Stroke Journal

FEBRUARY 5, 2025

Stroke, Ahead of Print. Conclusion:These results demonstrate that systemically delivered rGDF11 enhances neovascularization, reduces inflammation, promotes neurogenesis, and improves sensorimotor function post-injury in a rat model of ischemic stroke. All six studies revealed consistent improvement of sensorimotor outcomes with rGDF11.

Ischemia 45

Ischemia Strokes Stroke Biomarkers 45

ECG Cases

SEPTEMBER 12, 2023

Jesse MacLaren guides us through 10 cases of patients who present with generalized weakness or acute neurologic symptoms and discusses how to look for ECG signs of dysrhythmias, electrolyte emergencies, acute coronary occlusion, and demand ischemia in patients with generalized weakness and in patients with neurologic symptoms, to consider predisposing (..)

Dysrhythmia 131

Dysrhythmia Atrial Fibrillation Embolism Blog 131

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP12-AWMP12, February 1, 2024. Background:Malonate, a competitive inhibitor of succinate dehydrogenase, has shown much promise in ameliorating ischemia/reperfusion injury (IRI) in various diseases, including ischemic stroke. or low pH (6.0).

Ischemia 40

Ischemia Strokes Stroke Physiology 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP376-ATP376, February 1, 2025. The study was aimed to test the effects of GSNO in ischemia/reperfusion (I/R) Injury through relieving thrombo-inflammation.Methods:Male C57BL/6 mice (n=160) were 10-week-old (20-25 g) at the time of surgery.

Ischemia 40

Ischemia Strokes Stroke Hospital 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP395-AWP395, February 1, 2025. Introduction:Polymorphonuclear Neutrophils (PMNs) are the first blood-derived immune cells to respond in ischemia/reperfusion injury (I/RI). Mice were subject to 60 min or 90 min of ischemia to model strokes of varying severity.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP365-ATP365, February 1, 2025. Introduction:Polymorphonuclear leukocytes (PMNs) are among the first leukocytes recruited to the infarct following reperfusion in ischemic stroke. Infarct size was determined via triphenyl tetrazolium chloride staining.

Ischemia 40

Ischemia Strokes Stroke Circulation 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP354-ATP354, February 1, 2025. Cell death was examined by histopathology.Results:Autophagic flux was impaired in hippocampal CA1 neurons destined to die after brain ischemia, as indicated by the buildup of p62 and ubiquitinated proteins, depletion of NSF, and buildup of endolysosomal structures.

Ischemia 40

Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP367-AWP367, February 1, 2025. Introduction:Ischemia reperfusion injury (IRI) is a paradoxical and deleterious consequence of current interventions for acute ischemic stroke (AIS).

Ischemia 40

Ischemia Strokes Stroke Aneurysm 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionAcute spinal cord ischemia syndrome (ASCIS) is a rare disease that is thought to comprise roughly only 1.2% of all strokes [1, 2]. Due to the scarcity of these events, the patient outcomes are unclear.

Ischemia 40

Ischemia Myocardial Infarction Thrombosis Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP309-ATP309, February 1, 2024. Background and Purpose:Neutrophils are the first recruited leukocytes following ischemia/reperfusion injury in the brain; however, when and where neutrophils enter the brain parenchyma to exert their effects is controversial.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP371-AWP371, February 1, 2025. The significance of cranial bone marrow-derived leukocytes following ischemic stroke in the setting of ischemia/reperfusion remains uncertain.

Ischemia 40

Ischemia Circulation Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A113-A113, February 1, 2025. Background:Early detection and intervention of cerebral ischemia is critical to improving patient outcomes. This method has the potential to identify ischemic changes and facilitate expeditious intervention.

Ischemia 40

Ischemia Strokes Stroke Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP399-AWP399, February 1, 2025. Background:The neuroinflammation triggered by acute cerebral ischemia can be mediated through inflammasome such as NLRP3 (NOD-like receptor family, pyrin domain containing 3) and ASC (apoptosis-associated speck-like protein). 17/Icr-Jcl mice in this experiment.

Ischemia 40

Ischemia Stenosis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP317-ATP317, February 1, 2024. Background and rationale:Smooth muscle cell-specific cGK1 knock-out mice (SMKO) due to impaired blood vessel motility is a leading cause of reduced blood flow in ischemic stroke. Not only SMLC but also SMKO were the same.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP357-ATP357, February 1, 2025. Background:Despite the effectiveness of immediate treatment, such as thrombolytic therapy, after a stroke, many patients are unable to benefit due to time restrictions. In cases of acute ischemia, training improved complications and reduced glial activation.

Ischemia 40

Ischemia Dementia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP395-ATP395, February 1, 2025. Introduction:Ischemic stroke is one of the leading causes of death in the United States and is a known risk factor for Alzheimers Disease (AD) development.

Ischemia 40

Ischemia Risk Factors Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP32-ATP32, February 1, 2024. Ischemic stroke occurs when the blood supply to the brain is interrupted, reducing the access of affected tissue to oxygen and glucose. This study aims to understand the role of SIRT3 on ischemia and reperfusion-induced neuronal apoptosis.

Ischemia 40

Ischemia Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 17, 2025

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDIn people with suspected stroke the first assessment occurs under time pressure in the emergency department and is based solely on clinical information. Vessel occlusion was found in 227 of 410 people with ischemic stroke.

Hemorrhage 75

Hemorrhage Strokes Stroke Ischemia 75

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP325-AWP325, February 1, 2024. miR-155-5p ASO-treated PBMC administration increased VEGF expression 21 d after administration in ischemic rats (28 d after cerebral ischemia).

