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(MedPage Today) -- The FDA approved semaglutide (Ozempic) to reduce the risk of kidneydisease worsening, kidney failure, and death due to cardiovascular disease in adults with type 2 diabetes and chronic kidneydisease (CKD), making it the only.
Stanford University School of Medicineled researchers have found that intensive blood pressure (BP) control produces cardiovascular benefits and increases the risk of adverse events in people with chronic kidneydisease (CKD).
Hiddo Heerspink, PhD, PharmD, joins the podcast during Kidney Week 2024 to discuss the SMART trial and the potential of semaglutide in people with kidneydisease without diabetes.
mg reduced major kidneydisease events and slowed eGFR decline in patients with type 2 diabetes and chronic kidneydisease, according to the FLOW trial. Semaglutide 1.0
Diabetic kidneydisease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and a.
The new guidance reviews existing tools for weight management and provides recommendations for their use in clinical practice in patients with obesity and kidneydisease.
Nehad Soloman, MD, FACR; Andrew Sharobeem, DO, FACR, and Sunil Patel, MD, explore the nephrologist's vital role in gout diagnosis, treatment options for gout patients with chronic kidneydisease, and strategies for managing refractory gout and its associated challenges.
Check out this quiz on the NKF's KDOQI recommendations on nutrition in chronic kidneydisease, with a focus on their guidance for protein and energy intake!
Obesity was linked to an increased risk of focal segmental glomerulosclerosis and hypertensive nephropathy, with further analysis revealing its impact on the risk of developing end-stage kidneydisease.
Findings from the retrospective cohort study suggest an increased prevalence of advanced kidneydisease among individuals with Crohn disease and ulcerative colitis.
The consensus calls for the recognition of kidneydisease as a major non-communicable disease driver of premature mortality by the World Health Organization.
(MedPage Today) -- SGLT2 inhibitors significantly lowered the risk of death, major adverse kidney events (MAKE), and major adverse cardiovascular events (MACE) in people with type 2 diabetes and acute kidneydisease, according to a cohort study.
Research objectiveThis study is based on bioinformatics analysis to explore the co-expressed differentially expressed genes (DEGs) between atrial fibrillation (AF) and chronic kidneydisease (CKD), identify the biomarkers for the occurrence and development of the two diseases, investigate the potential connections between AF and CKD, and explore the (..)
Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the excess risk of kidneydisease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and G2 cause kidneydisease is poorly understood.
Compared to nonusers, patients with type 2 diabetes and acute kidneydisease administered SGLT-2is had a significantly lower risk of mortality, major adverse kidney events, and major adverse cardiovascular events.
Research Highlights: A study of nearly 4 million young adults under age 40 in South Korea found that those who had ideal cardiovascular health were nearly two-thirds less likely to develop heart disease, stroke and/or kidneydisease during a 12-year.
Limited evidence supports apixaban's use for atrial fibrillation (Af) in severe chronic kidneydisease (CKD) or end-stage kidneydisease (ESKD) patients, where warfarin is often contraindicated.
(MedPage Today) -- The dual SGLT1/2 inhibitor sotagliflozin (Inpefa) reduced the risk for myocardial infarction (MI) and stroke in high-risk patients with type 2 diabetes (T2D), chronic kidneydisease (CKD), and cardiovascular risk factors, a prespecified.
DALLAS, March 24, 2025 Globally, the rate of death from chronic kidneydisease increased 24% from 1990 to 2021, according to statistics published by the American Heart Association, a global force changing the future of health for all. The rise in.
Worldwide, over 800 million people are affected by kidneydisease, yet its pathogenesis remains elusive, hindering the development of novel therapeutics. Lipid accumulation and the expression of genes related to DNL were elevated in the kidneys of patients with fibrosis.
The dapagliflozin group had an average eGFR rate of -2.24 mL/min/1.73 m2 compared to -3.67 mL/min/1.73 m2 in the control group after about 1.5 years of follow-up.
The sNDA for furosemide seeks to expand the indication to include the treatment of edema due to fluid overload in patients with CKD, with a PDUFA date of March 6, 2025.
People living with diabetes mellitus (DM) and chronic kidneydisease (CKD) are at significantly high risk of cardiovascular events (CVEs), however the predictive performance of traditional risk prediction meth.
An analysis of more than 800 IgAN patients treated from 2002-2021 provides an overview of factors associated with anmeia as well as its impact on pgronosis.
Spigler provides insight into the development of new patient-focused guidelines for managing hyperkalemia in CKD and the importance of providing patients with such resources.
Patients with chronic kidneydisease (CKD) and heart failure have higher rates of inpatient dialysis initiation than those without heart failure, according to a study published online Feb. 18 in Mayo Clinic Proceedings.
Ten percent of the population worldwide suffers from chronic kidneydisease (CKD), but the mechanisms driving CKD pathology are incompletely understood. Identify acyl-CoA synthetase short-chain family 2 (ACSS2) as a disease risk gene and demonstrate a role for ACSS2 in de novo lipogenesis (DNL).
Mineralocorticoid receptor antagonists (MRAs) are often underutilized in patients with heart failure (HF), particularly those with diabetes and/or chronic kidneydisease (CKD). However, the impact of concurren.
BackgroundInhibition of prostaglandin synthesis by nonsteroidal anti‐inflammatory drugs is associated with cardiovascular mortality and kidneydisease. Future studies should address whether these associations are causal and can be targeted to improve cardiovascular and kidney outcomes.
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