Cardiology Update

JANUARY 14, 2024

As the medical community delves deeper into the intricacies of ANOCA, the study provides a compelling narrative for clinicians and researchers alike, aiming to decipher the complexities of myocardial bridges and their role in exercise-induced ischemia. Original article: Sinha A et al. Circ Cardiovasc Interv.

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Exercise Ischemia Angina Physiology 119

CardiacWire

NOVEMBER 8, 2024

Late-breaking second year results from the PROMISE II trial showed that the LimFlow system achieved strong outcomes for avoiding amputations and promoting limb salvage among “no-option” patients with chronic limb-threatening ischemia (CLTI). Ischemia in the treated limb also decreased significantly, with 65.8%

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Ischemia Research Diabetes Outcomes 64

DAIC

MAY 2, 2024

a developer of cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, today announced the primary endpoint results of the open label roll-in cohort of the CardiAMP Cell Therapy in Chronic Myocardial Ischemia Trial. Getty Images milla1cf Thu, 05/02/2024 - 10:12 May 2, 2024 — BioCardia, Inc. ,

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Ischemia Angina Heart Failure Outcomes 95

Dr. Smith's ECG Blog

MAY 30, 2024

ischemia) or it can be secondary to abnormal depolarization (e.g Discussion: The ECG in today's case does not have typical ST depression vector of diffuse subendocardial ischemia. The ST vector in subendocardial ischemia (SEI) usually has the largest amount of ST depression in leads II and V5, towards the apex of the heart. (ST

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Ischemia Coronary Angiogram Pulmonary STEMI 81

Dr. Smith's ECG Blog

SEPTEMBER 18, 2024

This confirms that the pain was ischemia and is now resovled. The cardiology fellow agreed with plan for emergent cath and escorted the patient to the cath lab. Another ECG was recorded after the nitroglycerine and now without pain: All findings are resolved. The i nitial hs troponin I returned 75%.

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Ischemia Plaque Stenosis Myocardial Infarction 124

Medical Xpress - Cardiology

JANUARY 9, 2024

However, reperfusion itself could induce more severe injury, called myocardial ischemia/reperfusion injury (MI/RI). The most effective treatment for MI in clinic is reperfusion, e.g., interventional or thrombolytic therapy.

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Ischemia Myocardial Infarction Research 75

Science Daily - Heart Disease

APRIL 10, 2024

Over 200 million people around the world experience peripheral artery disease (PAD) -- a condition caused by the narrowing of the blood vessels from the heart to the lower limbs that leads to pain when walking -- and for roughly 1-in-10 this advances to chronic limb-threatening ischemia (CLTI), an advanced form of PAD.

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Quality of Life Ischemia Peripheral Arterial Disease Plaque 71

Cardiovascular Diabetology

MAY 30, 2024

Ischemia and no obstructive coronary artery disease (INOCA) is increasingly recognized and associated with poor outcomes. The triglyceride-glucose (TyG) index is a reliable alternative measure of insulin resis.

Coronary Artery Disease 59

Coronary Artery Disease Ischemia Outcomes Research 59

Frontiers in Cardiovascular Medicine

FEBRUARY 1, 2024

In addition, with the prevalence of COVID-19 infection, more and more studies report that COVID-19 infection may lead to arteriovenous thrombosis, which could cause lower limb ischemia. This case reported that a 31-year-old male amateur football player who developed intermittent claudication after recovering from COVID-19.

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COVID-19 Ischemia Thrombosis 64

American College of Cardiology

JANUARY 2, 2024

The goal of the MINT trial was to compare the effect of a liberal vs. restrictive blood transfusion strategy on acute myocardial infarction (MI) in patients with concomitant anemia.

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Ischemia Myocardial Infarction Article 75

Cardiovascular Diabetology

DECEMBER 1, 2024

However, its role in diabetic hind-limb ischemia was not. Adipsin (complement factor D, CFD), as the first described adipokine, is well-known for its regulatory effects in diabetic cardiovascular complications.

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Ischemia Diabetes Research 52

Journal of Cardiothoracic Surgery

JANUARY 14, 2025

miRNA, circRNA, and lncRNA play crucial roles in the pathogenesis and progression of myocardial ischemia-reperfusion injury (MI/RI). This study aims to provide valuable insights into miRNA, circRNA, lncRNA, an.