Ischemia 40

Ischemia Stroke Strokes 40

American College of Cardiology

OCTOBER 29, 2024

Both acute and long-term colchicine use to treat patients with acute myocardial infarction (MI) did not reduce cardiovascular death, myocardial infarction, stroke or ischemia-driven revascularization.

Myocardial Infarction 58

Myocardial Infarction Research Ischemia Strokes 58

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025. Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH.

Ischemia 40

Ischemia Hemorrhage Biomarkers Aneurysm 40

DAIC

MAY 16, 2024

A new joint guideline from the American Heart Association (AHA), the American College of Cardiology (ACC) and nine other medical societies reports early diagnosis and treatment of peripheral artery disease is essential to improve outcomes and reduce amputation risk, heart attack, stroke and death for people with Peripheral Artery Disease (PAD).

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Ischemia Quality of Life 105

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A157-A157, February 1, 2025. Experimental diffuse cortical ischemia was induced in Aldh1l1-Cre-ert2/MetRS-floxed mice via a 20-minute bilateral common carotid artery occlusion (BCCAO), followed by 3-week Anl water supplementation.

Ischemia 40

Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target to prevent delayed cerebral ischemia in mice (DCI) with SAH. nucleosome.

Aneurysm 40

Aneurysm Biomarkers Ischemia Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP368-ATP368, February 1, 2025. Ischemic stroke affects more than 600,000 Americans annually. Brain edema in the acute phase of ischemia-reperfusion primarily associates with early-stage neurovascular damage and plays a major role in poor outcomes of stroke.

Strokes 40

Strokes Stroke Ischemia Outcomes 40

Stroke Journal

MARCH 31, 2025

Stroke, Ahead of Print. Preventing or reversing no-reflow has the potential to augment the clinical benefit of reperfusion treatment in ischemic stroke. BACKGROUND:Tissue-level hypoperfusion (no-reflow) persists in 30% of patients with seemingly successful upstream angiographic recanalization at thrombectomy.

Stroke 74

Stroke Strokes Outcomes Ischemia 74

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP112-AWMP112, February 1, 2024. Following ischemic stroke, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs). In this study, our hypothesis was that NETs cause vascular occlusion leading to delayed cerebral ischemia (DCI) and worse outcome after SAH.

Ischemia 40

Ischemia Hemorrhage Aneurysm Outcomes 40

Stroke Journal

MARCH 6, 2024

Stroke, Ahead of Print. BACKGROUND:Ischemic stroke is often accompanied by oxidative stress and inflammatory response, both of which work synergistically to exacerbate the disruption of the blood-brain barrier and ischemic brain injury. The ALK inhibitor alectinib was administered following the stroke.

Strokes 40

Strokes Stroke Ischemia Cancer 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 19, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. Acute ischemic stroke is a leading cause for neurological disability worldwide, and treatment strategies are rapidly evolving. Patient selection for recanalization therapy and postintervention management relies heavily on diagnostic imaging.

Strokes 40

Strokes Stroke Ischemia Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP233-ATP233, February 1, 2025. While nearly all stroke patients undergo neuroimaging during acute triage, many patients do not initially present to EVT-capable centers, and interhospital transfer for the EVT procedure can result in significant time delays. hours from initial neuroimaging.

Strokes 40

Strokes Stroke Ischemia Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP398-AWP398, February 1, 2025. Background:White matter or axonal injury is a key predictor of long-term functional outcome following ischemic stroke in humans. However, this type of injury is significantly understudied in animal stroke research.

Strokes 40

Strokes Stroke Ischemia Research 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A103-A103, February 1, 2024. Introduction:Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult after stroke. However, the microglial heterogeneity and the underlying mechanisms remain unclear.

Ischemia 40

Ischemia Pharmacology Strokes Stroke 40

HeartRhythm

APRIL 30, 2024

Strokes and silent ischemia remain a serious complication of atrial fibrillation catheter ablation (AFCA). This is mainly due to extensive ablation lesions in the left atrium that create large areas of endothelial injury that produces prothrombotic states during and after AFCA.

Atrial Fibrillation 40

Atrial Fibrillation Ablation Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP400-ATP400, February 1, 2025. Ischemic stroke is a leading cause of death and disability in the US, occurring when the blood supply to an area of the brain is disrupted. Using a combination of Gcamp voltage sensors and EEG. Using a combination of Gcamp voltage sensors and EEG.

Strokes 40

Strokes Stroke Ischemia 40

Dr. Smith's ECG Blog

OCTOBER 25, 2023

A prior ECG was available for comparison: Normal One might be tempted to interpret the ST depression as ischemia, but as Smith says, "when the QT is impossibly long, think of hypokalemia and a U-wave rather than T-wave." QUESTION #2: If it were not for the markedly prolonged QTc — Wouldn't ECG #1 look like diffuse subendocardial ischemia?

Chest Pain 124

Chest Pain Ischemia Cardiac Arrest Blog 124

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP29-ADP29, February 1, 2025. Introduction:The potential role of tRNA derived fragment (tRF&tiRNA) in ischemic stroke remains largely unknown. Small RNA sequencing analyses were conducted to explore the differentially expressed tRNA derived fragments.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP81-AWMP81, February 1, 2025. Background and purpose:Stroke as a world-wide prevalent disease, has brought a huge burden to health care and the national economy, accurate and fast stroke diagnosis can significantly increase reperfusion rate, mitigate disability, and reduce deaths.

Strokes 40

Strokes Stroke Ischemia Hemorrhage 40