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Chronic kidneydisease (CKD) is a progressive condition characterized by the gradual loss of kidney function, leading to the accumulation of uremic toxins in the bloodstream. This review article explores the intricate mechanisms by which uremic toxins accelerate vascular inflammation.
(MedPage Today) -- The dual SGLT1/2 inhibitor sotagliflozin (Inpefa) reduced the risk for myocardial infarction (MI) and stroke in high-risk patients with type 2 diabetes (T2D), chronic kidneydisease (CKD), and cardiovascular riskfactors, a prespecified.
Sotagliflozin, a drug recently approved by the Food and Drug Administration to treat type 2 diabetes and kidneydisease with additional cardiovascular riskfactors, can significantly reduce heart attack and stroke among these patients, according to results from an international clinical trial led by a Mount Sinai researcher.
METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.
BackgroundInhibition of prostaglandin synthesis by nonsteroidal anti‐inflammatory drugs is associated with cardiovascular mortality and kidneydisease. Longitudinal associations with cardiovascular mortality and kidney outcomes (eGFR <60 or <45 mL/min per 1.73
Officially published by the AHA six months ago, CKM syndrome defines the connections and risks associated with obesity, type 2 diabetes, chronic kidneydisease, and cardiovascular disease. White) to assess their CKM stages, finding the following breakdown: Stage 0 (no riskfactors) – 10.6%
Participants with an RHR of ≥80 bpm had a higher stage of chronic kidneydisease, lower estimated glomerular filtration rate, and more proteinuria than those with an RHR of 60 to 69 bpm. 1.90]) higher risk of ESRD, respectively. The risk of ESRD remained significantly elevated (HR, 1.32 [95% CI, 1.10–1.58]
The association between AF and various conditions—including hypertension, heart failure, sleep apnoea and chronic kidneydisease—is well-described, highlighting that AF is often a multisystem disorder. 2 Before the.
ABSTRACT: Albuminuria, an established biomarker of the progression of chronic kidneydisease, is also recognized as a biomarker for the risk of cardiovascular disease. Elevated urinary albumin excretion indicates kidney damage and systemic vascular disease, including myocardial capillary disease and arterial stiffness.
Diabetic kidneydisease is an established riskfactor for heart failure. However, the impact of incident heart failure on the subsequent risk of renal failure has not been systematically assessed in diabetic p.
Background To assess the roles of diabetic microvascular disease and modifiable riskfactors and their combination in the development of arrhythmias. Incorporating microvascular disease states into a model alongside 11 traditional riskfactors significantly enhanced arrhythmia prediction.
BackgroundStroke and dementia are leading causes of mortality and can be prevented through riskfactor management. Riskfactor assessment requires laboratory or physical measurements. Journal of the American Heart Association, Ahead of Print.
Hypertension represents a major modifiable riskfactor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidneydisease (CKD), and dementia.
Renal dysfunction, especially chronic kidneydisease, is the biggest riskfactor of mortality among thrombolysed stroke patients, according to a retrospective cohort observational study published in Medicine.
This can be mitigated through targeting modifiable riskfactors. Identification of those at-risk through screening tools could be facilitated by inclusion of self-reported riskfactors rather than reliance on clinical data.
Albuminuriaincreased urine albumin excretionis associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidneydisease, or heart failure, as well as among adults with few cardiovascular riskfactors.
Hypertension is a leading cause of morbidity and mortality worldwide and poses a major riskfactor for cardiovascular diseases and chronic kidneydisease.
BackgroundProteinuria is a riskfactor for cardiovascular events, but its prognostic value for sudden cardiac arrest (SCA) in young individuals remains unproven. Participants with proteinuria +34 showed a significant increase in the risk of SCA (2.94 [1.964.40],P<0.001).
Owing to improved management, the life expectancy of patients with hemophilia has increased significantly and predisposes them to risk of cardiovascular diseases and thrombotic events. The primary outcome was to estimate the prevalence of cardiovascular riskfactors in patients with hemophilia compared to the general population.
Background:Chronic kidneydisease (CKD) has emerged as an independent riskfactor for cerebral microhemorrhages (CMH). Stroke, Volume 56, Issue Suppl_1 , Page ADP60-ADP60, February 1, 2025. adenine diet to induce CKD, or angiotensin II (ATII) via subcutaneous osmotic pumps to induce HTN and compared with control mice.
Chronic kidneydisease (CKD) is an important independent riskfactor for stroke. Stroke, Volume 55, Issue Suppl_1 , Page ATP292-ATP292, February 1, 2024. To understand the mechanisms of CKD that exacerbates stroke pathogenesis, we developed a rodent CKD model by feeding adult C57BL/6 mice with adenine.
With an estimated incidence as high as 22% among these patients, current clinical guidelines recommend using implantable cardioverter defibrillators (ICDs) to help mitigate the risk of SCD. The study ultimately included 1,676 patients who had visited Fujita Health University Hospital for decompensated heart failure.
BackgroundBoth nighttime systolic blood pressure and pulse rate are associated with adverse outcomes in patients with chronic kidneydisease (CKD). Journal of the American Heart Association, Ahead of Print.