Ischemia 52

Ischemia Research 52

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Introduction Accurate identification of the myocardial texture features of fat around the coronary artery on coronary computed tomography angiography (CCTA) images are crucial to improve clinical diagnostic efficiency of myocardial ischemia (MI).

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Ischemia 59

Journal of Cardiothoracic Surgery

JUNE 30, 2024

Myocardial ischemia-reperfusion injury (MIRI) is defined as the restoration of blood flow to the myocardium after a brief interruption of blood supply, causing more severe damage to the ischemic myocardium.

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Ischemia Research 52

DAIC

MARCH 28, 2024

The study describes the validation of Cleerly's artificial intelligence-guided quantitative coronary CT angiography (AI-QCT) ISCHEMIA technology for diagnostic accuracy and prognostic risk stratification. High Diagnostic Accuracy of AI-ISCHEMIA in Comparison to PET, FFR-CT, SPECT, and Invasive FFR: A Pacific Substudy. 2024.01.007.

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Ischemia Chest Pain Atherosclerosis Coronary Artery Disease 110

Circulation: Cardiovascular Interventions

DECEMBER 28, 2023

BACKGROUND:Lower-limb amputation rates in patients with chronic limb-threatening ischemia vary across the United States, with marked disparities in amputation rates by gender, race, and income status. Circulation: Cardiovascular Interventions, Ahead of Print. Mean age, 76.6

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Vascular Care Ischemia Medicare Hospital 61

Cardiovascular Diabetology

JANUARY 17, 2025

Ischemia with nonobstructive coronary arteries (INOCA) has high morbidity, mortality, and poor quality of life. Metabolic syndrome (MetS) is a complex of multiple cardiac metabolic risk factors, significantly.

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Ischemia Quality of Life Risk Factors Research 52

American College of Cardiology

OCTOBER 31, 2024

What are the contemporary outcomes and predictors of adverse events following endovascular treatment of acute limb ischemia (ALI) in a broad, nationwide, multicenter peripheral vascular registry?

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Ischemia Outcomes Article 45

Dr. Smith's ECG Blog

APRIL 14, 2024

No ischemia. This is a conundrum, because it is clear that the patient is having an acute MI, the ECG is dynamic, but the pain is very mild and there is no ECG evidence of active transmural ischemia. We already know that the ischemia is ongoing, though mild (because of the persistent pain). Q-waves are even more pronounced.

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Chest Pain Ischemia Myocardial Infarction Ultrasound 119

Dr. Smith's ECG Blog

JULY 25, 2024

The ECG shows severe ischemia, possibly posterior OMI. But cardiac arrest is a period of near zero flow in the coronary arteries and causes SEVERE ischemia. It takes time for that ischemia to resolve. The patient was brought to the ED and had this ECG recorded: What do you think? And what do you want to do?

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Cardiac Arrest Ischemia Tachycardia Defibrillator 123

EMS 12-Lead

APRIL 9, 2024

Many of the changes seen are reminiscent of LVH with “strain,” and downstream Echo may very well corroborate such a suspicion, but since the ECG isn’t the best tool for definitively establishing the presence of LVH, we must favor a subendocardial ischemia pattern, instead. Type I ischemia. Type II ischemia.

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Ischemia Stenosis Chest Pain Coronary Artery Disease 116

Cardiovascular Diabetology

MAY 19, 2024

There is conflicting evidence whether prediabetes is associated with adverse clinical outcomes in patients with chronic coronary syndrome. We aimed to assess the effect of prediabetes in patients with chronic.

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Ischemia Outcomes Research 64

Med Page Today

APRIL 29, 2024

(MedPage Today) -- The FDA approved the Esprit BTK everolimus-eluting scaffold system for chronic limb-threatening ischemia (CLTI) below the knee, Abbott announced on Monday. This system represents the first drug-eluting resorbable scaffold with.

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Peripheral Arterial Disease Stents Stent Ischemia 107

Dr. Smith's ECG Blog

MAY 20, 2024

This EKG is diagnostic of transmural ischemia of the inferior wall. If it is angina, lowering the BP with IV Nitroglycerine may completely alleviate the pain and the (unseen) ECG ischemia. Transmural ischemia (as seen with the OMI findings on ECG) is not very common with demand ischemia, but is possible.

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Chest Pain Blood Pressure Ischemia STEMI 128

Journal of the American Heart Association

DECEMBER 13, 2024

BackgroundAlthough there has been limited research into the perturbation of electrophysiological activity in the brain after ischemia, the activity signatures during ischemia and reperfusion remain to be fully elucidated.

