Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP365-ATP365, February 1, 2025. Introduction:Polymorphonuclear leukocytes (PMNs) are among the first leukocytes recruited to the infarct following reperfusion in ischemic stroke. Infarct size was determined via triphenyl tetrazolium chloride staining.

Ischemia 40

Ischemia Stroke Strokes Circulation 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP309-ATP309, February 1, 2024. Background and Purpose:Neutrophils are the first recruited leukocytes following ischemia/reperfusion injury in the brain; however, when and where neutrophils enter the brain parenchyma to exert their effects is controversial.

Ischemia 40

Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP371-AWP371, February 1, 2025. The significance of cranial bone marrow-derived leukocytes following ischemic stroke in the setting of ischemia/reperfusion remains uncertain.

Ischemia 40

Ischemia Circulation Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A113-A113, February 1, 2025. Background:Early detection and intervention of cerebral ischemia is critical to improving patient outcomes. This method has the potential to identify ischemic changes and facilitate expeditious intervention.

Ischemia 40

Ischemia Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP399-AWP399, February 1, 2025. Background:The neuroinflammation triggered by acute cerebral ischemia can be mediated through inflammasome such as NLRP3 (NOD-like receptor family, pyrin domain containing 3) and ASC (apoptosis-associated speck-like protein). 17/Icr-Jcl mice in this experiment.

Ischemia 40

Ischemia Stenosis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP317-ATP317, February 1, 2024. Background and rationale:Smooth muscle cell-specific cGK1 knock-out mice (SMKO) due to impaired blood vessel motility is a leading cause of reduced blood flow in ischemic stroke. Not only SMLC but also SMKO were the same.

Ischemia 40

Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP357-ATP357, February 1, 2025. Background:Despite the effectiveness of immediate treatment, such as thrombolytic therapy, after a stroke, many patients are unable to benefit due to time restrictions. In cases of acute ischemia, training improved complications and reduced glial activation.

Ischemia 40

Ischemia Dementia Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 17, 2025

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDIn people with suspected stroke the first assessment occurs under time pressure in the emergency department and is based solely on clinical information. Vessel occlusion was found in 227 of 410 people with ischemic stroke.

Hemorrhage 75

Hemorrhage Stroke Strokes Ischemia 75

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP325-AWP325, February 1, 2024. miR-155-5p ASO-treated PBMC administration increased VEGF expression 21 d after administration in ischemic rats (28 d after cerebral ischemia).

Ischemia 40

Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025. Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH.

Ischemia 40

Ischemia Hemorrhage Biomarkers Aneurysm 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A157-A157, February 1, 2025. Experimental diffuse cortical ischemia was induced in Aldh1l1-Cre-ert2/MetRS-floxed mice via a 20-minute bilateral common carotid artery occlusion (BCCAO), followed by 3-week Anl water supplementation.

Ischemia 40

Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP368-ATP368, February 1, 2025. Ischemic stroke affects more than 600,000 Americans annually. Brain edema in the acute phase of ischemia-reperfusion primarily associates with early-stage neurovascular damage and plays a major role in poor outcomes of stroke.

Stroke 40

Stroke Strokes Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target to prevent delayed cerebral ischemia in mice (DCI) with SAH. nucleosome.

Aneurysm 40

Aneurysm Biomarkers Ischemia Hemorrhage 40

Stroke Journal

MARCH 6, 2024

Stroke, Ahead of Print. BACKGROUND:Ischemic stroke is often accompanied by oxidative stress and inflammatory response, both of which work synergistically to exacerbate the disruption of the blood-brain barrier and ischemic brain injury. The ALK inhibitor alectinib was administered following the stroke.

Stroke 40

Stroke Strokes Ischemia Cancer 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 19, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. Acute ischemic stroke is a leading cause for neurological disability worldwide, and treatment strategies are rapidly evolving. Patient selection for recanalization therapy and postintervention management relies heavily on diagnostic imaging.

Stroke 40

Stroke Strokes Ischemia Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP112-AWMP112, February 1, 2024. Following ischemic stroke, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs). In this study, our hypothesis was that NETs cause vascular occlusion leading to delayed cerebral ischemia (DCI) and worse outcome after SAH.

Ischemia 40

Ischemia Hemorrhage Aneurysm Outcomes 40

Stroke Journal

MARCH 31, 2025

Stroke, Ahead of Print. Preventing or reversing no-reflow has the potential to augment the clinical benefit of reperfusion treatment in ischemic stroke. BACKGROUND:Tissue-level hypoperfusion (no-reflow) persists in 30% of patients with seemingly successful upstream angiographic recanalization at thrombectomy.

Stroke 74

Stroke Strokes Outcomes Ischemia 74

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP233-ATP233, February 1, 2025. While nearly all stroke patients undergo neuroimaging during acute triage, many patients do not initially present to EVT-capable centers, and interhospital transfer for the EVT procedure can result in significant time delays. hours from initial neuroimaging.

Stroke 40

Stroke Strokes Ischemia Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A103-A103, February 1, 2024. Introduction:Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult after stroke. However, the microglial heterogeneity and the underlying mechanisms remain unclear.

