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Cardiology Update
JUNE 16, 2024
Recent research has illuminated the role of total coronary atherosclerotic plaque activity across the entire coronary arterial tree in predicting patient-level clinical outcomes. Vessel-level coronary atherosclerotic plaque activity was assessed using coronary 18 F-sodium fluoride positron emission tomography (PET). 3.72; P = 0.013).
Cardiometabolic Health Congress
JANUARY 15, 2025
The Hidden Threat: SMuRFless Myocardial Infarctions A concerning trend in CVD is the increase in myocardial infarctions (MI) among individuals without standard modifiable risk factors (SMuRFless MI).
American College of Cardiology
MAY 30, 2024
Is vessel-level coronary atherosclerotic plaque activity using coronary 18F-sodium fluoride positron emission tomography (PET) associated with patient vessel-level myocardial infarction (MI)?
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American College of Cardiology
NOVEMBER 7, 2024
The goal of the PACMAN-AMI trial was to demonstrate the efficacy of early administration of alirocumab on plaque characteristics among patients undergoing percutaneous coronary intervention (PCI) for an acute myocardial infarction (AMI).
Dr. Paddy Barrett
FEBRUARY 14, 2025
A heart attack is when that plaque ruptures and stops blood flow down the artery. This graph shows the absolute and relative risk reduction for statin therapy in preventing heart attacks (Myocardial Infarction), strokes and preventing death from any cause (All-cause mortality) 2. Cholesterol is an essential part of that process.
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CardiacWire
MARCH 8, 2024
A landmark NEJM study revealed that many patients with carotid artery disease might have microplastics and nanoplastics (MNPs) embedded in their carotid plaque, and those patients have a massive 4.5-fold of patients had polyethylene in their plaque and 12.1% in patients without MNPs in their plaque. An alarming 58.4%
119 
Dr. Smith's ECG Blog
SEPTEMBER 18, 2024
Thus, it has recently become generally accepted that most plaque ruptures resulting in myocardial infarction occur in plaques that narrow the lumen diameter by 40% of the arterial cross section may be involved by plaque. Fig 1 shows typical examples of two such plaques.
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Frontiers in Cardiovascular Medicine
AUGUST 6, 2024
Myocardial infarction (MI) stands at top global causes of death in developed countries, owing mostly to atherosclerotic plaque growth and endothelial injury-induced reduction in coronary blood flow. While early reperfusion techniques have improved outcomes, long-term treatment continues to be difficult.
Heart BMJ
FEBRUARY 23, 2024
For life-threatening events involving complete occlusion of a coronary artery, the activation of ST-elevation myocardial infarction protocols instructs the emergency services to provide immediate treatment and liaise directly with cardiac centres regarding invasive management, in turn, reducing morbidity and saving lives. 1 In this.
Frontiers in Cardiovascular Medicine
DECEMBER 13, 2023
Background To investigate the correlation between lg (circSCMH1/miR-874) and acute coronary syndrome (ACS), acute myocardial infarction (AMI), and carotid plaque stability. Compared with the low-risk plaque and control groups, the lg (circSCMH1/miR-874) value of medium-high risk plaque group decreased ( P < 0.05).
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DAIC
JULY 18, 2024
This registry will aim to provide world-wide physicians the most accurate information on coronary plaque to improve cardiovascular risk prediction and support the selection of patient-specific treatment,” said Dr. De Cecco. The ultimate goal is to positively impact cardiovascular health globally with a reduction in cardiovascular events."
105 
Journal of the American Heart Association
JANUARY 9, 2024
BackgroundProtruding aortic plaque is known to be associated with an increased risk for future cardiac and cerebrovascular events. Coronary plaque characteristics were compared to evaluate coronary plaque vulnerability in patients with protruding aortic plaque on computed tomography angiography.
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DAIC
OCTOBER 15, 2024
15, 2024 – Elucid has announced that four of the seven Medicare Administrative Contractors (MACs) will extend coverage for AI-enabled quantitative coronary plaque analysis, including its FDA-cleared PlaqueIQ image analysis software, beginning Nov. tim.hodson Tue, 10/15/2024 - 12:12 Oct.
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Frontiers in Cardiovascular Medicine
FEBRUARY 8, 2024
Objective Assessing the impact of lumbar disc herniation (LDH) on the plaque burden of coronary atherosclerosis is our objective. Gensini scores were calculated to assess the plaque burden of coronary. The association between lumbar disc lesions grading and coronary plaque burden was analysed by Spearman's correlation test.
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Cardiovascular Diabetology
JULY 10, 2024
Background The effect of empagliflozin, a sodium-glucose-co-transporter-2 inhibitor, on risk for myocardial infarction has not been fully characterized.
