Dr. Smith's ECG Blog

NOVEMBER 19, 2016

DISCUSSION: The 12-lead EKG EMS initially obtained for this patient showed severe ischemia, with profound "infero-lateral" ST depression and reciprocal ST elevation in lead aVR. The ECG cannot diagnose the etiology of ischemia; it only the presence of ischemia, from whatever etiology.

Ischemia 40

Ischemia Cardiogenic Shock Aortic Stenosis 40

Journal of the American Heart Association

APRIL 10, 2025

HCN channels were downregulated by pharmacological inhibitor or neuronspecific adenoassociated virus. Four weeks after middle cerebral artery occlusion, anxiety and depressionlike behaviors of mice were evaluated by various behavioral tests.

Ischemia 40

Ischemia Pharmacology Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Finally, the infarct size and neurological deficits were evaluated in MCAO mice after pharmacological manipulation of specific microglial subcluster.Results:We discovered stroke-associated microglial subclusters in MCAO mice.

Ischemia 40

Ischemia Pharmacology Stroke Strokes 40

Stroke Journal

MARCH 4, 2025

The major processes involved in such decline include early brain injury, delayed cerebral ischemia, neuroinflammation, superficial siderosis, and hydrocephalus. Other rehabilitation strategies that enhance cognitive reserve and pharmacological interventions are discussed about improving the quality of life in survivors.

Hemorrhage 40

Hemorrhage Genetic predisposition Genetic Markers Quality of Life 40

Stroke Journal

FEBRUARY 1, 2024

Signal Transducer and Activator of Transcription 3 (STAT3) activation is increased in the brain following cerebral ischemia. STAT3, a transcription factor, is a positive regulator of cell survival and is implicated in cytoprotection following ischemia in multiple cell types, including neurons and endothelial cells.

Stroke 40

Stroke Strokes Pharmacology Ischemia 40

Dr. Smith's ECG Blog

OCTOBER 23, 2023

Alternation in ST segment appearance ( or in the amount of ST elevation or depression ) — is often linked to ischemia. This may result from fluctuations in heart rate or in nervous system activity or from pharmacologic treatment. Repolarization Alternans — entails beat-to-beat variation in the ST segment and/or T wave.

Tachycardia 130

Tachycardia Cardiac Arrest ICU Blog 130

Stroke Journal

FEBRUARY 1, 2024

The findings also showed that Hhcy triggers GluN2A subunit containing NMDA receptor (GluN2A-NMDAR) stimulation that act in conjunction with ischemia-induced pathways involving GluN2B subunit containing NMDAR (GluN2B-NMDAR) stimulation to enhance stroke pathology.

Ischemia 40

Ischemia Pharmacology Stroke Strokes 40

Journal of Cardiovascular Pharmacology

OCTOBER 24, 2024

In the heart, autophagy is regulated mainly through mitophagy due to the metabolic changes of cardiomyocytes caused by ischemia and hypoxia. In the heart, autophagy is regulated mainly through mitophagy due to the metabolic changes of cardiomyocytes caused by ischemia and hypoxia.

Myocardial Infarction 40

Myocardial Infarction Ischemia Heart Failure Heart Disease 40

Journal of Cardiovascular Pharmacology

OCTOBER 9, 2023

Moreover, ALDH2 attenuated ischemia-induced oxidative stress and maintained Trx-1 levels by reducing 4-HNE, thereby promoting AMPK-PGC-1α signaling activation. Inhibiting Trx-1 or AMPK abolished the cardioprotective effect of ALDH2 on ischemia. Inhibiting Trx-1 or AMPK abolished the cardioprotective effect of ALDH2 on ischemia.

Myocardial Infarction 40

Myocardial Infarction Ischemia Article 40

Dr. Smith's ECG Blog

APRIL 22, 2022

ST-elevation myocardial infarction after pharmacologic persantine stress test in a patient with Wellens’ syndrome. We are told that the Stress Echo that was performed showed objective evidence of inducible ischemia ( confirmed apparently by both wall motion abnormalities and ECG changes ). Lancet 2015 6. Case Rep Emerg Med 2014 7.

Chest Pain 52

Chest Pain Ischemia Myocardial Infarction Angina 52

DAIC

FEBRUARY 29, 2024

24 will focus on the following three current guideline updates: American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines 2023 Atrial Fibrillation Guideline - Pharmacology II: Strokes vs. Bleeds, What Do the Guidelines Tell Us About Practical Management in A-fib? The Guidelines Sessions at ACC.24

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

Journal of Cardiovascular Pharmacology

MARCH 13, 2024

Specifically, CBD has shown promise in managing pain, moderating immune responses, and mitigating ischemia/reperfusion injury, underscoring its potential in postoperative care.

Open-Heart Surgery 40

Open-Heart Surgery Research Physiology Ischemia 40

Journal of Cardiovascular Pharmacology

FEBRUARY 28, 2024

The NNA-activating effects included increased resilience to ischemia, modulation of energy metabolism preference, and activation of angiogenesis. The NNA-activating effects included increased resilience to ischemia, modulation of energy metabolism preference, and activation of angiogenesis.

Cardiac Function 40

Cardiac Function Ischemia Article 40

Journal of Cardiovascular Pharmacology

NOVEMBER 16, 2023

The ischemia/reperfusion (I/R) injury mouse model and hypoxia/reoxygenation (H/R) cell model were established. The ischemia/reperfusion (I/R) injury mouse model and hypoxia/reoxygenation (H/R) cell model were established. In this study, we investigated the effects of demethylase ALKBH5 on cell apoptosis and oxidative stress in MI.

