally with a reduction in cardiovascular events."

Plaque 105

Plaque Heart attacks Heart Attack Cardiovascular Disease 105

DAIC

OCTOBER 15, 2024

15, 2024 – Elucid has announced that four of the seven Medicare Administrative Contractors (MACs) will extend coverage for AI-enabled quantitative coronary plaque analysis, including its FDA-cleared PlaqueIQ image analysis software, beginning Nov. tim.hodson Tue, 10/15/2024 - 12:12 Oct.

Medicare 52

Medicare Plaque Chest Pain Coronary Artery Disease 52

Cardiovascular Diabetology

JULY 10, 2024

Background The effect of empagliflozin, a sodium-glucose-co-transporter-2 inhibitor, on risk for myocardial infarction has not been fully characterized.

Myocardial Infarction 52

Myocardial Infarction Coronary Artery Bypass Graft Outcomes Plaque 52

Heart BMJ

JANUARY 10, 2024

Myocardial infarction with non-obstructive coronary arteries (MINOCA) defines a heterogeneous group of atherosclerotic and non-atherosclerotic conditions, causing myocardial injury in the absence of obstructive coronary artery disease.

Myocardial Infarction 40

Myocardial Infarction Coronary Artery Disease Ultrasound Plaque 40

Circulation

NOVEMBER 11, 2024

eGC shedding could contribute to atherosclerotic plaque vulnerability and acute myocardial infarction (AMI) installation. The integrity of this structure sustains some vascular properties such as shear stress-induced nitric oxide release and the prevention of platelets and neutrophils adhesion on the vessel surface.

Myocardial Infarction 40

Myocardial Infarction Plaque Technology Diabetes 40

DAIC

OCTOBER 30, 2024

Data confirm the use of FFR CT and Plaque Analysis helps assess long-term risks, informing more personalized and effective treatment plans for patients with coronary artery disease. The prospective data with long-term follow-up in ADVANCE-DK alongside Plaque Analysis data gave us far more than that. 27, 2024 — HeartFlow, Inc.

Plaque 52

Plaque Outcomes Coronary Artery Disease Chest Pain 52

Stroke Journal

DECEMBER 8, 2023

BACKGROUND:Aortic arch plaques are associated with an increased risk of ischemic stroke in patients with cryptogenic stroke or prior embolic events. Arch plaques were assessed by suprasternal transthoracic echocardiography; plaques ≥4 mm in thickness were classified as large plaques. Stroke, Ahead of Print.

Plaque 40

Plaque Aortic Stroke Strokes 40

Dr. Paddy Barrett

JANUARY 30, 2024

The CAC scan looks for deposits of calcium in the areas of the coronary arteries as a proxy marker for plaque. It tells you ‘ if ’ there is plaque and how much, as a score called a CAC score. MI = Myocardial Infarction/Heart Attack However, there are two very important caveats. Int J Cardiol.

Heart Disease 77

Heart Disease Heart attacks Heart Attack Plaque 77

NEJM Journal Watch - Cardiology

APRIL 11, 2024

However, many of the events prevented were subsequent PCIs, so future studies focused on death and myocardial infarction outcomes are needed.

Myocardial Infarction 40

Myocardial Infarction Plaque Outcomes 40

Dr. Smith's ECG Blog

NOVEMBER 15, 2023

MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection; myocardial disorders, including myocarditis, takotsubo cardiomyopathy, and other cardiomyopathies. MINOCA I do not have the bandwidth here to write a review of MINOCA.

Coronary Angiogram 100

Coronary Angiogram Plaque Thrombosis STEMI 100

Frontiers in Cardiovascular Medicine

JUNE 26, 2024

ACS may arise from the disruption of an atherosclerotic plaque, ultimately leading to acute ischemia and myocardial infarction. Colchicine exerts anti-inflammatory properties affecting both the myocardium and atherosclerotic plaque by modulating the activity of monocyte/macrophages, neutrophils, and platelets.

Plaque 52

Plaque Myocardial Infarction Atherosclerosis Ischemia 52

DAIC

MAY 8, 2024

It provides anatomic data, plaque identification and characterization, as well as the calculations of FFR CT , a coronary physiological simulation, computed from simulated pressure, velocity and blood flow information obtained from a 3D computer model generated from static coronary CT images.

Coronary Artery Disease 111

Coronary Artery Disease Chest Pain Ischemia Myocardial Infarction 111

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

We investigated whether treatment with LDE-paclitaxel changes plaque progression by coronary CT angiography and is safe in patients with chronic coronary artery disease. Among those, 58% had diabetes, 50% had myocardial infarction, and 91% were in use of statin and aspirin.