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Electrophysiology Ischemia Research 40

ECG Cases

JUNE 18, 2024

acute Q waves or loss of R waves, hyperacute T waves, or reciprocal STD/TWI) and if the ECG is nondiagnostic, consider other OMI signs including clinical (refractory ischemia, hemodynamic/electrical instability) and POCUS (new regional wall motion abnormalities).

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STEMI Ischemia 127

Frontiers in Cardiovascular Medicine

JANUARY 28, 2024

Background Impaired energy balance caused by lipid metabolism dysregulation is an essential mechanism of myocardial ischemia-reperfusion injury (MI/RI). This study aims to explore the lipid metabolism-related gene (LMRG) expression patterns in MI/RI and to find potential therapeutic agents.

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Ischemia 59

DAIC

MARCH 27, 2024

Food and Drug Administration (FDA) for its DynamX BTK System, a novel, adaptive implant for use in the treatment of narrowed or blocked vessels below-the-knee (BTK) in patients with chronic limb-threatening ischemia (CLTI). The natural history of untreated severe or critical limb ischemia. 2013;382(9901):1329-1340. J Vasc Surg.

Peripheral Arterial Disease 111

Peripheral Arterial Disease Ischemia Technology Coronary Artery Disease 111

HCPLive

MAY 6, 2024

BI 764524 was well tolerated following intravitreal administration of single and multiple doses in the phase 1/2a trial, with signs pointing to early efficacy.

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Ischemia Diabetes 59

ECG Cases

SEPTEMBER 12, 2023

Jesse MacLaren guides us through 10 cases of patients who present with generalized weakness or acute neurologic symptoms and discusses how to look for ECG signs of dysrhythmias, electrolyte emergencies, acute coronary occlusion, and demand ischemia in patients with generalized weakness and in patients with neurologic symptoms, to consider predisposing (..)

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Dysrhythmia Atrial Fibrillation Embolism Blog 129

Journal of Cardiothoracic Surgery

JANUARY 14, 2025

This article aims to use high-throughput sequencing to identify miRNAs associated with ferroptosis in myocardial ischemiareperfusion injury, select a target miRNA, and investigate its role in H9C2 cells hypox.

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Ischemia Article Research 52

The New England Journal of Medicine

SEPTEMBER 4, 2024

In a 57-year-old man with chest pain, an ECG obtained by EMS showed widespread ST-segment depressions. At the hospital, left main coronary-artery stenosis was seen on angiography (shown in a video).

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Ischemia Chest Pain Stenosis Hospital 48

Frontiers in Cardiovascular Medicine

DECEMBER 14, 2023

Mitochondrial transplantation provides a novel methodology for rescue of cell viability and cell function following ischemia-reperfusion injury and applications for other pathologies are expanding. In this review we present our methods and acquired data and evidence accumulated to support the use of mitochondrial transplantation.

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Transplant Ischemia 104

Dr. Smith's ECG Blog

NOVEMBER 22, 2023

Important point: when there is diffuse subendocardial ischemia but no OMI, a wall motion abnormality will not necessarily be present. They agreed ischemia was likely in the setting of demand given DKA and infection. That this is all demand ischemia is unlikely. Lung exam showed diffuse B lines bilaterally. Aslanger's pattern.

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Chest Pain Ischemia Echocardiogram Myocardial Infarction 115

Medical Xpress - Cardiology

MAY 17, 2024

Coronary artery bypass grafting (CABG) is a surgical procedure that improves blood flow to the heart tissue and can effectively treat myocardial ischemia caused by coronary artery disease.

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Coronary Artery Bypass Graft Coronary Artery Disease Research Ischemia 96

Journal of Cardiovascular Electrophysiology

NOVEMBER 15, 2024

Central illustration: In those presenting With monomorphic VT, undergoing coronary ischemia assessment was associated With improved 12-month event-free survival from the primary endpoint of VT recurrence, ICD therapy, heart failure hospitalization, and death.

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Ischemia Tachycardia Outcomes Heart Failure 40

Ken Grauer, MD

DECEMBER 28, 2024

Unless a potentially fixable cause of this rhythm can be found ( ie, acute ischemia from recent infarction; electrolyte disturbance, use of rate-slowing medication ) the patient will need a pacemaker. This strongly suggests ischemia which could be recent and a contributing ( or precipitating) cause of todays abnormal rhythm.

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Blog Ischemia Pacemaker 169