Introduction:Smoking is a well-known riskfactor for atherosclerotic cardiovascular disease and kidney failure among patients with chronic kidneydisease (CKD). Circulation, Volume 150, Issue Suppl_1 , Page A4142036-A4142036, November 12, 2024.
Here’s what you can expect at the biggest conference in cardiorenal metabolic health, the 19th Annual Cardiometabolic Congress (CMHC), DECODING THE CONSTELLATION of Cardiometabolic Health and RiskFactors. Learn more or secure your registration by clicking here.
Introduction:Chronic kidneydisease (CKD) is a well-established riskfactor for spontaneous intracerebral hemorrhage (ICH). Stroke, Volume 55, Issue Suppl_1 , Page AWP159-AWP159, February 1, 2024. However, the biological pathway underlying this association remains unclear.
Secondary hypertension : This type results from an underlying condition such as kidneydisease, hormonal disorders, or the use of certain medications. High blood pressure can be classified into two categories: Primary hypertension : This type develops gradually over time without an identifiable cause.
Introduction Myocardial injury in elderly Omicron variant patients is a leading cause of severe disease and death. This study focuses on elucidating the clinical characteristics and potential riskfactors associated with myocardial injury in elderly patients infected with the Omicron variant.
BackgroundIn 2023, the American Heart Association defined the concept of cardiovascularkidneymetabolic (CKM) syndrome as a health disorder ascribed to connections among obesity, diabetes, chronic kidneydisease, and cardiovascular disease. CKM syndrome stages 3 and 4 are considered advanced.
METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.
had no CKM syndrome riskfactors, while 26% were at Stage 1 (overweight, prediabetes), 49% were Stage 2 (hypertension, diabetes, CKD), 5% had Stage 3 (kidneydisease or high CVD risks), and 9% were Stage 4 (heart disease, with or without kidneydisease).
As a riskfactor for death, high blood pressure is responsible for more deaths than any other riskfactor, including smoking. High blood pressure is the riskfactor associated with the most early deaths compared to any other riskfactor. And if it’s not, your risk of: Heart disease.
As evidence has mounted pointing to their benefits in reducing heart failure and other forms of heart disease, researchers have sought to determine whether these drugs could help to prevent heart failure even in people without diabetes or chronic kidneydisease.
Logistic regression was used to determine the association between 5-HTP levels and calcification severity, adjusting for age, gender, smoking status, chronic kidneydisease, hyperlipidemia, and diabetes. For other factors, the OR for smokers was 0.97 (0.53 to 2.31); chronic kidneydisease 1.07 (0.33 95% CI = 2.6
Implementation of a multispecialty care team approach, including expertise in riskfactor management, guideline directed medical therapies, wound and foot care and endovascular and surgical revascularization procedures, may improve outcomes for people with PAD. and Global Data From the American Heart Association.
Compared to subjects with low CVH, participants with moderate and high CVH exhibited lower risks of 47% and 76%, respectively. Our findings suggest that implementing various healthy lifestyle practices and managing known cardiovascular riskfactors could be a feasible comprehensive preventive approach to aTRH.
to 5.12; p=0.049), chronic kidneydisease (HR 1.89; 95% CI 1.03 to 3.49; p=0.041) as well as severe valvular heart disease (HR 3.08; 95% CI 1.68 p<0.001) and only 9% in patients without these riskfactors (log rank p<0.001). The planned intervention was deferred by a median of 23 (19–36) days.
Six multimorbidity patterns were identified, including 4 specific patterns: (1) pattern 1, cerebrovascular cluster (histories of cerebrovascular disease and hypertension); (2) pattern 2, traditional cardiovascular diseaseriskfactors cluster (histories of hyperlipidemia, obesity, anddiabetes, and family history of cardiovascular disease and smoking); (..)
HTN accelerates the progression of atherosclerosis and leads to increased risk of major cardiac events like heart attack, heart failure, kidneydisease and other end organ damage. HTN is the leading global riskfactor for death, affecting an estimated 1.28 billion adults worldwide.
Education and Empowerment Educating patients about their condition and the importance of managing cardiometabolic riskfactors can empower them to take control of their health, improve healthcare outcomes, and reduce clinician burnout. This ensures clear communication and identifies areas that need further explanation.
As evidence has mounted pointing to their benefits in reducing heart failure and other forms of heart disease, researchers have sought to determine whether these drugs could help to prevent heart failure even in people without diabetes or chronic kidneydisease.
Excess dietary sodium intake and insufficient dietary potassium intake are both well-established riskfactors for hypertension. We found incomplete and inconsistent recommendations about the use of potassium-enriched salt substitutes in the 32 hypertension and 14 kidney guidelines that we reviewed. Hypertension, Ahead of Print.
We examined trends in incidence, urgent dialysis, mortality, and its riskfactors using Poisson regression models. RESULTS:The median age of the patients was 76 years, and 54.9% were women. Urgent dialysis rates increased from 1.52% (95% CI, 1.12–2.06) 2.06) to 2.60% (2.17–3.1;
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