Coronary Artery Disease 59

Coronary Artery Disease Laboratory Plaque Biomarkers 59

DAIC

FEBRUARY 29, 2024

ET Main Tent (Hall B1) - A Double-blind, Randomized Placebo Procedure-controlled Trial of an Interatrial Shunt in Patients with HFrEF and HFpEF: Principal Results From the RELIEVE-HF Trial - Empagliflozin After Acute Myocardial Infarction: Results of the EMPACT-MI Trial - CSL112 (Apolipoprotein A-I) Infusions and Cardiovascular Outcomes in Patients (..)

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

Frontiers in Cardiovascular Medicine

FEBRUARY 5, 2024

Anaphylaxis leads to plaque rupture or erosion leading to acute myocardial infarction (type II) and acute coronary stent thrombosis (type III). Here we share a case of Kounis syndrome type I caused by an allergy caused by a Cryptopteran bite.

Coronary Artery Disease 64

Coronary Artery Disease Electrocardiogram Myocardial Infarction Thrombosis 64

DAIC

APRIL 6, 2024

Although we missed our primary endpoint, our data support the hypothesis that HDL cholesterol plays a role in reducing subsequent coronary plaque disruption events like heart attack via enhanced cholesterol efflux attacks,” Gibson said. Other studies have shown that high levels of HDL cholesterol are associated with reduced heart attack risk.

Heart Attack 98

Heart Attack Heart attacks Cholesterol Blood Clot 98

Dr. Smith's ECG Blog

APRIL 22, 2024

A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty. Electrocardiographic diagnosis of reperfusion during thrombolytic therapy in acute myocardial infarction. Am Heart J. 2000;139:430–436. Am J Cardiol.

Chest Pain 119

Chest Pain Myocardial Infarction Anatomy Angina 119

Open Heart

APRIL 18, 2022

Methods and analysis The SPECTRUM study is a prospective investigator-initiated single-centre single-arm observational cohort study aiming to enrol 200 patients presenting with ST-segment elevation myocardial infarct undergoing IVUS-guided primary PCI.

Ultrasound 52

Ultrasound Myocardial Infarction Cardiovascular Imaging Plaque 52

DAIC

OCTOBER 1, 2024

tim.hodson Tue, 10/01/2024 - 10:50 PHOTO CAPTION: The Elucid PlaqueIQ user interface is a fully interactive visualization of the patient’s coronary anatomy, showing specific plaque type and amount across various views to inform physician assessment of risk and patient-specific treatment pathway.

Cardiovascular Disease 52

Cardiovascular Disease Plaque Quality of Life Myocardial Infarction 52

Dr. Paddy Barrett

APRIL 5, 2024

2 Trends and Predictors of Participation in Cardiac Rehabilitation Following Acute Myocardial Infarction: Data From the Behavioral Risk Factor Surveillance System. 7 Secondary prevention following myocardial infarction: a clinical update. 11 Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction.

Heart Disease 107

Heart Disease Coronary Artery Disease Heart attacks Heart Attack 107

DAIC

JANUARY 25, 2024

Among patients who had no plaque and zero calcium at time of CCTA, those with the most abnormal CaRi-Heart test results experienced 11-fold higher risk for cardiac mortality and 5-fold higher risk for major adverse cardiac events (MACE) than those who had normal CaRi-Heart test results. In June 2023, the U.S.

Heart Attack 110

Heart Attack Heart attacks Technology Cardiovascular Disease 110

The British Journal of Cardiology

AUGUST 1, 2024

Elevated Lp(a) concentrations in patients with ischaemic heart disease have been linked to higher rates of peri-procedural myocardial infarction (MI) during percutaneous coronary intervention (PCI). This review summarises the available data on the modulatory effect of Lp(a) on plaque morphology and recurrent ischaemic events.

Peripheral Arterial Disease 40

Peripheral Arterial Disease Myocardial Infarction Plaque Cardiovascular Disease 40

All About Cardiovascular System and Disorders

MARCH 7, 2024

Detailed analysis of the excised carotid plaques were carried out with pyrolysis-gas chromatography-mass spectrometry, stable isotope analysis, and electron microscopy. Primary endpoint of the study was a composite of myocardial infarction, stroke, or death from any cause in those who had micro and nanoplastics in the carotid plaque.

