Remove Ischemia Remove Myocardial Infarction Remove Pharmacology
article thumbnail

Role of autophagy in myocardial remodeling after myocardial infarction

Journal of Cardiovascular Pharmacology

In the heart, autophagy is regulated mainly through mitophagy due to the metabolic changes of cardiomyocytes caused by ischemia and hypoxia. Myocardial remodeling is characterized by gradual heart enlargement, cardiac dysfunction, and extraordinary molecular changes.

article thumbnail

ALKBH5 regulates N(6)-methyladenosine (m6A) methylation of MG53 to attenuate myocardial infarction by inhibiting apoptosis and oxidative stress

Journal of Cardiovascular Pharmacology

Abstract: N(6)-methyladenosine (m6A) methylation modification is involved in the progression of myocardial infarction (MI). The ischemia/reperfusion (I/R) injury mouse model and hypoxia/reoxygenation (H/R) cell model were established. The results provided a theoretical basis that ALKBH5 is a potential target for MI treatment.

article thumbnail

American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

DAIC

24 will focus on the following three current guideline updates: American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines 2023 Atrial Fibrillation Guideline - Pharmacology II: Strokes vs. Bleeds, What Do the Guidelines Tell Us About Practical Management in A-fib? The Guidelines Sessions at ACC.24

article thumbnail

Diffuse Subendocardial Ischemia on the ECG. Left main? 3-vessel disease? No!

Dr. Smith's ECG Blog

DISCUSSION: The 12-lead EKG EMS initially obtained for this patient showed severe ischemia, with profound "infero-lateral" ST depression and reciprocal ST elevation in lead aVR. The ECG cannot diagnose the etiology of ischemia; it only the presence of ischemia, from whatever etiology.

article thumbnail

Aldehyde dehydrogenase 2 preserves mitochondrial function in the ischemic heart: a redox-dependent mechanism for AMPK activation by thioredoxin-1

Journal of Cardiovascular Pharmacology

ALDH2 activation reduced ischemic-induced myocardial infarct size and apoptosis. ALDH2 protected mitochondrial function by enhancing mitochondrial RCR and ATP production, alleviated mitochondrial oxidative stress, and suppressed myocardial apoptosis. Copyright © 2023 Wolters Kluwer Health, Inc.

article thumbnail

Chest pain, a ‘normal’ ECG, a 'normal trop', and low HEART and EDACS scores: Discharge home? Stress test? Many errors here.

Dr. Smith's ECG Blog

ST-elevation myocardial infarction after pharmacologic persantine stress test in a patient with Wellens’ syndrome. Single High-Sensitivity Cardiac Troponin I to Rule Out Acute Myocardial Infarction. Was this objective evidence of inducible ischemia accompanied by chest pain? Lancet 2015 6.

article thumbnail

Arrhythmia? Ischemia? Both? Electricity, drugs, lytics, cath lab? You decide.

Dr. Smith's ECG Blog

In some cases the ischemia can be seen "through" the flutter waves, whereas in other cases the arrhythmia must be terminated before the ischemia can be clearly distinguished. First , there can simply be diffuse ST depressions (which obligates reciprocal STE in aVR) associated with tachycardia which are not indicative of ischemia.