Exploring the Interplay Between Chronic Kidney Disease and Cardiovascular Disease
HCPLive
OCTOBER 31, 2024
In this first of this 5-part series, Lerma and Lala-Trindade discuss the interplay between chronic kidney disease and cardiovascular disease.
Kidney Disease Related Topics 
Vitamin D Deficiency More Common in Lupus Nephritis Than Lupus Without Kidney Disease
HCPLive
NOVEMBER 25, 2024
Hypovitaminosis D was more prevalent in patients with lupus nephritis compared to patients with systemic lupus erythematosus without kidney disease.
Kidney Disease 
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Kidney Compass: Semaglutide for Nondiabetic Kidney Disease, with Hiddo Heerspink, PhD, PharmD, at Kidney Week 2024
HCPLive
OCTOBER 27, 2024
Hiddo Heerspink, PhD, PharmD, joins the podcast during Kidney Week 2024 to discuss the SMART trial and the potential of semaglutide in people with kidney disease without diabetes.
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FLOW Trial Fortifies Semaglutide's Role in Chronic Kidney Disease and Type 2 Diabetes
HCPLive
MAY 24, 2024
mg reduced major kidney disease events and slowed eGFR decline in patients with type 2 diabetes and chronic kidney disease, according to the FLOW trial. Semaglutide 1.0
Kidney Disease 116
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Diagnosis of Crohn’s Disease Linked to Chronic Kidney Disease Risk
HCPLive
MAY 18, 2024
A diagnosis of chronic kidney disease was approximately 3-times more likely in Crohn's disease than in ulcerative colitis.
Kidney Disease 111
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Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial
Cardiovascular Diabetology
AUGUST 23, 2024
Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and a.
Kidney Disease 129
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Obesity Associated With Renal Function Decline, Kidney Disease Risk
HCPLive
FEBRUARY 2, 2024
Obesity was linked to an increased risk of focal segmental glomerulosclerosis and hypertensive nephropathy, with further analysis revealing its impact on the risk of developing end-stage kidney disease.
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IgAN, Kidney Disease Common Among Patients with Inflammatory Bowel Disease
HCPLive
JANUARY 23, 2024
Findings from the retrospective cohort study suggest an increased prevalence of advanced kidney disease among individuals with Crohn disease and ulcerative colitis.
Kidney Disease 105
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ASN Releases New Guidance on Obesity Management in Kidney Disease
HCPLive
SEPTEMBER 18, 2024
The new guidance reviews existing tools for weight management and provides recommendations for their use in clinical practice in patients with obesity and kidney disease.
Kidney Disease 104
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Quantifying variant contributions in cystic kidney disease using national-scale whole-genome sequencing
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
of cases, a qualifying potentially disease-causing rare variant in an established gene was found.
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In Acute Kidney Disease, SGLT2 inhibitors Were All-Around Protective
Med Page Today
JANUARY 4, 2024
(MedPage Today) -- SGLT2 inhibitors significantly lowered the risk of death, major adverse kidney events (MAKE), and major adverse cardiovascular events (MACE) in people with type 2 diabetes and acute kidney disease, according to a cohort study.
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Moving Beyond the Joint: The Interplay Between Gout and Kidney Disease
HCPLive
SEPTEMBER 20, 2024
Nehad Soloman, MD, FACR; Andrew Sharobeem, DO, FACR, and Sunil Patel, MD, explore the nephrologist's vital role in gout diagnosis, treatment options for gout patients with chronic kidney disease, and strategies for managing refractory gout and its associated challenges.
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Clinical Quiz: Protein and Energy Intake in Chronic Kidney Disease from KDOQI Guidelines
HCPLive
MAY 17, 2024
Check out this quiz on the NKF's KDOQI recommendations on nutrition in chronic kidney disease, with a focus on their guidance for protein and energy intake!
Kidney Disease 104
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APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and G2 cause kidney disease is poorly understood.
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International Consensus Statement Calls for Prioritization of Kidney Disease by the WHO
HCPLive
APRIL 17, 2024
The consensus calls for the recognition of kidney disease as a major non-communicable disease driver of premature mortality by the World Health Organization.
