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Ischemia with no obstructed coronary arteries and microvascular testing procedures: a review of utility, pharmacotherapy, and current challenges

Frontiers in Cardiovascular Medicine

Ischemia with no obstructive coronary arteries (INOCA) is an increasingly recognized condition in patients presenting with angina and positive stress tests but without significant coronary artery stenosis.

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Cleerly Launches Cleerly ISCHEMIA Solution for Heart Disease Analysis

DAIC

milla1cf Tue, 01/09/2024 - 11:32 January 9, 2024 — Cleerly , the company working to create a new standard of care for the diagnosis of heart disease, announced the launch of Cleerly ISCHEMIA , which recently received U.S. Cleerly ISCHEMIA is a transformative addition poised to reshape the landscape of cardiac care.”

Ischemia 119
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Correlation between CT-derived fractional flow reserve and myocardial strain in ischemic heart disease patients with single coronary artery stenosis assessed based on CCTA

Frontiers in Cardiovascular Medicine

Receiver operator characteristic curve (ROC) analysis indicated that CTFFR were effective in diagnosing impaired myocardial strain, particularly LS.ConclusionThere is a strong correlation between CTFFR, which is a functional measure for assessing coronary artery stenosis, and myocardial strain.

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Dynamic OMI ECG. Negative trops and negative angiogram does not rule out coronary ischemia or ACS.

Dr. Smith's ECG Blog

This confirms that the pain was ischemia and is now resovled. Because the pathologist determines the degree of stenosis by dividing the lumen area by the total area, the degree of stenosis will be overestimated. The angiographer uses a denominator that is too small, thereby underestimating the degree of stenosis.

Ischemia 122
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Elder Male with Syncope

EMS 12-Lead

Many of the changes seen are reminiscent of LVH with “strain,” and downstream Echo may very well corroborate such a suspicion, but since the ECG isn’t the best tool for definitively establishing the presence of LVH, we must favor a subendocardial ischemia pattern, instead. Type I ischemia. He was taken to the Cath Lab.

Ischemia 116
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Robust Diagnostic Accuracy and Prognostic Utility in Analyses from Large Scale Clinical Trials

DAIC

The study describes the validation of Cleerly's artificial intelligence-guided quantitative coronary CT angiography (AI-QCT) ISCHEMIA technology for diagnostic accuracy and prognostic risk stratification. High Diagnostic Accuracy of AI-ISCHEMIA in Comparison to PET, FFR-CT, SPECT, and Invasive FFR: A Pacific Substudy. 2024.01.007.

Ischemia 110
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Electrocardiographic Findings in Diffuse Subendocardial Ischemia

The New England Journal of Medicine

At the hospital, left main coronary-artery stenosis was seen on angiography (shown in a video). In a 57-year-old man with chest pain, an ECG obtained by EMS showed widespread ST-segment depressions.