Myocardial Infarction 40

Myocardial Infarction Cardiac Function Ischemia Article 40

Journal of Cardiovascular Pharmacology

FEBRUARY 7, 2024

Future randomized controlled trials should evaluate the optimal PRU threshold to balance risks of ischemia and bleeding. Future randomized controlled trials should evaluate the optimal PRU threshold to balance risks of ischemia and bleeding. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Ischemia 40

Ischemia Outcomes Article 40

Journal of Cardiovascular Pharmacology

SEPTEMBER 28, 2023

The hearts were exposed to 15-second ischemia, and CRH was assessed in 10 mice each. The hearts were exposed to 15-second ischemia, and CRH was assessed in 10 mice each. We hypothesized that Ang-II exacerbates CRH-reduction in Tie2-sEH Tr versus WT. Coronary flow in Tie2-sEH Tr and WT was measured by Langendorff system. to 4.49 ± 0.8

Ischemia 40

Ischemia Cardiovascular Disease Article 40

Journal of Cardiovascular Pharmacology

OCTOBER 30, 2023

Isolated C57BL/6J mouse hearts were perfused via Langendorff apparatus for 20 minutes to obtain baseline function followed by 30 minutes of global ischemia. Isolated C57BL/6J mouse hearts were perfused via Langendorff apparatus for 20 minutes to obtain baseline function followed by 30 minutes of global ischemia.

Ischemia 40

Ischemia Outcomes Article 40

Dr. Smith's ECG Blog

NOVEMBER 28, 2022

Alternation in ST segment appearance ( or in the amount of ST elevation or depression ) — is often linked to ischemia. This may result from fluctuations in heart rate or in nervous system activity or from pharmacologic treatment. Repolarization Alternans — entails beat-to-beat variation in the ST segment and/or T wave.

Tachycardia 40

Tachycardia Pericarditis Ultrasound Blood Pressure 40

Dr. Smith's ECG Blog

SEPTEMBER 7, 2020

If the rhythm converts and then reverts to tachycardia with either adenosine or electricity, Neither one of those modalities should be attempted until some longer acting pharmacological solution is given. WPW does not always have delta waves on the baseline ECG. This is called "Concealed conduction".

Tachycardia 52

Tachycardia Heart Disease Dysrhythmia Ablation 52

Dr. Smith's ECG Blog

NOVEMBER 26, 2018

In some cases the ischemia can be seen "through" the flutter waves, whereas in other cases the arrhythmia must be terminated before the ischemia can be clearly distinguished. First , there can simply be diffuse ST depressions (which obligates reciprocal STE in aVR) associated with tachycardia which are not indicative of ischemia.

Ischemia 52

Ischemia Atrial Flutter Arrhythmia Tachycardia 52

DAIC

APRIL 11, 2024

PCI is commonly used to open blocked arteries to treat significant myocardial ischemia , which occurs when the heart muscle does not get enough oxygenated blood. Half of the participants were randomly assigned to receive PCI plus medical therapy and half received medical therapy alone.

Plaque 111

Plaque Heart attacks Heart Attack Coronary Artery Disease 111

DAIC

MAY 16, 2024

Pharmacological and behavioral-based strategies often increase the smoking cessation rate in people with PAD, however, these strategies are underused. If left untreated, PAD may progress to severe forms known as chronic limb-threatening ischemia (CLTI) and acute limb ischemia (ALI).

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Ischemia Quality of Life 105

Cardiometabolic Health Congress

MAY 10, 2024

In MSIMI (Mental Stress-induced Myocardial Ischemia) studies , mental stress activities like public speaking were evaluated for their impact on ischemia, measured via myocardial SPECT and vascular function (microvascular function, endothelial function). Combining behavioral and pharmacological treatment is most effective.

Coronary Artery Disease 59

Coronary Artery Disease Obesity Chest Pain Ischemia 59

DAIC

JANUARY 23, 2024

mg reduced the risk of cardiovascular death, MI or heart attack, ischemic stroke, or ischemia-driven coronary revascularization by 31% compared with placebo.34 Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review. This in turn leads to an overall reduction in IL-6 production and CRP concentration.12

Cardiovascular Disease 111

Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

Dr. Smith's ECG Blog

APRIL 8, 2016

If there is polymorphic VT with a long QT on the baseline ECG, then generally we call that Torsades, but Non-Torsades Polymorphic VT can result from ischemia alone. I have read articles that say that patients without ischemia are at low risk of complications from hypokalemia, But it is not entirely without risk.

STEMI 52

STEMI Myocardial Infarction Cardiac Arrest Arrhythmia 52

DAIC

FEBRUARY 7, 2024

Maeda’s award-winning presentation, Abstract 15, “Pharmacological Activation of Efferocytosis Prevents Intracranial Aneurysm Rupture,” was presented in a morning session Feb.

Stroke 105

Stroke Strokes Research Health Disparities 105

Stroke Journal

DECEMBER 30, 2024

Reperfusion injury (RI) refers to an array of detrimental cellular and biochemical processes that are widely believed to be triggered by reperfusion following focal cerebral ischemia and to contribute to infarct extension and poor outcome despite complete recanalization.

Pharmacology 40

Pharmacology Ischemia Stroke Strokes 40