Ischemia 40

Ischemia Pharmacology Stroke Strokes 40

HeartRhythm

APRIL 30, 2024

Strokes and silent ischemia remain a serious complication of atrial fibrillation catheter ablation (AFCA). This is mainly due to extensive ablation lesions in the left atrium that create large areas of endothelial injury that produces prothrombotic states during and after AFCA.

Atrial Fibrillation 40

Atrial Fibrillation Ablation Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP29-ADP29, February 1, 2025. Introduction:The potential role of tRNA derived fragment (tRF&tiRNA) in ischemic stroke remains largely unknown. Small RNA sequencing analyses were conducted to explore the differentially expressed tRNA derived fragments.

Ischemia 40

Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP20-AWMP20, February 1, 2025. Background:Neuronal circuitry remodeling which compromises excitatory and inhibitory neurons is critical to improve neurological outcome after stroke.

Stroke 40

Stroke Strokes Ischemia Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP303-AWP303, February 1, 2024. Introduction:Chronic hypertension decreases collateral blood flow through leptomeningeal anastomoses (LMAs) during ischemic stroke, which has been linked to worsened stroke outcome. mmHg at 60 min. However, oxygenation did not recover in SHR (5.9±0.23

Hypertension 40

Hypertension Stroke Strokes Ischemia 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP296-AWP296, February 1, 2024. Introduction:Stroke patients with type-2 diabetes exhibit exacerbated cerebrovascular dysfunction and increased neurological deficits compared to non-diabetic stroke patients.

Diabetes 40

Diabetes Stroke Strokes Ischemia 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A45-A45, February 1, 2024. Introduction:Telestroke enables timely and remote evaluation of patients with acute stroke syndromes. However, stroke mimics represent more than 30% of this population. To predict stroke mimic, TS had the highest AUC (68.3)

Academic 40

Academic Stroke Strokes Ischemia 40

Stroke Journal

NOVEMBER 9, 2023

Stroke, Volume 54, Issue 12 , Page 3190-3201, December 1, 2023. STAIR XII (12th Stroke Treatment Academy Industry Roundtable) included a workshop to discuss the priorities for advancements in neuroimaging in the diagnostic workup of acute ischemic stroke.

Stroke 40

Stroke Strokes Academic Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP372-AWP372, February 1, 2025. Introduction:Recent advances in brain cytoprotection therapies following cerebral ischemia-reperfusion (I/R) injury have become an emerging interest.

Ischemia 40

Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP115-AWMP115, February 1, 2025. Intro:Resources for studying stroke are limited to clinical trials with sparse access to physiological and biochemical details, and pre-clinical animal studies with limited relation to humans. International Stroke Conference, February 7-9 2024, Phoenix2.

Stroke 40

Stroke Strokes Physiology Ischemia 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP287-ATP287, February 1, 2024. Introduction:Previous stroke studies in female rodents have demonstrated that the severity of ischemic damage is differentially impacted by the estrous cycle. Keywords: stroke, estrous cycle, CBF, estrogen

Stroke 40

Stroke Strokes Ischemia 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP9-AWP9, February 1, 2024. Introduction:Early neurologic deterioration (END) and poor functional outcomes are more frequent with night than daytime onset of ischemic stroke. female, initial NIHSS 7 (IQR 2-15), LKW to randomization 59 mins (IQR 46-80), and 473 (38%) treated with IV lytics.

Stroke 40

Stroke Strokes Ischemia Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. This is secondary to delayed postoperative cerebral ischemia and infarction caused by vasospasm.7 This is secondary to delayed postoperative cerebral ischemia and infarction caused by vasospasm.7 compared to a median age of 55 (44.0‐64.0)

Aneurysm 40

Aneurysm Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP372-ATP372, February 1, 2025. Introduction:Ischemic stroke is highly heterogeneous, with patient-to-patient differences in infarct location, severity, and degree of reperfusion, among other factors.

Physiology 40

Physiology Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP26-ADP26, February 1, 2025. The function of these novel RNAs within the post-stroke brain remains virtually unexplored. Results:We discovered 46 eSINE-RNAs upregulated in the cortex following MCAO, 33 of which were unique to stroke and not detected in the sham group.

Stroke 40

Stroke Strokes Outcomes Ablation 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A90-A90, February 1, 2025. Introduction:Post-Stroke Cognitive Impairment (PSCI) is increasingly recognized as a major factor in long-term disability. Therefore, new therapies that enhance post-stroke brain function (plasticity) are appealing in translational research.

Ischemia 40

Ischemia Stroke Strokes Research 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP119-ATP119, February 1, 2024. Introduction:“Stroke code” activation is a uniform process to summon healthcare stakeholders to orchestrate the rapid sequential steps for urgent management in patients with possible stroke.

Circulation 40

Circulation Stroke Strokes Ischemia 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 1, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. Patients transported to a more distant Thrombectomy Stroke Center traveled an average of 5.7 Patients transported to a more distant Thrombectomy Stroke Center traveled an average of 5.7 minutes shorter. minutes shorter.

Stroke 40

Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. Investigating the post-reperfusion inflammatory milieu could provide valuable insights into the mechanisms that influence stroke outcomes.

Biomarkers 40

Biomarkers Stroke Strokes Ischemia 40