Heart BMJ
JANUARY 10, 2024
Myocardial infarction with non-obstructive coronary arteries (MINOCA) defines a heterogeneous group of atherosclerotic and non-atherosclerotic conditions, causing myocardial injury in the absence of obstructive coronary artery disease.
Circulation
NOVEMBER 11, 2024
eGC shedding could contribute to atherosclerotic plaque vulnerability and acute myocardial infarction (AMI) installation. The integrity of this structure sustains some vascular properties such as shear stress-induced nitric oxide release and the prevention of platelets and neutrophils adhesion on the vessel surface.
Stroke Journal
DECEMBER 8, 2023
BACKGROUND:Aortic arch plaques are associated with an increased risk of ischemic stroke in patients with cryptogenic stroke or prior embolic events. Arch plaques were assessed by suprasternal transthoracic echocardiography; plaques ≥4 mm in thickness were classified as large plaques. Stroke, Ahead of Print.
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Dr. Paddy Barrett
JANUARY 30, 2024
The CAC scan looks for deposits of calcium in the areas of the coronary arteries as a proxy marker for plaque. It tells you ‘ if ’ there is plaque and how much, as a score called a CAC score. MI = Myocardial Infarction/Heart Attack However, there are two very important caveats. Int J Cardiol.
Dr. Smith's ECG Blog
NOVEMBER 15, 2023
MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection; myocardial disorders, including myocarditis, takotsubo cardiomyopathy, and other cardiomyopathies. MINOCA I do not have the bandwidth here to write a review of MINOCA.
NEJM Journal Watch - Cardiology
APRIL 11, 2024
However, many of the events prevented were subsequent PCIs, so future studies focused on death and myocardial infarction outcomes are needed.
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Frontiers in Cardiovascular Medicine
JUNE 26, 2024
ACS may arise from the disruption of an atherosclerotic plaque, ultimately leading to acute ischemia and myocardial infarction. Colchicine exerts anti-inflammatory properties affecting both the myocardium and atherosclerotic plaque by modulating the activity of monocyte/macrophages, neutrophils, and platelets.
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DAIC
MAY 8, 2024
It provides anatomic data, plaque identification and characterization, as well as the calculations of FFR CT , a coronary physiological simulation, computed from simulated pressure, velocity and blood flow information obtained from a 3D computer model generated from static coronary CT images.
DAIC
APRIL 6, 2024
Although we missed our primary endpoint, our data support the hypothesis that HDL cholesterol plays a role in reducing subsequent coronary plaque disruption events like heart attack via enhanced cholesterol efflux attacks,” Gibson said. Other studies have shown that high levels of HDL cholesterol are associated with reduced heart attack risk.
Dr. Smith's ECG Blog
APRIL 22, 2024
A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty. Electrocardiographic diagnosis of reperfusion during thrombolytic therapy in acute myocardial infarction. Am Heart J. 2000;139:430–436. Am J Cardiol.
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Dr. Paddy Barrett
APRIL 5, 2024
2 Trends and Predictors of Participation in Cardiac Rehabilitation Following Acute Myocardial Infarction: Data From the Behavioral Risk Factor Surveillance System. 7 Secondary prevention following myocardial infarction: a clinical update. 11 Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction.
118 
Frontiers in Cardiovascular Medicine
FEBRUARY 20, 2024
We investigated whether treatment with LDE-paclitaxel changes plaque progression by coronary CT angiography and is safe in patients with chronic coronary artery disease. Among those, 58% had diabetes, 50% had myocardial infarction, and 91% were in use of statin and aspirin.
DAIC
FEBRUARY 29, 2024
ET Main Tent (Hall B1) - A Double-blind, Randomized Placebo Procedure-controlled Trial of an Interatrial Shunt in Patients with HFrEF and HFpEF: Principal Results From the RELIEVE-HF Trial - Empagliflozin After Acute Myocardial Infarction: Results of the EMPACT-MI Trial - CSL112 (Apolipoprotein A-I) Infusions and Cardiovascular Outcomes in Patients (..)
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Frontiers in Cardiovascular Medicine
FEBRUARY 5, 2024
Anaphylaxis leads to plaque rupture or erosion leading to acute myocardial infarction (type II) and acute coronary stent thrombosis (type III). Here we share a case of Kounis syndrome type I caused by an allergy caused by a Cryptopteran bite.
Open Heart
APRIL 18, 2022
Methods and analysis The SPECTRUM study is a prospective investigator-initiated single-centre single-arm observational cohort study aiming to enrol 200 patients presenting with ST-segment elevation myocardial infarct undergoing IVUS-guided primary PCI.
