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Chronic kidneydisease (CKD) is a progressive condition characterized by the gradual loss of kidney function, leading to the accumulation of uremic toxins in the bloodstream. This review article explores the intricate mechanisms by which uremic toxins accelerate vascular inflammation.
(MedPage Today) -- The dual SGLT1/2 inhibitor sotagliflozin (Inpefa) reduced the risk for myocardial infarction (MI) and stroke in high-risk patients with type 2 diabetes (T2D), chronic kidneydisease (CKD), and cardiovascular riskfactors, a prespecified.
Sotagliflozin, a drug recently approved by the Food and Drug Administration to treat type 2 diabetes and kidneydisease with additional cardiovascular riskfactors, can significantly reduce heart attack and stroke among these patients, according to results from an international clinical trial led by a Mount Sinai researcher.
METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.
BackgroundInhibition of prostaglandin synthesis by nonsteroidal anti‐inflammatory drugs is associated with cardiovascular mortality and kidneydisease. Longitudinal associations with cardiovascular mortality and kidney outcomes (eGFR <60 or <45 mL/min per 1.73
Officially published by the AHA six months ago, CKM syndrome defines the connections and risks associated with obesity, type 2 diabetes, chronic kidneydisease, and cardiovascular disease. White) to assess their CKM stages, finding the following breakdown: Stage 0 (no riskfactors) – 10.6%
Participants with an RHR of ≥80 bpm had a higher stage of chronic kidneydisease, lower estimated glomerular filtration rate, and more proteinuria than those with an RHR of 60 to 69 bpm. 1.90]) higher risk of ESRD, respectively. The risk of ESRD remained significantly elevated (HR, 1.32 [95% CI, 1.10–1.58]
The association between AF and various conditions—including hypertension, heart failure, sleep apnoea and chronic kidneydisease—is well-described, highlighting that AF is often a multisystem disorder. 2 Before the.
ABSTRACT: Albuminuria, an established biomarker of the progression of chronic kidneydisease, is also recognized as a biomarker for the risk of cardiovascular disease. Elevated urinary albumin excretion indicates kidney damage and systemic vascular disease, including myocardial capillary disease and arterial stiffness.
Diabetic kidneydisease is an established riskfactor for heart failure. However, the impact of incident heart failure on the subsequent risk of renal failure has not been systematically assessed in diabetic p.
Background To assess the roles of diabetic microvascular disease and modifiable riskfactors and their combination in the development of arrhythmias. Incorporating microvascular disease states into a model alongside 11 traditional riskfactors significantly enhanced arrhythmia prediction.
Hypertension represents a major modifiable riskfactor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidneydisease (CKD), and dementia.
Renal dysfunction, especially chronic kidneydisease, is the biggest riskfactor of mortality among thrombolysed stroke patients, according to a retrospective cohort observational study published in Medicine.
Owing to improved management, the life expectancy of patients with hemophilia has increased significantly and predisposes them to risk of cardiovascular diseases and thrombotic events. The primary outcome was to estimate the prevalence of cardiovascular riskfactors in patients with hemophilia compared to the general population.
Albuminuriaincreased urine albumin excretionis associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidneydisease, or heart failure, as well as among adults with few cardiovascular riskfactors.
Hypertension is a leading cause of morbidity and mortality worldwide and poses a major riskfactor for cardiovascular diseases and chronic kidneydisease.
Background:Chronic kidneydisease (CKD) has emerged as an independent riskfactor for cerebral microhemorrhages (CMH). Stroke, Volume 56, Issue Suppl_1 , Page ADP60-ADP60, February 1, 2025. adenine diet to induce CKD, or angiotensin II (ATII) via subcutaneous osmotic pumps to induce HTN and compared with control mice.
BackgroundProteinuria is a riskfactor for cardiovascular events, but its prognostic value for sudden cardiac arrest (SCA) in young individuals remains unproven. Participants with proteinuria +34 showed a significant increase in the risk of SCA (2.94 [1.964.40],P<0.001).
Introduction:Smoking is a well-known riskfactor for atherosclerotic cardiovascular disease and kidney failure among patients with chronic kidneydisease (CKD). Circulation, Volume 150, Issue Suppl_1 , Page A4142036-A4142036, November 12, 2024.
Here’s what you can expect at the biggest conference in cardiorenal metabolic health, the 19th Annual Cardiometabolic Congress (CMHC), DECODING THE CONSTELLATION of Cardiometabolic Health and RiskFactors. Learn more or secure your registration by clicking here.
Introduction:Chronic kidneydisease (CKD) is a well-established riskfactor for spontaneous intracerebral hemorrhage (ICH). Stroke, Volume 55, Issue Suppl_1 , Page AWP159-AWP159, February 1, 2024. However, the biological pathway underlying this association remains unclear.
Secondary hypertension : This type results from an underlying condition such as kidneydisease, hormonal disorders, or the use of certain medications. High blood pressure can be classified into two categories: Primary hypertension : This type develops gradually over time without an identifiable cause.
