Remove Ischemia Remove Pharmacology Remove Strokes
article thumbnail

Abstract 103: Acute Ischemia Induces Spatially and Transcriptionally Distinct Microglial Subclusters

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page A103-A103, February 1, 2024. Introduction:Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult after stroke. However, the microglial heterogeneity and the underlying mechanisms remain unclear.

article thumbnail

Downregulation of the HCN1 Channel Alleviates Anxiety‐ and Depression‐Like Behaviors in Mice With Cerebral Ischemia–Reperfusion Injury by Suppressing the NLRP3 Inflammasome

Journal of the American Heart Association

BackgroundPoststroke depression (PSD) is a prevalent neuropsychiatric complication of stroke. HCN channels were downregulated by pharmacological inhibitor or neuronspecific adenoassociated virus. Journal of the American Heart Association, Ahead of Print. However, the mechanisms underlying PSD are still unclear.

article thumbnail

Abstract WP301: STAT3 Inhibition Reduces Infarct and Neuroinflammation in Experimental Stroke

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page AWP301-AWP301, February 1, 2024. Signal Transducer and Activator of Transcription 3 (STAT3) activation is increased in the brain following cerebral ischemia. Interestingly Stattic-treated mice had larger spleens (66.31 ± 5.40 g) compared to vehicle-treated mice (46.43 ± 4.60

Stroke 40
article thumbnail

Long-Term Cognitive Decline After Subarachnoid Hemorrhage: Pathophysiology, Management, and Future Directions

Stroke Journal

Stroke, Ahead of Print. Subarachnoid hemorrhage is a critical neurological condition accounting for about 5% of all strokes, and survivors experience long-term cognitive deterioration and increased risk of dementia. Management techniques reviewed include long-term cognitive health, such as endovascular coiling and surgical clipping.

article thumbnail

Abstract WP322: GluN2A-NMDAR Mediated Increased Neuronal Prostaglandin E2 Release and Microglial Activation Exacerbates Ischemic Brain Injury Under Hyperhomocysteinemic Condition

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page AWP322-AWP322, February 1, 2024. Hyperhomocysteinemia (Hhcy), a metabolic disorder is recognized as a risk factor for ischemic stroke. However, the impact of Hhcy on stroke outcome is not known.

article thumbnail

American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

DAIC

24 will focus on the following three current guideline updates: American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines 2023 Atrial Fibrillation Guideline - Pharmacology II: Strokes vs. Bleeds, What Do the Guidelines Tell Us About Practical Management in A-fib? The Guidelines Sessions at ACC.24

article thumbnail

New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

DAIC

A new joint guideline from the American Heart Association (AHA), the American College of Cardiology (ACC) and nine other medical societies reports early diagnosis and treatment of peripheral artery disease is essential to improve outcomes and reduce amputation risk, heart attack, stroke and death for people with Peripheral Artery Disease (PAD).