article thumbnail

Short-Chain Acyl-CoA Dehydrogenase as a Therapeutic Target for Cardiac Fibrosis

Journal of Cardiovascular Pharmacology

Short-chain acyl-CoA dehydrogenase (SCAD) negatively regulates pathological cardiac hypertrophy. The purpose of this study was to investigate the possible role of SCAD in cardiac fibrosis. Short-chain acyl-CoA dehydrogenase (SCAD) negatively regulates pathological cardiac hypertrophy.

SCAD 40
article thumbnail

Flavin adenine dinucleotide ameliorates pressure overload-induced heart failure by activating the short-chain acyl-CoA dehydrogenase

Journal of Cardiovascular Pharmacology

Flavin adenine dinucleotide (FAD), a cofactor that catalyzes the reaction of flavin protein, participates in fatty acid -oxidation, which has been shown to inhibit pathological cardiac hypertrophy and fibrosis in spontaneously hypertensive rats. However, the therapeutic advantage of FAD for heart failure treatment has not been investigated.

article thumbnail

A review of the risk and precipitating factors for spontaneous coronary artery dissection

Frontiers in Cardiovascular Medicine

Introduction Spontaneous coronary artery dissection (SCAD) accounts for 1%–4% of cases of acute coronary syndrome (ACS). SCAD is caused by separation occurring within or between any of the three tunics of the coronary artery wall. The incidence of SCAD is higher in women than in men, with a ratio of approximately 9:1.

SCAD 88
article thumbnail

Management and outcomes of spontaneous coronary artery dissection: a systematic review of the literature

Frontiers in Cardiovascular Medicine

Background Contemporary management of spontaneous coronary artery dissection (SCAD) is still controversial. Results The systematic review included 13 observational studies evaluating 1,801 patients with SCAD. Results The systematic review included 13 observational studies evaluating 1,801 patients with SCAD. Approximately 48.5%

SCAD 75
article thumbnail

Rise of the Lysenkoist Cardiologists

Dr. Anish Koka

Women also had more cardiovascular risk factors, including hypertension (66.6% MINOCA now encompasses Spontaneous Coronary Artery Dissection (SCAD), a rare condition that is known to manifest primarily in women and affects the epicardial coronary artery. versus 63.2%; P <0.001), hyperlipidemia (68.9% years of age versus 59.0±8.4

article thumbnail

Update on sex specific risk factors in cardiovascular disease

Frontiers in Cardiovascular Medicine

For example, women with history of traditional cardiovascular risk factors including hypertension, tobacco use, and diabetes carry a higher risk of major cardiovascular events and mortality when compared to men. Sex differences exist in the prevalence and effect of cardiovascular risk factors.

article thumbnail

Which patient needs a CT scan?

Dr. Smith's ECG Blog

It was not SCAD (coronary dissection) Highest troponin I was 37,000 ng/L, but it was not measured to peak. As a result IV NTG was started, with complete resolution of the patient's CP ( and presumably significant improvement in her marked hypertension )! This was ruptured plaque with thrombus. See below ). 29, 2024 ). 29, 2024 ).