BackgroundIn 2023, the American Heart Association defined the concept of cardiovascularkidneymetabolic (CKM) syndrome as a health disorder ascribed to connections among obesity, diabetes, chronic kidneydisease, and cardiovascular disease. CKM syndrome stages 3 and 4 are considered advanced.
METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.
Logistic regression was used to determine the association between 5-HTP levels and calcification severity, adjusting for age, gender, smoking status, chronic kidneydisease, hyperlipidemia, and diabetes. For other factors, the OR for smokers was 0.97 (0.53 to 2.31); chronic kidneydisease 1.07 (0.33 95% CI = 2.6
Compared to subjects with low CVH, participants with moderate and high CVH exhibited lower risks of 47% and 76%, respectively. Our findings suggest that implementing various healthy lifestyle practices and managing known cardiovascular riskfactors could be a feasible comprehensive preventive approach to aTRH.
Six multimorbidity patterns were identified, including 4 specific patterns: (1) pattern 1, cerebrovascular cluster (histories of cerebrovascular disease and hypertension); (2) pattern 2, traditional cardiovascular diseaseriskfactors cluster (histories of hyperlipidemia, obesity, anddiabetes, and family history of cardiovascular disease and smoking); (..)
Themed “Decoding the Constellation of Cardiometabolic Health and RiskFactors,” this year’s congress will tackle the growing health threat posed by cardiometabolic diseases, affecting 47 million people in the US.
Hypertension, diabetes, hyperlipidemia, and chronic kidneydisease are well-known cardiovascular riskfactors for ICH. However, the relationship between the polygenic profiles (PP) of these riskfactors and ICH risk in AF patients on anticoagulation remains unclear.
Riskfactors such as smoking, chronic kidneydisease, and aging can contribute to plaque formation. This study aims to assess the effect of aging on NaF uptake in the left common carotid artery (LCC) in subjects with known cardiovascular risk factors.MethodsIn total, 36 subjects (mean age 55.4 ± 12.3
The prevalence of HF riskfactors was high: hypertension, 61.9%; former or current smoking, 53.7%; obesity 34.8%; diabetes; 24.7%; and chronic kidneydisease; 22%. Overt cardiovascular disease, which ranged from 2.1% (HF) to 13.6% (atrial fibrillation), was less common. were female, 25.6% were Black, 12.8%
Introduction:Migraine is a riskfactor for cerebral ischemic stroke. However, it is not known if migraine is a riskfactor for retinal stroke (central retinal artery occlusion, CRAO).Methods:We vs. 6.9%, SD 0.1), chronic kidneydisease (1.9% Patients with migraine were younger (40.2±15.2 vs. 5.1%, SD 0.12).
For secondary prevention, dual antiplatelet therapy, high intensity statin, and optimization of his riskfactors were initiated.ConclusionThis case report demonstrates that dysphagia can be the initial symptom of an acute ischemic stroke. Later he noticed that he was unable to keep his balance.
Background:The Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) trial showed cardiovascular disease (CVD) benefits of semaglutide therapy in patients with type 2 diabetes mellitus (T2DM).Purpose:To year follow-up time).Results:Among Results:Among 5002 (projected to 34.0
Further, the guideline sets forth a new way to classify AFib, using stages, that reinforces the continuum of the disease and underscores the need to use a variety of strategies at the different stages, including prevention, lifestyle and riskfactor modification, screening, and therapy.
6.04]), kidneydisease (OR, 18.98 [95% CI, 1.80–200.47]), CONCLUSIONHypertension is prevalent among adult and pediatric patients with MMD with contributions from known vascular riskfactors. In adults, this was significantly associated with age (odds ratio [OR] 1.05 [95% CI, 1.02–1.09]), After a mean follow‐up of 34.3±18.1
It is riskfactor for cardiovascular disease, stroke and kidneydisease. Hence, this study aimed to assess blood pressure (BP) self-monitoring practice and associated factors among adult hypertensive patients on follow-up in South Wollo Zone public hospitals, Northeast Ethiopia.
” Learners can see some of the CMHC experts in person on Aug. 17-20, 2023, at the Laguna Cliffs Marriott Resort and Spa for the Women’s Cardiometabolic Health and Wellness Masterclass.
Barb, continuing that in 2000 the NASH Clinical Research Network focused on the etiology, contributing factors, natural history, complications, and therapy for what was then termed nonalcoholic steatohepatitis. Nonalcoholic fatty liver disease (NAFLD) & NASH. National Institute of Diabetes and Digestive and KidneyDiseases.
tim.hodson Tue, 04/22/2025 - 09:55 April 22, 2025 Research teams from Augusta University, Massachusetts General Hospital and The Ohio State University will lead a $15 million project dedicated to studying the various ways that riskfactors for cardiovascular and kidneydiseases impact women.
Background Heart failure (HF), type 2 diabetes (T2D) and chronic kidneydisease (CKD) commonly coexist. Compared with CKD and T2D, those with CKD and HF and HF and T2D had more severe riskfactor profile. We studied characteristics, prognosis and healthcare utilisation of individuals with two of these conditions.
This can be mitigated through targeting modifiable riskfactors. Identification of those at-risk through screening tools could be facilitated by inclusion of self-reported riskfactors rather than reliance on clinical data.
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