SGLT-2is Mitigate Risk of Cardiovascular, Kidney Diseases in Patients with Type 2 Diabetes and AKD
HCPLive
JANUARY 4, 2024
Compared to nonusers, patients with type 2 diabetes and acute kidney disease administered SGLT-2is had a significantly lower risk of mortality, major adverse kidney events, and major adverse cardiovascular events.
Kidney Disease 104
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Gut Microbiota Dysbiosis Significantly Influences Chronic Kidney Disease Progression
HCPLive
DECEMBER 14, 2023
Microbiota-based interventions may be a novel strategy to benefit the mitigation of chronic kidney disease advancement.
Adults younger than 40 with ideal heart health had lower heart disease, stroke, and kidney disease risk
American Heart News - Heart News
MARCH 21, 2024
Research Highlights: A study of nearly 4 million young adults under age 40 in South Korea found that those who had ideal cardiovascular health were nearly two-thirds less likely to develop heart disease, stroke and/or kidney disease during a 12-year.
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ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis remains elusive, hindering the development of novel therapeutics. Lipid accumulation and the expression of genes related to DNL were elevated in the kidneys of patients with fibrosis.
Heart failure causally linked to chronic kidney disease
Medical Xpress - Cardiology
DECEMBER 19, 2023
Heart failure is causally associated with chronic kidney disease (CKD), according to a study published online Dec. 11 in PLOS ONE.
Targeting de novo lipogenesis to mitigate kidney disease
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Ten percent of the population worldwide suffers from chronic kidney disease (CKD), but the mechanisms driving CKD pathology are incompletely understood. Identify acyl-CoA synthetase short-chain family 2 (ACSS2) as a disease risk gene and demonstrate a role for ACSS2 in de novo lipogenesis (DNL).
Finerenone Treatment Slows Chronic Kidney Disease Progression After Heart Failure Hospitalization
HCPLive
MAY 20, 2024
A numerically slower decline in eGFR was reported in the finerenone cohort after hospitalization for heart failure when compared with placebo.
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Don't Miss a Beat: Semaglutide and the Future of Kidney Disease, with Brendon Neuen, MBBS, PhD
HCPLive
MAY 29, 2024
Brendon Neuen, MBBS, PhD, joins the podcast to discuss the latest updates in nephrology, including the landmark FLOW trial.
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Depagliflozin Lowers Risk of Decline in Late-Stage Kidney Disease
HCPLive
OCTOBER 26, 2024
The dapagliflozin group had an average eGFR rate of -2.24 mL/min/1.73 m2 compared to -3.67 mL/min/1.73 m2 in the control group after about 1.5 years of follow-up.
Kidney Disease 111
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Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease
Journal of the American Heart Association
FEBRUARY 16, 2024
BackgroundInhibition of prostaglandin synthesis by nonsteroidal anti‐inflammatory drugs is associated with cardiovascular mortality and kidney disease. Future studies should address whether these associations are causal and can be targeted to improve cardiovascular and kidney outcomes.
FDA Accepts sNDA for Furosemide (Furoscix) in Chronic Kidney Disease
HCPLive
JULY 25, 2024
The sNDA for furosemide seeks to expand the indication to include the treatment of edema due to fluid overload in patients with CKD, with a PDUFA date of March 6, 2025.
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Anemia Increases Risk of End-Stage Kidney Disease in IgA Nephropathy
HCPLive
MAY 27, 2024
An analysis of more than 800 IgAN patients treated from 2002-2021 provides an overview of factors associated with anmeia as well as its impact on pgronosis.
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Empowering Patients with Educational Resources for Kidney Disease, with Mike Spigler
HCPLive
JULY 23, 2024
Spigler provides insight into the development of new patient-focused guidelines for managing hyperkalemia in CKD and the importance of providing patients with such resources.
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People With Psoriatic Arthritis at Risk For Chronic Kidney Disease
HCPLive
NOVEMBER 13, 2024
People with diabetes, kidney stones, damaged joints, high uric acids, and daily use of NSAID were more likely to develop CKD than others.
Kidney Disease 105
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Hemoglobin Levels Predict Renal Outcomes in Diabetic Kidney Disease
HCPLive
MARCH 26, 2024
A study in China identified a negative and non-linear relationship between hemoglobin levels and a renal composite end point in patients with DKD.