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DAIC
OCTOBER 1, 2024
tim.hodson Tue, 10/01/2024 - 10:50 PHOTO CAPTION: The Elucid PlaqueIQ user interface is a fully interactive visualization of the patient’s coronary anatomy, showing specific plaque type and amount across various views to inform physician assessment of risk and patient-specific treatment pathway.
The British Journal of Cardiology
AUGUST 1, 2024
Elevated Lp(a) concentrations in patients with ischaemic heart disease have been linked to higher rates of peri-procedural myocardial infarction (MI) during percutaneous coronary intervention (PCI). This review summarises the available data on the modulatory effect of Lp(a) on plaque morphology and recurrent ischaemic events.
Dr. Smith's ECG Blog
JANUARY 5, 2024
So there is probability of myocardial injury here (and because it is in the correct clinical setting, then myocardial infarction.) Although it is statistically unlikely, multiple plaque ruptures are possible. The PDA plaque was also bulky, but was not described as inflamed or ulcerated. Heitner et al.
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Journal of the American Heart Association
MARCH 13, 2025
In the subsample of patients without clinical CAD but with femoral plaque on ultrasound (n=58) who underwent cardiac computed tomography, 46% (n=27) had nonobstructive CAD and 28% (n=16) had obstructive CAD. In patients without previous CAD, but femoral plaque on ultrasound, nearly a half had nonobstructive and onefourth had obstructive CAD.
DAIC
APRIL 6, 2024
Although we missed our primary endpoint, our data support the hypothesis that HDL cholesterol plays a role in reducing subsequent coronary plaque disruption events like heart attack via enhanced cholesterol efflux attacks,” Gibson said. Other studies have shown that high levels of HDL cholesterol are associated with reduced heart attack risk.
All About Cardiovascular System and Disorders
MARCH 7, 2024
Detailed analysis of the excised carotid plaques were carried out with pyrolysis-gas chromatography-mass spectrometry, stable isotope analysis, and electron microscopy. Primary endpoint of the study was a composite of myocardial infarction, stroke, or death from any cause in those who had micro and nanoplastics in the carotid plaque.
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Dr. Smith's ECG Blog
MAY 20, 2024
The scan also showed “scattered coronary artery plaques”. __ Smith comment 1 : the appropriate management at this point is to lower the blood pressure (lower afterload, which increases myocardial oxygen demand). Smith comment : Is the ACS (rupture plaque) with occlusion that is now reperfusing? Murakami MM.
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Dr. Paddy Barrett
AUGUST 1, 2023
A CTCA provides much more anatomical detail and can identify advanced plaque often missed by CT Coronary Artery Calcium Score scans alone. There are 3 types of coronary atherosclerosis visible on CTCA: Calcified Plaque - Easily Identified on both CT CAC & CTCA scans. Subscribe now How Often Does A CT CAC Scan Miss Plaque?
Circulation
NOVEMBER 11, 2024
Background:The no-reflow has been reported to be associated with larger infarct size and mortality after acute myocardial infarction (AMI). The incidence of no-reflow was higher in patients with attenuated plaque ≥5 mm in length as evaluated by intravascular ultrasound (IVUS).Objective:The vs. 8.6%, p < 0.001).
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All About Cardiovascular System and Disorders
APRIL 30, 2024
Plaque regression can be demonstrated by ultrasound evaluation of the carotids which are easily accessible. Maintaining normal blood pressure also reduces the risk of stroke and myocardial infarction. Of course, exercise burns out extra calories and reduces body weight, which in turn is due to a decrease in the fat deposits.
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DAIC
JANUARY 23, 2024
Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heart attack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4
Dr. Smith's ECG Blog
NOVEMBER 30, 2022
To prove there is no plaque rupture, you need to do intravascular ultrasound (IVUS). An angiogram is a "lumenogram;" most plaque is EXTRALUMINAL!! Such cases are classified as MINOCA (Myocardial Infarction with Non-Obstructed Coronary Arteries). It can only be seen by IVUS. MINOCA has many etiologies. Learning Points: 1.
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Dr. Smith's ECG Blog
MAY 19, 2020
If the arrest was caused by acute MI due to plaque rupture, then the diagnosis is MINOCA. MINOCA: Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease). Here is my comment on MINOCA: "Non-obstructive coronary disease" does not necessarily imply "no plaque rupture with thrombus." FFR can be useful.
Cardiology Update
APRIL 9, 2024
EMPACT-MI 1 ( NCT04509674 ) studied the effects of empagliflozin in patients who have experienced myocardial infarction (MI). The PREVENT 12 ( NCT02316886 ) trial aimed to determine if performing preventive PCI on non-flow-limiting vulnerable plaques yields better clinical outcomes compared to relying solely on optimal medical therapy.
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