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Targeting allograft inflammatory factor 1 reprograms kidney macrophages to enhance repair

Journal of Clinical Investigation - Cardiology

The role of macrophages (Ms) remains incompletely understood in kidney injury and repair. The plasticity of Ms offers an opportunity to polarize them toward mediating injury resolution in both native and transplanted kidneys undergoing ischemia and/or rejection.

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Abstract TP292: Chronic Kidney Disease Exacerbates Post-Stroke Cell Death and Inflammatory Mechanisms

Stroke Journal

Chronic kidney disease (CKD) is an important independent risk factor for stroke. The CKD cohort showed significant vascular fibrosis, collagen deposition, microvascular rarefaction, and tubulointerstitial abnormalities in the kidneys compared to the control.

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New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

DAIC

Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. If left untreated, PAD may progress to severe forms known as chronic limb-threatening ischemia (CLTI) and acute limb ischemia (ALI).

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Long‐Term Outcomes of Peripheral Artery Disease in Veterans: Analysis of the Peripheral Artery Disease Long‐Term Survival Study (PEARLS)

Journal of the American Heart Association

Study end points include mortality, cardiovascular events (hospitalization for acute myocardial infarction or stroke) and limb events (hospitalization for critical limb ischemia or major amputation) and were identified using Veterans Affairs and nonVeterans Affairs encounters.ResultsThe mean age was 70.6 were male, and 18.5% At 1 year, 9.4%

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Why the sudden shock after a few days of malaise?

Dr. Smith's ECG Blog

A VSR is more likely to occur in patients who are older, female, hypertensive, have chronic kidney disease, and have no prior history of smoking. It commonly occurs in the setting of a first myocardial infarction (MI) in the background of delayed or absent reperfusion therapy.

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Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

35 In a large multicenter double-blind randomized trial (LoDoCo2) involving 5,522 patients with clinically stable coronary artery disease, almost all of them on statin therapy, colchicine, 0.5 colchicine which poses the greatest risk among patients 65 or older who may have declining liver or kidney function.38 12 Colchicine, 0.5

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STEMI with Life-Threatening Hypokalemia and Incessant Torsades de Pointes

Dr. Smith's ECG Blog

He also had a history of chronic kidney disease, stage III. Angio had shown some acute disease in the saphenous vein graft to the posterior descending artery off of the RCA. I have read articles that say that patients without ischemia are at low risk of complications from hypokalemia, But it is not entirely without risk.

STEMI 52