Structural Racism Linked to Increased Prevalence of Kidney Disease, Diabetes, & Cardiovascular Disease
HCPLive
DECEMBER 21, 2023
A new study is raising awareness around the effects of structural racism on the prevalence of chronic health conditions.
Kidney Disease 122
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Tricuspid Regurgitation Velocity Linked to Cerebrovascular, Kidney Disease in SCD
HCPLive
APRIL 26, 2024
A higher TRV was significantly associated with cerebrovascular disease and persistent albuminuria in children with SCD across two large cohorts.
The Critical Role of RAASi Therapy in Chronic Kidney Disease, with Wei Ling Lau, MD
HCPLive
MAY 18, 2024
Wei Ling Lau, MD, explains the importance of medication adherence to maximize the benefits of RAASi therapy.
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BMI in Late Adolescence Linked to Early Chronic Kidney Disease
HCPLive
DECEMBER 14, 2023
These results highlight the potential of preventing increasing CKD burden and of preventing subsequent cardiovascular conditions, especially given current rates of obesity among adolescents.
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Adeno-associated virus–based gene therapy treats inflammatory kidney disease in mice
Journal of Clinical Investigation - Cardiology
SEPTEMBER 3, 2024
The development of AAV2-GEC and its successful application in the treatment of antibody-mediated kidney disease represents a significant step forward and opens up promising avenues for kidney medicine. Taken together, this study showcases the potential of AAV as a gene delivery platform for challenging cell types.
Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study
Cardiovascular Diabetology
APRIL 9, 2024
Hypertension and chronic kidney disease (CKD) pose significant public health challenges, sharing intertwined pathophysiological mechanisms. Prediabetes is recognized as a precursor to diabetes and is often acc.
Insulin sensitivity estimates and their longitudinal association with coronary artery disease in type 1 diabetes. Does it matter?
Cardiovascular Diabetology
MAY 2, 2024
Insulin resistance and chronic kidney disease are both associated with increased coronary artery disease risk. Many formulae estimating glucose disposal rate in type 1 diabetes infer insulin sensitivity from c.
Empagliflozin Benefits on Kidney Disease Progression, Death Continue for 1 Year Post-Discontinuation
HCPLive
OCTOBER 25, 2024
After discontinuing therapy, treated participants still had an overall 13% reduction in the risk of kidney disease progression or cardiovascular death.
Integration of Cardiovascular Care Into CKD Management
HCPLive
DECEMBER 9, 2024
Panelists discuss the role of cardiovascular risk management for patients with chronic kidney disease (CKD) and how cardiovascular care can be effectively integrated into CKD management strategies.
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Remote monitoring and pharmacist helped improve hard-to-control blood pressure
American Heart News - Heart News
SEPTEMBER 5, 2024
Research Highlights: A new study finds that up to 74% of participants with resistant or difficult-to-control high blood pressure, including those with chronic kidney disease, were able to improve control of their blood pressure within 12 months after.
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Prognostic potential of inflammatory markers in chronic kidney disease patients combined with acute myocardial infarction
Frontiers in Cardiovascular Medicine
DECEMBER 18, 2024
BackgroundInflammation significantly impacts chronic kidney disease (CKD) and acute myocardial infarction (AMI).
Associations between cardiometabolic indices and the risk of diabetic kidney disease in patients with type 2 diabetes
Cardiovascular Diabetology
APRIL 24, 2024
This study was designed to assess the associations between emerging cardiometabolic indices—the atherogenic index of plasma (AIP), the stress hyperglycemia ratio (SHR), the triglyceride-glucose (TyG) index, an.
Association of long-term triglyceride-glucose index patterns with the incidence of chronic kidney disease among non-diabetic population: evidence from a functional community cohort
Cardiovascular Diabetology
JANUARY 2, 2024
The triglyceride-glucose (TyG) index is a reliable surrogate marker of insulin resistance and previous studies have confirmed the association of TyG index with incident chronic kidney disease (CKD). However, t.
Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists
Journal of Clinical Investigation - Cardiology
JANUARY 2, 2024
Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. This gene signature also showed a potential for classifying human kidney samples. In our study, we used single-cell expression and chromatin accessibility tools to characterize the mineralocorticoid target genes and cell types.
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