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Meta-analysis on the main outcomes of angiotensin receptorneprilysin inhibitor (ARNI) in heart failure (HF) patients with end-stage kidneydisease (ESKD) on dialysis. However, the evidence on the benefits of ARNI in HF patients with end-stage kidneydisease (ESKD) undergoing dialysis is limited.
Patients with heart failure and mildly reduced or preservedejectionfraction (HFmrEF/HFpEF) have a high risk of developing LRTI. CI, confidence interval; HR, hazard ratio. Aims Lower respiratory tract infections (LRTI) are common worldwide. Patients who developed LRTI had a 2.7-fold
Spironolactone reduced HF events in some patients with HF with preservedejectionfraction, but the results were not generalizable to all patients with HF with preservedejectionfraction. The use of MRAs has been limited due to excessive concern about hyperkalemia.
Additionally, 10% of the global population suffers from chronic kidneydisease , with diabetes and hypertension as significant risk factors. Disparities in care are also concerning, with diagnosed cardiometabolic diseases varying up to twofold among different racial and ethnic groups. In the U.S.,
HF with preservedejectionfraction (HFpEF) was the most common phenotype and increased significantly compared with the first period (46.3% Frailty, chronic kidneydisease and ischaemic heart disease increased significantly versus the first period (p<0.001). and 29.2%, p<0.001).
4] More recently, at least at the epidemiologic level, the obesity paradox has been confirmed in both heart failure with reduced ejectionfraction (HFrEF) and heart failure with preservedejectionfraction (HFpEF), but also in those with coronary heart disease. [5, Carbone, Salvatore, et al. 2017): 451-463.
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