Plaque 52

Plaque Myocardial Infarction Laboratory Cardiac Function 52

Dr. Smith's ECG Blog

JANUARY 5, 2024

So there is probability of myocardial injury here (and because it is in the correct clinical setting, then myocardial infarction.) Although it is statistically unlikely, multiple plaque ruptures are possible. The PDA plaque was also bulky, but was not described as inflamed or ulcerated. Heitner et al.

Angina 107

Angina Plaque Document Stents 107

DAIC

APRIL 6, 2024

Although we missed our primary endpoint, our data support the hypothesis that HDL cholesterol plays a role in reducing subsequent coronary plaque disruption events like heart attack via enhanced cholesterol efflux attacks,” Gibson said. Other studies have shown that high levels of HDL cholesterol are associated with reduced heart attack risk.

Heart Attack 78

Heart Attack Heart attacks Research Cholesterol 78

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heart attack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4

Cardiovascular Disease 111

Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

Dr. Smith's ECG Blog

MAY 20, 2024

The scan also showed “scattered coronary artery plaques”. __ Smith comment 1 : the appropriate management at this point is to lower the blood pressure (lower afterload, which increases myocardial oxygen demand). Smith comment : Is the ACS (rupture plaque) with occlusion that is now reperfusing? Murakami MM.

Chest Pain 124

Chest Pain Blood Pressure Ischemia STEMI 124

Dr. Paddy Barrett

AUGUST 1, 2023

A CTCA provides much more anatomical detail and can identify advanced plaque often missed by CT Coronary Artery Calcium Score scans alone. There are 3 types of coronary atherosclerosis visible on CTCA: Calcified Plaque - Easily Identified on both CT CAC & CTCA scans. Subscribe now How Often Does A CT CAC Scan Miss Plaque?

Coronary Angiogram 52

Coronary Angiogram Plaque Coronary Artery Disease Chest Pain 52

Circulation

NOVEMBER 11, 2024

Background:The no-reflow has been reported to be associated with larger infarct size and mortality after acute myocardial infarction (AMI). The incidence of no-reflow was higher in patients with attenuated plaque ≥5 mm in length as evaluated by intravascular ultrasound (IVUS).Objective:The vs. 8.6%, p &lt; 0.001).

Ultrasound 40

Ultrasound Plaque Blood Pressure Myocardial Infarction 40

All About Cardiovascular System and Disorders

APRIL 30, 2024

Plaque regression can be demonstrated by ultrasound evaluation of the carotids which are easily accessible. Maintaining normal blood pressure also reduces the risk of stroke and myocardial infarction. Of course, exercise burns out extra calories and reduces body weight, which in turn is due to a decrease in the fat deposits.

Exercise 52

Exercise Heart Disease Blood Pressure Cholesterol 52

Dr. Smith's ECG Blog

NOVEMBER 30, 2022

To prove there is no plaque rupture, you need to do intravascular ultrasound (IVUS). An angiogram is a "lumenogram;" most plaque is EXTRALUMINAL!! Such cases are classified as MINOCA (Myocardial Infarction with Non-Obstructed Coronary Arteries). It can only be seen by IVUS. MINOCA has many etiologies. Learning Points: 1.

Plaque 52

Plaque Chest Pain Thrombosis Stenosis 52

Dr. Smith's ECG Blog

MAY 19, 2020

If the arrest was caused by acute MI due to plaque rupture, then the diagnosis is MINOCA. MINOCA: Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease). Here is my comment on MINOCA: "Non-obstructive coronary disease" does not necessarily imply "no plaque rupture with thrombus." FFR can be useful.

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Defibrillator Circulation Plaque Cardiac Arrest 52

Cardiology Update

APRIL 9, 2024

EMPACT-MI 1 ( NCT04509674 ) studied the effects of empagliflozin in patients who have experienced myocardial infarction (MI). The PREVENT 12 ( NCT02316886 ) trial aimed to determine if performing preventive PCI on non-flow-limiting vulnerable plaques yields better clinical outcomes compared to relying solely on optimal medical therapy.

Myocardial Infarction 52

Myocardial Infarction Angina Aortic valve Coronary Artery Disease 52

Stroke Journal

NOVEMBER 9, 2023

This article describes the pathway from gene discovery to novel therapeutic approaches that are now entering man.HDAC9expression is elevated in human atherosclerotic plaque, while in animal and cellular models, reducing HDAC9 (histone deacetylase 9) protein is associated with reduced disease.

Stroke 40

Stroke Strokes Atherosclerosis Coronary Artery Disease 40